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Research Article

Effect of zinc and paraquat co-exposure on neurodegeneration: Modulation of oxidative stress and expression of metallothioneins, toxicant responsive and transporter genes in rats

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Pages 950-965 | Received 20 Apr 2010, Published online: 17 Jun 2010

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Read on this site (3)

Nor Haliza Mohamad Najib, Mohamad Fairuz Yahaya, Srijit Das & Seong Lin Teoh. (2023) The effects of metallothionein in paraquat-induced Parkinson disease model of zebrafish. International Journal of Neuroscience 133:8, pages 822-833.
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Brajesh Kumar Singh, Ashutosh Kumar, Israr Ahmad, Vinod Kumar, Devendra Kumar Patel, Swatantra Kumar Jain & Chetna Singh. (2011) Oxidative stress in zinc-induced dopaminergic neurodegeneration: Implications of superoxide dismutase and heme oxygenase-1. Free Radical Research 45:10, pages 1207-1222.
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Articles from other publishers (44)

Garima Singh, Namrata Mittra & Chetna Singh. (2022) Tempol and silymarin rescue from zinc-induced degeneration of dopaminergic neurons through modulation of oxidative stress and inflammation. Molecular and Cellular Biochemistry 478:8, pages 1705-1718.
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Jieun Lee, Suyeon Park & Wooyoung Jang. (2023) Serum zinc deficiency could be associated with dementia conversion in Parkinson’s disease. Frontiers in Aging Neuroscience 15.
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Aaina Singh Rathore, Saumitra Sen Singh, Hareram Birla, Walia Zahra, Priyanka Kumari Keshri, Hagera Dilnashin, Richa Singh, Shekhar Singh & Surya Pratap Singh. (2023) Curcumin Modulates p62–Keap1–Nrf2-Mediated Autophagy in Rotenone-Induced Parkinson’s Disease Mouse Models. ACS Chemical Neuroscience.
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Shunfeng Liu, Nan Wang, Yaqian Long, Zhuan Wu & Shouhong Zhou. (2023) Zinc Homeostasis: An Emerging Therapeutic Target for Neuroinflammation Related Diseases. Biomolecules 13:3, pages 416.
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María I. Martínez-Hernández, Leonor C. Acosta-Saavedra, Luisa C. Hernández-Kelly, Jaqueline Loaeza-Loaeza & Arturo Ortega. (2023) Microglial Activation in Metal Neurotoxicity: Impact in Neurodegenerative Diseases. BioMed Research International 2023, pages 1-27.
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Gaurav Mishra, Rajendra Awasthi, Anurag Kumar Singh, Snigdha Singh, Sunil Kumar Mishra, Santosh Kumar Singh & Manmath K. Nandi. (2022) Intranasally Co-administered Berberine and Curcumin Loaded in Transfersomal Vesicles Improved Inhibition of Amyloid Formation and BACE-1. ACS Omega 7:47, pages 43290-43305.
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Walia Zahra, Hareram Birla, Saumitra Sen Singh, Aaina Singh Rathore, Hagera Dilnashin, Richa Singh, Priyanka Kumari Keshri, Priyanka Gautam & Surya Pratap Singh. (2022) Neuroprotection by Mucuna pruriens in Neurodegenerative Diseases. Neurochemical Research 47:7, pages 1816-1829.
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Amit Kumar Chauhan, Namrata Mittra, Garima Singh & Chetna Singh. (2022) Mitochondrial Dysfunction Contributes To Zinc-induced Neurodegeneration: a Link with NADPH Oxidase. Journal of Molecular Neuroscience 72:6, pages 1413-1427.
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Anurag Kumar Singh, Saumitra Sen Singh, Aaina Singh Rathore, Surya Pratap Singh, Gaurav Mishra, Rajendra Awasthi, Sunil Kumar Mishra, Vibhav Gautam & Santosh Kumar Singh. (2021) Lipid-Coated MCM-41 Mesoporous Silica Nanoparticles Loaded with Berberine Improved Inhibition of Acetylcholine Esterase and Amyloid Formation. ACS Biomaterials Science & Engineering 7:8, pages 3737-3753.
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Joanna Sikora & Abdel-Mouttalib Ouagazzal. (2021) Synaptic Zinc: An Emerging Player in Parkinson’s Disease. International Journal of Molecular Sciences 22:9, pages 4724.
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Walia Zahra, Sachchida Nand Rai, Hareram Birla, Saumitra Sen Singh, Aaina Singh Rathore, Hagera Dilnashin, Richa Singh, Chetan Keswani, Rakesh K. Singh & Surya Pratap Singh. (2020) Neuroprotection of Rotenone-Induced Parkinsonism by Ursolic Acid in PD Mouse Model. CNS & Neurological Disorders - Drug Targets 19:7, pages 527-540.
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Namrata Mittra, Amit Kumar Chauhan, Garima Singh, Devendra Kumar Patel & Chetna Singh. (2020) Postnatal zinc or paraquat administration increases paraquat or zinc-induced loss of dopaminergic neurons: insight into augmented neurodegeneration. Molecular and Cellular Biochemistry 467:1-2, pages 27-43.
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Joanna Sikora, Brigitte L. Kieffer, Pierre Paoletti & Abdel-Mouttalib Ouagazzal. (2020) Synaptic zinc contributes to motor and cognitive deficits in 6-hydroxydopamine mouse models of Parkinson's disease. Neurobiology of Disease 134, pages 104681.
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Sachchida Nand Rai, Walia Zahra, Saumitra Sen Singh, Hareram Birla, Chetan Keswani, Hagera Dilnashin, Aaina Singh Rathore, Rajan Singh, Rakesh K. Singh & Surya Pratap Singh. (2019) Anti-inflammatory Activity of Ursolic Acid in MPTP-Induced Parkinsonian Mouse Model. Neurotoxicity Research 36:3, pages 452-462.
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Haruna Tamano, Hiroki Morioka, Ryusuke Nishio, Azusa Takeuchi & Atsushi Takeda. (2018) Blockade of Rapid Influx of Extracellular Zn2+ into Nigral Dopaminergic Neurons Overcomes Paraquat-Induced Parkinson’s Disease in Rats. Molecular Neurobiology 56:6, pages 4539-4548.
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Hareram Birla, Sachchida Nand Rai, Saumitra Sen Singh, Walia Zahra, Arun Rawat, Neeraj Tiwari, Rakesh K. Singh, Abhishek Pathak & Surya Pratap Singh. (2019) Tinospora cordifolia Suppresses Neuroinflammation in Parkinsonian Mouse Model. NeuroMolecular Medicine 21:1, pages 42-53.
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Amit Kumar Chauhan, Namrata Mittra, Brajesh Kumar Singh & Chetna Singh. (2018) Inhibition of glutathione S-transferase-pi triggers c-jun N-terminal kinase-dependent neuronal death in Zn-induced Parkinsonism. Molecular and Cellular Biochemistry 452:1-2, pages 95-104.
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Fangjie Cao, Christopher L. Souders II, Veronica Perez-Rodriguez & Christopher J. Martyniuk. (2019) Elucidating Conserved Transcriptional Networks Underlying Pesticide Exposure and Parkinson's Disease: A Focus on Chemicals of Epidemiological Relevance. Frontiers in Genetics 9.
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Saumitra S. Singh, Sachchida N. Rai, Hareram Birla, Walia Zahra, Gaurav Kumar, Mallikarjuna R. Gedda, Neeraj Tiwari, Ranjana Patnaik, Rakesh K. Singh & Surya P. Singh. (2018) Effect of Chlorogenic Acid Supplementation in MPTP-Intoxicated Mouse. Frontiers in Pharmacology 9.
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Vinod Kumar, Deepali Singh, Brajesh Kumar Singh, Shweta Singh, Namrata Mittra, Rakesh Roshan Jha, Devendra Kumar Patel & Chetna Singh. (2017) Alpha-synuclein aggregation, Ubiquitin proteasome system impairment, and l-Dopa response in zinc-induced Parkinsonism: resemblance to sporadic Parkinson’s disease. Molecular and Cellular Biochemistry 444:1-2, pages 149-160.
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Mohammad Naderi, Arash Salahinejad, Maud C.O. Ferrari, Som Niyogi & Douglas P. Chivers. (2018) Dopaminergic dysregulation and impaired associative learning behavior in zebrafish during chronic dietary exposure to selenium. Environmental Pollution 237, pages 174-185.
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Amit Kumar Chauhan, Namrata Mittra, Devendra Kumar Patel & Chetna Singh. (2017) Cyclooxygenase-2 Directs Microglial Activation-Mediated Inflammation and Oxidative Stress Leading to Intrinsic Apoptosis in Zn-Induced Parkinsonism. Molecular Neurobiology 55:3, pages 2162-2173.
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Sachchida N. Rai, Hareram Birla, Saumitra S. Singh, Walia Zahra, Ravishankar R. Patil, Jyoti P. Jadhav, Mallikarjuna R. Gedda & Surya P. Singh. (2017) Mucuna pruriens Protects against MPTP Intoxicated Neuroinflammation in Parkinson’s Disease through NF-κB/pAKT Signaling Pathways. Frontiers in Aging Neuroscience 9.
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Satyndra Kumar Yadav, Shivani Pandey & Babita Singh. (2017) Role of estrogen and levodopa in 1-methyl-4-pheny-l-1, 2, 3, 6-tetrahydropyridine (mptp)-induced cognitive deficit in Parkinsonian ovariectomized mice model: A comparative study. Journal of Chemical Neuroanatomy 85, pages 50-59.
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Brajesh Kumar Singh, Vinod Kumar, Amit Kumar Chauhan, Ashish Dwivedi, Shweta Singh, Ashutosh Kumar, Deepali Singh, Devendra Kumar Patel, Ratan Singh Ray, Swatantra Kumar Jain & Chetna Singh. (2016) Neuronal Nitric Oxide Synthase Negatively Regulates Zinc-Induced Nigrostriatal Dopaminergic Neurodegeneration. Molecular Neurobiology 54:4, pages 2685-2696.
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Satyndra Kumar Yadav, Sachchida Nand Rai & Surya Pratap Singh. (2017) Mucuna pruriens reduces inducible nitric oxide synthase expression in Parkinsonian mice model. Journal of Chemical Neuroanatomy 80, pages 1-10.
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Ashutosh Kumar, Douglas Ganini & Ronald P. Mason. (2016) Role of cytochrome c in α-synuclein radical formation: implications of α-synuclein in neuronal death in Maneb- and paraquat-induced model of Parkinson’s disease. Molecular Neurodegeneration 11:1.
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Amit Kumar Chauhan, Namrata Mittra, Vinod Kumar, Devendra Kumar Patel & Chetna Singh. (2015) Inflammation and B-cell Lymphoma-2 Associated X Protein Regulate Zinc-Induced Apoptotic Degeneration of Rat Nigrostriatal Dopaminergic Neurons. Molecular Neurobiology 53:8, pages 5782-5795.
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Vinod Kumar, Brajesh Kumar Singh, Amit Kumar Chauhan, Deepali Singh, Devendra Kumar Patel & Chetna Singh. (2015) Minocycline Rescues from Zinc-Induced Nigrostriatal Dopaminergic Neurodegeneration: Biochemical and Molecular Interventions. Molecular Neurobiology 53:5, pages 2761-2777.
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Sachchida Nand Rai, Satyndra Kumar Yadav, Divakar Singh & Surya Pratap Singh. (2016) Ursolic acid attenuates oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in MPTP-induced Parkinsonian mouse model. Journal of Chemical Neuroanatomy 71, pages 41-49.
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Ashutosh Kumar, Smriti Shukla, Amit Kumar Chauhan, Deepali Singh, Haushila Prasad Pandey & Chetna Singh. (2015) The manganese-salen compound EUK-134 and N-acetyl cysteine rescue from zinc- and paraquat-induced toxicity in rat polymorphonuclear leukocytes. Chemico-Biological Interactions 231, pages 18-26.
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Israr Ahmad, Smriti Shukla, Deepali Singh, Amit Kumar Chauhan, Vinod Kumar, Brajesh Kumar Singh, Devendra Kumar Patel, Haushila Prasad Pandey & Chetna Singh. (2014) CYP2E1-mediated oxidative stress regulates HO-1 and GST expression in maneb- and paraquat-treated rat polymorphonuclear leukocytes. Molecular and Cellular Biochemistry 393:1-2, pages 209-222.
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Bruno Nunes, Ricardo Campinho Capela, Tânia Sérgio, Carina Caldeira, Fernando Gonçalves & Alberto Teodorico Correia. (2014) Effects of chronic exposure to lead, copper, zinc, and cadmium on biomarkers of the European eel, Anguilla anguilla. Environmental Science and Pollution Research 21:8, pages 5689-5700.
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Naveen Kumar Singhal, Amit Kumar Chauhan, Swatantra Kumar Jain, Rishi Shanker, Chetna Singh & Mahendra Pratap Singh. (2013) Silymarin- and melatonin-mediated changes in the expression of selected genes in pesticides-induced Parkinsonism. Molecular and Cellular Biochemistry 384:1-2, pages 47-58.
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Jay Prakash, Satyndra Kumar Yadav, Shikha Chouhan & Surya Pratap Singh. (2013) Neuroprotective Role of Withania somnifera Root Extract in Maneb–Paraquat Induced Mouse Model of Parkinsonism. Neurochemical Research 38:5, pages 972-980.
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Jay Prakash, Satyndra Kumar Yadav, Shikha Chouhan, Satya Prakash & Surya Pratap Singh. (2013) Synergistic effect of Mucuna pruriens and Withania somnifera in a paraquat induced Parkinsonian mouse model. Advances in Bioscience and Biotechnology 04:11, pages 1-9.
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Manindra Nath Tiwari, Anand Kumar Singh, Sonal Agrawal, Satya Prakash Gupta, Anurag Jyoti, Rishi Shanker, Om Prakash & Mahendra Pratap Singh. (2012) Cypermethrin Alters the Expression Profile of mRNAs in the Adult Rat Striatum: A Putative Mechanism of Postnatal Pre-exposure Followed by Adulthood Re-exposure-Enhanced Neurodegeneration. Neurotoxicity Research 22:4, pages 321-334.
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Sharawan Yadav, Anubhuti Dixit, Sonal Agrawal, Ashish Singh, Garima Srivastava, Anand Kumar Singh, Pramod Kumar Srivastava, Om Prakash & Mahendra Pratap Singh. (2012) Rodent Models and Contemporary Molecular Techniques: Notable Feats yet Incomplete Explanations of Parkinson’s Disease Pathogenesis. Molecular Neurobiology 46:2, pages 495-512.
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Ashutosh Kumar, Brajesh Kumar Singh, Israr Ahmad, Smriti Shukla, Devendra Kumar Patel, Garima Srivastava, Vinod Kumar, Haushila Prasad Pandey & Chetna Singh. (2012) Involvement of NADPH oxidase and glutathione in zinc-induced dopaminergic neurodegeneration in rats: Similarity with paraquat neurotoxicity. Brain Research 1438, pages 48-64.
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Naveen Kumar Singhal, Garima Srivastava, Sonal Agrawal, Swatantra Kumar Jain & Mahendra Pratap Singh. (2011) Melatonin as a Neuroprotective Agent in the Rodent Models of Parkinson’s Disease: Is it All Set to Irrefutable Clinical Translation?. Molecular Neurobiology 45:1, pages 186-199.
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Jing Shi, Chun-lin Hu, Yu-feng Gao, Xiao-xing Liao & Hope Xu. (2012) The relationship between platelet endothelial cell adhesion molecule-1 and paraquat-induced lung injury in rabbits. World Journal of Emergency Medicine 3:1, pages 60.
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Awadhesh K. Arya, Deepa Pokharia & Kamlakar Tripathi. (2011) Relationship between oxidative stress and apoptotic markers in lymphocytes of diabetic patients with chronic non healing wound. Diabetes Research and Clinical Practice 94:3, pages 377-384.
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Israr Ahmad, Smriti Shukla, Ashutosh Kumar, Brajesh Kumar Singh, Devendra Kumar Patel, Haushila Prasad Pandey & Chetna Singh. (2010) Maneb and paraquat-induced modulation of toxicant responsive genes in the rat liver: Comparison with polymorphonuclear leukocytes. Chemico-Biological Interactions 188:3, pages 566-579.
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Naveen Kumar Singhal, Garima Srivastava, Devendra Kumar Patel, Swatantra Kumar Jain & Mahendra Pratap Singh. (2010) Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson’s disease phenotype in the mouse. Journal of Pineal Research, pages no-no.
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