Citations (111)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (8)
Mitchell R. McGill & Jack A. Hinson. (2020) The development and hepatotoxicity of acetaminophen: reviewing over a century of progress. Drug Metabolism Reviews 52:4, pages 472-500.
Read now
Read now
Daren R. Ure, Daniel J. Trepanier, Patrick R. Mayo & Robert T. Foster. (2020) Cyclophilin inhibition as a potential treatment for nonalcoholic steatohepatitis (NASH). Expert Opinion on Investigational Drugs 29:2, pages 163-178.
Read now
Read now
Otto Kučera, René Endlicher, David Rychtrmoc, Halka Lotková, Ondřej Sobotka & Zuzana Červinková. (2017) Acetaminophen toxicity in rat and mouse hepatocytes in vitro. Drug and Chemical Toxicology 40:4, pages 448-456.
Read now
Read now
Somsubhra Thakur Choudhury, Nirmalendu Das, Swarupa Ghosh, Debasree Ghosh, Somsuta Chakraborty & Nahid Ali. (2016) Vesicular (liposomal and nanoparticulated) delivery of curcumin: a comparative study on carbon tetrachloride–mediated oxidative hepatocellular damage in rat model. International Journal of Nanomedicine 11, pages 2179-2193.
Read now
Read now
Kuo Du, Yuchao Xie, Mitchell R McGill & Hartmut Jaeschke. (2015) Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity. Expert Opinion on Drug Metabolism & Toxicology 11:11, pages 1769-1779.
Read now
Read now
Mitchell R McGill & Hartmut Jaeschke. (2014) Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients. Expert Opinion on Drug Metabolism & Toxicology 10:7, pages 1005-1017.
Read now
Read now
Hartmut Jaeschke, Mitchell R. McGill & Anup Ramachandran. (2012) Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity. Drug Metabolism Reviews 44:1, pages 88-106.
Read now
Read now
Claudia V Pereira, Sashi Nadanaciva, Paulo J Oliveira & Yvonne Will. (2012) The contribution of oxidative stress to drug-induced organ toxicity and its detection in vitro and in vivo
. Expert Opinion on Drug Metabolism & Toxicology 8:2, pages 219-237.
Read now
Read now
Articles from other publishers (103)
Mitchell R. McGill & Steven C. Curry. (2023) The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review. Livers 3:4, pages 569-596.
Crossref
Crossref
Divya Saro Varghese, Deepu Oommen, Anne John & Bassam R. Ali. (2023) GRP78/BiP alleviates oxLDL-induced hepatotoxicity in familial hypercholesterolemia caused by missense variants of LDLR in a HepG2 cellular model. Lipids in Health and Disease 22:1.
Crossref
Crossref
Anup Ramachandran & Hartmut Jaeschke. (2023) Mitochondria in Acetaminophen-Induced Liver Injury and Recovery: A Concise Review. Livers 3:2, pages 219-231.
Crossref
Crossref
Qiang Ding, Yue Wang, Shu-Wen Xia, Fang Zhao, Ji-Feng Zhong, Hui-Li Wang & Kun-Lin Chen. (2022) SIRT4 Expression Ameliorates the Detrimental Effect of Heat Stress via AMPK/mTOR Signaling Pathway in BMECs. International Journal of Molecular Sciences 23:21, pages 13307.
Crossref
Crossref
Xiaopeng Cai, Huiqiang Cai, Jing Wang, Qin Yang, Jun Guan, Jingwen Deng & Zhi Chen. (2022) Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options对乙酰氨基酚诱导的肝损伤的分子发病机制及治疗策略. Journal of Zhejiang University-SCIENCE B 23:4, pages 265-285.
Crossref
Crossref
Dejiu Zhang, Fei Wang, Peifeng Li & Yanyan Gao. (2022) Mitochondrial Ca2+ Homeostasis: Emerging Roles and Clinical Significance in Cardiac Remodeling. International Journal of Molecular Sciences 23:6, pages 3025.
Crossref
Crossref
Xinlei Wang, Yang Zhang, Kun Wuyun & Haixia Gong. (2021) Therapeutic effect and mechanism of 4‑phenyl butyric acid on renal ischemia‑reperfusion injury in mice. Experimental and Therapeutic Medicine 23:2.
Crossref
Crossref
Hartmut Jaeschke, Olamide B. Adelusi, Jephte Y. Akakpo, Nga T. Nguyen, Giselle Sanchez-Guerrero, David S. Umbaugh, Wen-Xing Ding & Anup Ramachandran. (2021) Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls. Acta Pharmaceutica Sinica B 11:12, pages 3740-3755.
Crossref
Crossref
Svetlana Rodimova, Vadim Elagin, Maria Karabut, Irina Koryakina, Alexander Timin, Vladimir Zagainov, Mikhail Zyuzin, Elena Zagaynova & Daria Kuznetsova. (2021) Toxicological Analysis of Hepatocytes Using FLIM Technique: In Vitro versus Ex Vivo Models. Cells 10:11, pages 2894.
Crossref
Crossref
Hartmut Jaeschke, Olamide B. Adelusi & Anup Ramachandran. (2021) Ferroptosis and Acetaminophen Hepatotoxicity: Are We Going Down Another Rabbit Hole?. Gene Expression 20:3, pages 169-178.
Crossref
Crossref
Hartmut Jaeschke, F. Jay Murray, Andrew D. Monnot, David Jacobson-Kram, Samuel M. Cohen, Jerry F. Hardisty, Evren Atillasoy, Anne Hermanowski-Vosatka, Edwin Kuffner, Daniele Wikoff, Grace A. Chappell, Suren B. Bandara, Milind Deore, Suresh Kumar Pitchaiyan & Gary Eichenbaum. (2021) Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential. Regulatory Toxicology and Pharmacology 120, pages 104859.
Crossref
Crossref
Seong Eun Jin, Hyeun-Kyoo Shin & Hyekyung Ha. (2021) Hepatoprotective effects of Gamisoyo-san against acetaminophen-induced liver injuries. Integrative Medicine Research 10:1, pages 100466.
Crossref
Crossref
Darshpreet Kaur & Rahul Deshmukh. 2021. Clinical Perspectives and Targeted Therapies in Apoptosis. Clinical Perspectives and Targeted Therapies in Apoptosis
23
78
.
Layla Shojaie, Andrea Iorga & Lily Dara. (2020) Cell Death in Liver Diseases: A Review. International Journal of Molecular Sciences 21:24, pages 9682.
Crossref
Crossref
Manuel Gutiérrez-Aguilar. (2020) Mitochondrial calcium transport and permeability transition as rational targets for plant protection. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1861:12, pages 148288.
Crossref
Crossref
Bharat Bhushan & Udayan Apte. (2020) Acetaminophen Test Battery (ATB): A Comprehensive Method to Study Acetaminophen-Induced Acute Liver Injury. Gene Expression 20:2, pages 125-138.
Crossref
Crossref
Yugo Ikeyama, Tomoyuki Sato, Akinori Takemura, Shuichi Sekine & Kousei Ito. (2020) Hypoxia/reoxygenation exacerbates drug-induced cytotoxicity by opening mitochondrial permeability transition pore: Possible application for toxicity screening. Toxicology in Vitro 67, pages 104889.
Crossref
Crossref
Anup Ramachandran & Hartmut Jaeschke. (2020) A mitochondrial journey through acetaminophen hepatotoxicity. Food and Chemical Toxicology 140, pages 111282.
Crossref
Crossref
Xiaowen Ma, Tara McKeen, Jianhua Zhang & Wen-Xing Ding. (2020) Role and Mechanisms of Mitophagy in Liver Diseases. Cells 9:4, pages 837.
Crossref
Crossref
Rodrigo L. Castillo, Mauricio Ibacache, Ignacio Cortínez, Catalina Carrasco-Pozo, Jorge G. Farías, Rodrigo A. Carrasco, Patricio Vargas-Errázuriz, Daniel Ramos, Rafael Benavente, Daniela Henríquez Torres & Aníbal Méndez. (2020) Dexmedetomidine Improves Cardiovascular and Ventilatory Outcomes in Critically Ill Patients: Basic and Clinical Approaches. Frontiers in Pharmacology 10.
Crossref
Crossref
John J. Lemasters & Hartmut Jaeschke. 2020. The Liver. The Liver
714
727
.
Lily Dara & Neil Kaplowitz. 2020. The Liver. The Liver
701
713
.
Yoichi Ishitsuka, Yuki Kondo & Daisuke Kadowaki. (2020) Toxicological Property of Acetaminophen: The Dark Side of a Safe Antipyretic/Analgesic Drug?. Biological and Pharmaceutical Bulletin 43:2, pages 195-206.
Crossref
Crossref
Satoka Aizawa, Gurmehr Brar & Hidekazu Tsukamoto. (2020) Cell Death and Liver Disease. Gut and Liver 14:1, pages 20-29.
Crossref
Crossref
Erika Ramos‐Tovar & Pablo Muriel. (2019) Free radicals, antioxidants, nuclear factor‐E2‐related factor‐2 and liver damage. Journal of Applied Toxicology 40:1, pages 151-168.
Crossref
Crossref
Jephte Y Akakpo, Anup Ramachandran, Luqi Duan, Matthew A Schaich, Matthew W Jaeschke, Bret D Freudenthal, Wen-Xing Ding, Barry H Rumack & Hartmut Jaeschke. (2019) Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase. Toxicological Sciences 170:1, pages 57-68.
Crossref
Crossref
Ahmed R.G.. (2019) Overdoses of Acetaminophen Disrupt the Thyroid-Liver Axis in Neonatal Rats. Endocrine, Metabolic & Immune Disorders - Drug Targets 19:5, pages 705-714.
Crossref
Crossref
Melissa M. Clemens, Mitchell R. McGill & Udayan Apte. 2019. Drug-induced Liver Injury. Drug-induced Liver Injury
241
262
.
Anup Ramachandran & Hartmut Jaeschke. 2019. Drug-induced Liver Injury. Drug-induced Liver Injury
195
219
.
Andrea Iorga & Lily Dara. 2019. Drug-induced Liver Injury. Drug-induced Liver Injury
31
74
.
Kuo Du, Anup Ramachandran, James L. Weemhoff, Benjamin L. Woolbright, Andrew H. Jaeschke, Xiaojuan Chao, Wen-Xing Ding & Hartmut Jaeschke. (2018) Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity. Archives of Toxicology 93:1, pages 163-178.
Crossref
Crossref
Hui Ye, Leonard J Nelson, Manuel Gómez del Moral, Eduardo Martínez-Naves & Francisco Javier Cubero. (2018) Dissecting the molecular pathophysiology of drug-induced liver injury. World Journal of Gastroenterology 24:13, pages 1373-1385.
Crossref
Crossref
Anup Ramachandran & Hartmut Jaeschke. (2018) Acetaminophen Toxicity: Novel Insights Into Mechanisms and Future Perspectives. Gene Expression 18:1, pages 19-30.
Crossref
Crossref
Benjamin L. Woolbright & Hartmut Jaeschke. 2018. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants
373
382
.
Dong Seok Lee & Yong Wook Jung. (2018) Protective Effect of Right Ventricular Mitochondrial Damage by Cyclosporine A in Monocrotaline-induced Pulmonary Hypertension. Korean Circulation Journal 48:12, pages 1135.
Crossref
Crossref
H. Jaeschke, M.L. Bajt & A. Ramachandran. 2018. Comprehensive Toxicology. Comprehensive Toxicology
460
482
.
Bernd Gesslbauer & Valery Bochkov. (2017) Biochemical targets of drugs mitigating oxidative stress via redox-independent mechanisms. Biochemical Society Transactions 45:6, pages 1225-1252.
Crossref
Crossref
Hiroki Yoshioka, Haruki Usuda, Hirohisa Fujii & Tsunemasa Nonogaki. (2017) Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice. Environmental Health and Preventive Medicine 22:1.
Crossref
Crossref
Si Shi, Limei Yao, Kunbin Guo, Xiangyu Wang, Qi Wang & Weirong Li. (2017) Hepatocellular toxicity of oxalicumone A via oxidative stress injury and mitochondrial dysfunction in healthy human liver cells. Molecular Medicine Reports.
Crossref
Crossref
Hiroki Yoshioka, Yutaka Aoyagi, Nobuyuki Fukuishi, Ming-Yu Gui, Yong-Ri Jin, Xu-Wen Li, Yoshiyuki Adachi, Naohito Ohno, Koichi Takeya, Yukio Hitotsuyanagi, Nobuhiko Miura & Tsunemasa Nonogaki. (2017) Suppressive effect of kamebakaurin on acetaminophen-induced hepatotoxicity by inhibiting lipid peroxidation and inflammatory response in mice. Pharmacological Reports 69:5, pages 903-907.
Crossref
Crossref
Kuo Du, Anup Ramachandran, Mitchell R. McGill, Abdellah Mansouri, Tarik Asselah, Anwar Farhood, Benjamin L. Woolbright, Wen-Xing Ding & Hartmut Jaeschke. (2017) Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity. Food and Chemical Toxicology.
Crossref
Crossref
Andrea Iorga, Lily Dara & Neil Kaplowitz. (2017) Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis. International Journal of Molecular Sciences 18:5, pages 1018.
Crossref
Crossref
Amina Ibrahim Shehu, Xiaochao Ma & Raman Venkataramanan. (2017) Mechanisms of Drug-Induced Hepatotoxicity. Clinics in Liver Disease 21:1, pages 35-54.
Crossref
Crossref
Kuo Du, Anwar Farhood & Hartmut Jaeschke. (2016) Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Archives of Toxicology 91:2, pages 761-773.
Crossref
Crossref
A. Ramachandran & H. Jaeschke. 2017. Liver Pathophysiology. Liver Pathophysiology
101
112
.
Lily Dara & Neil Kaplowitz. 2017. Cellular Injury in Liver Diseases. Cellular Injury in Liver Diseases
1
35
.
Luqi Duan, John S. Davis, Benjamin L. Woolbright, Kuo Du, Mala Cahkraborty, James Weemhoff, Hartmut Jaeschke & Mohammed Bourdi. (2016) Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J. Food and Chemical Toxicology 98, pages 107-118.
Crossref
Crossref
Lily Dara, Zhang-Xu Liu & Neil Kaplowitz. (2016) A murder mystery in the liver: who done it and how?. Journal of Clinical Investigation 126:11, pages 4068-4071.
Crossref
Crossref
Sanda Win, Tin Aung Than, Robert Win Maw Min, Mariam Aghajan & Neil Kaplowitz. (2016) c‐Jun N‐terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)‐dependent pathway leading to inactivation of intramitochondrial Src. Hepatology 63:6, pages 1987-2003.
Crossref
Crossref
Jiangting Hu, Venkat K. Ramshesh, Mitchell R. McGill, Hartmut Jaeschke & John J. Lemasters. (2016) Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver. Toxicological Sciences 150:1, pages 204-215.
Crossref
Crossref
Hilal Bektas Uysal, Bekir Da?l?, Mustafa Y?lmaz, Fadime Kahyao?lu, Alparslan G?k?imen, ?mran Kurt ?m?rl? & Buket Demirci. (2016) Biochemical and Histological Effects of Thiamine Pyrophosphate against Acetaminophen-Induced Hepatotoxicity. Basic & Clinical Pharmacology & Toxicology 118:1, pages 70-76.
Crossref
Crossref
A. Ramachandran & H. Jaeschke. 2016. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.
Yuchao Xie, Mitchell R. McGill, Kuo Du, Kenneth Dorko, Sean C. Kumer, Timothy M. Schmitt, Wen-Xing Ding & Hartmut Jaeschke. (2015) Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes. Toxicology and Applied Pharmacology 289:2, pages 213-222.
Crossref
Crossref
Mitchell R. McGill, Kuo Du, James L. Weemhoff & Hartmut Jaeschke. (2015) Critical review of resveratrol in xenobiotic-induced hepatotoxicity. Food and Chemical Toxicology 86, pages 309-318.
Crossref
Crossref
Kuo Du, Mitchell R. McGill, Yuchao Xie & Hartmut Jaeschke. (2015) Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses. Food and Chemical Toxicology 86, pages 253-261.
Crossref
Crossref
Lily Dara, Heather Johnson, Jo Suda, Sanda Win, William Gaarde, Derick Han & Neil Kaplowitz. (2015) Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. Hepatology 62:6, pages 1847-1857.
Crossref
Crossref
Lily Dara, Heather Johnson & Neil Kaplowitz. 2015. Mitochondria in Liver Disease. Mitochondria in Liver Disease
195
212
.
Mitchell R. McGill, Yuchao Xie & Hartmut Jaeschke. 2015. Signaling Pathways in Liver Diseases. Signaling Pathways in Liver Diseases
469
478
.
Yuchao Xie, Anup Ramachandran, David G. Breckenridge, John T. Liles, Margitta Lebofsky, Anwar Farhood & Hartmut Jaeschke. (2015) Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury. Toxicology and Applied Pharmacology 286:1, pages 1-9.
Crossref
Crossref
Jason KarchJeffery D. Molkentin. (2015) Regulated Necrotic Cell Death. Circulation Research 116:11, pages 1800-1809.
Crossref
Crossref
Anup Ramachandran, Margitta Lebofsky, Hui-Min Yan, Steven A. Weinman & Hartmut Jaeschke. (2015) Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice. Archives of Toxicology 89:5, pages 773-783.
Crossref
Crossref
M Bonora, M R Wieckowski, C Chinopoulos, O Kepp, G Kroemer, L Galluzzi & P Pinton. (2014) Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition. Oncogene 34:12, pages 1475-1486.
Crossref
Crossref
Mitchell R. McGill, C. David Williams & Hartmut Jaeschke. 2015. Mammalian Toxicology. Mammalian Toxicology
453
471
.
Shakila Tobwala, Ahdab Khayyat, Weili Fan & Nuran Ercal. (2014) Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells. Experimental Biology and Medicine 240:2, pages 261-272.
Crossref
Crossref
Jennifer Q. Kwong & Jeffery D. Molkentin. (2015) Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart. Cell Metabolism 21:2, pages 206-214.
Crossref
Crossref
Constance Mobley & Ali Zarrinpar. 2015. Transplantation of the Liver. Transplantation of the Liver
40
57
.
Mitchell R. McGill & Hartmut Jaeschke. 2015. Studies on Hepatic Disorders. Studies on Hepatic Disorders
199
214
.
Qingyan Cai, Jingjing Wei, Wei Zhao, Si Shi, Yu Zhang, Renrong Wei, Yue Zhang, Weirong Li & Qi Wang. (2014) Toxicity of Evodiae fructus on Rat Liver Mitochondria: The Role of Oxidative Stress and Mitochondrial Permeability Transition. Molecules 19:12, pages 21168-21182.
Crossref
Crossref
Kuo Du, C. David Williams, Mitchell R. McGill & Hartmut Jaeschke. (2014) Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase. Toxicology and Applied Pharmacology 281:1, pages 58-66.
Crossref
Crossref
Nikolai V. Naoumov. (2014) Cyclophilin inhibition as potential therapy for liver diseases. Journal of Hepatology 61:5, pages 1166-1174.
Crossref
Crossref
Nayeema Akther, Khursheed Andrabi, Albeena Nissar, Showkat Ganaie, B.K. Chandan, A.P. Gupta, Manoj Khuswant, Sarwat Sultana & Abdul S. Shawl. (2014) Hepatoprotective activity of LC?ESI-MS standardized Iris spuria rhizome extract on its main bioactive constituents. Phytomedicine 21:10, pages 1202-1207.
Crossref
Crossref
C. David Williams, Mitchell R. McGill, Margitta Lebofsky, Mary Lynn Bajt & Hartmut Jaeschke. (2014) Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning. Toxicology and Applied Pharmacology 274:3, pages 417-424.
Crossref
Crossref
Jörn M. Schattenberg & Mark J. Czaja. (2014) Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling. Redox Biology 3, pages 7-15.
Crossref
Crossref
Deepa K. Ingawale, Satish K. Mandlik & Suresh R. Naik. (2014) Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism(s): A critical discussion. Environmental Toxicology and Pharmacology 37:1, pages 118-133.
Crossref
Crossref
B.L. Woolbright, C.D. Williams, M.R. McGill & H. Jaeschke. 2014. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Mitchell R. McGill, Anup Ramachandran & Hartmut Jaeschke. 2014. Systems Biology of Free Radicals and Antioxidants. Systems Biology of Free Radicals and Antioxidants
1757
1785
.
Kuo Du, C. David Williams, Mitchell R. McGill, Yuchao Xie, Anwar Farhood, Mathieu Vinken & Hartmut Jaeschke. (2013) The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation. Toxicology and Applied Pharmacology 273:3, pages 484-491.
Crossref
Crossref
Anup Ramachandran, Mitchell R. McGill, Yuchao Xie, Hong-Min Ni, Wen-Xing Ding & Hartmut Jaeschke. (2013) Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice. Hepatology 58:6, pages 2099-2108.
Crossref
Crossref
Mitchell R. McGill & Hartmut Jaeschke. (2013) Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis. Pharmaceutical Research 30:9, pages 2174-2187.
Crossref
Crossref
C. David Williams, Mitchell R. McGill, Anwar Farhood & Hartmut Jaeschke. (2013) Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress. Food and Chemical Toxicology 58, pages 228-235.
Crossref
Crossref
Mitchell R. McGill, Margitta Lebofsky, Hye-Ryun K. Norris, Matthew H. Slawson, Mary Lynn Bajt, Yuchao Xie, C. David Williams, Diana G. Wilkins, Douglas E. Rollins & Hartmut Jaeschke. (2013) Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications. Toxicology and Applied Pharmacology 269:3, pages 240-249.
Crossref
Crossref
Hartmut Jaeschke, C. David Williams, Mitchell R. McGill, Yuchao Xie & Anup Ramachandran. (2013) Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products. Food and Chemical Toxicology 55, pages 279-289.
Crossref
Crossref
Maria Eugenia Guicciardi, Harmeet Malhi, Justin L. Mott & Gregory J. Gores. 2011. Comprehensive Physiology. Comprehensive Physiology
977
1010
.
Sara Menazza, Renee Wong, Tiffany Nguyen, Guanghui Wang, Marjan Gucek & Elizabeth Murphy. (2013) CypD−/− hearts have altered levels of proteins involved in Krebs cycle, branch chain amino acid degradation and pyruvate metabolism. Journal of Molecular and Cellular Cardiology 56, pages 81-90.
Crossref
Crossref
Wenwen Gou, Lizhi Xu, Yucai Wang, Wen Yu, Zengtao Zhong, Jing Gao, Huimei Chen & Yaping Wang. (2013)
Mitochondrial Protective Effects of
Myrica rubra
Extract Against Acetaminophen-Induced Toxicity
. The American Journal of Chinese Medicine 41:05, pages 1053-1064.
Crossref
Crossref
Yuchao Xie, C. David Williams, Mitchell R. McGill, Margitta Lebofsky, Anup Ramachandran & Hartmut Jaeschke. (2013) Purinergic Receptor Antagonist A438079 Protects Against Acetaminophen-Induced Liver Injury by Inhibiting P450 Isoenzymes, Not by Inflammasome Activation. Toxicological Sciences 131:1, pages 325-335.
Crossref
Crossref
Jack A. Hinson. 2013. Drug-Induced Liver Disease. Drug-Induced Liver Disease
305
329
.
Lily Dara, Derick Han & Neil Kaplowitz. 2013. Drug-Induced Liver Disease. Drug-Induced Liver Disease
101
122
.
John J. Lemasters. 2013. Drug-Induced Liver Disease. Drug-Induced Liver Disease
85
100
.
Mitchell R. McGill & Hartmut Jaeschke. 2013. Drug-Induced Liver Disease. Drug-Induced Liver Disease
71
84
.
Benjamin L. Woolbright, Anup Ramachandran, Mitchell R. McGill, Hui‐min Yan, Mary Lynn Bajt, Matthew R. Sharpe, John J. Lemasters & Hartmut Jaeschke. (2012)
Lysosomal Instability and Cathepsin
B
Release during Acetaminophen Hepatotoxicity
. Basic & Clinical Pharmacology & Toxicology 111:6, pages 417-425.
Crossref
Crossref
Mitchell R. McGill, C. David Williams, Yuchao Xie, Anup Ramachandran & Hartmut Jaeschke. (2012) Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. Toxicology and Applied Pharmacology 264:3, pages 387-394.
Crossref
Crossref
Xiaoming Zhao, Xiaonan Cong, Lingli Zheng, Lina Xu, Lianhong Yin & Jinyong Peng. (2012) Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo. Toxicology Letters 214:1, pages 69-80.
Crossref
Crossref
Mitchell R. McGill, Matthew R. Sharpe, C. David Williams, Mohammad Taha, Steven C. Curry & Hartmut Jaeschke. (2012) The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. Journal of Clinical Investigation 122:4, pages 1574-1583.
Crossref
Crossref
Otto Kučera, Tomáš Roušar, Pavla Staňková, Lenka Haňáčková, Halka Lotková, Miroslav Podhola & Zuzana Červinková. (2012) Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. Journal of Gastroenterology and Hepatology 27:2, pages 323-330.
Crossref
Crossref
Hartmut Jaeschke, C. David Williams, Anup Ramachandran & Mary L. Bajt. (2012) Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity. Liver International 32:1, pages 8-20.
Crossref
Crossref
Hong-Min Ni, Abigail Bockus, Nikki Boggess, Hartmut Jaeschke & Wen-Xing Ding. (2012) Activation of autophagy protects against acetaminophen-induced hepatotoxicity. Hepatology 55:1, pages 222-232.
Crossref
Crossref
Tiffany Greco, Jonathan Shafer & Gary Fiskum. (2011) Sulforaphane inhibits mitochondrial permeability transition and oxidative stress. Free Radical Biology and Medicine 51:12, pages 2164-2171.
Crossref
Crossref
James W. Dear, Kenneth J. Simpson, Melianthe P. J. Nicolai, James H. Catterson, Jonathan Street, Tineke Huizinga, Darren G. Craig, Kevin Dhaliwal, Sheila Webb, D. Nicholas Bateman & David J. Webb. (2011) Cyclophilin A Is a Damage-Associated Molecular Pattern Molecule That Mediates Acetaminophen-Induced Liver Injury. The Journal of Immunology 187:6, pages 3347-3352.
Crossref
Crossref
Amanda LoGuidice & Urs A. Boelsterli. (2011) Acetaminophen overdose-induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D-regulated permeability transition. Hepatology 54:3, pages 969-978.
Crossref
Crossref
Mary Lynn Bajt, Anup Ramachandran, Hui-Min Yan, Margitta Lebofsky, Anwar Farhood, John J. Lemasters & Hartmut Jaeschke. (2011) Apoptosis-Inducing Factor Modulates Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity. Toxicological Sciences 122:2, pages 598-605.
Crossref
Crossref
Hartmut Jaeschke, Mitchell R. McGill, C. David Williams & Anup Ramachandran. (2011) Current issues with acetaminophen hepatotoxicity—A clinically relevant model to test the efficacy of natural products. Life Sciences 88:17-18, pages 737-745.
Crossref
Crossref
Anup Ramachandran, Margitta Lebofsky, Steven A. Weinman & Hartmut Jaeschke. (2011) The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity. Toxicology and Applied Pharmacology 251:3, pages 226-233.
Crossref
Crossref