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Free Radical Research Volume 45, 2011 - Issue 2
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Review Article

Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site

Ivan Spasojevic Department of Medicine, Duke University Medical School, Durham, NC 27710, USACorrespondence[email protected]
,
Ivan Kos Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA; Department of Analytical Chemistry, Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia
,
Ludmil T. Benov Department of Biochemistry, Faculty of Medicine, Kuwait University, 13110 Safat, Kuwait
,
Zrinka Rajic Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
,
Diane Fels Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
,
Casey Dedeugd Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
,
Xiaodong Ye Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
,
Zeljko Vujaskovic Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
,
Julio S. Reboucas Departamento de Química, CCEN, Universidade Federal da Paraíba, João Pessoa, PB 58051-970, Brazil
,
Kam W. Leong Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
,
Mark W. Dewhirst Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
&
Ines Batinic-Haberle Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USACorrespondence[email protected]
 show all
Pages 188-200 | Received 01 Jul 2010, Published online: 13 Oct 2010

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Bader Hasan, Artak Tovmasyan, Ines Batinic-Haberle & Ludmil Benov. (2021) Ascorbate-dependent and ascorbate-independent Mn porphyrin cytotoxicity: anticancer activity of Mn porphyrin-based SOD mimics through ascorbate-dependent and -independent routes. Redox Report 26:1, pages 85-93.
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Xiaodong Ye, Diane Fels, Artak Tovmasyan, Katherine M. Aird, Casey Dedeugd, Jennifer L. Allensworth, Ivan Kos, Won Park, Ivan Spasojevic, Gayathri R. Devi, Mark W. Dewhirst, Kam W. Leong & Ines Batinic-Haberle. (2011) Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate. Free Radical Research 45:11-12, pages 1289-1306.
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Articles from other publishers (24)

Clotilde Policar, Jean Bouvet, Hélène C. Bertrand & Nicolas Delsuc. (2022) SOD mimics: From the tool box of the chemists to cellular studies. Current Opinion in Chemical Biology 67, pages 102109.
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Clarissa G. C. Maia, Bárbara C. R. de Araujo, Maria B. de Freitas-Marques, Israel F. da Costa, Maria Irene Yoshida, Wagner da Nova Mussel, Rita de Cássia O. Sebastião & Júlio S. Rebouças. (2021) Thermal Stability Kinetics and Shelf Life Estimation of the Redox-Active Therapeutic and Mimic of Superoxide Dismutase Enzyme, Mn(III) meso-Tetrakis(N-ethylpyridinium-2-yl)porphyrin Chloride (MnTE-2-PyPCl5, BMX-010). Oxidative Medicine and Cellular Longevity 2021, pages 1-12.
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Tiago H.S. Souza, José F. Sarmento-Neto, Sueden O. Souza, Bruno L. Raposo, Bruna P. Silva, Christiane P.F. Borges, Beate S. Santos, Paulo E. Cabral Filho, Júlio S. Rebouças & Adriana Fontes. (2021) Advances on antimicrobial photodynamic inactivation mediated by Zn(II) porphyrins. Journal of Photochemistry and Photobiology C: Photochemistry Reviews 49, pages 100454.
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Tiago H.S. Souza, Camila G. Andrade, Fernanda V. Cabral, José F. Sarmento-Neto, Júlio S. Rebouças, Beate S. Santos, Martha S. Ribeiro, Regina C.B.Q. Figueiredo & Adriana Fontes. (2021) Efficient photodynamic inactivation of Leishmania parasites mediated by lipophilic water-soluble Zn(II) porphyrin ZnTnHex-2-PyP4+. Biochimica et Biophysica Acta (BBA) - General Subjects 1865:7, pages 129897.
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Artak TovmasyanJacqueline C. Bueno-JaniceMelba C. JaramilloRomulo S. SampaioJulio S. ReboucasNatalia KyuiLudmil BenovBrian DengTing-Ting HuangMargaret E. TomeIvan SpasojevicInes Batinic-Haberle. (2018) Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate. Antioxidants & Redox Signaling 29:13, pages 1196-1214.
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Sebastián Carballal, Valeria Valez, Damián Alvarez-Paggi, Artak Tovmasyan, Ines Batinic-Haberle, Gerardo Ferrer-Sueta, Daniel H. Murgida & Rafael Radi. (2018) Manganese porphyrin redox state in endothelial cells: Resonance Raman studies and implications for antioxidant protection towards peroxynitrite. Free Radical Biology and Medicine 126, pages 379-392.
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Zrinka Rajic, Artak Tovmasyan, Otávio L. de Santana, Isabelle N. Peixoto, Ivan Spasojevic, Silmar A. do Monte, Elizete Ventura, Júlio S. Rebouças & Ines Batinic-Haberle. (2017) Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues. Journal of Inorganic Biochemistry 169, pages 50-60.
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Ines Batinic-Haberle & Artak Tovmasyan. 2016. Oxidative Stress and Antioxidant Protection. Oxidative Stress and Antioxidant Protection 415 470 .
Victor Hugo A. Pinto, Nathália K. S. M. Falcão, Jacqueline C. Bueno-Janice, Ivan Spasojević, Ines Batinić-Haberle & Júlio S. Rebouças. 2016. Redox-Active Therapeutics. Redox-Active Therapeutics 213 243 .
Ines Batinić-Haberle, Artak Tovmasyan & Ivan Spasojević. 2016. Redox-Active Therapeutics. Redox-Active Therapeutics 165 212 .
Huaxin Sheng & David S. Warner. 2016. Redox-Active Therapeutics. Redox-Active Therapeutics 541 561 .
Artak Tovmasyan, Clarissa G.C. Maia, Tin Weitner, Sebastián Carballal, Romulo S. Sampaio, Dominik Lieb, Robert Ghazaryan, Ivana Ivanovic-Burmazovic, Gerardo Ferrer-Sueta, Rafael Radi, Julio S. Reboucas, Ivan Spasojevic, Ludmil Benov & Ines Batinic-Haberle. (2015) A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics. Free Radical Biology and Medicine 86, pages 308-321.
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Ines Batinic-Haberle, Artak Tovmasyan & Ivan Spasojevic. (2015) An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins – From superoxide dismutation to H2O2-driven pathways. Redox Biology 5, pages 43-65.
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Artak TovmasyanJulio S. ReboucasLudmil Benov. (2014) Simple Biological Systems for Assessing the Activity of Superoxide Dismutase Mimics. Antioxidants & Redox Signaling 20:15, pages 2416-2436.
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Ines Batinic-HaberleArtak TovmasyanEmily R. H. RobertsZeljko VujaskovicKam W. LeongIvan Spasojevic. (2014) SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways. Antioxidants & Redox Signaling 20:15, pages 2372-2415.
Crossref
Benjamin Gauter-Fleckenstein, Julio S. Reboucas, Katharina Fleckenstein, Artak Tovmasyan, Kouros Owzar, Chen Jiang, Ines Batinic-Haberle & Zeljko Vujaskovic. (2014) Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP5+. Redox Biology 2, pages 400-410.
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Artak Tovmasyan, Tin Weitner, Huaxin Sheng, MiaoMiao Lu, Zrinka Rajic, David S. Warner, Ivan Spasojevic, Julio S. Reboucas, Ludmil Benov & Ines Batinic-Haberle. (2013) Differential Coordination Demands in Fe versus Mn Water-Soluble Cationic Metalloporphyrins Translate into Remarkably Different Aqueous Redox Chemistry and Biology. Inorganic Chemistry 52:10, pages 5677-5691.
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Tin Weitner, Ivan Kos, Zoran Mandić, Ines Batinić-Haberle & Mladen Biruš. (2013) Acid–base and electrochemical properties of manganese meso(ortho- and meta-N-ethylpyridyl)porphyrins: voltammetric and chronocoulometric study of protolytic and redox equilibria. Dalton Transactions 42:41, pages 14757.
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Victor H.A. Pinto, Dayse CarvalhoDa-Silva, Jonas L.M.S. Santos, Tin Weitner, Maria Gard?nnia Fonseca, Maria Irene Yoshida, Ynara M. Idemori, Ines Batini?-Haberle & J?lio S. Rebou?as. (2013) Thermal stability of the prototypical Mn porphyrin-based superoxide dismutase mimic and potent oxidative-stress redox modulator Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride, MnTE-2-PyP5+. Journal of Pharmaceutical and Biomedical Analysis 73, pages 29-34.
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Vladimir MouravievTalaignair N. VenkatramanArtak TovmasyanMasaki KimuraMatvey TsivianVladimira MouravievaTom J. PolascikHaichen WangTimothy J. AmrheinInes Batinic-HaberleChristopher Lascola. (2012) Mn Porphyrins as Novel Molecular Magnetic Resonance Imaging Contrast Agents. Journal of Endourology 26:11, pages 1420-1424.
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Sumitra Miriyala, Ivan Spasojevic, Artak Tovmasyan, Daniela Salvemini, Zeljko Vujaskovic, Daret St. Clair & Ines Batinic-Haberle. (2012) Manganese superoxide dismutase, MnSOD and its mimics. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1822:5, pages 794-814.
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Serdar Dogan, Mustafa Unal, Nihal Ozturk, Piraye Yargicoglu, Aysegul Cort, Ivan Spasojevic, Ines Batinic-Haberle & Mutay Aslan. (2011) Manganese porphyrin reduces retinal injury induced by ocular hypertension in rats. Experimental Eye Research 93:4, pages 387-396.
Crossref
Huaxin Sheng, Ivan Spasojevic, Hubert M. Tse, Jin Yong Jung, Jun Hong, Zhiquan Zhang, Jon D. Piganelli, Ines Batinic-Haberle & David S. Warner. (2011) Neuroprotective Efficacy from a Lipophilic Redox-Modulating Mn(III) N -Hexylpyridylporphyrin, MnTnHex-2-PyP: Rodent Models of Ischemic Stroke and Subarachnoid Hemorrhage . Journal of Pharmacology and Experimental Therapeutics 338:3, pages 906-916.
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Ines Batinic-Haberle, Zrinka Rajic, Artak Tovmasyan, Julio S. Reboucas, Xiaodong Ye, Kam W. Leong, Mark W. Dewhirst, Zeljko Vujaskovic, Ludmil Benov & Ivan Spasojevic. (2011) Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics. Free Radical Biology and Medicine 51:5, pages 1035-1053.
Crossref

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