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Review Article

Effect of Apocynin, an inhibitor of NADPH oxidase, in the inflammatory process induced by an experimental model of spinal cord injury

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Pages 221-236 | Received 07 Sep 2010, Published online: 18 Oct 2010

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Lokman H. Tanriverdi, Hakan Parlakpinar, Onural Ozhan, Necip Ermis, Alaadin Polat, Nigar Vardi, Kevser Tanbek, Azibe Yildiz & Ahmet Acet. (2017) Inhibition of NADPH oxidase by apocynin promotes myocardial antioxidant response and prevents isoproterenol-induced myocardial oxidative stress in rats. Free Radical Research 51:9-10, pages 772-786.
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S. J. Cooney, Y. Zhao & K. R. Byrnes. (2014) Characterization of the expression and inflammatory activity of NADPH oxidase after spinal cord injury. Free Radical Research 48:8, pages 929-939.
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Daniela Impellizzeri, Emanuela Mazzon, Rosanna Di Paola, Irene Paterniti, Placido Bramanti & Salvatore Cuzzocrea. (2011) Effect of NADPH-oxidase inhibitors in the experimental model of zymosan-induced shock in mice. Free Radical Research 45:7, pages 820-834.
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Articles from other publishers (32)

S. M. Sabbir Alam, Yuichiro Watanabe, Brooke L. Steeno, Soumyajit Dutta, Halie A. Szilagyi, Alexander Wei & Daniel M. Suter. (2023) Neuronal NADPH oxidase is required for neurite regeneration of Aplysia bag cell neurons . Journal of Neurochemistry 167:4, pages 505-519.
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Ahmed Kouki, Wafa Ferjani, Pham My-Chan Dang, Néziha Ghanem-Boughanmi, Abdelaziz Souli, Mossadok Ben-Attia & Jamel El-Benna. (2023) Preventive Anti-inflammatory Effects of Apocynin on Acetic Acid–Induced Colitis in Rats. Inflammation.
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Gui-Qin Fu, Qin-Ting Liao, Zhi-Qing Wang, Zhi-Ke Tan, Guo-Jiang Mao, Bin Yang & Chun-Yan Li. (2022) A HPQ-based far-red fluorescent probe for monitoring viscosity in mice model of acute inflammation. Analytica Chimica Acta 1226, pages 340192.
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Ximena Freyermuth-Trujillo, Julia J. Segura-Uribe, Hermelinda Salgado-Ceballos, Carlos E. Orozco-Barrios & Angélica Coyoy-Salgado. (2022) Inflammation: A Target for Treatment in Spinal Cord Injury. Cells 11:17, pages 2692.
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Fahadul Islam, Sristy Bepary, Mohamed H. Nafady, Md. Rezaul Islam, Talha Bin Emran, Sharifa Sultana, Md. Amdadul Huq, Saikat Mitra, Hitesh Chopra, Rohit Sharma, Sherouk Hussein Sweilam, Mayeen Uddin Khandaker & Abubakr M. Idris. (2022) Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision. Oxidative Medicine and Cellular Longevity 2022, pages 1-21.
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K. Krupashree, P. Rachitha & Farhath khanum. (2022) Apocynin ameliorates fumonisin b1 induced hepatotoxicity via NADPH oxidase inhibition and quantification of sphingosine and sphinganine. Pharmacological Research - Modern Chinese Medicine 2, pages 100036.
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Gagandeep Jaiswal & Puneet Kumar. (2022) Neuroprotective role of apocynin against pentylenetetrazole kindling epilepsy and associated comorbidities in mice by suppression of ROS/RNS. Behavioural Brain Research 419, pages 113699.
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Sajad Fakhri, Fatemeh Abbaszadeh, Seyed Zachariah Moradi, Hui Cao, Haroon Khan & Jianbo Xiao. (2022) Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury. Oxidative Medicine and Cellular Longevity 2022, pages 1-34.
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Andrew N. Stewart, Katelyn E. McFarlane, Hemendra J. Vekaria, William M. Bailey, Stacey A. Slone, Lauren A. Tranthem, Bei Zhang, Samir P. Patel, Patrick G. Sullivan & John C. Gensel. (2021) Mitochondria exert age-divergent effects on recovery from spinal cord injury. Experimental Neurology 337, pages 113597.
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Fatemeh Abbaszadeh, Sajad Fakhri & Haroon Khan. (2020) Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals. Pharmacological Research 160, pages 105069.
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A. L. Cross, J. Hawkes, H. L. Wright, R. J. Moots & S. W. Edwards. (2020) APPA (apocynin and paeonol) modulates pathological aspects of human neutrophil function, without supressing antimicrobial ability, and inhibits TNFα expression and signalling. Inflammopharmacology 28:5, pages 1223-1235.
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Yubao Lu, Jingjing Yang, Xuexi Wang, Zhanjun Ma, Sheng Li, Zhaoyang Liu & Xuegong Fan. (2020) Research progress in use of traditional Chinese medicine for treatment of spinal cord injury. Biomedicine & Pharmacotherapy 127, pages 110136.
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Tsang, Liu & Lo. (2019) Vascular and Neuronal Protection in the Developing Retina: Potential Therapeutic Targets for Retinopathy of Prematurity. International Journal of Molecular Sciences 20:17, pages 4321.
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Bei Zhang, William M. Bailey, Anna Leigh McVicar, Andrew N. Stewart, Amy K. Veldhorst & John C. Gensel. (2019) Reducing age-dependent monocyte-derived macrophage activation contributes to the therapeutic efficacy of NADPH oxidase inhibition in spinal cord injury. Brain, Behavior, and Immunity 76, pages 139-150.
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Reham Mokhtar Aman, Irhan Ibrahim Abu Hashim & Mahasen Mohamed Meshali. (2018) Novel chitosan-based solid-lipid nanoparticles to enhance the bio-residence of the miraculous phytochemical “Apocynin”. European Journal of Pharmaceutical Sciences 124, pages 304-318.
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Lemen Pan & Shuxia Qian. (2018) Apocynin promotes neural function recovery and suppresses neuronal apoptosis by inhibiting Tlr4/NF-κB signaling pathway in a rat model of cerebral infarction. International Journal of Immunopathology and Pharmacology 32, pages 205873841881770.
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Yijun Sun, Futai Gong, Jichao Yin, Xiaoyan Wang, Xiangyang Wang, Qing Sun, Zhiqiang Zhu, Xiaoqiang Su, Jie Zheng, Li Liu, Yang Li, Xinglv Hu & Jia Li. (2017) Therapeutic effect of apocynin through antioxidant activity and suppression of apoptosis and inflammation after spinal cord injury. Experimental and Therapeutic Medicine.
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MARCO ANTONIO EDUARDO KOFF, LUKMAN OLALEKAN AJIBOYE, NATÁLIA DIEL LISBOA & ASDRUBAL FALAVIGNA. (2017) SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY. Coluna/Columna 16:1, pages 67-73.
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Hansen Chen, Binghe Guan & Jiangang Shen. (2016) Targeting ONOO<sup>-</sup>/HMGB1/MMP-9 Signaling Cascades: Potential for Drug Development from Chinese Medicine to Attenuate Ischemic Brain Injury and Hemorrhagic Transformation Induced by Thrombolytic Treatment. Integrative Medicine International 3:1-2, pages 32-52.
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Sara Bermudez, Guzal Khayrullina, Yujia Zhao & Kimberly R. Byrnes. (2016) NADPH oxidase isoform expression is temporally regulated and may contribute to microglial/macrophage polarization after spinal cord injury. Molecular and Cellular Neuroscience 77, pages 53-64.
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Guzal Khayrullina, Sara Bermudez & Kimberly R. Byrnes. (2015) Inhibition of NOX2 reduces locomotor impairment, inflammation, and oxidative stress after spinal cord injury. Journal of Neuroinflammation 12:1.
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Renato Carlos do Vale Ramos & Nuno Alegrete. (2015) The role of pharmacotherapy in modifying the neurological status of patients with spinal and spinal cord injuries. Revista Brasileira de Ortopedia (English Edition) 50:6, pages 617-624.
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Renato Carlos do Vale Ramos & Nuno Alegrete. (2015) O papel da farmacoterapia na modificação do estado neurológico de traumatizados vértebro‐medulares. Revista Brasileira de Ortopedia 50:6, pages 617-624.
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Yasir Furkan Cagin, Mehmet Ali Erdogan, Nurhan Sahin, Hakan Parlakpinar, Yahya Atayan, Alaadin Polat, Nigar Vardi, Azibe Yildiz & Kevser Tanbek. (2015) Protective Effects of Apocynin on Cisplatin-induced Hepatotoxicity in Rats. Archives of Medical Research 46:7, pages 517-526.
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Changxuan Liu, Yi Song, Lei Qu, Jiawei Tang, Liqiang Meng & Yu Wang. (2015) Involvement of NOX in the Regulation of Renal Tubular Expression of Na/K-ATPase in Acute Unilateral Ureteral Obstruction Rats. Nephron 130:1, pages 66-76.
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Shayne N. Hassler, Kathia M. Johnson & Claire E. Hulsebosch. (2014) Reactive oxygen species and lipid peroxidation inhibitors reduce mechanical sensitivity in a chronic neuropathic pain model of spinal cord injury in rats. Journal of Neurochemistry 131:4, pages 413-417.
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Xiang Ling, Feng Bao, Hao Qian & Danxia Liu. (2013) The temporal and spatial profiles of cell loss following experimental spinal cord injury: effect of antioxidant therapy on cell death and functional recovery. BMC Neuroscience 14:1.
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Joshua T. Johnstone, Paul D. Morton, Arumugam R. Jayakumar, Andrea L. Johnstone, Han Gao, Valerie Bracchi-Ricard, Damien D. Pearse, Michael D. Norenberg & John R. Bethea. (2013) Inhibition of NADPH Oxidase Activation in Oligodendrocytes Reduces Cytotoxicity Following Trauma. PLoS ONE 8:11, pages e80975.
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Kaiyu Wang, Linlin Li, Yan Song, Xiaocui Ye, Shaolian Fu, Jie Jiang & Sha Li. (2013) Improvement of Pharmacokinetics Behavior of Apocynin by Nitrone Derivatization: Comparative Pharmacokinetics of Nitrone-Apocynin and its Parent Apocynin in Rats. PLoS ONE 8:7, pages e70189.
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Anamitra Ghosh, Arthi Kanthasamy, Joy Joseph, Vellareddy Anantharam, Pallavi Srivastava, Brian P Dranka, Balaraman Kalyanaraman & Anumantha G Kanthasamy. (2012) Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson’s disease. Journal of Neuroinflammation 9:1.
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J. Stefanska, A. Sarniak, A. Wlodarczyk, M. Sokolowska, Z. Doniec, P. Bialasiewicz, D. Nowak & R. Pawliczak. (2012) Hydrogen peroxide and nitrite reduction in exhaled breath condensate of COPD patients. Pulmonary Pharmacology & Therapeutics 25:5, pages 343-348.
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Ahdeah Pajoohesh-Ganji & Kimberly R. Byrnes. (2011) Novel Neuroinflammatory Targets in the Chronically Injured Spinal Cord. Neurotherapeutics 8:2, pages 195-205.
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