509
Views
63
CrossRef citations to date
0
Altmetric
Research Article

Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice

, , , , , , , , & show all
Pages 966-974 | Received 19 Jan 2011, Accepted 22 Feb 2011, Published online: 22 Mar 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Min Luo, Ren-You Gan, Bang-Yan Li, Qian-Qian Mao, Ao Shang, Xiao-Yu Xu, Hang-Yu Li & Hua-Bin Li. (2023) Effects and Mechanisms of Tea on Parkinson’s Disease, Alzheimer’s Disease and Depression. Food Reviews International 39:1, pages 278-306.
Read now
Yang Wei, Jia Xu, Siwei Miao, Kang Wei, Lanlan Peng, Yuanfeng Wang & Xinlin Wei. (2022) Recent advances in the utilization of tea active ingredients to regulate sleep through neuroendocrine pathway, immune system and intestinal microbiota. Critical Reviews in Food Science and Nutrition 0:0, pages 1-29.
Read now
Tomoko Kayashima, Koji Nagao, Mituki Umino, Hiroko Kaikiri, Sachi Shibata & Kiminori Matsubara. (2020) Anti-stress effects of rosemary (Rosmarinus officinalis L.) leaf extract on intestinal goblet cells and immobility of forced-swimming test in BALB/c mice. Bioscience, Biotechnology, and Biochemistry 84:11, pages 2385-2389.
Read now
Xi-Chong Yu, Bo-La Wu, Jin-Chao Gao & Wei Yang. (2016) Theanine enhanced both the toxicity of strychnine and anticonvulsion of pentobarbital sodium. Drug and Chemical Toxicology 39:2, pages 217-223.
Read now

Articles from other publishers (58)

Carey E. Lyons, Maria Razzoli & Alessandro Bartolomucci. (2023) The impact of life stress on hallmarks of aging and accelerated senescence: Connections in sickness and in health. Neuroscience & Biobehavioral Reviews 153, pages 105359.
Crossref
Ahmad Shamabadi, Farnaz Kafi, Melika Arab Bafrani, Hassan Asadigandomani, Fatemeh A. Basti & Shahin Akhondzadeh. (2023) l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial. Journal of Affective Disorders 333, pages 38-43.
Crossref
Chalita Jantharanijkorn, Ariya Salikaphuti, Karnt Wongsuphasawat, Wongdyan Pundee, Azizudin Khan & Phakkharawat Sittiprapaporn. (2023) The Effects of Oral L-Theanine on Short-Term Memory in Middle-Aged Population. The Effects of Oral L-Theanine on Short-Term Memory in Middle-Aged Population.
Keiko Unno, Kyoko Taguchi, Tomokazu Konishi, Makoto Ozeki & Yoriyuki Nakamura. (2023) Theanine, a Tea-Leaf-Specific Amino Acid, Alleviates Stress through Modulation of Npas4 Expression in Group-Housed Older Mice. International Journal of Molecular Sciences 24:4, pages 3983.
Crossref
Daisuke FURUSHIMA, Ibuki SUGIYAMA, Yuzuki NOMURA, Keiko UNNO & Hiroshi YAMADA. (2022) Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study. Journal of Nutritional Science and Vitaminology 68:6, pages 540-546.
Crossref
Ko Ito, Masamichi Shinoda, Kumi Soma, Daisuke Ikutame, Eiji Ikami, Yosuke Mizuno, Michihiko Usui, Seiji Asoda & Tsuyoshi Sato. (2022) Psychosocial Stress Induces Orofacial Mechanical Allodynia Due to the Enhancement of Transient Receptor Potential Ankyrin 1 Expression in Trigeminal Ganglion Neurons via the Increment of the Trace Amine-Associated Receptor 7f Expression. Stresses 3:1, pages 58-68.
Crossref
Xinrong Dong, Yeqing Gu, Sabina Rayamajhi, Amrish Thapa, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Shunming Zhang, Tingjing Zhang, Xuena Wang, Huiping Li, Juanjuan Zhang, Jun Dong, Xiaoxi Zheng, Zhixia Cao, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Hong Chang, Yunliang Zheng & Kaijun Niu. (2022) Green tea consumption and risk of depressive symptoms: Results from the TCLSIH Cohort Study. Journal of Affective Disorders 310, pages 183-188.
Crossref
Tetsuo Nakajima, Yasuharu Ninomiya, Keiko Unno, Takamitsu Morioka, Mayumi Nishimura & Shizuko Kakinuma. (2022) Impacts of psychological stress on high dose-rate radiation acute effects in a mouse experimental model. Journal of Radiation Research 63:4, pages 602-608.
Crossref
Klaus W. Lange, Yukiko Nakamura, Katharina M. Lange & Hui Zhao. (2022) Tea and depression. Food Science and Human Wellness 11:3, pages 476-482.
Crossref
Sagar Bag, Anupam Mondal, Anusha Majumder & Avishek Banik. (2022) Tea and its phytochemicals: Hidden health benefits & modulation of signaling cascade by phytochemicals. Food Chemistry 371, pages 131098.
Crossref
Keiko Unno & Yoriyuki Nakamura. (2021) Green Tea Suppresses Brain Aging. Molecules 26:16, pages 4897.
Crossref
Yoshitake Baba, Shun Inagaki, Sae Nakagawa, Makoto Kobayashi, Toshiyuki Kaneko & Takanobu Takihara. (2021) Effects of Daily Matcha and Caffeine Intake on Mild Acute Psychological Stress-Related Cognitive Function in Middle-Aged and Older Adults: A Randomized Placebo-Controlled Study. Nutrients 13:5, pages 1700.
Crossref
Meiyan Feng, Xin Zheng, Juan Wan, Wenjing Pan, Xinya Xie, Baozhu Hu, Yingzi Wang, Haitao Wen & Shuxian Cai. (2021) Research progress on the potential delaying skin aging effect and mechanism of tea for oral and external use. Food & Function 12:7, pages 2814-2828.
Crossref
Yoshitake BabaShun InagakiSae NakagawaToshiyuki KanekoMakoto KobayashiTakanobu Takihara. (2021) Effects of l -Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study . Journal of Medicinal Food 24:4, pages 333-341.
Crossref
Yoshitake Baba, Toshiyuki Kaneko & Takanobu Takihara. (2021) Matcha consumption maintains attentional function following a mild acute psychological stress without affecting a feeling of fatigue: A randomized placebo-controlled study in young adults. Nutrition Research 88, pages 44-52.
Crossref
Monira Pervin, Keiko Unno, Tomokazu Konishi & Yoriyuki Nakamura. (2021) L-Arginine Exerts Excellent Anti-Stress Effects on Stress-Induced Shortened Lifespan, Cognitive Decline and Depression. International Journal of Molecular Sciences 22:2, pages 508.
Crossref
Keiko Unno, Yoshio Muguruma, Koichi Inoue, Tomokazu Konishi, Kyoko Taguchi, Sanae Hasegawa-Ishii, Atsuyoshi Shimada & Yoriyuki Nakamura. (2020) Theanine, Antistress Amino Acid in Tea Leaves, Causes Hippocampal Metabolic Changes and Antidepressant Effects in Stress-Loaded Mice. International Journal of Molecular Sciences 22:1, pages 193.
Crossref
Keiko UNNO. (2020) テアニン. KAGAKU TO SEIBUTSU 58:12, pages 667-672.
Crossref
Keiko Unno, Daisuke Furushima, Yuzuki Nomura, Hiroshi Yamada, Kazuaki Iguchi, Kyoko Taguchi, Toshikazu Suzuki, Makoto Ozeki & Yoriyuki Nakamura. (2020) Antidepressant Effect of Shaded White Leaf Tea Containing High Levels of Caffeine and Amino Acids. Molecules 25:15, pages 3550.
Crossref
Yukio Yoneda, Koichi Kawada & Nobuyuki Kuramoto. (2020) Selective Upregulation by Theanine of Slc38a1 Expression in Neural Stem Cell for Brain Wellness. Molecules 25:2, pages 347.
Crossref
Keiko Unno, Akira Sumiyoshi, Tomokazu Konishi, Michiko Hayashi, Kyoko Taguchi, Yoshio Muguruma, Koichi Inoue, Kazuaki Iguchi, Hiroi Nonaka, Ryuta Kawashima, Sanae Hasegawa-Ishii, Atsuyoshi Shimada & Yoriyuki Nakamura. (2020) Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses. Nutrients 12:1, pages 174.
Crossref
Shinobu Yasuo. 2020. Neurological Modulation of Sleep. Neurological Modulation of Sleep 375 383 .
Keiko Unno & Yoriyuki Nakamura. 2020. Neurological Modulation of Sleep. Neurological Modulation of Sleep 307 314 .
Hidese, Ogawa, Ota, Ishida, Yasukawa, Ozeki & Kunugi. (2019) Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients 11:10, pages 2362.
Crossref
Yukio Yoneda, Nobuyuki Kuramoto & Koichi Kawada. (2019) The role of glutamine in neurogenesis promoted by the green tea amino acid theanine in neural progenitor cells for brain health. Neurochemistry International 129, pages 104505.
Crossref
Keiko Unno, Shigenori Noda, Hirohiko Nii, Yohei Kawasaki, Kazuaki Iguchi & Hiroshi Yamada. (2019) Anti-stress Effect of β-Cryptoxanthin in Satsuma Mandarin Orange on Females. Biological and Pharmaceutical Bulletin 42:8, pages 1402-1408.
Crossref
Dylan O’Neill Rothenberg & Lingyun Zhang. (2019) Mechanisms Underlying the Anti-Depressive Effects of Regular Tea Consumption. Nutrients 11:6, pages 1361.
Crossref
Keiko Unno, Daisuke Furushima, Shingo Hamamoto, Kazuaki Iguchi, Hiroshi Yamada, Akio Morita, Monira Pervin & Yoriyuki Nakamura. (2019) Stress-reducing effect of cookies containing matcha green tea: essential ratio among theanine, arginine, caffeine and epigallocatechin gallate. Heliyon 5:5, pages e01653.
Crossref
Bao Trong Nguyen, Naveen Sharma, Eun-Joo Shin, Ji Hoon Jeong, Sung Hoon Lee, Choon-Gon Jang, Seung-Yeol Nah, Toshitaka Nabeshima, Yukio Yoneda & Hyoung-Chun Kim. (2019) Theanine attenuates memory impairments induced by klotho gene depletion in mice . Food & Function 10:1, pages 325-332.
Crossref
Keiko Unno & Yoriyuki Nakamura. 2019. Caffeinated and Cocoa Based Beverages. Caffeinated and Cocoa Based Beverages 209 234 .
Dami Kang, Youngyo Kim & Youjin Je. (2018) Non-alcoholic beverage consumption and risk of depression: epidemiological evidence from observational studies. European Journal of Clinical Nutrition 72:11, pages 1506-1516.
Crossref
Keiko Unno, Daisuke Furushima, Shingo Hamamoto, Kazuaki Iguchi, Hiroshi Yamada, Akio Morita, Hideki Horie & Yoriyuki Nakamura. (2018) Stress-Reducing Function of Matcha Green Tea in Animal Experiments and Clinical Trials. Nutrients 10:10, pages 1468.
Crossref
Jiwon Kim & Jihye Kim. (2018) Green Tea, Coffee, and Caffeine Consumption Are Inversely Associated with Self-Report Lifetime Depression in the Korean Population. Nutrients 10:9, pages 1201.
Crossref
A. B. Katasonov. (2018) Neurobiological effects of theanine and its possible use in neurology and psychiatry. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 118:11, pages 118.
Crossref
Shintaro Ogawa, Miho Ota, Jun Ogura, Koichi Kato & Hiroshi Kunugi. (2017) Effects of l-theanine on anxiety-like behavior, cerebrospinal fluid amino acid profile, and hippocampal activity in Wistar Kyoto rats. Psychopharmacology 235:1, pages 37-45.
Crossref
Bryant Villeponteau & Yvonne L. Still. (2017) Treating multiple antiaging pathways improves health markers in open label clinical study. Translational Medicine Communications 2:1.
Crossref
Keiko Unno, Shigenori Noda, Yohei Kawasaki, Hiroshi Yamada, Akio Morita, Kazuaki Iguchi & Yoriyuki Nakamura. (2017) Reduced Stress and Improved Sleep Quality Caused by Green Tea Are Associated with a Reduced Caffeine Content. Nutrients 9:7, pages 777.
Crossref
Shinsuke Hidese, Miho Ota, Chisato Wakabayashi, Takamasa Noda, Hayato Ozawa, Tsutomu Okubo & Hiroshi Kunugi. (2016) Effects of chronic l -theanine administration in patients with major depressive disorder: an open-label study . Acta Neuropsychiatrica 29:2, pages 72-79.
Crossref
Keiko Unno, Shigenori Noda, Yohei Kawasaki, Hiroshi Yamada, Akio Morita, Kazuaki Iguchi & Yoriyuki Nakamura. (2017) Ingestion of green tea with lowered caffeine improves sleep quality of the elderly via suppression of stress. Journal of Clinical Biochemistry and Nutrition 61:3, pages 210-216.
Crossref
Keiko Unno, Hiroshi Yamada, Kazuaki Iguchi, Hitoshi Ishida, Yasunori Iwao, Akio Morita & Yoriyuki Nakamura. (2017) Anti-stress Effect of Green Tea with Lowered Caffeine on Humans: A Pilot Study. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 40:6, pages 902-909.
Crossref
Keiko Unno, Ayane Hara, Aimi Nakagawa, Kazuaki Iguchi, Megumi Ohshio, Akio Morita & Yoriyuki Nakamura. (2016) Anti-stress effects of drinking green tea with lowered caffeine and enriched theanine, epigallocatechin and arginine on psychosocial stress induced adrenal hypertrophy in mice. Phytomedicine 23:12, pages 1365-1374.
Crossref
Yi ZengHuashuai ChenTing NiRongping RuanChao NieXiaomin LiuLei FengFengyu ZhangJiehua LuJianxin LiYang LiWei TaoSimon G. GregoryWilliam GottschalkMichael W. LutzKenneth C. LandAnatoli YashinQihua TanZe YangLars BolundQi MingHuanming YangJunxia MinD. Craig WillcoxBradley J. WillcoxJun GuElizabeth HauserXiao-Li TianJames W. Vaupel. (2016) Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages . Rejuvenation Research 19:3, pages 195-203.
Crossref
Takeshi Takarada, Noritaka Nakamichi, Ryota Nakazato, Takami Kakuda, Hiroshi Kokubo, Shinsuke Ikeno, Saki Nakamura, Nobuyuki Kuramoto, Eiichi Hinoi & Yukio Yoneda. (2016) Possible activation by the green tea amino acid theanine of mammalian target of rapamycin signaling in undifferentiated neural progenitor cells in vitro. Biochemistry and Biophysics Reports 5, pages 89-95.
Crossref
Takeshi Takarada, Masato Ogura, Noritaka Nakamichi, Takami Kakuda, Ryota Nakazato, Hiroshi Kokubo, Shinsuke Ikeno, Saki Nakamura, Takaya Kutsukake, Eiichi Hinoi & Yukio Yoneda. (2015) Upregulation of Slc38a1 Gene Along with Promotion of Neurosphere Growth and Subsequent Neuronal Specification in Undifferentiated Neural Progenitor Cells Exposed to Theanine. Neurochemical Research 41:1-2, pages 5-15.
Crossref
Keiko Unno. (2016) Prevention of brain aging by green tea components: Role of catechins and theanine. The Journal of Physical Fitness and Sports Medicine 5:2, pages 117-122.
Crossref
Keiko Unno, Shigenori Noda, Yohei Kawasaki, Kazuaki Iguchi & Hiroshi Yamada. (2016) Possible Gender Difference in Anti-stress Effect of β-Cryptoxanthin. YAKUGAKU ZASSHI 136:9, pages 1255-1262.
Crossref
Bryant Villeponteau, Kennedy Matsagas, Amber C. Nobles, Cristina Rizza, Marc Horwitz, Gregory Benford & Robin J. Mockett. (2015) Herbal Supplement Extends Life Span Under Some Environmental Conditions and Boosts Stress Resistance. PLOS ONE 10:4, pages e0119068.
Crossref
Xiaoxin Dong, Chen Yang, Shiyi Cao, Yong Gan, Huilian Sun, Yanhong Gong, Huajie Yang, Xiaoxu Yin & Zuxun Lu. (2015) Tea consumption and the risk of depression: A meta-analysis of observational studies. Australian & New Zealand Journal of Psychiatry 49:4, pages 334-345.
Crossref
Takeshi Takarada, Noritaka Nakamichi, Takami Kakuda, Ryota Nakazato, Hiroshi Kokubo, Shinsuke Ikeno, Saki Nakamura, Eiichi Hinoi & Yukio Yoneda. (2015) Daily oral intake of theanine prevents the decline of 5-bromo-2′-deoxyuridine incorporation in hippocampal dentate gyrus with concomitant alleviation of behavioral abnormalities in adult mice with severe traumatic stress. Journal of Pharmacological Sciences 127:3, pages 292-297.
Crossref
Yan Zhao & Baolu Zhao. (2014) The neuroprotective effect of L-Theanine and its inhibition on nicotine dependence. Chinese Science Bulletin 59:31, pages 4014-4019.
Crossref
Susumu Ikehara & Ming Li. (2014) Stem cell transplantation improves aging-related diseases. Frontiers in Cell and Developmental Biology 2.
Crossref
Rongping Ruan, Lei Feng, Jialiang Li, Tze-Pin Ng & Yi Zeng. (2013) Tea Consumption and Mortality in the Oldest-Old Chinese. Journal of the American Geriatrics Society 61:11, pages 1937-1942.
Crossref
Lei Feng, Zhongrui Yan, Binglun Sun, Chuanzhu Cai, Hui Jiang, Ee-Heok Kua, Tze-Pin Ng & Chengxuan Qiu. (2013) Tea Consumption and Depressive Symptoms in Older People in Rural China. Journal of the American Geriatrics Society 61:11, pages 1943-1947.
Crossref
Keiko Unno, Naoki Tanida, Naoto Ishii, Hiroyuki Yamamoto, Kazuaki Iguchi, Minoru Hoshino, Atsushi Takeda, Hayato Ozawa, Tsutomu Ohkubo, Lekh Raj Juneja & Hiroshi Yamada. (2013) Anti-stress effect of theanine on students during pharmacy practice: Positive correlation among salivary α-amylase activity, trait anxiety and subjective stress. Pharmacology Biochemistry and Behavior 111, pages 128-135.
Crossref
Marcia da Silva Pinto. (2013) Tea: A new perspective on health benefits. Food Research International 53:2, pages 558-567.
Crossref
Keiko Unno, Kazuaki Iguchi, Naoki Tanida, Keisuke Fujitani, Nina Takamori, Hiroyuki Yamamoto, Naoto Ishii, Hiroko Nagano, Takashi Nagashima, Ayane Hara, Kayoko Shimoi & Minoru Hoshino. (2013) Ingestion of theanine, an amino acid in tea, suppresses psychosocial stress in mice. Experimental Physiology 98:1, pages 290-303.
Crossref
Michel Vignes. 2013. Tea in Health and Disease Prevention. Tea in Health and Disease Prevention 1399 1409 .
Yushun Gong, Yunfeng Luo, Jian-an Huang, Jianwei Zhang, Yuxuan Peng, Zhonghua Liu & Zhao Baolu. (2012) Theanine improves stress resistance in Caenorhabditis elegans. Journal of Functional Foods 4:4, pages 988-993.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.