352
Views
39
CrossRef citations to date
0
Altmetric
Research Article

Differential antioxidant/pro-oxidant activity of dimethoxycurcumin, a synthetic analogue of curcumin

, , &
Pages 959-965 | Received 20 Jan 2011, Accepted 01 Mar 2011, Published online: 26 May 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Siou-Min Luo, Yi-Ping Wu, Li-Chun Huang, Shih-Ming Huang & Dueng-Yuan Hueng. (2021) The Anti-Cancer Effect of Four Curcumin Analogues on Human Glioma Cells. OncoTargets and Therapy 14, pages 4345-4359.
Read now
Qu-Tong Zheng, Ze-Hua Yang, Liu-Ying Yu, Yu-Yan Ren, Qiu-Xia Huang, Qiu Liu, Xiang-Yu Ma, Zi-Kang Chen, Zong-Bao Wang & Xing Zheng. (2017) Synthesis and antioxidant activity of curcumin analogs. Journal of Asian Natural Products Research 19:5, pages 489-503.
Read now

Articles from other publishers (36)

Nageswaran Sivalingam, Thennavan Ulaganathan, Ganshyam Jayakumar, Siddarth Venkatt, Aadhavan Balakumar & Sruthi Sritharan. 2023. Multidisciplinary Applications of Natural Science for Drug Discovery and Integrative Medicine. Multidisciplinary Applications of Natural Science for Drug Discovery and Integrative Medicine 61 115 .
Pramod Kumar, Aarti Singh, Anurag Kumar, Rahul Kumar, Rishi Pal, Amod Kumar Sachan, Rakesh Kumar Dixit & Rajendra Nath. (2023) Effect of Curcumin and Coenzyme Q10 Alone and in Combination on Learning and Memory in an Animal Model of Alzheimer’s Disease. Biomedicines 11:5, pages 1422.
Crossref
Jessica Maiuolo, Rosa Maria Bulotta, Francesca Oppedisano, Francesca Bosco, Federica Scarano, Saverio Nucera, Lorenza Guarnieri, Stefano Ruga, Roberta Macri, Rosamaria Caminiti, Vincenzo Musolino, Micaela Gliozzi, Cristina Carresi, Antonio Cardamone, Annarita Coppoletta, Martina Nicita, Adriano Carnevali, Vincenzo Scorcia & Vincenzo Mollace. (2022) Potential Properties of Natural Nutraceuticals and Antioxidants in Age-Related Eye Disorders. Life 13:1, pages 77.
Crossref
Sepideh Nikoo, Ali Maghari, Mehran Habibi-Rezaei & Ali Akbar Moosavi-Movahedi. (2021) Mechanistic study of lysozyme glycation by fructose and modulation by curcumin derivatives. Journal of Molecular Liquids 344, pages 117917.
Crossref
Korosh Morshedi, Sarina Borran, Mohammad Saeid Ebrahimi, Mohammad Jaber Masoud khooy, Zeynab Sadat Seyedi, Atefeh Amiri, Mohammad Abbasi‐Kolli, Maryam Fallah, Haroon Khan, Amirhossein Sahebkar & Hamed Mirzaei. (2021) Therapeutic effect of curcumin in gastrointestinal cancers: A comprehensive review. Phytotherapy Research 35:9, pages 4834-4897.
Crossref
Gerwyn Morris, Elizabeth Gamage, Nikolaj Travica, Michael Berk, Felice N. Jacka, Adrienne O'Neil, Basant K. Puri, Andre F. Carvalho, Chiara C. Bortolasci, Ken Walder & Wolfgang Marx. (2021) Polyphenols as adjunctive treatments in psychiatric and neurodegenerative disorders: Efficacy, mechanisms of action, and factors influencing inter-individual response. Free Radical Biology and Medicine 172, pages 101-122.
Crossref
Muhammad Sohail, Wenna Guo, Xin Yang, Zhiyong Li, Yanli Li, Hui Xu & Feng Zhao. (2021) A Promising Anticancer Agent Dimethoxycurcumin: Aspects of Pharmacokinetics, Efficacy, Mechanism, and Nanoformulation for Drug Delivery. Frontiers in Pharmacology 12.
Crossref
Sheshank Sethi, Shalki Choudhary, Deepika Sharma, Vaskuri G S Sainaga Jyothi, Ashish Baldi & Neelesh Kumar Mehrac Jitender Madan. (2021) Armamentarium of anticancer analogues of curcumin: Portray of structural insight, bioavailability, drug-target interaction and therapeutic efficacy. Journal of Molecular Structure 1231, pages 129691.
Crossref
Chao Lai, Hang Hu & Defeng Xu. (2021) Encapsulation and Delivery of Dimethylcurcumin by Using Nanoparticles of a Polyethylene‐Glycol‐Based Dimethylcurcumin Prodrug. ChemistrySelect 6:12, pages 3013-3021.
Crossref
Natividad Sebastià, Lorena Olivares-González, Alegría Montoro, Joan-Francesc Barquinero, Antonio José Canyada-Martinez, David Hervás, Pilar Gras, Juan Ignacio Villaescusa, Luis Martí-Bonmatí, Bianca Tabita Muresan, José Miguel Soriano, Juan Manuel Campayo, Joaquin Andani, Oscar Alonso & Regina Rodrigo. (2020) Redox Status, Dose and Antioxidant Intake in Healthcare Workers Occupationally Exposed to Ionizing Radiation. Antioxidants 9:9, pages 778.
Crossref
Thalita Alves Zanetti, Bruna Isabela Biazi, Giuliana Castello Coatti, Adrivanio Baranoski, Lilian Areal Marques, Amanda Cristina Corveloni & Mario Sergio Mantovani. (2019) Mitotic spindle defects and DNA damage induced by dimethoxycurcumin lead to an intrinsic apoptosis pathway in HepG2/C3A cells. Toxicology in Vitro 61, pages 104643.
Crossref
Jin Yeop Kim, Dong Min Lee, Hyun Goo Woo, Ki Deok Kim, Hong Jae Lee, Yong-Jun Kwon & Kyeong Sook Choi. (2019) RNAi Screening-based Identification of USP10 as a Novel Regulator of Paraptosis. Scientific Reports 9:1.
Crossref
Mohd Imtiaz Nawaz, Abdullah S. Alhomida & Mohammad Shamsul Ola. 2019. Curcumin for Neurological and Psychiatric Disorders. Curcumin for Neurological and Psychiatric Disorders 401 417 .
Sita S. Withers, Daniel York, Eric Johnson, Sami Al-Nadaf, Katherine A. Skorupski, Carlos O. RodriguezJrJr, Jenna H. Burton, Teri Guerrero, Kriste Sein, Luke Wittenburg & Robert B. Rebhun. (2018) In vitro and in vivo activity of liposome-encapsulated curcumin for naturally occurring canine cancers. Veterinary and Comparative Oncology 16:4, pages 571-579.
Crossref
Zhiyuan Sun, Tao Wei & Xiaoying Zhou. (2018) Liposomes encapsulated dimethyl curcumin regulates dipeptidyl peptidase I activity, gelatinase release and cell cycle of spleen lymphocytes in-vivo to attenuate collagen induced arthritis in rats. International Immunopharmacology 65, pages 511-521.
Crossref
Rashmin C. Savani. (2018) Modulators of inflammation in Bronchopulmonary Dysplasia. Seminars in Perinatology 42:7, pages 459-470.
Crossref
Andreas Spaeth, Andre Graeler, Tim Maisch & Kristjan Plaetzer. (2018) CureCuma–cationic curcuminoids with improved properties and enhanced antimicrobial photodynamic activity. European Journal of Medicinal Chemistry 159, pages 423-440.
Crossref
Srinivasa Reddy Bonam, Yuan Seng Wu, Lakshmi Tunki, Ranjithkumar Chellian, Mahabalarao Sampath Kumar Halmuthur, Sylviane Muller & Vijayapandi Pandy. (2018) What Has Come out from Phytomedicines and Herbal Edibles for the Treatment of Cancer?. ChemMedChem 13:18, pages 1854-1872.
Crossref
Cai-Jun Xie, Ai-Ping Gu, Jun Cai, Yi Wu & Rui-Cong Chen. (2018) Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic stroke. Brain and Behavior 8:2, pages e00921.
Crossref
Yung-Ting Hsiao, Chao-Lin Kuo, Fu-Shin Chueh, Kuo-Ching Liu, Da-Tian Bau & Jing-Gung Chung. (2018) Curcuminoids Induce Reactive Oxygen Species and Autophagy to Enhance Apoptosis in Human Oral Cancer Cells. The American Journal of Chinese Medicine 46:05, pages 1145-1168.
Crossref
Manouchehr Teymouri, Nastaran Barati, Matteo Pirro & Amirhosein Sahebkar. (2017) Biological and pharmacological evaluation of dimethoxycurcumin: A metabolically stable curcumin analogue with a promising therapeutic potential. Journal of Cellular Physiology 233:1, pages 124-140.
Crossref
Stephen Young, Sharleen Dea & Nitin Nitin. (2017) Vacuum facilitated infusion of bioactives into yeast microcarriers: Evaluation of a novel encapsulation approach. Food Research International 100, pages 100-112.
Crossref
Huiying Zhao, Qingchun Liu, Saisai Wang, Fang Dai, Xiaofei Cheng, Xiaobin Cheng, Wenbin Chen, Min Zhang & Dong Chen. (2017) In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells. Cancer Medicine 6:7, pages 1698-1706.
Crossref
Lily Arrue, Tomas Barra, María Belén Camarada, Ximena Zarate & Eduardo Schott. (2017) Electrochemical and theoretical characterization of the electro-oxidation of dimethoxycurcumin. Chemical Physics Letters 677, pages 35-40.
Crossref
Roberta Bonfanti, Teresa Musumeci, Cristina Russo & Rosalia Pellitteri. (2017) The protective effect of curcumin in Olfactory Ensheathing Cells exposed to hypoxia. European Journal of Pharmacology 796, pages 62-68.
Crossref
Yanping Miao, Sheng Zhao, Yang Gao, Ruijun Wang, Qiong Wu, Hui Wu & Tianyou Luo. (2016) Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling. Brain Research Bulletin 121, pages 9-15.
Crossref
Jin Chen, Zheng-Min He, Feng-Ling Wang, Zheng-Sheng Zhang, Xiu-zhen Liu, Dan-Dan Zhai & Wei-Dong Chen. (2016) Curcumin and its promise as an anticancer drug: An analysis of its anticancer and antifungal effects in cancer and associated complications from invasive fungal infections. European Journal of Pharmacology 772, pages 33-42.
Crossref
Dong ChenFang DaiZhehang ChenSaisai WangXiaobin ChengQinsong ShengJianjiang LinWenbin Chen. (2016) Dimethoxy Curcumin Induces Apoptosis by Suppressing Survivin and Inhibits Invasion by Enhancing E-Cadherin in Colon Cancer Cells. Medical Science Monitor 22, pages 3215-3222.
Crossref
Yingjuan Li, Danyang Tian, Chunhua Zhu & Liqun Ren. (2016) Demethoxycurcumin Preserves Renovascular Function by Downregulating COX-2 Expression in Hypertension. Oxidative Medicine and Cellular Longevity 2016, pages 1-10.
Crossref
Barbara Sottero, Simona Gargiulo, Isabella Russo, Cristina Barale, Giuseppe Poli & Franco Cavalot. (2015) Postprandial Dysmetabolism and Oxidative Stress in Type 2 Diabetes: Pathogenetic Mechanisms and Therapeutic Strategies. Medicinal Research Reviews 35:5, pages 968-1031.
Crossref
M J Yoon, Y J Kang, J A Lee, I Y Kim, M A Kim, Y S Lee, J H Park, B Y Lee, I A Kim, H S Kim, S-A Kim, A-R Yoon, C-O Yun, E-Y Kim, K Lee & K S Choi. (2014) Stronger proteasomal inhibition and higher CHOP induction are responsible for more effective induction of paraptosis by dimethoxycurcumin than curcumin. Cell Death & Disease 5:3, pages e1112-e1112.
Crossref
Parth Malik & Tapan K. Mukherjee. (2014) Structure-Function Elucidation of Antioxidative and Prooxidative Activities of the Polyphenolic Compound Curcumin. Chinese Journal of Biology 2014, pages 1-8.
Crossref
Hiroki Sato, Victor Tuan Giam Chuang, Keishi Yamasaki, Noriyuki Yamaotsu, Hiroshi Watanabe, Kohei Nagumo, Makoto Anraku, Daisuke Kadowaki, Yu Ishima, Shuichi Hirono, Masaki Otagiri & Toru Maruyama. (2014) Differential Effects of Methoxy Group on the Interaction of Curcuminoids with Two Major Ligand Binding Sites of Human Serum Albumin. PLoS ONE 9:2, pages e87919.
Crossref
Yang Yang, Weixun Duan, Yan Lin, Wei Yi, Zhenxing Liang, Juanjuan Yan, Ning Wang, Chao Deng, Song Zhang, Yue Li, Wensheng Chen, Shiqiang Yu, Dinghua Yi & Zhenxiao Jin. (2013) SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury. Free Radical Biology and Medicine 65, pages 667-679.
Crossref
Atanu Barik & K. Indira Priyadarsini. (2013) Solvent dependent photophysical properties of dimethoxy curcumin. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 105, pages 267-272.
Crossref
Raghavendra S. Patwardhan, Rahul Checker, Deepak Sharma, Vineet Kohli, K.I. Priyadarsini & Santosh K. Sandur. (2011) Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochemical Pharmacology 82:6, pages 642-657.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.