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Research Article

Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice

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Pages 950-958 | Received 20 Jan 2010, Accepted 01 Mar 2011, Published online: 26 May 2011

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Hua Li, Jidan Zhang, Huaxiang Ke, Meihong Fu, Jing Fang & Bin Yang. (2020) Nonlinear response surface in the study of aqueous two-phase system and ionic liquid extraction of lignans from Schisandrae chinensis and mechanism clarification. Separation Science and Technology 55:7, pages 1330-1338.
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Vijayasree V. Giridharan, Rajarajan A. Thandavarayan, Hari N. Bhilwade, Kam M. Ko, Kenichi Watanabe & Tetsuya Konishi. (2012) Schisandrin B, attenuates cisplatin-induced oxidative stress, genotoxicity and neurotoxicity through modulating NF-κB pathway in mice. Free Radical Research 46:1, pages 50-60.
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Rakesh Rai, Hemant K. Singh & S. Prasad. (2015) A Special Extract of Bacopa monnieri (CDRI-08) Restores Learning and Memory by Upregulating Expression of the NMDA Receptor Subunit GluN2B in the Brain of Scopolamine-Induced Amnesic Mice . Evidence-Based Complementary and Alternative Medicine 2015, pages 1-13.
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Ke-Wu Zeng, Tai Zhang, Hong Fu, Geng-Xin Liu & Xue-Mei Wang. (2012) Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia. European Journal of Pharmacology 692:1-3, pages 29-37.
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Bhupesh Sharma & Nirmal Singh. (2012) Experimental hypertension induced vascular dementia: Pharmacological, biochemical and behavioral recuperation by angiotensin receptor blocker and acetylcholinesterase inhibitor. Pharmacology Biochemistry and Behavior 102:1, pages 101-108.
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Mianzhi Zhang, Miao Liu, Min Xiong, Junbo Gong & Xiaoyue Tan. (2012) Schisandra chinensis fruit extract attenuates albuminuria and protects podocyte integrity in a mouse model of streptozotocin-induced diabetic nephropathy. Journal of Ethnopharmacology 141:1, pages 111-118.
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Philip Y. Lam & Kam Ming Ko. (2012) Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity 2012, pages 1-9.
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Vijayasree Vayalanellore Giridharan, Rajarajan Amirthalingam Thandavarayan & Tetsuya Konishi. (2011) Amelioration of scopolamine induced cognitive dysfunction and oxidative stress by Inonotus obliquus– a medicinal mushroom. Food & Function 2:6, pages 320.
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