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Free Radical Research Volume 45, 2011 - Issue 8: Diet and Health: Proceedings from the International Niigata symposium on Diet and Health 2010; Guest Editors: Tetsuya Konishi, Shinya Toyokuni
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Original Contributions

3,3′-Diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts

I. M. A. ErnstInstitute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Hermann-Rodewald-Strasse 6, 24118 Kiel, Germany
,
C. SchuemannInstitute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Hermann-Rodewald-Strasse 6, 24118 Kiel, Germany
,
A. E. WagnerInstitute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Hermann-Rodewald-Strasse 6, 24118 Kiel, Germany
&
G. RimbachInstitute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Hermann-Rodewald-Strasse 6, 24118 Kiel, GermanyCorrespondence[email protected]
Pages 941-949 | Received 20 Jan 2011, Accepted 07 Mar 2011, Published online: 26 May 2011

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Tetsuya Konishi. (2011) “From herb to kitchen and bedside: food factors are pharmacological molecules with antioxidant activity”. Free Radical Research 45:8, pages 863-863.
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Nadia Salem Alrawaiq, Ahmed Atia & Azman Abdullah. (2023) Effect of Administration of an Equal Dose of Selected Dietary Chemicals on Nrf2 Nuclear Translocation in the Mouse Liver. Oxidative Medicine and Cellular Longevity 2023, pages 1-14.
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Melford C. Egbujor, Paolo Tucci, Ugomma C. Onyeije, Chigbundu N. Emeruwa & Luciano Saso. (2023) NRF2 Activation by Nitrogen Heterocycles: A Review. Molecules 28:6, pages 2751.
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Evagelia C. Laiakis, Elizabeth A. McCart, Annabella Deziel, W. Bradley Rittase, Roxane M. Bouten, Jyoti Jha, W. Louis Wilkins, Regina M. Day & Albert J. Fornace. (2020) Effect of 3,3’-Diindolylmethane on Pulmonary Injury Following Thoracic Irradiation in CBA Mice. Health Physics 119:6, pages 746-757.
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Craig S. Charron, Janet A. Novotny, Elizabeth H. Jeffery, Matthew Kramer, Sharon A. Ross & Harold E. Seifried. (2020) Consumption of baby kale increased cytochrome P450 1A2 (CYP1A2) activity and influenced bilirubin metabolism in a randomized clinical trial. Journal of Functional Foods 64, pages 103624.
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Sharadha Dayalan Naidu, Lidia Brodziak-Jarosz, Clarissa Gerhäuser & Albena T. Dinkova-Kostova. 2020. Natural Products for Cancer Chemoprevention. Natural Products for Cancer Chemoprevention 271 318 .
Ahmed M. Kabel, Aisha H. Al-Shehri, Rehab A. Al-Talhi & Maaly A. Abd Elmaaboud. (2017) The promising effect of linagliptin and/or indole-3-carbinol on experimentally-induced polycystic ovarian syndrome. Chemico-Biological Interactions 273, pages 190-199.
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Lu Lu, Jiali Dong, Deguan Li, Junling Zhang & Saijun Fan. (2016) 3,3′-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice. Free Radical Biology and Medicine 99, pages 463-471.
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Joonki Kim, David Yang-Wei Fann, Raymond Chee Seong Seet, Dong-Gyu Jo, Mark P. Mattson & Thiruma V. Arumugam. (2016) Phytochemicals in Ischemic Stroke. NeuroMolecular Medicine 18:3, pages 283-305.
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Talon Becker & John Juvik. (2016) The Role of Glucosinolate Hydrolysis Products from Brassica Vegetable Consumption in Inducing Antioxidant Activity and Reducing Cancer Incidence. Diseases 4:4, pages 22.
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QIUYUE ZHAO, AIHONG MAO, JIAWEI YAN, CHAO SUN, CUIXIA DI, XIN ZHOU, HONGYAN LI, RUOSHUI GUO & HONG ZHANG. (2016) Downregulation of Nrf2 promotes radiation-induced apoptosis through Nrf2 mediated Notch signaling in non-small cell lung cancer cells. International Journal of Oncology 48:2, pages 765-773.
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Agnieszka Gęgotek & Elżbieta Skrzydlewska. (2015) The role of transcription factor Nrf2 in skin cells metabolism. Archives of Dermatological Research 307:5, pages 385-396.
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Craig A. Cooney. 2015. Nutrition, Exercise and Epigenetics: Ageing Interventions. Nutrition, Exercise and Epigenetics: Ageing Interventions 29 47 .
Gregory W. Watson, Laura M. Beaver, David E. Williams, Roderick H. Dashwood & Emily Ho. (2013) Phytochemicals from Cruciferous Vegetables, Epigenetics, and Prostate Cancer Prevention. The AAPS Journal 15:4, pages 951-961.
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Y-C Fang, C-T Chou, C-C Chi, K-L Lin, Y-D Li, H-H Cheng, Y-C Lu, J-S Cheng, C-C Kuo & C-R Jan. (2012) Effect of diindolylmethane on Ca 2+ homeostasis and viability in MDCK renal tubular cells . Human & Experimental Toxicology 32:4, pages 344-353.
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Jing Zong, Wei Deng, Heng Zhou, Zhou-yan Bian, Jia Dai, Yuan Yuan, Jie-yu Zhang, Rui Zhang, Yan Zhang, Qing-qing Wu, Hai-peng Guo, Hong-liang Li & Qi-zhu Tang. (2013) 3,3′-Diindolylmethane Protects against Cardiac Hypertrophy via 5′-Adenosine Monophosphate-Activated Protein Kinase-α2. PLoS ONE 8:1, pages e53427.
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Mei-Lin Wang, Chun-Kuang Shih, Hsiao-Pei Chang & Yue-Hwa Chen. (2012) Antiangiogenic activity of indole-3-carbinol in endothelial cells stimulated with activated macrophages. Food Chemistry 134:2, pages 811-820.
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