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Free Radical Research Volume 46, 2012 - Issue 2
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Research Articles

D(+) galactosamine induced oxidative and nitrosative stress-mediated renal damage in rats via NF-κB and inducible nitric oxide synthase (iNOS) pathways is ameliorated by a polyphenol xanthone, mangiferin

Manoranjan GhoshDivision of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata, India
,
Joydeep DasDivision of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata, India
&
Parames C. SilDivision of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata, IndiaCorrespondence[email protected] [email protected]
Pages 116-132 | Received 14 Sep 2011, Accepted 21 Nov 2011, Published online: 12 Jan 2012

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Peramaiyan Rajendran, Thamaraiselvan Rengarajan, Natarajan Nandakumar, H. Divya & Ikuo Nishigaki. (2015) Mangiferin in cancer chemoprevention and treatment: pharmacokinetics and molecular targets. Journal of Receptors and Signal Transduction 35:1, pages 76-84.
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Emad H.M. Hassanein, Wafaa R. Mohamed, Osama S. Ahmed, Mohamed M. Abdel-Daim & Ahmed M. Sayed. (2022) The role of inflammation in cadmium nephrotoxicity: NF-κB comes into view. Life Sciences 308, pages 120971.
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Dastagul Mahmarzayeva, Bertan Boran Bayrak, Ismet Burcu Turkyilmaz, Ozlem Sacan & Refiye Yanardag. (2022) Oxidative brain and cerebellum injury induced by d ‐galactosamine: Protective effect of S ‐methyl methionine sulfonium chloride . Journal of Biochemical and Molecular Toxicology 36:9.
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L.D. Denova & D.D. Ivanov. (2022) Influence of oxidative, carbonyl, and nitrosative stresses on the course of chronic kidney disease (analytical review). KIDNEYS 11:1, pages 53-61.
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Ashok Jangra, Mandeep Kumar Arora, Anglina Kisku & Sonal Sharma. (2020) The multifaceted role of mangiferin in health and diseases: a review. Advances in Traditional Medicine 21:4, pages 619-643.
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Manhuayun Zhai, Dandan Gong, Qiannan Gao, Hong Zhang & Guoxiang Sun. (2021) Evaluating the spectrum-effect profiling and pharmacokinetics of Tieshuang Anshen Prescription with better sedative-hypnotic effect based on Fe2+ than Hg2+. Biomedicine & Pharmacotherapy 141, pages 111923.
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Sawsan M. El‐sonbaty, Fatma S. M. Moawed & Mustafa M. M. Elbakry. (2020) Amphora algae with low‐level ionizing radiation exposure ameliorate D‐galactosamine‐induced inflammatory impairment in rat kidney. Environmental Toxicology 36:4, pages 451-459.
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Saurabh Mittal, Mohammad Kashif Iqubal, Babar Iqbal, Madan Mohan Gupta, Javed Ali & Sanjula Baboota. (2021) A pervasive scientific overview on mangiferin in the prevention and treatment of various diseases with preclinical and clinical updates. Journal of Complementary and Integrative Medicine 18:1, pages 9-21.
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Tingjun Liu, Yuanjian Song & Ankang Hu. (2021) Neuroprotective mechanisms of mangiferin in neurodegenerative diseases. Drug Development Research.
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Peng Chen, Jiexin Lei, Fuchao Chen & Benhong Zhou. (2020) Ameliorative effect of urolithin A on d -gal-induced liver and kidney damage in aging mice via its antioxidative, anti-inflammatory and antiapoptotic properties . RSC Advances 10:14, pages 8027-8038.
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Sushweta Mahalanobish, Sukanya Saha, Sayanta Dutta & Parames C. Sil. (2019) Mangiferin alleviates arsenic induced oxidative lung injury via upregulation of the Nrf2-HO1 axis. Food and Chemical Toxicology 126, pages 41-55.
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Sharmistha Chatterjee, Uday Hossain & Parames C. Sil. 2019. Modulation of Oxidative Stress in Heart Disease. Modulation of Oxidative Stress in Heart Disease 457 487 .
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Pritam Sadhukhan, Sukanya Saha, Sayanta Dutta & Parames C. Sil. (2018) Mangiferin Ameliorates Cisplatin Induced Acute Kidney Injury by Upregulating Nrf-2 via the Activation of PI3K and Exhibits Synergistic Anticancer Activity With Cisplatin. Frontiers in Pharmacology 9.
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Mansour Sobeh, Mona F. Mahmoud, Mohamed A.O. Abdelfattah, Haroan Cheng, Assem M. El-Shazly & Michael Wink. (2018) A proanthocyanidin-rich extract from Cassia abbreviata exhibits antioxidant and hepatoprotective activities in vivo. Journal of Ethnopharmacology 213, pages 38-47.
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Eli Mireya Sandoval-GallegosEsther Ramírez-MorenoJuan Gayosso De LucioJosé Arias-RicoNelly Cruz-CansinoMario I. OrtizRaquel Cariño-Cortés. (2018) In Vitro Bioaccessibility and Effect of Mangifera indica (Ataulfo) Leaf Extract on Induced Dyslipidemia . Journal of Medicinal Food 21:1, pages 47-56.
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Sharmistha Banerjee, Krishnendu Sinha, Sayantani Chowdhury & Parames C. Sil. (2018) Unfolding the mechanism of cisplatin induced pathophysiology in spleen and its amelioration by carnosine. Chemico-Biological Interactions 279, pages 159-170.
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Shorouk M. El-Sayyad, Ayman A. Soubh, Azza S. Awad & Hanan S. El-Abhar. (2017) Mangiferin protects against ‭intestinal ischemia/reperfusion-induced ‭liver injury: ‬‬Involvement of PPAR-‭γ, GSK-3β and Wnt/β-catenin pathway‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬. European Journal of Pharmacology 809, pages 80-86.
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K. Rashid & P.C. Sil. 2017. Discovery and Development of Antidiabetic Agents from Natural Products. Discovery and Development of Antidiabetic Agents from Natural Products 63 111 .
Jitender Kumar Bhardwaj & Priyanka Saraf. (2017) N -acetyl cysteine-mediated effective attenuation of methoxychlor-induced granulosa cell apoptosis by counteracting reactive oxygen species generation in caprine ovary . Environmental Toxicology 32:1, pages 156-166.
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Adnan Ayhanci, Mustafa Cengiz, H. Mehtap Kutlu & Djanan Vejselova. (2015) Protective effects of ellagic acid in d-galactosamine-induced kidney damage in rats. Cytotechnology 68:5, pages 1763-1770.
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Sukanya Saha, Pritam Sadhukhan & Parames C. Sil. (2016) Mangiferin: A xanthonoid with multipotent anti-inflammatory potential. BioFactors 42:5, pages 459-474.
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Magesh Salai Bojan, Rashmi Rajappa, Dhana Rangesh Kumar Vijayakumar & Jayathi Gopalan. (2016) Protective effect of Raphanus sativus on D-galactosamine induced nephrotoxicity in rats. Nutrition Clinique et Métabolisme 30:1, pages 22-28.
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Sukanya Saha, Pritam Sadhukhan, Krishnendu Sinha, Namrata Agarwal & Parames C. Sil. (2016) Mangiferin attenuates oxidative stress induced renal cell damage through activation of PI3K induced Akt and Nrf-2 mediated signaling pathways. Biochemistry and Biophysics Reports 5, pages 313-327.
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YANG LUO, CHANGFENG FU, ZHENYU WANG, ZHUO ZHANG, HONGXIA WANG & YI LIU. (2015) Mangiferin attenuates contusive spinal cord injury in rats through the regulation of oxidative stress, inflammation and the Bcl-2 and Bax pathway. Molecular Medicine Reports 12:5, pages 7132-7138.
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Seok-Joo Kim, Hyo-Sun Choi, Hong-Ik Cho, Young-Woo Jin, Eun-Kyong Lee, Jeung Youb Ahn & Sun-Mee Lee. (2015) Protective effect of wild ginseng cambial meristematic cells on d-galactosamine-induced hepatotoxicity in rats. Journal of Ginseng Research 39:4, pages 376-383.
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Magdy Mahmoud-Awny, Ahmed S. Attia, Mohamed F. Abd-Ellah & Hanan Salah El-Abhar. (2015) Mangiferin Mitigates Gastric Ulcer in Ischemia/ Reperfused Rats: Involvement of PPAR-γ, NF-κB and Nrf2/HO-1 Signaling Pathways. PLOS ONE 10:7, pages e0132497.
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Xia Zhu, Ya-Qin Cheng, Lei Du, Yu Li, Fan Zhang, Hao Guo, Yao-Wu Liu & Xiao-Xing Yin. (2015) Mangiferin Attenuates Renal Fibrosis Through Down-Regulation of Osteopontin in Diabetic Rats. Phytotherapy Research 29:2, pages 295-302.
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Jyotirmoy Ghosh & Parames C. Sil. 2015. 457 483 .
Pabitra Bikash Pal, Krishnendu Sinha & Parames C. Sil. (2014) Mangiferin Attenuates Diabetic Nephropathy by Inhibiting Oxidative Stress Mediated Signaling Cascade, TNFα Related and Mitochondrial Dependent Apoptotic Pathways in Streptozotocin-Induced Diabetic Rats. PLoS ONE 9:9, pages e107220.
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Jeong-Eun Huh, Pil-Seong Koh, Byung-Kwan Seo, Yeon-Chul Park, Yong-Hyun Baek, Jae-Dong Lee & Dong-Suk Park. (2014) Mangiferin Reduces the Inhibition of Chondrogenic Differentiation by IL-1β in Mesenchymal Stem Cells from Subchondral Bone and Targets Multiple Aspects of the Smad and SOX9 Pathways. International Journal of Molecular Sciences 15:9, pages 16025-16042.
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Rafal Bartoszewski, Anna Hering, Marcin Marszałł, Justyna Stefanowicz Hajduk, Sylwia Bartoszewska, Niren Kapoor, Kinga Kochan & Renata Ochocka. (2014) Mangiferin Has an Additive Effect on the Apoptotic Properties of Hesperidin in Cyclopia sp. Tea Extracts. PLoS ONE 9:3, pages e92128.
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Liyu He, Xiaofei Peng, Jiefu Zhu, Xian Chen, Hong Liu, Chengyuan Tang, Zheng Dong, Fuyou Liu & Youming Peng. (2014) Mangiferin Attenuate Sepsis-Induced Acute Kidney Injury via Antioxidant and Anti-Inflammatory Effects. American Journal of Nephrology 40:5, pages 441-450.
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Manoranjan Ghosh, Sankhadeep Pal & Parames C. Sil. (2014) Taurine attenuates nano-copper-induced oxidative hepatic damage via mitochondria-dependent and NF-κB/TNF-α-mediated pathway. Toxicol. Res. 3:6, pages 474-486.
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Kahkashan Rashid, Krishnendu Sinha & Parames C. Sil. (2013) An update on oxidative stress-mediated organ pathophysiology. Food and Chemical Toxicology 62, pages 584-600.
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Krishnendu Sinha, Joydeep Das, Pabitra Bikash Pal & Parames C. Sil. (2013) Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis. Archives of Toxicology 87:7, pages 1157-1180.
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Jiang Pi, Jing Zeng, Jian-Jun Luo, Pei-Hui Yang & Ji-Ye Cai. (2013) Synthesis and biological evaluation of Germanium(IV)–polyphenol complexes as potential anti-cancer agents. Bioorganic & Medicinal Chemistry Letters 23:10, pages 2902-2908.
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Pabitra Bikash Pal, Krishnendu Sinha & Parames C. Sil. (2013) Mangiferin, a Natural Xanthone, Protects Murine Liver in Pb(II) Induced Hepatic Damage and Cell Death via MAP Kinase, NF-κB and Mitochondria Dependent Pathways. PLoS ONE 8:2, pages e56894.
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Norma Alva, David Cruz, Sergio Sanchez, Juana Ma Valentín, Jordi Bermudez & Teresa Carbonell. (2013) Nitric oxide as a mediator of fructose 1,6-bisphosphate protection in galactosamine-induced hepatotoxicity in rats. Nitric Oxide 28, pages 17-23.
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Joydeep Das, Jyotirmoy Ghosh, Anandita Roy & Parames C. Sil. (2012) Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2–NFκB pathways. Toxicology and Applied Pharmacology 260:1, pages 35-47.
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Periyar Selvam Sellamuthu, Palanisamy Arulselvan, Balu Periamallipatti Muniappan & Murugesan Kandasamy. (2012) Effect of mangiferin isolated from Salacia chinensis regulates the kidney carbohydrate metabolism in streptozotocin–induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine 2:3, pages S1583-S1587.
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