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Review Article

How a calculated oxidative stress can yield multiple therapeutic effects

Pages 1068-1075 | Received 02 Mar 2012, Accepted 10 May 2012, Published online: 28 May 2012

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Velio Bocci, Emma Borrelli, Iacopo Zanardi & Valter Travagli. (2015) The usefulness of ozone treatment in spinal pain. Drug Design, Development and Therapy 9, pages 2677-2685.
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Articles from other publishers (35)

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Anibal Martin Grangeat & Maria de los Angeles Erario. (2023) The Use of Medical Ozone in Chronic Intervertebral Disc Degeneration Can Be an Etiological and Conservative Treatment. International Journal of Molecular Sciences 24:7, pages 6538.
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Maria Assunta Lacavalla, Chiara Rita Inguscio, Barbara Cisterna, Paolo Bernardi, Manuela Costanzo, Mirco Galiè, Ilaria Scambi, Osvaldo Angelini, Gabriele Tabaracci & Manuela Malatesta. (2022) Ozone at low concentration modulates microglial activity in vitro: A multimodal microscopy and biomolecular study. Microscopy Research and Technique 85:12, pages 3777-3792.
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Jiying Hou, Lu Wang, Chen Wang, Ruoxiang Ma, Ziling Wang, Hanxianzhi Xiao, Di Zeng, Li Ling & Yaping Wang. (2022) Ginsenoside Rg1 Reduces Oxidative Stress Via Nrf2 Activation to Regulate Age-Related Mesenchymal Stem Cells Fate Switch Between Osteoblasts and Adipocytes. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-17.
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Luis Campos, Liana Fernandes, Francisco Campos, Isabela Amaduro, Anneliese Campos & Claudio Fernandes. (2022) Use of ozone on regeneration of 3D critical size bone defects. BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY, pages 94-100.
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Raiza R Pereira, Bruno G Nogueira, Bruno Milan, Bianca R Acacio, Camila P Freitas- Dell'Aqua, Maria IL Souza & Breno FB Sampaio. (2022) Use Low Ozone Dosages has Positive Effects on the Cooling and Cryopreservation of Equine Semen. Journal of Equine Veterinary Science 108, pages 103800.
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Barbara Cisterna, Manuela Costanzo, Maria Assunta Lacavalla, Mirco Galiè, Osvaldo Angelini, Gabriele Tabaracci & Manuela Malatesta. (2021) Low Ozone Concentrations Differentially Affect the Structural and Functional Features of Non-Activated and Activated Fibroblasts In Vitro. International Journal of Molecular Sciences 22:18, pages 10133.
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María de los Ángeles Erario, Eduardo Croce, Maria Teresita Moviglia Brandolino, Gustavo Moviglia & Aníbal M. Grangeat. (2021) Ozone as Modulator of Resorption and Inflammatory Response in Extruded Nucleus Pulposus Herniation. Revising Concepts. International Journal of Molecular Sciences 22:18, pages 9946.
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Jair Camargo Ferreira, Rafael Silva Amaral, Letícia Mara Cardoso, Sophia Panelli Marchió, Marcela Aldrovani Rodrigues, Carlos Eduardo Fonseca Alves & Cezinande Meira. (2021) Endometrial angiogenesis induced by uterine insufflation with an oxygen–ozone gas mixture in mares. Reproduction in Domestic Animals 56:9, pages 1176-1183.
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Enrica Cappellozza, Manuela Costanzo, Laura Calderan, Mirco Galiè, Osvaldo Angelini, Gabriele Tabaracci & Manuela Malatesta. (2021) Low Ozone Concentrations Affect the Structural and Functional Features of Jurkat T Cells. Processes 9:6, pages 1030.
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Morteza Izadi, Luca Cegolon, Mohammad Javanbakht, Ali Sarafzadeh, Hassan Abolghasemi, Gholamhossein Alishiri, Shi Zhao, Behzad Einollahi, Mandana Kashaki, Nematollah Jonaidi-Jafari, Mosa Asadi, Ramezan Jafari, Saeid Fathi, Hassan Nikoueinejad, Mehrdad Ebrahimi, Sina Imanizadeh & Amir Hosein Ghazale. (2021) Ozone therapy for the treatment of COVID-19 pneumonia: A scoping review. International Immunopharmacology 92, pages 107307.
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Alessandro de Sire, Francesco Agostini, Lorenzo Lippi, Massimiliano Mangone, Simone Marchese, Carlo Cisari, Andrea Bernetti & Marco Invernizzi. (2021) Oxygen–Ozone Therapy in the Rehabilitation Field:State of the Art on Mechanisms of Action, Safety andEffectiveness in Patients with Musculoskeletal Disorders. Biomolecules 11:3, pages 356.
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Juan Paz García, Félix Manuel Hernández Alemán & Herminia Farías López. (2021) Exéresis de quiste branquial lateral: presentación de un caso manejado con solución electrolizada de superoxidación con pH neutro. Revista Mexicana de Cirugía Bucal y Maxilofacial 17:1, pages 28-33.
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Catia Scassellati, Antonio Carlo Galoforo, Cristian Bonvicini, Ciro Esposito & Giovanni Ricevuti. (2020) Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders. Ageing Research Reviews 63, pages 101138.
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Barbara Cisterna, Manuela Costanzo, Alice Nodari, Mirco Galiè, Serena Zanzoni, Paolo Bernardi, Viviana Covi, Gabriele Tabaracci & Manuela Malatesta. (2020) Ozone Activates the Nrf2 Pathway and Improves Preservation of Explanted Adipose Tissue In Vitro. Antioxidants 9:10, pages 989.
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AM Grangeat, EA Crocce, MA Erario, MT Moviglia Brandolino, SL Piccone, MA Lopez & GA Moviglia. (2020) Ozone therapy with local cellular immune modulation and disc progenitor cell implant is safe, effective and efficient. Open Journal of Orthopedics and Rheumatology 5:1, pages 024-033.
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Catia Scassellati, Miriam Ciani, Antonio Carlo Galoforo, Roberta Zanardini, Cristian Bonvicini & Cristina Geroldi. (2020) Molecular mechanisms in cognitive frailty: potential therapeutic targets for oxygen-ozone treatment. Mechanisms of Ageing and Development 186, pages 111210.
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Mirco Galiè, Viviana Covi, Gabriele Tabaracci & Manuela Malatesta. (2019) The Role of Nrf2 in the Antioxidant Cellular Response to Medical Ozone Exposure. International Journal of Molecular Sciences 20:16, pages 4009.
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Ismail Hakki Akbudak, Vural Kucukatay, Ozgen Kilic-Erkek, Yasin Ozdemir & Melek Bor-Kucukatay. (2019) Investigation of the effects of major ozone autohemotherapy application on erythrocyte deformability and aggregation. Clinical Hemorheology and Microcirculation 71:3, pages 365-372.
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Evgenios Agathokleous, Regina G. Belz, Vicent Calatayud, Alessandra De Marco, Yasutomo Hoshika, Mitsutoshi Kitao, Costas J. Saitanis, Pierre Sicard, Elena Paoletti & Edward J. Calabrese. (2019) Predicting the effect of ozone on vegetation via linear non-threshold (LNT), threshold and hormetic dose-response models. Science of The Total Environment 649, pages 61-74.
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Shahenda A. Abu ElEla, Evgenios Agathokleous, Nirvina A. Ghazawy, Tarek R. Amin, Wael M. ElSayed & Takayoshi Koike. (2018) Enzyme activity modification in adult beetles (Agelastica coerulea) inhabiting birch trees in an ozone-enriched atmosphere. Environmental Science and Pollution Research 25:32, pages 32675-32683.
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Mirco Galiè, Manuela Costanzo, Alice Nodari, Federico Boschi, Laura Calderan, Silvia Mannucci, Viviana Covi, Gabriele Tabaracci & Manuela Malatesta. (2018) Mild ozonisation activates antioxidant cell response by the Keap1/Nrf2 dependent pathway. Free Radical Biology and Medicine 124, pages 114-121.
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Cynthia do Prado Vendruscolo, Juliana Junqueira Moreira, Sarah Raphaela Torquato Seidel, Joice Fülber, Henrique Macedo Neuenschwander, Giancarlo Bonagura, Fernanda Rodrigues Agreste & Raquel Yvonne Arantes Baccarin. (2018) Effects of medical ozone upon healthy equine joints: Clinical and laboratorial aspects. PLOS ONE 13:5, pages e0197736.
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Mingdong Yu, Yong Zhao & Xiaoxia Zhang. (2018) Gardenoside combined with ozone inhibits the expression of P2X3 and P2X7 purine receptors in rats with sciatic nerve injury. Molecular Medicine Reports.
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Dario Siniscalco, Maria Trotta, Anna Brigida, Rosa Maisto, Margherita Luongo, Franca Ferraraccio, Michele D’Amico & Clara Di Filippo. (2018) Intraperitoneal Administration of Oxygen/Ozone to Rats Reduces the Pancreatic Damage Induced by Streptozotocin. Biology 7:1, pages 10.
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C. Scassellati, M. Costanzo, B. Cisterna, A. Nodari, M. Galiè, A. Cattaneo, V. Covi, G. Tabaracci, C. Bonvicini & M. Malatesta. (2017) Effects of mild ozonisation on gene expression and nuclear domains organization in vitro. Toxicology in Vitro 44, pages 100-110.
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A. Barone, M. Otero-Losada, A.M. Grangeat, G. Cao, F. Azzato, A. Rodríguez & J. Milei. (2016) Ozonetherapy protects from in-stent coronary neointimal proliferation. Role of redoxins. International Journal of Cardiology 223, pages 258-261.
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Xiaoyi Li, Fang Ye, Lili Li, Wei Chang, Xiongwen Wu & Jun Chen. (2016) The role of HO-1 in protection against lead-induced neurotoxicity. NeuroToxicology 52, pages 1-11.
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Jie ChenIgor L. LeskovArif YurdagulJr.Jr., Bonnie ThielChristopher G. KevilKaren Y. StokesA. Wayne Orr. (2015) Recruitment of the adaptor protein Nck to PECAM-1 couples oxidative stress to canonical NF-κB signaling and inflammation. Science Signaling 8:365.
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C. Di Filippo, M. C. Trotta, R. Maisto, D. Siniscalco, M. Luongo, L. Mascolo, R. Alfano, M. Accardo, C. Rossi, F. Ferraraccio & M. D’Amico. (2015) Daily Oxygen/O 3 Treatment Reduces Muscular Fatigue and Improves Cardiac Performance in Rats Subjected to Prolonged High Intensity Physical Exercise . Oxidative Medicine and Cellular Longevity 2015, pages 1-11.
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Livan Delgado-Roche, Julio R. Fernández & Dalia R. Álvarez. (2014) Glutathione peroxidase-1 expression is up-regulated by ozone therapy in ApoE deficient mice. Biomedicine & Aging Pathology 4:4, pages 323-326.
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Velio Bocci, Iacopo Zanardi, Maya S.P. Huijberts & Valter Travagli. (2014) An integrated medical treatment for type-2 diabetes. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 8:1, pages 57-61.
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Alessandra Pecorelli, Velio Bocci, Alessandra Acquaviva, Giuseppe Belmonte, Concetta Gardi, Fabio Virgili, Lucia Ciccoli & Giuseppe Valacchi. (2013) NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells. Toxicology and Applied Pharmacology 267:1, pages 30-40.
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Velio Bocci, Emma Borrelli, Iacopo Zanardi & Valter Travagli. (2013) The orthodox therapy of cardiovascular diseases integrated by ozone-therapy is able to normalize the redox system. World Journal of Cardiovascular Diseases 03:03, pages 308-311.
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