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Free Radical Research Volume 47, 2013 - Issue 1
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Research Article

Short-term exercise worsens cardiac oxidative stress and fibrosis in 8-month-old db/db mice by depleting cardiac glutathione

Ismail LaherDepartment of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, BC, Canada
,
Julianne BeamDepartment of Biology, IK Barber School of Arts and Sciences, University of British Columbia-Okanagan Campus, BC, Canada
,
Amy BottaDepartment of Biology, IK Barber School of Arts and Sciences, University of British Columbia-Okanagan Campus, BC, Canada
,
Rebekah BarendregtDepartment of Biology, IK Barber School of Arts and Sciences, University of British Columbia-Okanagan Campus, BC, Canada
,
Dian SulistyoningrumDepartment of Pediatrics, University of British Columbia, Child & Family Research Institute, Vancouver, BC, Canada
,
Angela DevlinDepartment of Pediatrics, University of British Columbia, Child & Family Research Institute, Vancouver, BC, Canada
,
Mark RheaultDepartment of Biology, IK Barber School of Arts and Sciences, University of British Columbia-Okanagan Campus, BC, Canada
&
Sanjoy GhoshDepartment of Biology, IK Barber School of Arts and Sciences, University of British Columbia-Okanagan Campus, BC, CanadaCorrespondence[email protected]
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Pages 44-54 | Received 07 Aug 2012, Accepted 03 Oct 2012, Published online: 02 Nov 2012

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S. K. Powers, K. J. Sollanek, M. P. Wiggs, H. A. Demirel & A. J. Smuder. (2014) Exercise-induced improvements in myocardial antioxidant capacity: the antioxidant players and cardioprotection. Free Radical Research 48:1, pages 43-51.
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Articles from other publishers (11)

Ye Jiayu, Amy Botta, Svetlana Simtchouk, John Winkler, Lisa M Renaud, Hansika Dadlani, Betina Rasmussen, Rajavel Elango & Sanjoy Ghosh. (2020) Egg white consumption increases GSH and lowers oxidative damage in 110-week-old geriatric mice hearts. The Journal of Nutritional Biochemistry 76, pages 108252.
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Shi-Qiang Wang, Dan Li & Yang Yuan. (2019) Long-term moderate intensity exercise alleviates myocardial fibrosis in type 2 diabetic rats via inhibitions of oxidative stress and TGF-β1/Smad pathway. The Journal of Physiological Sciences 69:6, pages 861-873.
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Andrew D. Spearman, Rohit S. Loomba, Michael Danduran & Joshua Kovach. (2018) Intrauterine growth restriction is not associated with decreased exercise capacity in adolescents with congenital heart disease. Congenital Heart Disease 13:3, pages 369-376.
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Sudhakar Veeranki, Srikanth Givvimani, Sourav Kundu, Naira Metreveli, Sathnur Pushpakumar & Suresh C. Tyagi. (2016) Moderate intensity exercise prevents diabetic cardiomyopathy associated contractile dysfunction through restoration of mitochondrial function and connexin 43 levels in db/db mice. Journal of Molecular and Cellular Cardiology 92, pages 163-173.
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Laura M. Reyes, Raven Kirschenman, Anita Quon, Jude S. Morton, Amin Shah & Sandra T. Davidge. (2015) Aerobic exercise training reduces cardiac function in adult male offspring exposed to prenatal hypoxia. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 309:5, pages R489-R498.
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Julianne Beam, Amy Botta, Jiayu Ye, Hesham Soliman, Brieanne J. Matier, Mary Forrest, Kathleen M. MacLeod & Sanjoy Ghosh. (2015) Excess Linoleic Acid Increases Collagen I/III Ratio and “Stiffens” the Heart Muscle Following High Fat Diets. Journal of Biological Chemistry 290:38, pages 23371-23384.
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Anne D. HafstadNeoma BoardmanEllen Aasum. (2015) How Exercise May Amend Metabolic Disturbances in Diabetic Cardiomyopathy. Antioxidants & Redox Signaling 22:17, pages 1587-1605.
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S Golbidi, A Botta, S Gottfred, A Nusrat, I Laher & S Ghosh. (2014) Glutathione administration reduces mitochondrial damage and shifts cell death from necrosis to apoptosis in ageing diabetic mice hearts during exercise. British Journal of Pharmacology 171:23, pages 5345-5360.
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Julianne Beam, Amy Botta, Rebekah Barendregt & Sanjoy Ghosh. 2014. Systems Biology of Free Radicals and Antioxidants. Systems Biology of Free Radicals and Antioxidants 1497 1522 .
L. Conde de la Rosa, C. García-Ruiz & Jose C. Fernández-Checa. 2014. Systems Biology of Free Radicals and Antioxidants. Systems Biology of Free Radicals and Antioxidants 617 644 .
Amy Botta, Ismail Laher, Julianne Beam, Daniella DeCoffe, Kirsty Brown, Swagata Halder, Angela Devlin, Deanna L. Gibson & Sanjoy Ghosh. (2013) Short Term Exercise Induces PGC-1α, Ameliorates Inflammation and Increases Mitochondrial Membrane Proteins but Fails to Increase Respiratory Enzymes in Aging Diabetic Hearts. PLoS ONE 8:8, pages e70248.
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