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Free Radical Research Volume 47, 2013 - Issue 9
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Research Article

N-acetylcysteine amide, a thiol antioxidant, prevents bleomycin-induced toxicity in human alveolar basal epithelial cells (A549)

S. TobwalaDepartment of Chemistry, Missouri University of Science and Technology, Rolla, MO, USA
,
W. FanDepartment of Chemistry, Missouri University of Science and Technology, Rolla, MO, USA
,
T. StoegerInstitute Lung Biology and Disease, Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, Neuherberg, Germany
&
N. ErcalDepartment of Chemistry, Missouri University of Science and Technology, Rolla, MO, USACorrespondence[email protected]
Pages 740-749 | Received 05 Apr 2013, Accepted 24 Jun 2013, Published online: 24 Jul 2013

Citations (16)

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Zhao-Li Wu & Jia Wang. (2019) Dioscin attenuates Bleomycin-Induced acute lung injury via inhibiting the inflammatory response in mice. Experimental Lung Research 45:8, pages 236-244.
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Articles from other publishers (15)

Zhang Jieting, Xue Shuyi, Chen Xiaolin & Yang Hai. (2023) Bleomycin overdose in a patient with stage II Hodgkin lymphoma: A case report of a medication error. British Journal of Clinical Pharmacology.
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Annalise Pfaff, Anna Chernatynskaya, Hannah Vineyard & Nuran Ercal. (2022) Thiol antioxidants protect human lens epithelial (HLE B-3) cells against tert-butyl hydroperoxide-induced oxidative damage and cytotoxicity. Biochemistry and Biophysics Reports 29, pages 101213.
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Karthika Muthuramalingam, Moonjae Cho & Youngmee Kim. (2019) Cellular senescence and EMT crosstalk in bleomycin‐induced pathogenesis of pulmonary fibrosis—an in vitro analysis. Cell Biology International 44:2, pages 477-487.
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Yasaswi Maddirala, Shakila Tobwala, Humeyra Karacal & Nuran Ercal. (2017) Prevention and reversal of selenite-induced cataracts by N-acetylcysteine amide in Wistar rats. BMC Ophthalmology 17:1.
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Souhir Brahim, Sonia Aroui, Rahamata Ali, Jean F. Jeannin, Abderraouf Kenani & Ali Bettaieb. (2017) The combination of Bleomycin with TRAIL agonists or PKC inhibitors sensitizes solid tumor cells to BLM-mediated apoptosis: new strategies to overcome chemotherapy resistance of tumors. Medicinal Chemistry Research 26:9, pages 2105-2111.
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Usmah Kawoos, Richard M. McCarron & Mikulas Chavko. (2017) Protective Effect of N-Acetylcysteine Amide on Blast-Induced Increase in Intracranial Pressure in Rats. Frontiers in Neurology 8.
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Serdar Turkyilmaz, Arif Usta, Arif Burak Cekic, Etem Alhan, Birgül Vanizor Kural & Cengiz Ercin. (2016) N-acetylcysteine amid reduces pancreatic damage in a rat model of acute necrotizing pancreatitis. Journal of Surgical Research 203:2, pages 383-389.
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Stéphanie Anaís Castaldo, Joana Raquel Freitas, Nadine Vasconcelos Conchinha & Patrícia Alexandra Madureira. (2016) The Tumorigenic Roles of the Cellular REDOX Regulatory Systems. Oxidative Medicine and Cellular Longevity 2016, pages 1-17.
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Ahdab Khayyat, Shakila Tobwala, Marcia Hart & Nuran Ercal. (2016) N -acetylcysteine amide, a promising antidote for acetaminophen toxicity. Toxicology Letters 241, pages 133-142.
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Deepmala, John Slattery, Nihit Kumar, Leanna Delhey, Michael Berk, Olivia Dean, Charles Spielholz & Richard Frye. (2015) Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review. Neuroscience & Biobehavioral Reviews 55, pages 294-321.
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Yang Li, Yong Liu, XiangPing Peng, Wei Liu, FeiYan Zhao, DanDan Feng, JianZhong Han, YanHong Huang, SiWei Luo, Lian Li, Shao Jie Yue, QingMei Cheng, XiaoTing Huang & ZiQiang Luo. (2015) NMDA Receptor Antagonist Attenuates Bleomycin-Induced Acute Lung Injury. PLOS ONE 10:5, pages e0125873.
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Yasaswi Maddirala, Shakila Tobwala & Nuran Ercal. (2015) N-acetylcysteineamide protects against manganese-induced toxicity in SHSY5Y cell line. Brain Research 1608, pages 157-166.
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Tao Qin, Yinyan Yin, Qinghua Yu & Qian Yang. (2015) Bursopentin (BP5) Protects Dendritic Cells from Lipopolysaccharide-Induced Oxidative Stress for Immunosuppression. PLOS ONE 10:2, pages e0117477.
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Shakila Tobwala, Ahdab Khayyat, Weili Fan & Nuran Ercal. (2014) Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells. Experimental Biology and Medicine 240:2, pages 261-272.
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Shakila Tobwala, Eylem Y. Pinarci, Yasaswi Maddirala & Nuran Ercal. (2014) N-acetylcysteine amide protects against dexamethasone-induced cataract related changes in cultured rat lenses. Advances in Biological Chemistry 04:01, pages 26-34.
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