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Original Article

Ameliorative effect of naringenin on hyperglycemia-mediated inflammation in hepatic and pancreatic tissues of Wistar rats with streptozotocin- nicotinamide-induced experimental diabetes mellitus

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Pages 793-803 | Received 20 Apr 2013, Accepted 05 Jul 2013, Published online: 08 Aug 2013

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Tajdar Husain Khan, Majid Ahmad Ganaie, Khalid Mofleh Alharthy, Hassan Madkhali, Basit Latief Jan & Ishfaq Ahmad Sheikh. (2020) Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats. Archives of Physiology and Biochemistry 126:4, pages 300-307.
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Song Park, Kyu-Sang Sim, Yeop Hwangbo, Sung-Jin Park, Young-Jun Kim & Jun-Ho Kim. (2022) Naringenin and Phytoestrogen 8-Prenylnaringenin Protect against Islet Dysfunction and Inhibit Apoptotic Signaling in Insulin-Deficient Diabetic Mice. Molecules 27:13, pages 4227.
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Zhengqi Dong, Rui Wang, Mingyue Wang, Zheng Meng, Xiaotong Wang, Meihua Han, Yifei Guo & Xiangtao Wang. (2022) Preparation of Naringenin Nanosuspension and Its Antitussive and Expectorant Effects. Molecules 27:3, pages 741.
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Mengjie Kong, Kang Xie, Minghui Lv, Jufei Li, Jianyu Yao, Kaixuan Yan, Xiaoqin Wu, Ying Xu & Dewei Ye. (2021) Anti-inflammatory phytochemicals for the treatment of diabetes and its complications: Lessons learned and future promise. Biomedicine & Pharmacotherapy 133, pages 110975.
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Azher Arafah, Muneeb U. Rehman, Tahir Maqbool Mir, Adil Farooq Wali, Rayeesa Ali, Wajhul Qamar, Rehan Khan, Ajaz Ahmad, Syed Sameer Aga, Saeed Alqahtani & Nada M. Almatroudi. (2020) Multi-Therapeutic Potential of Naringenin (4′,5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms. Plants 9:12, pages 1784.
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Pratishtha Singh, Seema Bansal, Anurag Kuhad, Anil Kumar & Kanwaljit Chopra. (2020) Naringenin ameliorates diabetic neuropathic pain by modulation of oxidative-nitrosative stress, cytokines and MMP-9 levels. Food & Function 11:5, pages 4548-4560.
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Naymul Karim, Zhenquan Jia, Xiaodong Zheng, Sunliang Cui & Wei Chen. (2018) A recent review of citrus flavanone naringenin on metabolic diseases and its potential sources for high yield-production. Trends in Food Science & Technology 79, pages 35-54.
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HadjMostefa Khelladi, Djamil Krouf & Nawal Taleb-Dida. (2018) Sardine proteins (Sardina pilchardus) combined with green lemon zest (Citrus latifolia) improve blood pressure, lipid profile and redox status in diabetic hypertensive rats. Nutrition & Food Science 48:4, pages 654-668.
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Muneeb U. Rehman, Manzoor Ur Rahman Mir, Adil Farooq, Shahzada Mudasir Rashid, Bilal Ahmad, Sheikh Bilal Ahmad, Rayeesa Ali, Ishraq Hussain, Mubashir Masoodi, Showkeen Muzamil, Hassan Madkhali & Majid Ahmad Ganaie. (2018) Naringenin (4,5,7-trihydroxyflavanone) suppresses the development of precancerous lesions via controlling hyperproliferation and inflammation in the colon of Wistar rats. Environmental Toxicology 33:4, pages 422-435.
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Ye Jin Lim, Jung Ho Kim, Jeong Hoon Pan, Jae Kyeom Kim, Tae-Sik Park, Young Jun Kim, Jin Hyup Lee & Jun Ho Kim. (2018) Naringin Protects Pancreatic β-Cells Against Oxidative Stress-Induced Apoptosis by Inhibiting Both Intrinsic and Extrinsic Pathways in Insulin-Deficient Diabetic Mice. Molecular Nutrition & Food Research 62:5, pages 1700810.
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Abdel K. Raffoul-Orozco, Ana E. Ávila-González, Christian M. Rodríguez-Razón, Teresa A. García-Cobian, Edsaul E. Pérez-Guerrero, Trinidad García-Iglesias & Edy David Rubio-Arellano. (2018) Combination effect naringin and pravastatin in lipid profile and glucose in obese rats. Life Sciences 193, pages 87-92.
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İ. Koçak, S. Sarac, E. Aydogan, E. Şentürk, D. Akakın, K. Koroglu & Ö.F. Özer. (2017) Evaluation of the possible protective role of naringenin on gentamicin-induced ototoxicity: A preliminary study. International Journal of Pediatric Otorhinolaryngology 100, pages 247-253.
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KK Vattam, HRB Raghavendran, MR Murali, H Savatey & T Kamarul. (2016) Coadministration of alloxan and nicotinamide in rats produces biochemical changes in blood and pathological alterations comparable to the changes in type II diabetes mellitus. Human & Experimental Toxicology 35:8, pages 893-901.
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Yassine Chtourou, Zeineb Kamoun, Wissem Zarrouk, Mohammed Kebieche, Choumous Kallel, Radhouane Gdoura & Hamadi Fetoui. (2016) Naringenin ameliorates renal and platelet purinergic signalling alterations in high-cholesterol fed rats through the suppression of ROS and NF-κB signaling pathways. Food & Function 7:1, pages 183-193.
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Renata Vargas, Elena Ryder, María Diez-Ewald, Jesús Mosquera, Anyelo Durán, Nereida Valero, Adriana Pedreañez, Caterina Peña & Erika Fernández. (2016) Increased C-reactive protein and decreased Interleukin-2 content in serum from obese individuals with or without insulin resistance: Associations with leukocyte count and insulin and adiponectin content. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 10:1, pages S34-S41.
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Margherita Dall’Asta, Morgane Bayle, Jérémie Neasta, Francesca Scazzina, Renato Bruni, Gérard Cros, Daniele Del Rio & Catherine Oiry. (2015) Protection of pancreatic β-cell function by dietary polyphenols. Phytochemistry Reviews 14:6, pages 933-959.
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Mohamed Fizur Nagoor Meeran, Govindan Sangaran Jagadeesh & Palanisamy Selvaraj. (2015) Thymol attenuates altered lipid metabolism in β-adrenergic agonist induced myocardial infarcted rats by inhibiting tachycardia, altered electrocardiogram, apoptosis and cardiac hypertrophy. Journal of Functional Foods 14, pages 51-62.
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Yassine Chtourou, Hamadi Fetoui, Raoua Jemai, Ahlem Ben Slima, Mohamed Makni & Radhouane Gdoura. (2015) Naringenin reduces cholesterol-induced hepatic inflammation in rats by modulating matrix metalloproteinases-2, 9 via inhibition of nuclear factor κB pathway. European Journal of Pharmacology 746, pages 96-105.
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Elena Ryder, María Diez-Ewald, Jesús Mosquera, Erika Fernández, Adriana Pedreañez, Renata Vargas, Caterina Peña & Nelson Fernández. (2014) Association of obesity with leukocyte count in obese individuals without metabolic syndrome. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 8:4, pages 197-204.
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Amr A. Fouad, Waleed H. Albuali, Ahmed Zahran & Wafaey Gomaa. (2014) Protective effect of naringenin against gentamicin-induced nephrotoxicity in rats. Environmental Toxicology and Pharmacology 38:2, pages 420-429.
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M. Ashraful Alam, Nusrat Subhan, M. Mahbubur Rahman, Shaikh J. Uddin, Hasan M. Reza & Satyajit D. Sarker. (2014) Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action. Advances in Nutrition 5:4, pages 404-417.
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Debarati Chattopadhyay, Ashok Somaiah, Divya Raghunathan & Kavitha Thirumurugan. (2014) Dichotomous Effect of Caffeine, Curcumin, and Naringenin on Genomic DNA of Normal and Diabetic Subjects. Scientifica 2014, pages 1-7.
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Radhika Kapoor & Poonam Kakkar. (2014) Naringenin accords hepatoprotection from streptozotocin induced diabetes in vivo by modulating mitochondrial dysfunction and apoptotic signaling cascade. Toxicology Reports 1, pages 569-581.
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