650
Views
59
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

Ergothioneine and melatonin attenuate oxidative stress and protect against learning and memory deficits in C57BL/6J mice treated with D-galactose

, , , , &
Pages 1049-1060 | Received 15 Jan 2014, Accepted 30 Apr 2014, Published online: 21 Jul 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Y. Chen, W. Qing, M. Sun, L. Lv, D. Guo & Y. Jiang. (2015) Melatonin protects hepatocytes against bile acid-induced mitochondrial oxidative stress via the AMPK-SIRT3-SOD2 pathway. Free Radical Research 49:10, pages 1275-1284.
Read now
Daniel Tsun-Yee Chiu & Yau-Huei Wei. (2014) Special issue on “Oxidative stress and mitochondrial alterations in aging and disease”. Free Radical Research 48:9, pages 967-969.
Read now

Articles from other publishers (57)

Izabela Szućko-Kociuba, Alicja Trzeciak-Ryczek, Patrycja Kupnicka & Dariusz Chlubek. (2023) Neurotrophic and Neuroprotective Effects of Hericium erinaceus. International Journal of Molecular Sciences 24:21, pages 15960.
Crossref
İnci TURAN, Veysel Haktan ÖZAÇMAK & Hale SAYAN ÖZAÇMAK. (2023) Melatonin Improves Postoperative Cognitive Dysfunction in Aged Rats: Relevance of Oxidative Stress, PSD95 and Ca2+/Calmoduline Dependent Protein KinaseMelatonin Yaşlı Sıçanlarda Postoperatif Kognitif Disfonksiyonu İyileştirir: Oksidatif Stres, PSD95 ve Ca2+/Kalmodulin Bağımlı Protein Kinazın Önemi. Batı Karadeniz Tıp Dergisi 7:2, pages 225-233.
Crossref
Jin Feng, Youle Zheng, Mingyue Guo, Irma Ares, Marta Martínez, Bernardo Lopez-Torres, María-Rosa Martínez-Larrañaga, Xu Wang, Arturo Anadón & María-Aránzazu Martínez. (2023) Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants. Acta Pharmaceutica Sinica B.
Crossref
Wei-Yi Ong, Mei-Han Kao, Wai-Mui Cheung, Damien Meng-Kiat Leow, Irwin Kee-Mun Cheah & Teng-Nan Lin. (2022) Protective Effect of Ergothioneine Against Stroke in Rodent Models. NeuroMolecular Medicine 25:2, pages 205-216.
Crossref
Federico Brandalise, Elisa Roda, Daniela Ratto, Lorenzo Goppa, Maria Letizia Gargano, Fortunato Cirlincione, Erica Cecilia Priori, Maria Teresa Venuti, Emanuela Pastorelli, Elena Savino & Paola Rossi. (2023) Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline?. Journal of Fungi 9:5, pages 551.
Crossref
Grazia Maria Liuzzi, Tania Petraglia, Tiziana Latronico, Aniello Crescenzi & Rocco Rossano. (2023) Antioxidant Compounds from Edible Mushrooms as Potential Candidates for Treating Age-Related Neurodegenerative Diseases. Nutrients 15:8, pages 1913.
Crossref
Jefferson Luiz da Silva, Lia Vezenfard Barbosa, Camila Figueiredo Pinzan, Viviani Nardini, Irislene Simões Brigo, Cássia Aparecida Sebastião, Jefferson Elias-Oliveira, Vânia Brazão, José Clóvis do Prado Júnior, Daniela Carlos & Cristina Ribeiro de Barros Cardoso. (2023) The Microbiota-Dependent Worsening Effects of Melatonin on Gut Inflammation. Microorganisms 11:2, pages 460.
Crossref
Jana Tchekalarova & Rumiana Tzoneva. (2023) Oxidative Stress and Aging as Risk Factors for Alzheimer’s Disease and Parkinson’s Disease: The Role of the Antioxidant Melatonin. International Journal of Molecular Sciences 24:3, pages 3022.
Crossref
Elisa Roda, Fabrizio De Luca, Daniela Ratto, Erica Cecilia Priori, Elena Savino, Maria Grazia Bottone & Paola Rossi. (2023) Cognitive Healthy Aging in Mice: Boosting Memory by an Ergothioneine-Rich Hericium erinaceus Primordium Extract. Biology 12:2, pages 196.
Crossref
Juliana Garcia, Jani Silva, Irene Gouvinhas, Rafaela Guimarães, António Bovolini, Maria José Saavedra & Maria José Alves. 2023. Natural Secondary Metabolites. Natural Secondary Metabolites 647 672 .
Yasaaswini Apparoo, Chia Wei Phan, Umah Rani Kuppusamy & Vikneswary Sabaratnam. (2022) Ergothioneine and its prospects as an anti-ageing compound. Experimental Gerontology 170, pages 111982.
Crossref
Zhenwei Zhai, Danni Xie, Tao Qin, Yanmei Zhong, Ying Xu & Tao Sun. (2022) Effect and Mechanism of Exogenous Melatonin on Cognitive Deficits in Animal Models of Alzheimer’s Disease: A Systematic Review and Meta-analysis. Neuroscience 505, pages 91-110.
Crossref
Haiqin Ren, Shouqin Gao, Shihui Wang, Jiamin Wang, Yangang Cheng, Yan Wang & Yingli Wang. (2022) Effects of Dangshen Yuanzhi Powder on learning ability and gut microflora in rats with memory disorder. Journal of Ethnopharmacology 296, pages 115410.
Crossref
Noritaka Nakamichi, Sota Tsuzuku & Fumiya Shibagaki. (2022) Ergothioneine and central nervous system diseases. Neurochemical Research 47:9, pages 2513-2521.
Crossref
Liu-Yun Wu, Cheuk Ni Kan, Irwin K. Cheah, Joyce Ruifen Chong, Xin Xu, Henri Vrooman, Saima Hilal, Narayanaswamy Venketasubramanian, Christopher P. Chen, Barry Halliwell & Mitchell K.P. Lai. (2022) Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in an Elderly Cohort Attending Memory Clinics. Antioxidants 11:9, pages 1717.
Crossref
Makoto Katsube, Hiroshi Watanabe, Kosuke Suzuki, Takahiro Ishimoto, Yoshitaka Tatebayashi, Yukio Kato & Norihito Murayama. (2022) Food-derived antioxidant ergothioneine improves sleep difficulties in humans. Journal of Functional Foods 95, pages 105165.
Crossref
Clayton A. Whitmore, Justin R. Haynes, William J. Behof, Adam J. Rosenberg, Mohammed N. Tantawy, Brian C. Hachey, Brian E. Wadzinski, Benjamin W. Spiller, Todd E. Peterson, Krista C. Paffenroth, Fiona E. Harrison, Robert B. Beelman, Printha Wijesinghe, Joanne A. Matsubara & Wellington Pham. (2022) Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer’s Disease. Pharmaceuticals 15:6, pages 742.
Crossref
Bindu D. Paul. (2022) Ergothioneine: A Stress Vitamin with Antiaging, Vascular, and Neuroprotective Roles?. Antioxidants & Redox Signaling 36:16-18, pages 1306-1317.
Crossref
Takahiro Ishimoto & Yukio Kato. (2022) Ergothioneine in the brain. FEBS Letters 596:10, pages 1290-1298.
Crossref
Ayobami Dare, Mahendra L. Channa & Anand Nadar. (2022) L-ergothioneine; a potential adjuvant in the management of diabetic nephropathy. Pharmacological Research - Modern Chinese Medicine 2, pages 100033.
Crossref
Halimat Amin Abdulrahim, Isiaka Abdullateef Alagbonsi, Oluwasola Amuda, Noah Adavize Omeiza, Abdul-Rahuf Aderemi Feyitimi & Luqman Aribidesi Olayaki. (2021) Cannabis sativa and/or melatonin do not alter brain lipid but alter oxidative mechanisms in female rats. Journal of Cannabis Research 3:1.
Crossref
Liu-Yun Wu, Irwin K. Cheah, Joyce Ruifen Chong, Yuek Ling Chai, Jia Yun Tan, Saima Hilal, Henri Vrooman, Christopher P. Chen, Barry Halliwell & Mitchell K.P. Lai. (2021) Low plasma ergothioneine levels are associated with neurodegeneration and cerebrovascular disease in dementia. Free Radical Biology and Medicine 177, pages 201-211.
Crossref
Fan Yao, Xinxiang Wang, Xinxin Cao, Kangqing Zhang, Jing Sun, Yuanhang Li, Jinling Sui & Yujun Liu. (2021) Integration of transcriptomics and metabolomics confirmed hepatoprotective effects of steamed shoot extracts of ginseng (Panax ginseng C.A. Meyer) on toxicity caused by overdosed acetaminophen. Biomedicine & Pharmacotherapy 143, pages 112177.
Crossref
Jan Homolak, Ana Babic Perhoc, Ana Knezovic, Ivan Kodvanj, Davor Virag, Jelena Osmanovic Barilar, Peter Riederer & Melita Salkovic‐Petrisic. (2021) Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network. Molecular Nutrition & Food Research 65:21.
Crossref
William J. Behof, Clayton A. Whitmore, Justin R. Haynes, Adam J. Rosenberg, Mohammed N. Tantawy, Todd E. Peterson, Fiona E. Harrison, Robert B. Beelman & Wellington Pham. (2021) A novel antioxidant ergothioneine PET radioligand for in vivo imaging applications. Scientific Reports 11:1.
Crossref
Ayobami Dare, Mahendra L. Channa & Anand Nadar. (2021) L-ergothioneine and its combination with metformin attenuates renal dysfunction in type-2 diabetic rat model by activating Nrf2 antioxidant pathway. Biomedicine & Pharmacotherapy 141, pages 111921.
Crossref
Julio A. Flores-Cuadra, Alanna Madrid, Patricia L. Fernández, Ambar R. Pérez-Lao, Diana C. Oviedo, Gabrielle B. Britton & Maria B. Carreira. (2021) Critical Review of the Alzheimer’s Disease Non-Transgenic Models: Can They Contribute to Disease Treatment?. Journal of Alzheimer's Disease 82:s1, pages S227-S250.
Crossref
Elisa Roda, Erica Cecilia Priori, Daniela Ratto, Fabrizio De Luca, Carmine Di Iorio, Paola Angelone, Carlo Alessandro Locatelli, Anthea Desiderio, Lorenzo Goppa, Elena Savino, Maria Grazia Bottone & Paola Rossi. (2021) Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging. International Journal of Molecular Sciences 22:12, pages 6379.
Crossref
Irwin K. Cheah & Barry Halliwell. (2021) Ergothioneine, recent developments. Redox Biology 42, pages 101868.
Crossref
Takahiro Ishimoto & Yukio Kato. 2021. Organic Cation Transporters in the Central Nervous System. Organic Cation Transporters in the Central Nervous System 281 300 .
Noritaka Nakamichi, Shunsuke Nakao, Misa Nishiyama, Yuka Takeda, Takahiro Ishimoto, Yusuke Masuo, Satoshi Matsumoto, Makoto Suzuki & Yukio Kato. (2020) Oral Administration of the Food-Derived Hydrophilic Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice. Current Molecular Pharmacology 14:2, pages 220-233.
Crossref
Irina Borodina, Louise C. Kenny, Cathal M. McCarthy, Kalaivani Paramasivan, Etheresia Pretorius, Timothy J. Roberts, Steven A. van der Hoek & Douglas B. Kell. (2020) The biology of ergothioneine, an antioxidant nutraceutical. Nutrition Research Reviews 33:2, pages 190-217.
Crossref
Sonu Kumar Yadav, Reshma Ir, Rajesh Jeewon, Mukesh Doble, Kevin D. Hyde, Ilango Kaliappan, Ravindrian Jeyaraman, Rambabu N. Reddi, Jayalakshmi Krishnan, Min Li & Siva Sundara Kumar Durairajan. (2020) A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders. Planta Medica 86:16, pages 1161-1175.
Crossref
Irwin K. Cheah & Barry Halliwell. (2020) Could Ergothioneine Aid in the Treatment of Coronavirus Patients?. Antioxidants 9:7, pages 595.
Crossref
Ioannis Zalachoras, Fiona Hollis, Eva Ramos-Fernández, Laura Trovo, Sarah Sonnay, Eveline Geiser, Nicolas Preitner, Pascal Steiner, Carmen Sandi & Laia Morató. (2020) Therapeutic potential of glutathione-enhancers in stress-related psychopathologies. Neuroscience & Biobehavioral Reviews 114, pages 134-155.
Crossref
Yoshiki Matsuda, Nobuyuki Ozawa, Takiko Shinozaki, Ken-ichi Wakabayashi, Kosuke Suzuki, Yusuke Kawano, Iwao Ohtsu & Yoshitaka Tatebayashi. (2020) Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances. Translational Psychiatry 10:1.
Crossref
Steven A. van der Hoek, Behrooz Darbani, Karolina E. Zugaj, Bala Krishna Prabhala, Mathias Bernfried Biron, Milica Randelovic, Jacqueline B. Medina, Douglas B. Kell & Irina Borodina. (2019) Engineering the Yeast Saccharomyces cerevisiae for the Production of L-(+)-Ergothioneine. Frontiers in Bioengineering and Biotechnology 7.
Crossref
Jiqu Xu, Hui Gao, Li Zhang, Shuang Rong, Wei Yang, Congcong Ma, Meng Chen, Qingde Huang, Qianchun Deng & Fenghong Huang. (2019) Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high‐fat diet. Journal of Pineal Research 67:2.
Crossref
Alice Maurer, Florian Leisinger, David Lim & Florian P. Seebeck. (2019) Structure and Mechanism of Ergothionase from Treponema denticola . Chemistry – A European Journal 25:44, pages 10298-10303.
Crossref
Irwin K. Cheah, Li‐Theng Ng, Li‐Fang Ng, Vanessa Y. Lam, Jan Gruber, Cheryl Y.W. Huang, Fang‐Qin Goh, Keith H.C. Lim & Barry Halliwell. (2019) Inhibition of amyloid‐induced toxicity by ergothioneine in a transgenic Caenorhabditis elegans model . FEBS Letters 593:16, pages 2139-2150.
Crossref
Noritaka Nakamichi, Yusuke Masuo & Yukio Kato. (2019) Possible Treatment of Neuropsychiatric Disorders by Promotion of Neuronal Differentiation through Organic Cation Transporters有機カチオン膜輸送体による神経幹細胞の機能制御と精神神経疾患治療への応用. YAKUGAKU ZASSHI 139:6, pages 847-852.
Crossref
Noritaka NakamichiShunsuke NakaoYusuke MasuoAyaka KoikeNaoto MatsumuraMisa NishiyamaAya Hasan Al-ShammariHirotaka SekiguchiKeita SutohKoji UsumiYukio Kato. (2019) Hydrolyzed Salmon Milt Extract Enhances Object Recognition and Location Memory Through an Increase in Hippocampal Cytidine Nucleoside Levels in Normal Mice. Journal of Medicinal Food 22:4, pages 408-415.
Crossref
Takahiro Ishimoto, Yusuke Masuo, Yukio Kato & Noritaka Nakamichi. (2019) Ergothioneine-induced neuronal differentiation is mediated through activation of S6K1 and neurotrophin 4/5-TrkB signaling in murine neural stem cells. Cellular Signalling 53, pages 269-280.
Crossref
Saraswathy Nachimuthu, Ruckmani Kandasamy, Ramalingam Ponnusamy, Jack Deruiter, Muralikrishnan Dhanasekaran & Sivasudha Thilagar. 2019. Medicinal Mushrooms. Medicinal Mushrooms 391 407 .
Barry Halliwell, Irwin K. Cheah & Richard M. Y. Tang. (2018) Ergothioneine – a diet‐derived antioxidant with therapeutic potential. FEBS Letters 592:20, pages 3357-3366.
Crossref
Robert N. Kerley, Cathal McCarthy, Douglas B. Kell & Louise C. Kenny. (2018) The potential therapeutic effects of ergothioneine in pre-eclampsia. Free Radical Biology and Medicine 117, pages 145-157.
Crossref
Reto Burn, Laëtitia Misson, Marcel Meury & Florian P. Seebeck. (2017) Anaerobic Origin of Ergothioneine. Angewandte Chemie International Edition 56:41, pages 12508-12511.
Crossref
Reto Burn, Laëtitia Misson, Marcel Meury & Florian P. Seebeck. (2017) Anaerobic Origin of Ergothioneine. Angewandte Chemie 129:41, pages 12682-12685.
Crossref
Irwin K. CheahRichard M.Y. TangTerry S.Z. YewKeith H.C. LimBarry Halliwell. (2017) Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation. Antioxidants & Redox Signaling 26:5, pages 193-206.
Crossref
Noritaka Nakamichi & Yukio Kato. (2017) Physiological Roles of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Neural Cells. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 40:8, pages 1146-1152.
Crossref
Tuzz-Ying Song, Nae-Cherng Yang, Chien-Lin Chen & Thuy Lan Vo Thi. (2017) Protective Effects and Possible Mechanisms of Ergothioneine and Hispidin against Methylglyoxal-Induced Injuries in Rat Pheochromocytoma Cells. Oxidative Medicine and Cellular Longevity 2017, pages 1-10.
Crossref
Chia-Wei PhanPamela DavidVikineswary Sabaratnam. (2017) Edible and Medicinal Mushrooms: Emerging Brain Food for the Mitigation of Neurodegenerative Diseases. Journal of Medicinal Food 20:1, pages 1-10.
Crossref
Irwin K. Cheah, Lei Feng, Richard M.Y. Tang, Keith H.C. Lim & Barry Halliwell. (2016) Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration?. Biochemical and Biophysical Research Communications 478:1, pages 162-167.
Crossref
Yushu Dong, Chongxi Fan, Wei Hu, Shuai Jiang, Zhiqiang Ma, Xiaolong Yan, Chao Deng, Shouyin Di, Zhenlong Xin, Guiling Wu, Yang Yang, Russel J. Reiter & Guobiao Liang. (2016) Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling. Journal of Pineal Research 60:3, pages 253-262.
Crossref
Barry Halliwell, Irwin K. Cheah & Chester L. Drum. (2016) Ergothioneine, an adaptive antioxidant for the protection of injured tissues? A hypothesis. Biochemical and Biophysical Research Communications 470:2, pages 245-250.
Crossref
Lei Zhao, Rui An, Yang Yang, Xiangmin Yang, Haixiao Liu, Liang Yue, Xia Li, Yan Lin, Russel J. Reiter & Yan Qu. (2015) Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling. Journal of Pineal Research 59:2, pages 230-239.
Crossref
Yang Yang, Shuai Jiang, Yushu Dong, Chongxi Fan, Lei Zhao, Xiangmin Yang, Juan Li, Shouyin Di, Liang Yue, Guobiao Liang, Russel J. Reiter & Yan Qu. (2015) Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice. Journal of Pineal Research 58:1, pages 61-70.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.