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Free Radical Research Volume 48, 2014 - Issue 9: Oxidative stress and mitochondrial alterations in ageing and disease
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REVIEW ARTICLE

Cisd2 mediates lifespan: is there an interconnection among Ca2+ homeostasis, autophagy, and lifespan?

C.-H. WangInstitute of Biochemistry and Molecular Biology, School of Life Science, National Yang-Ming University, Taipei, Taiwan
,
C.-H. KaoCenter of General Education, Chang Gung University, Taoyuan, Taiwan
,
Y.-F. ChenPhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan
,
Y.-H. WeiInstitute of Biochemistry and Molecular Biology, School of Life Science, National Yang-Ming University, Taipei, Taiwan;Department of Medicine, Mackay Medical College, New Taipei City, Taiwan
&
T.-F. TsaiDepartment of Life Sciences and Institute of Genome Sciences, School of Life Science, National Yang-Ming University, Taipei, Taiwan;Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli County, Taiwan;Genome Research Center, National Yang-Ming University, Taipei, Taiwan;Aging and Health Research Center, National Yang-Ming University, Taipei, TaiwanCorrespondence[email protected]
Pages 1109-1114 | Received 11 Mar 2014, Accepted 13 Jun 2014, Published online: 29 Jul 2014

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Zhao-Qing Shen, Yi-Long Huang & Ting-Fen Tsai. (2018) Cisd2 haploinsufficiency: A driving force for hepatocellular carcinoma. Molecular & Cellular Oncology 5:3.
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Daniel Tsun-Yee Chiu & Yau-Huei Wei. (2014) Special issue on “Oxidative stress and mitochondrial alterations in aging and disease”. Free Radical Research 48:9, pages 967-969.
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Chi-Hsiao Yeh, Zhao-Qing Shen, Tai-Wen Wang, Cheng-Heng Kao, Yuan-Chi Teng, Teng-Kuang Yeh, Chung-Kuang Lu & Ting-Fen Tsai. (2022) Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice. Journal of Biomedical Science 29:1.
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Yanchun Li, Bing Xu, Xueying Ren, Luyang Wang, Yaqing Xu, Yefeng Zhao, Chen Yang, Chen Yuan, Huanjuan Li, Xiangmin Tong, Ying Wang & Jing Du. (2022) Inhibition of CISD2 promotes ferroptosis through ferritinophagy-mediated ferritin turnover and regulation of p62–Keap1–NRF2 pathway. Cellular & Molecular Biology Letters 27:1.
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Yi‐Long Huang, Zhao‐Qing Shen, Chen‐Hua Huang, Chao‐Hsiung Lin & Ting‐Fen Tsai. (2021) Cisd2 slows down liver aging and attenuates age‐related metabolic dysfunction in male mice. Aging Cell 20:12.
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Ola Karmi, Yang-Sung Sohn, Sara I. Zandalinas, Linda Rowland, Skylar D. King, Rachel Nechushtai & Ron Mittler. (2021) Disrupting CISD2 function in cancer cells primarily impacts mitochondrial labile iron levels and triggers TXNIP expression. Free Radical Biology and Medicine 176, pages 92-104.
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Chi-Hsiao Yeh, Yi-Ju Chou, Ting-Kuan Chu & Ting-Fen Tsai. (2021) Rejuvenating the Aging Heart by Enhancing the Expression of the Cisd2 Prolongevity Gene. International Journal of Molecular Sciences 22:21, pages 11487.
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Hai-Yang Liao, Bei Liao & Hai-Hong Zhang. (2021) CISD2 plays a role in age-related diseases and cancer. Biomedicine & Pharmacotherapy 138, pages 111472.
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Yi-Long Huang, Zhao-Qing Shen, Chen-Hua Huang, Yuan-Chi Teng, Chao-Hsiung Lin & Ting-Fen Tsai. (2021) Cisd2 Protects the Liver from Oxidative Stress and Ameliorates Western Diet-Induced Nonalcoholic Fatty Liver Disease. Antioxidants 10:4, pages 559.
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Zhao-Qing Shen, Yi-Long Huang, Yuan-Chi Teng, Tai-Wen Wang, Cheng-Heng Kao, Chi-Hsiao Yeh & Ting-Fen Tsai. (2021) CISD2 maintains cellular homeostasis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1868:4, pages 118954.
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Laura Sanchez Caballero, Vyron Gorgogietas, Maria Nicol Arroyo & Mariana Igoillo-Esteve. 2021. Pancreatic ß-Cell Biology in Health and Disease. Pancreatic ß-Cell Biology in Health and Disease 139 256 .
Chi-Hsiao Yeh, Yi-Ju Chou, Cheng-Heng Kao & Ting-Fen Tsai. (2020) Mitochondria and Calcium Homeostasis: Cisd2 as a Big Player in Cardiac Ageing. International Journal of Molecular Sciences 21:23, pages 9238.
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Rachel Nechushtai, Ola Karmi, Ke Zuo, Henri-Baptiste Marjault, Merav Darash-Yahana, Yang-Sung Sohn, Skylar D. King, Sara I. Zandalinas, Paolo Carloni & Ron Mittler. (2020) The balancing act of NEET proteins: Iron, ROS, calcium and metabolism. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1867:11, pages 118805.
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Jude Gibson, Tom C. Russ, Toni-Kim Clarke, David M. Howard, Robert F. Hillary, Kathryn L. Evans, Rosie M. Walker, Mairead L. Bermingham, Stewart W. Morris, Archie Campbell, Caroline Hayward, Alison D. Murray, David J. Porteous, Steve Horvath, Ake T. Lu, Andrew M. McIntosh, Heather C. Whalley & Riccardo E. Marioni. (2019) A meta-analysis of genome-wide association studies of epigenetic age acceleration. PLOS Genetics 15:11, pages e1008104.
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Werner J. Geldenhuys, Robert Skolik, Mary E. Konkle, Michael A. Menze, Timothy E. Long & Aaron R. Robart. (2019) Binding of thiazolidinediones to the endoplasmic reticulum protein nutrient-deprivation autophagy factor-1. Bioorganic & Medicinal Chemistry Letters 29:7, pages 901-904.
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Alberto La SpadaAikaterini NtaiStefano GenoveseMaurizio RondinelliPasquale De BlasioIda Biunno. (2018) Generation of Human-Induced Pluripotent Stem Cells from Wolfram Syndrome Type 2 Patients Bearing the c.103 + 1G>A CISD2 Mutation for Disease Modeling . Stem Cells and Development 27:4, pages 287-295.
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Yi-Long Huang, Zhao-Qing Shen, Chia-Yu Wu, Yuan-Chi Teng, Chen-Chung Liao, Cheng-Heng Kao, Liang-Kung Chen, Chao-Hsiung Lin & Ting-Fen Tsai. (2018) Comparative proteomic profiling reveals a role for Cisd2 in skeletal muscle aging. Aging Cell 17:1, pages e12705.
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Ai-Gang Sun, Fan-Guo Meng & Ming-Guang Wang. (2017) CISD2 promotes the proliferation of glioma cells via suppressing beclin-1-mediated autophagy and is targeted by microRNA-449a. Molecular Medicine Reports 16:6, pages 7939-7948.
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Monica Cattaneo, Lucia La Sala, Maurizio Rondinelli, Edoardo Errichiello, Orsetta Zuffardi, Annibale Alessandro Puca, Stefano Genovese & Antonio Ceriello. (2017) A donor splice site mutation in CISD2 generates multiple truncated, non-functional isoforms in Wolfram syndrome type 2 patients. BMC Medical Genetics 18:1.
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Hanno Schmidt, Assaf Malik, Anne Bicker, Gesa Poetzsch, Aaron Avivi, Imad Shams & Thomas Hankeln. (2017) Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax – a liver transcriptomics approach. Scientific Reports 7:1.
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Chiao-Yin Sun, Mei-Ling Cheng, Heng-Chih Pan, Jia-Hung Lee & Chin-Chan Lee. (2017) Protein-bound uremic toxins impaired mitochondrial dynamics and functions. Oncotarget 8:44, pages 77722-77733.
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Cécile Rouzier, David Moore, Cécile Delorme, Sandra Lacas-Gervais, Samira Ait-El-Mkadem, Konstantina Fragaki, Florence Burté, Valérie Serre, Sylvie Bannwarth, Annabelle Chaussenot, Martin Catala, Patrick Yu-Wai-Man & Véronique Paquis-Flucklinger. (2017) A novel CISD2 mutation associated with a classical Wolfram syndrome phenotype alters Ca2+ homeostasis and ER-mitochondria interactions. Human Molecular Genetics 26:9, pages 1599-1611.
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Adele Chedraoui, Abdul Ghani Kibbi & Mazen Kurban. 2017. Textbook of Aging Skin. Textbook of Aging Skin 1529 1547 .
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John E. Morley. (2015) Pharmacologic Options for the Treatment of Sarcopenia. Calcified Tissue International 98:4, pages 319-333.
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