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Research Article

Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3-L1 adipocytes via its antioxidant potential

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Pages 1206-1217 | Received 10 May 2014, Accepted 14 Jul 2014, Published online: 21 Jul 2014

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Damu Lin, Hongqiang Wu, Zongwei Zhou, Zhenyu Tao, Tanghong Jia & Weiyang Gao. (2021) Ginkgolide B improves multiterritory perforator flap survival by inhibiting endoplasmic reticulum stress and oxidative stress . Journal of Investigative Surgery 34:6, pages 610-616.
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Ailin Cao & Xiangting Li. (2019) RETRACTED ARTICLE: Bilobalide protects H9c2 cell from oxygen-glucose-deprivation-caused damage via upregulation of miR-27a. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 2980-2988.
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Articles from other publishers (29)

Juan Hou, Yijing Jiang, Yangming Xu, Chunhui Zhao, Yali Cao, Wu Song & Bingmei Wang. (2023) Inhibitory effect of bilobalide on Staphylococcus aureus von Willebrand factor-binding protein and its therapeutic effect in mice with pneumonia . Journal of Applied Microbiology 134:10.
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Mohammad Saeid Ebrahimi, Zohreh Hosseini, Alireza Khatami, Mohammad Abbasi-Kolli, Javid Sadri Nahand, Ebrahim Kouchaki & Hamed Mirzaei. 2023. Phytonutrients and Neurological Disorders. Phytonutrients and Neurological Disorders 201 226 .
Peng Shang, Bo Zhang, Pan Li, Zulfiqar Ahmed, Xiaoxiang Hu, Yangzom Chamba & Hao Zhang. (2022) Plateau Adaptation Gene Analyses Reveal Transcriptomic, Proteomic, and Dual Omics Expression in the Lung Tissues of Tibetan and Yorkshire Pigs. Animals 12:15, pages 1919.
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Tian-Tong Niu, He Yin, Bao-Lei Xu, Ting-Ting Yang, Hui-Qin Li, Yi Sun & Guang-Zhi Liu. (2022) Protective Effects of Ginkgolide on a Cellular Model of Alzheimer’s Disease via Suppression of the NF-κB Signaling Pathway. Applied Biochemistry and Biotechnology 194:6, pages 2448-2464.
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Xiaojuan Zhang, Chuanchuan He & Guangya Xiang. (2022) Engineering nanomedicines to inhibit hypoxia-inducible Factor-1 for cancer therapy. Cancer Letters 530, pages 110-127.
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Jing Lu, Long Xie, Kai Liu, Xuming Zhang, Xian Wang, Xiaolin Dai, Youdan Liang, Yi Cao & Xiaofang Li. (2021) Bilobalide: A review of its pharmacology, pharmacokinetics, toxicity, and safety. Phytotherapy Research 35:11, pages 6114-6130.
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Ying Li, Jiliang Jiang, Liangcheng Tong, Tingting Gao, Lei Bai, Qing Xue, Jianxin Xing, Qin Wang, Haoran Lyu, Min Cai & Zhongyang Sun. (2020) Bilobalide protects against ischemia/reperfusion-induced oxidative stress and inflammatory responses via the MAPK/NF-κB pathways in rats. BMC Musculoskeletal Disorders 21:1.
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Tingting Wu, Xianying Fang, Jiahui Xu, Yan Jiang, Fuliang Cao & Linguo Zhao. (2020) Synergistic Effects of Ginkgolide B and Protocatechuic Acid on the Treatment of Parkinson’s Disease. Molecules 25:17, pages 3976.
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Valerie Politis-Barber, Henver S. Brunetta, Sabina Paglialunga, Heather L. Petrick & Graham P. Holloway. (2020) Long-term, high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration. American Journal of Physiology-Endocrinology and Metabolism 319:2, pages E376-E387.
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Qiaozhi Zhang & Elvira Gonzalez de Mejia. (2020) Protocatechuic acid attenuates adipogenesis-induced inflammation and mitochondrial dysfunction in 3T3-L1 adipocytes by regulation of AMPK pathway. Journal of Functional Foods 69, pages 103972.
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Kyung In Jeong, Su-Gwan Kim, Dae-San Go & Do Kyung Kim. (2020) Inhibition of cell growth and induction of apoptosis by bilobalide in FaDu human pharyngeal squamous cell carcinoma. International Journal of Oral Biology 45:1, pages 8-14.
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Jing‐ying Liu, Ting Geng, Kun Duan, Xia Gao, Chao‐jie Huang, Jia‐jia Wang, Wen‐zhe Huang, Lou‐sheng Huang, Zhen‐zhong Wang & Wei Xiao. (2019) Cellular pharmacokinetics and pharmacodynamics mechanisms of ginkgo diterpene lactone and its modulation of P‐glycoprotein expression in human SH‐SY5Y cells. Biomedical Chromatography 33:12.
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Guangxu Xiao, Ming Lyu, Yule Wang, Shuang He, Xinyan Liu, Jingyu Ni, Lan Li, Guanwei Fan, Jihong Han, Xiumei Gao, Xiaoying Wang & Yan Zhu. (2019) Ginkgo Flavonol Glycosides or Ginkgolides Tend to Differentially Protect Myocardial or Cerebral Ischemia–Reperfusion Injury via Regulation of TWEAK-Fn14 Signaling in Heart and Brain. Frontiers in Pharmacology 10.
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Bruna K.S. Hirata, Amanda P. Pedroso, Meira M.F. Machado, Nelson I.P. Neto, Bruna O. Perestrelo, Roberta D.C.C. de Sá, Maria Isabel C. Alonso-Vale, Fernando N. Nogueira, Lila M. Oyama, Eliane B. Ribeiro, Alexandre K. Tashima & Monica M. Telles. (2019) Ginkgo biloba Extract Modulates the Retroperitoneal Fat Depot Proteome and Reduces Oxidative Stress in Diet-Induced Obese Rats. Frontiers in Pharmacology 10.
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Hui Dai, Yue Yuan, Shuangli Yin, Yun Zhang, Yu Han, Li Sun, Tiankai Li, Jicheng Xu, Li Sheng, Yongtai Gong & Yue Li. (2019) Metoprolol Inhibits Profibrotic Remodeling of Epicardial Adipose Tissue in a Canine Model of Chronic Obstructive Sleep Apnea. Journal of the American Heart Association 8:3.
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Solomon Habtemariam. 2019. Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases. Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases 1049 1134 .
Xin-wei Liu, Jun-ling Yang, Wei Niu, Wei-wei Jia, Olajide E. Olaleye, Qi Wen, Xiao-na Duan, Yü-hong Huang, Feng-qing Wang, Fei-fei Du, Chen-chun Zhong, Yan-fen Li, Fang Xu, Qi Gao, Li Li & Chuan Li. (2018) Human pharmacokinetics of ginkgo terpene lactones and impact of carboxylation in blood on their platelet-activating factor antagonistic activity. Acta Pharmacologica Sinica 39:12, pages 1935-1946.
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Shuqin Liu, Xiaoye Hou, Lina Chen, Hao Hu, Qiang Sun, Feng Zhao & Chuanhao Liu. (2018) Enhancing amplification of late‐outgrowth endothelial cells by bilobalide. Journal of Cellular and Molecular Medicine 22:7, pages 3340-3352.
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Gui-ping Li, Hao Yang, Shao-bo Zong, Qiu Liu, Liang Li, Zhi-liang Xu, Jun Zhou, Zhen-zhong Wang & Wei Xiao. (2018) Diterpene ginkgolides meglumine injection protects against paraquat-induced lung injury and pulmonary fibrosis in rats. Biomedicine & Pharmacotherapy 99, pages 746-754.
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Shu-Yao WANG, Ji-Ye A, Fei FEI, Jian-Liang GENG, Ying PENG, Bing-Chen OUYANG, Pei WANG, Xiao-Liang JIN, Yu-Qing ZHAO, Jian-Kun WANG, Ting GENG, Yan-Jing LI, Wen-Zhe HUANG, Zhen-Zhong WANG, Wei XIAO & Guang-Ji WANG. (2017) Pharmacokinetics of the prototype and hydrolyzed carboxylic forms of ginkgolides A, B, and K administered as a ginkgo diterpene lactones meglumine injection in beagle dogs. Chinese Journal of Natural Medicines 15:10, pages 775-784.
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Minjee Kim, Kwangho Song & Yeong Shik Kim. (2017) Alantolactone improves palmitate-induced glucose intolerance and inflammation in both lean and obese states in vitro: Adipocyte and adipocyte-macrophage co-culture system. International Immunopharmacology 49, pages 187-194.
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Aleksandra Jankovic, Aleksandra Korac, Biljana Buzadzic, Ana Stancic, Vesna Otasevic, Péter Ferdinandy, Andreas Daiber & Bato Korac. (2017) Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management. British Journal of Pharmacology 174:12, pages 1570-1590.
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Lucia Biasutto, Michele Azzolini, Ildikò Szabò & Mario Zoratti. (2016) The mitochondrial permeability transition pore in AD 2016: An update. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:10, pages 2515-2530.
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Priyanka A., Anupama Nair, Anusree S. S., Nisha V. M. & Raghu K. G.. (2016) Bilobalide safeguards 3T3-L1 adipocytes from hypoxia through protecting mitochondrial bioenergetics, biogenesis and dynamics. RSC Advances 6:116, pages 114969-114979.
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Aleksandra Jankovic, Aleksandra Korac, Biljana Buzadzic, Vesna Otasevic, Ana Stancic, Andreas Daiber & Bato Korac. (2015) Redox implications in adipose tissue (dys)function—A new look at old acquaintances. Redox Biology 6, pages 19-32.
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Antonella Rocca, Stefania Moscato, Francesca Ronca, Simone Nitti, Virgilio Mattoli, Mario Giorgi & Gianni Ciofani. (2015) Pilot in vivo investigation of cerium oxide nanoparticles as a novel anti-obesity pharmaceutical formulation. Nanomedicine: Nanotechnology, Biology and Medicine 11:7, pages 1725-1734.
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Jinglou Chen, Jun Xu, Jingjing Li, Lifen Du, Tao Chen, Ping Liu, Sisi Peng, Mingwei Wang & Hongping Song. (2015) Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK mediated inflammatory responses and oxidative stress. International Immunopharmacology 26:1, pages 147-152.
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Kevin M. NashZahoor A. Shah. (2015) Current Perspectives on the Beneficial Role of Ginkgo biloba in Neurological and Cerebrovascular Disorders . Integrative Medicine Insights 10, pages IMI.S25054.
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Florence Boyer, Jennifer Baraka Vidot, Alexis Guerin Dubourg, Philippe Rondeau, M. Faadiel Essop & Emmanuel Bourdon. (2015) Oxidative Stress and Adipocyte Biology: Focus on the Role of AGEs. Oxidative Medicine and Cellular Longevity 2015, pages 1-9.
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