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Free Radical Research Communications Volume 2, 1986 - Issue 1-2
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Original Article

Oxidative Ionic Metabolites of L-Methyl-4-Phenyl-L, 2, 3, 6-Tetrahydropy-Ridine (MPTP): Correlation of Electro-Reduction with Physiological Behavior

James R. Ames Department of Chemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, 53201
,
Neal Castagnoli Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, 94143
,
Michael D. Ryan Department of Chemistry, Marquette University, Milwaukee, WI, 53233
&
Peter Kovacic Department of Chemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, 53201
Pages 107-113 | Received 22 Jan 1986, Published online: 07 Jul 2009

Citations (22)

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Peter Kovacic, W. Daniel Edwards & Gu Ming. (1991) Theoretical Studies on Mechanism of Mptp Action: Et Interference by Mpp+ (1-Methyl-4-Phenylpyridinium) With Mitochondrial Respiration vs. Oxidative Stress. Free Radical Research Communications 14:1, pages 25-32.
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Philip W. Crawford, Paavo Lumme, Hannu Elo, Michael D. Ryan & Peter Kovacic. (1987) Charge Transfer-Oxy Radical Mechanism for Anticancer Agents: mAMSA Derivatives, Rhodamine 123, and Nickel Salicylaldoximate. Free Radical Research Communications 3:6, pages 347-356.
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Articles from other publishers (20)

Yovani Marrero-Ponce, Juan A. Castillo-Garit, Ervelio Olazabal, Hector S. Serrano, Alcidez Morales, Nilo Castañedo, Froylán Ibarra-Velarde, Alma Huesca-Guillen, Alicia M. Sánchez, Francisco Torrens & Eduardo A. Castro. (2005) Atom, atom-type and total molecular linear indices as a promising approach for bioorganic and medicinal chemistry: theoretical and experimental assessment of a novel method for virtual screening and rational design of new lead anthelmintic. Bioorganic & Medicinal Chemistry 13:4, pages 1005-1020.
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Yovani Marrero-Ponce, Juan A. Castillo-Garit, Ervelio Olazabal, Hector S. Serrano, Alcidez Morales, Nilo Casta�edo, Froyl�n Ibarra-Velarde, Alma Huesca-Guillen, Elisa Jorge, Arletys del Valle, Francisco Torrens & Eduardo A. Castro. (2005) Tomocomd-Cardd, a novel approach for computer-aided ? rational? drug design: I. Theoretical and experimental assessment of a promising method for computational screening and in silico design of new anthelmintic compounds. Journal of Computer-Aided Molecular Design 18:10, pages 615-634.
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Peter Kovacic, James R. Ames & Michael D. Ryan. (1989) Reduction potentials of antimycobacterial agents: Relationship to activity. Bioelectrochemistry and Bioenergetics 21:3, pages 269-278.
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Peter Kovacic, James R. Ames & Michael D. Ryan. (1989) Reduction potentials of antimycobacterial agents: relationship to activity. Journal of Electroanalytical Chemistry and Interfacial Electrochemistry 275:3, pages 269-278.
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Peter Kovacic, William J. Popp, Jack W. Timberlake & Michael D. Ryan. (1989) Electrochemistry of cyclic α-imino carboxylates and their metal complexes: Correlation with physiological activity. Chemico-Biological Interactions 69:2-3, pages 235-244.
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François Darchen, Daniel Scherman, Claire Desnos & Jean-Pierre Henry. (1988) Characteristics of the transport of the quaternary ammonium 1-methyl-4-phenylpyridinium by chromaffin granules. Biochemical Pharmacology 37:22, pages 4381-4387.
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Clovis A. Linkous, Karen M. Schaich, Arthur Forman & Donald C. Borg. (1988) An electrochemical study of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its oxidation products. Bioelectrochemistry and Bioenergetics 19:3, pages 477-490.
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Clovis A. Linkous, Karen M. Schaich, Arthur Forman & Donald C. Borg. (1988) An electrochemical study of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its oxidation products. Journal of Electroanalytical Chemistry and Interfacial Electrochemistry 253:3, pages 477-490.
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Peter Kovacic, James R. Ames & Michael D. Ryan. (1988) Electron transfer mechanism for β-lactam antibiotic action via side-chain imine. Bioorganic Chemistry 16:2, pages 149-164.
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Peter Kovacic, James R. Ames & Michael D. Ryan. 1989. Redox Chemistry and Interfacial Behavior of Biological Molecules. Redox Chemistry and Interfacial Behavior of Biological Molecules 345 357 .
Peter Kovacic, James R. Ames, Mikolaj Jawdosiuk & Michael D. Ryan. 1989. Redox Chemistry and Interfacial Behavior of Biological Molecules. Redox Chemistry and Interfacial Behavior of Biological Molecules 323 331 .
Charles Eric Brown, Peter Kovacic, Kenneth J. Welch, Robert B. Cody, R. E. Hein & James A. Kinsinger. (2003) Laser desorption/fourier transform mass spectra of poly(phenylene sulfide), polyaniline, poly(vinyl phenol), polypyrene, and related oligomers: Evidence for carbon clusters and feasibility of physical dimension measurement. Journal of Polymer Science Part A: Polymer Chemistry 26:1, pages 131-148.
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Peter Kovacic, Mikolaj Jawdosiuk, James R. Ames & Michael D. Ryan. (1987) A novel approach to β-lactam chemistry in vivo: Electron transfer and oxy radical formation by iminium. Bioorganic Chemistry 15:4, pages 423-441.
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James R. Ames, Michael D. Ryan & Peter Kovacic. (1987) Mode of action of antiprotozoan agents. Electron transfer and oxy radicals. Life Sciences 41:16, pages 1895-1902.
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W. Korytowski, C.C. Felix & B. Kalyanaraman. (1987) Evidence for the one-electron oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+). Biochemical and Biophysical Research Communications 147:1, pages 354-360.
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Philip W. Crawford, William O. Foye, Michael D. Ryan & Peter Kovacic. (1987) Cyclic Voltammetry of Quinolinium Salts and Related Compounds: Correlation with Structure and Anticancer Activity. Journal of Pharmaceutical Sciences 76:6, pages 481-484.
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James R. Ames, Ulrich Hollstein, Anré R. Gagneux, Michael D. Ryan & Peter Kovacic. (1987) An integrated concept of amebicidal action: Electron transfer and oxy radicals. Free Radical Biology and Medicine 3:2, pages 85-96.
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Philip W. Crawford, Richard G. Scamehorn, Ulrich Hollstein, Michael D. Ryan & Peter Kovacic. (1986) Cyclic voltammetry of phenazines and quinoxalines including mono- and di-N-oxides. Relation to structure and antimicrobial activity. Chemico-Biological Interactions 60:1, pages 67-84.
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James R. Ames, Michael D. Ryan & Peter Kovacic. (1986) Mechanism of antibacterial action: Electron transfer and oxy radicals. Journal of Free Radicals in Biology & Medicine 2:5-6, pages 377-391.
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James R. Ames, Michael D. Ryan, Daniel L. Klyman & Peter Kovacic. (1985) Charge transfer and oxy radicals in antimalarial action. Quinones, dapsone metabolites, metal complexes, imunium ions, and peroxides. Journal of Free Radicals in Biology & Medicine 1:5-6, pages 353-361.
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