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Free Radical Research Communications Volume 2, 1987 - Issue 4-6
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Original Article

Dna Radiation Damage and its Modification by Metallothionein

C. L. Greenstock Medical Biophysics Branch, Atomic Energy of Canada Limited Research Company, Whiteshell Nuclear Research Establishment, Pinawa, Manitoba, Canada, R0E 1L0
,
C. P. Jinot Medical Biophysics Branch, Atomic Energy of Canada Limited Research Company, Whiteshell Nuclear Research Establishment, Pinawa, Manitoba, Canada, R0E 1L0
,
R. P. Whitehouse Medical Biophysics Branch, Atomic Energy of Canada Limited Research Company, Whiteshell Nuclear Research Establishment, Pinawa, Manitoba, Canada, R0E 1L0
&
M. D. Sargent Medical Biophysics Branch, Atomic Energy of Canada Limited Research Company, Whiteshell Nuclear Research Establishment, Pinawa, Manitoba, Canada, R0E 1L0
Pages 233-239 | Received 21 Jul 1986, Published online: 07 Jul 2009

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Priyanka Saha, Debasis Das, Sumana Roy, Arunabha Chakrabarti & Sarmistha Sen Raychaudhuri. (2013) Effect of gamma irradiation on metallothionein protein expression in Plantago ovata Forsk. International Journal of Radiation Biology 89:2, pages 88-96.
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Md Mahbub Hasan, Setsuko Todoriki, Akihiro Miyanoshita & Taro Imamura. (2008) Detection of gamma radiation-induced DNA damage in maize weevil, Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae) assessed using the comet assay. International Journal of Radiation Biology 84:10, pages 815-820.
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Articles from other publishers (34)

Abd El-Fattah B. M. El-Beltagy, Samaa M. Bakr, Samah S. G. Mekhaimer, Noura F. Ghanem & Amany Attaallah. (2023) Zinc-nanoparticles alleviate the ovarian damage induced by bacterial lipopolysaccharide (LPS) in pregnant rats and their fetuses. Histochemistry and Cell Biology 160:5, pages 453-475.
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Guangfeng Kan, Yun Ju, Ying Zhou, Cuijuan Shi, Yongping Qiao, Yu Yang, Ruiqi Wang & Xiaofei Wang. (2019) Cloning and functional characterization of a novel metallothionein gene in Antarctic sea-ice yeast ( Rhodotorula mucilaginosa ) . Journal of Basic Microbiology 59:9, pages 879-889.
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Min Zhang, Tetsuo Takano, Shenkui Liu & Xinxin Zhang. (2014) Abiotic stress response in yeast and metal-binding ability of a type 2 metallothionein-like protein (PutMT2) from Puccinellia tenuiflora. Molecular Biology Reports 41:9, pages 5839-5849.
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Shinichiro Takahashi. (2012) Molecular functions of metallothionein and its role in hematological malignancies. Journal of Hematology & Oncology 5:1.
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Li Jing, Yingliang Wu, Jing Wu, Jun Zhao, Daiying Zuo & Shuangqing Peng. (2011) Peroxiredoxins are involved in metallothionein protection from doxorubicin cardiotoxicity. European Journal of Pharmacology 659:2-3, pages 224-232.
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Emilie Farcy, Claire Voiseux, Jean-Marc Lebel & Bruno Fievet. (2007) Seasonal changes in mRNA encoding for cell stress markers in the oyster Crassostrea gigas exposed to radioactive discharges in their natural environment. Science of The Total Environment 374:2-3, pages 328-341.
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Clemens von Sonntag. 2006. Free-Radical-Induced DNA Damage and Its Repair. Free-Radical-Induced DNA Damage and Its Repair 357 482 .
Evgeny Denisov & Igor Afanas’ev. 2005. Oxidation and Antioxidants in Organic Chemistry and Biology. Oxidation and Antioxidants in Organic Chemistry and Biology 1 284 .
Hye Gwang Jeong, Cha-Kyung Youn, Hyun-Ju Cho, Soo-Hyun Kim, Mi-Hwa Kim, Hong-Beum Kim, In-Youb Chang, Yun-Sil Lee, Myung-Hee Chung & Ho Jin You. (2004) Metallothionein-III Prevents γ-Ray-induced 8-Oxoguanine Accumulation in Normal and hOGG1-depleted Cells. Journal of Biological Chemistry 279:33, pages 34138-34149.
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María José Pérez & Arthur I Cederbaum. (2003) Metallothionein 2A induction by zinc protects HEPG2 cells against CYP2E1-dependent toxicity. Free Radical Biology and Medicine 34:4, pages 443-455.
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Lu Cai & M.George Cherian. (2003) Zinc-metallothionein protects from DNA damage induced by radiation better than glutathione and copper- or cadmium-metallothioneins. Toxicology Letters 136:3, pages 193-198.
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L Z Fan & M G Cherian. (2002) Potential role of p53 on metallothionein induction in human epithelial breast cancer cells. British Journal of Cancer 87:9, pages 1019-1026.
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Peter Eck & Josef Pallauf. (2001) Induction of metallothionein by exposure to normobaric 100% oxygen atmosphere in rats with different zinc supply. Journal of Trace Elements in Medicine and Biology 15:4, pages 229-235.
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Walter Pierpaoli, Daniele Bulian & Silvana Arrighi. (2000) Transferrin treatment corrects aging-related immunologic and hormonal decay in old mice. Experimental Gerontology 35:3, pages 401-408.
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Craig.C. Conrad, David T. Grabowski, Christi A. Walter, Marian Sabia & Arlan Richardson. (2000) Using MT−/− mice to study metallothionein and oxidative stress. Free Radical Biology and Medicine 28:3, pages 447-462.
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Diana Xi Deng, Lu Cai, Subrata Chakrabarti & M.George Cherian. (1999) Increased radiation-induced apoptosis in mouse thymus in the absence of metallothionein. Toxicology 134:1, pages 39-49.
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Lu Cai, Masahiko Satoh, Chiharu Tohyama & M.George Cherian. (1999) Metallothionein in radiation exposure: its induction and protective role. Toxicology 132:2-3, pages 85-98.
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Danielle Blain, Stan Kubow & Hing Man Chan. (1998) Zinc Pretreatment Inhibits Isotretinoin Teratogenicity and Induces Embryonic Metallothionein in CD-1 Mice. The Journal of Nutrition 128:7, pages 1239-1246.
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Vikram Arora, Patrick L. Iversen & Manuchair Ebadi. (1998) Manipulation of Metallothionein Expression in the Regenerating Rat Liver Using Antisense Oligonucleotides. Biochemical and Biophysical Research Communications 246:3, pages 711-718.
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Gamal Abou-Mohamed, Andreas Papapetropoulos, John D. Catravas & Robert W Caldwell. (1998) Zn2+ inhibits nitric oxide formation in response to lipopolysaccharides: Implication in its anti-inflammatory activity. European Journal of Pharmacology 341:2-3, pages 265-272.
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G. M. Rott, O. A. Smoryzanova, V. A. Romantsova, E. P. Savina & F. A. Trofimov. (1997) Arbidol as the metallothionein inductor in mice. Pharmaceutical Chemistry Journal 31:9, pages 449-451.
Crossref
I. Jiménez, M. Gotteland, A. Zarzuelo, R. Uauy & H. Speisky. (1997) Loss of the metal binding properties of metallothionein induced by hydrogen peroxide and free radicals. Toxicology 120:1, pages 37-46.
Crossref
Lu Cai & M.George Cherian. (1996) Adaptive response to ionizing radiation-induced chromosome aberrations in rabbit lymphocytes: Effect of pre-exposure to zinc, and copper salts. Mutation Research/Genetic Toxicology 369:3-4, pages 233-241.
Crossref
J. W. Neal, S. K. Singhrao, B. Jasanit & G. R. Newman. (2008) Immunocytochemically detectable metallothionein is expressed by astrocytes in the ischaemic human brain. Neuropathology and Applied Neurobiology 22:3, pages 243-247.
Crossref
Lester Packer, Maret Traber & Wenjuan XinX Fang, W Wang & J Wu. 1996. Proceedings of the International Symposium on Natural Antioxidants. Proceedings of the International Symposium on Natural Antioxidants 261 271 .
Lu Cai, James Koropatnick & M.George Cherian. (1995) Metallothionein protects DNA from copper-induced but not iron-induced cleavage in vitro. Chemico-Biological Interactions 96:2, pages 143-155.
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N. Fabris & Eugenio Mocchegiani. (2013) Zinc, human diseases and aging. Aging Clinical and Experimental Research 7:2, pages 77-93.
Crossref
A. N. Koterov, M. V. Shagova, N. V. Shilina & I. Ya. Kon'. (1995) Lowering of lipid peroxidation and acute toxicity of bromobenzene by a polymeric form of zinc-metallothionein. Bulletin of Experimental Biology and Medicine 119:1, pages 37-39.
Crossref
A. N. Koterov, Z. A. Trebenok & I. V. Filippovich. (1994) Use of zinc metallothioneine to protect mice from ionizing radiation. Bulletin of Experimental Biology and Medicine 118:2, pages 828-830.
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NICOLA FABRIS. (1994) Neuroendocrine-Immune Aging: an Integrative View on the Role of Zinc. Annals of the New York Academy of Sciences 719:1 The Aging Clo, pages 353-368.
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C.L. Greenstock. (1993) Radiation and aging: Free radical damage, biological response and possible antioxidant intervention. Medical Hypotheses 41:5, pages 473-482.
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Kang Jong-Hon, Yuji Togashi, Hiroshi Kasai, Masuo Hosokawa & Noritoshi Takeichi. (1993) Prevention of spontaneous hepatocellular carcinoma in long-evans cinnamon rats with hereditary hepatitis by th administration of d-penicillamine. Hepatology 18:3, pages 614-620.
Crossref
Masao Sato & Ian Bremner. (1993) Oxygen free radicals and metallothionein. Free Radical Biology and Medicine 14:3, pages 325-337.
Crossref
R. L. Willson. 1989. Zinc in Human Biology. Zinc in Human Biology 147 172 .

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