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Original Article

Ascorbic Acid Oxidation and DNA Scission Catalyzed by Iron and Copper Chelates

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Pages 241-258 | Received 21 Jul 1986, Published online: 07 Jul 2009

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Read on this site (5)

H. Jacobi, J. Metzger & I. Witte. (1992) Synergistic Effects of Cu(II) and Dimethylammonium 2,4-Dichlorophenoxyacetate (U46 D Fluid) on PM2 DNA and Mechanism of Dna Damage. Free Radical Research Communications 16:2, pages 123-130.
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J. Aronovitch, D. Godinger & G. Czapski. (1991) Hydrogen Peroxide Dependent Oxidative Degradation of DNA by Copper Epinephrine. Free Radical Research Communications 13:1, pages 499-508.
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J. Aronovitch, D. Godinger & G. Czapski. (1991) Bactericidal Activity of Catecholamine Copper Complexes. Free Radical Research Communications 13:1, pages 479-488.
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Stella Harel & Joseph Kanner. (1989) Haemoglobin and Myoglobin as Inhibitors of Hydroxyl Radical Generation in a Model System of “Iron Redox” Cycle. Free Radical Research Communications 6:1, pages 1-10.
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Articles from other publishers (17)

Martin Doseděl, Eduard Jirkovský, Kateřina Macáková, Lenka Krčmová, Lenka Javorská, Jana Pourová, Laura Mercolini, Fernando Remião, Lucie Nováková & Přemysl Mladěnka. (2021) Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination. Nutrients 13:2, pages 615.
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Yanhong Sun, Rulong Ma, Shijin Wang, Guiying Li, Yongjie Sheng, Hongyue Rui, Jin Zhang, Jiacui Xu & Dazhi Jiang. (2017) New cofactors and inhibitors for a DNA-cleaving DNAzyme: superoxide anion and hydrogen peroxide mediated an oxidative cleavage process. Scientific Reports 7:1.
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Yanchun Wei, Jiaxing Song, Qun Chen & Da Xing. (2012) Enhancement of photodynamic antitumor effect with pro-oxidant ascorbate. Lasers in Surgery and Medicine 44:1, pages 69-75.
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Beenamma Jimmy, Sandra Kentish & Muthupandian Ashokkumar. (2011) Dynamics of counterion binding during acoustic nebulisation of surfactant solutions. Ultrasonics Sonochemistry 18:5, pages 958-962.
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Philippe Simon, Fabio Cannata, Loïc Perrouault, Ludovic Halby, Jean-Paul Concordet, Alexandre Boutorine, Vladimir Ryabinin, Alexandre Sinyakov & Carine Giovannangeli. (2008) Sequence-specific DNA cleavage mediated by bipyridine polyamide conjugates. Nucleic Acids Research 36:11, pages 3531-3538.
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Min-Young Seo & Sun-Mee Lee. (2002) Protective effect of low dose of ascorbic acid on hepatobiliary function in hepatic ischemia/reperfusion in rats. Journal of Hepatology 36:1, pages 72-77.
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Jun-ichi Ueda, Mamiko Takai, Yoshie Shimazu & Toshihiko Ozawa. (1998) Reactive Oxygen Species Generated from the Reaction of Copper(II) Complexes with Biological Reductants Cause DNA Strand Scission. Archives of Biochemistry and Biophysics 357:2, pages 231-239.
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Malgorzata Jezowska-Bojczuk, Wojciech Bal & Kazimierz S. Kasprzak. (1996) Copper(II) interactions with an experimental antiviral agent, 1-deoxynojirimycin, and oxygen activation by resulting complexes. Journal of Inorganic Biochemistry 64:4, pages 231-246.
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Regen Drouin, Henry Rodriguez, Shu-Wei Gao, Zewdu Gebreyes, Timothy R. O'Connor, Gerald P. Holmquist & Steven A. Akman. (1996) Cupric ion/ascorbate/hydrogen peroxide-induced DNA damage: DNA-bound copper ion primarily induces base modifications. Free Radical Biology and Medicine 21:3, pages 261-273.
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Fusako Takayama, Toru Egashira, Yoshikuni Kudo & Yasumitsu Yamanaka. (1993) Effects of anti-free radical intervention on phosphatidylcholine hydroperoxide in plasma after ischemia-reperfusion in the liver of rats. Biochemical Pharmacology 46:10, pages 1749-1757.
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Garry R. Buettner & Pope L. Moseley. (2002) Ascorbate both activates and inactivates bleomycin by free radical generation. Biochemistry 31:40, pages 9784-9788.
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Kazimierz S. Kasprzak, Susan L. North & Lidia Hernandez. (1992) Reversal by nickel(II) of inhibitory effects of some scavengers of active oxygen species upon hydroxylation of 2′-deoxyguanosine in vitro. Chemico-Biological Interactions 84:1, pages 11-19.
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Achim G. Rieth, Stephan L. Baader, Holger N. Lode, Gernot Bruchelt & Dietrich Niethammer. (1992) Ferritin enhances production of DNA strand breaks by 6-hydroxydopamine, ascorbic acid and H2O2 in CCC PM2 bacteriophage DNA. BioMetals 5:4, pages 223-227.
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H. Jacobi & I. Witte. (1991) Synergistic effects of U46 D Fluid (dimethylammonium salt of 2,4-D) and CuCl2 on cytotoxicity and DNA repair in human fibroblasts. Toxicology Letters 58:2, pages 159-167.
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Amram Samuni, Dina Godinger, Jacob Aronovitch, Angelo Russo & James B. Mitchell. (2002) Nitroxides block DNA scission and protect cells from oxidative damage. Biochemistry 30:2, pages 555-561.
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SARA GOLDSTEIN & GIDON CZAPSKI. 1990. Transition Metal Toxicity. Transition Metal Toxicity 133 164 .
Yori J. Appelbaum, Jeffrey Kuvin, Joseph B. Borman, Gideon Uretzky & Mordechai Chevion. (1990) The protective role of neocuproine against cardiac damage in isolated perfused rat hearts. Free Radical Biology and Medicine 8:2, pages 133-143.
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