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Original Article

Action of Uric Acid, Allopurinol and Oxypurinol on the Myeloperoxidase-Derived Oxidant Hypochlorous Acid

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Pages 69-76 | Received 19 Nov 1986, Published online: 07 Jul 2009

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Simon RJ Maxwell. (1997) Anti-oxidant therapy: does it have a role in the treatment of human disease?. Expert Opinion on Investigational Drugs 6:3, pages 211-236.
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Luis P. Candeias, Michael R.L. Stratford & Peter Wardman. (1994) Formation of Hydroxyl Radicals on Reaction of Hypochlorous Acid with Ferrocyanide, a Model IRON(II) Complex. Free Radical Research 20:4, pages 241-249.
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Roland Stocker & Ernst Peterhans. (1989) Antioxidant Properties of Conjugated Bilirubin and Biliverdin: Biologically Relevant Scavenging of Hypochlorous Acid. Free Radical Research Communications 6:1, pages 57-66.
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Marcela Franco Mineiro, Eliziane de Souza Patricio, Álbert Souza Peixoto, Thaís Larissa Silva Araujo, Railmara Pereira da Silva, Ana Iochabel Soares Moretti, Filipe Silva Lima, Francisco Rafael Martins Laurindo & Flavia Carla Meotti. (2020) Urate hydroperoxide oxidizes endothelial cell surface protein disulfide isomerase-A1 and impairs adherence. Biochimica et Biophysica Acta (BBA) - General Subjects 1864:3, pages 129481.
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Sayaka Iida, Yuki Ohkubo, Yorihiro Yamamoto & Akio Fujisawa. (2017) Parabanic acid is the singlet oxygen specific oxidation product of uric acid. Journal of Clinical Biochemistry and Nutrition 61:3, pages 169-175.
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Eliziane S. Patrício, Fernanda M. Prado, Railmara P. da Silva, Larissa A. C. Carvalho, Marcus V. C. Prates, Tony Dadamos, Mauro Bertotti, Paolo Di Mascio, Anthony J. Kettle & Flavia C. Meotti. (2015) Chemical Characterization of Urate Hydroperoxide, A Pro-oxidant Intermediate Generated by Urate Oxidation in Inflammatory and Photoinduced Processes. Chemical Research in Toxicology 28:8, pages 1556-1566.
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Jan GruberSoon Yew TangAndrew M. JennerIan MudwayAnders BlombergAnnelie BehndigKatherine KasimanChung-Yung J. LeeRaymond C.S. SeetWenxia ZhangChristopher ChenFrank J. KellyBarry Halliwell. (2009) Allantoin in Human Plasma, Serum, and Nasal-Lining Fluids as a Biomarker of Oxidative Stress: Avoiding Artifacts and Establishing Real in vivo Concentrations . Antioxidants & Redox Signaling 11:8, pages 1767-1776.
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Melvin F Simoyi, Elizabeth Falkenstein, Knox Van Dyke, Kenneth P Blemings & Hillar Klandorf. (2003) Allantoin, the oxidation product of uric acid is present in chicken and turkey plasma. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 135:2, pages 325-335.
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W. Sekundo, A.J. Augustin & I. Strempel. (2018) Topical Allopurinol or Corticosteroids and Acetylcysteine in the Early Treatment of Experimental Corneal Alkali Burns: A Pilot Study. European Journal of Ophthalmology 12:5, pages 366-372.
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Stephanie C. Tjen‐A‐Looi, Liang‐Wu Fu & John C. Longhurst. (2002) Xanthine oxidase, but not neutrophils, contributes to activation of cardiac sympathetic afferents during myocardial ischaemia in cats. The Journal of Physiology 543:1, pages 327-336.
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W. Sekundo & A.J. Augustin. (2018) Differences in the Composition of Inflammatory Cell Infiltrate in Lens-Induced Uveitis under Therapy with Allopurinol or Steroids. European Journal of Ophthalmology 11:3, pages 264-268.
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A. J. Augustin, F. H. Grus & S. Hunt. (1997) Effects of allopurinol on free-radical-induced reduction of the proliferation of retinal pigment epithelial cells. Documenta Ophthalmologica 93:3, pages 231-236.
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Carl-Magnus Andersson, Anders Hallberg & Thomas Högberg. 1996. Advances in Drug Research Volume 28. Advances in Drug Research Volume 28 65 180 .
D van Zoeren-Grobben, JH Lindeman, E Houdkamp, R Brand, J Schrijver & HM Berger. (1994) Postnatal changes in plasma chain-breaking antioxidants in healthy preterm infants fed formula and/or human milk. The American Journal of Clinical Nutrition 60:6, pages 900-906.
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Carroll E. Cross, Paul A. Motchnik, Bernd A. Bruener, Daniel A. Jones, Harparkash Kaur, Bruce N. Ames & Barry Halliwell. (1992) Oxidative damage to plasma constituents by ozone. FEBS Letters 298:2-3, pages 269-272.
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A. J. Augustin, R. K. Goldstein, J. Milz & J. Lutz. 1992. Oxygen Transport to Tissue XIII. Oxygen Transport to Tissue XIII 239 251 .
B Frei. (1991) Ascorbic acid protects lipids in human plasma and low-density lipoprotein against oxidative damage. The American Journal of Clinical Nutrition 54:6, pages 1113S-1118S.
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S W WernsC M GrumA VenturaR A HahnP P HoR D TownerJ C FantoneM A SchorkB R Lucchesi. (1991) Xanthine oxidase inhibition does not limit canine infarct size.. Circulation 83:3, pages 995-1005.
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Albert J. Augustin & Joachim Lutz. (1991) Intestinal, hepatic and renal production of thiobarbituric acid reactive substances and myeloperoxidase activity after temporary aortic occlusion and reperfusion. Life Sciences 49:13, pages 961-968.
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Barry Halliwell & John M.C. Gutteridge. 1990. Oxygen Radicals in Biological Systems Part B: Oxygen Radicals and Antioxidants. Oxygen Radicals in Biological Systems Part B: Oxygen Radicals and Antioxidants 1 85 .
Harparkash Kaur & Barry Halliwell. (1990) Action of biologically-relevant oxidizing species upon uric acid. Identification of uric acid oxidation products. Chemico-Biological Interactions 73:2-3, pages 235-247.
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J. Lutz, A. Augustin & E. Friedrich. 1990. Oxygen Transport to Tissue XII. Oxygen Transport to Tissue XII 683 690 .
F. Piccinini, E. Monti, L. Paracchini & G. Perletti. 1990. Antioxidants in Therapy and Preventive Medicine. Antioxidants in Therapy and Preventive Medicine 349 352 .
Balz Frei, Roland Stocker, Laura England & Bruce N. Ames. 1990. Antioxidants in Therapy and Preventive Medicine. Antioxidants in Therapy and Preventive Medicine 155 163 .
Philip E. Hartman & Delbert M. Shankel. (2008) Antimutagens and anticarcinogens: A survey of putative interceptor molecules. Environmental and Molecular Mutagenesis 15:3, pages 145-182.
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Okezie I. Aruoma & Barry Halliwell. (1989) Inactivation of α 1 -antiproteinase by hydroxyl radicals The effect of uric acid . FEBS Letters 244:1, pages 76-80.
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Mohammad Wasil, Barry Halliwell & Christopher P. Moorhouse. (1988) Scavenging of hypochlorous acid by tetracycline, rifampicin and some other antibiotics: a possible antioxidant action of rifampicin and tetracycline?. Biochemical Pharmacology 37:4, pages 775-778.
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Mohammad Wasil, Barry Halliwell, Christopher P. Moorhouse, Duncan C.S. Hutchison & Harold Baum. (1987) Biologically-significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by some anti-inflammatory drugs. Biochemical Pharmacology 36:22, pages 3847-3850.
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