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Free Radical Research Communications Volume 4, 1988 - Issue 6
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Original Article

Factors Influencing the Formation of the Carbon Dioxide Radical Anion (CO2−) Spin Adduct of Pbn in the Rat Liver Metabolism of Halocarbons

Edward G. Janzen Department of Chemistry and Biochemistry, Guelph-Waterloo Centre for Graduate Work in Chemistry, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
,
Rheal A. Towner Department of Chemistry and Biochemistry, Guelph-Waterloo Centre for Graduate Work in Chemistry, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
&
Manfred Brauer Department of Chemistry and Biochemistry, Guelph-Waterloo Centre for Graduate Work in Chemistry, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
Pages 359-369 | Received 30 Oct 1987, Published online: 07 Jul 2009

Citations (28)

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Read on this site (5)

Rheal A. Towner, Renat I. Zhdanov & Edward G. Janzen. (1993) Use of Nitroxides as MRI Contrast Agents to Study in vivo Carbon Tetrachloride Induced Hepatotoxicity in Rats. Free Radical Research Communications 19:sup1, pages s211-s218.
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Edward G. Janzen, Rheal A. Towner, Peter H. Krygsman, Edward K. Lai, J. Lee Poyer, Gemma Brueggemann & Paul B. McCay. (1990) Mass Spectroscopy and Chromatography of the Trichloromethyl Radical Adduct of Phenyl Ter T-Butyl Nitrone. Free Radical Research Communications 9:3-6, pages 353-360.
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Edward G. Janzen, Rheal A. Towner & S. Yamashiro. (1990) The Effect of Phenyl Tert-Butyl Nitrone (Pbn) on Ccl4-Induced Rat Liver Injury Detected by Proton Magnetic Resonance Imaging (Mri) in vivo and Electron Microscopy (Em). Free Radical Research Communications 9:3-6, pages 325-335.
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James M. Rau, Lester A. Reinke & Paul B. McCay. (1990) Direct Observation of Spin-Trapped Carbon Dioxide Radicals in Hepatocytes Exposed to Carbon Tetrachloride. Free Radical Research Communications 9:3-6, pages 197-204.
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PeterH. Krygsman, EdwardG. Janzen, RhealA. Towner & D. Larry Haire. (1989) Enhanced Recognition of Spin Trapped Radicals In Complex Mixtures: Deuterated Nitronyl Adducts Provide A Gas Chromatographic/Mass Spectrometric Marker. Analytical Letters 22:4, pages 1009-1020.
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Articles from other publishers (23)

Wei Xiao, Jun Zhang & Jie Wu. (2023) Recent Advances in Reactions Involving Carbon Dioxide Radical Anion. ACS Catalysis, pages 15991-16011.
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Amol U. Pawar, Umapada Pal, Jin You Zheng, Chang Woo Kim & Young Soo Kang. (2022) Thermodynamically controlled photo-electrochemical CO2 reduction at Cu/rGO/PVP/Nafion multi-layered dark cathode for selective production of formaldehyde and acetaldehyde. Applied Catalysis B: Environmental 303, pages 120921.
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Witcha Imaram, Benjamin T. Saylor, Christopher P. Centonze, Nigel G.J. Richards & Alexander Angerhofer. (2011) EPR spin trapping of an oxalate-derived free radical in the oxalate decarboxylase reaction. Free Radical Biology and Medicine 50:8, pages 1009-1015.
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Hee Sock Park, Hee Yoon Lee & Yong Hae Kim. (2005) Facile Barton−McCombie Deoxygenation of Alcohols with Tetrabutylammonium Peroxydisulfate and Formate Ion. Organic Letters 7:15, pages 3187-3190.
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Nadeem Khan & Harold Swartz. 2002. Oxygen/Nitrogen Radicals: Cell Injury and Disease. Oxygen/Nitrogen Radicals: Cell Injury and Disease 341 357 .
Patrick M. Winter, Viswanathan Seshan, Janice D. MakosA. Dean SherryCraig R. Malloy & Navin Bansal. (1998) Quantitation of intracellular [Na + ] in vivo by using TmDOTP 5−  as an NMR shift reagent and extracellular marker . Journal of Applied Physiology 85:5, pages 1806-1812.
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Feng-Ling Qing & Dong-Peng Wan. (1998) The addition of dibromodifluoromethane to (trimethylsilyl)acetylene and transformation of the products. Tetrahedron 54:47, pages 14189-14200.
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H.D Connor, R.G Thurman, G Chen, J.L Poyer, E.G Janzen & Ronald P Mason. (1998) Clarification of the Relationship Between Free Radical Spin Trapping and Carbon Tetrachloride Metabolism in Microsomal Systems. Free Radical Biology and Medicine 24:9, pages 1364-1368.
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Hong Sang, Edward G. Janzen, J.Lee Poyer & Paul B. McCay. (1997) The Structure of Free Radical Metabolites Detected by EPR Spin Trapping and Mass Spectroscopy from Halocarbons in Rat Liver Microsomes. Free Radical Biology and Medicine 22:5, pages 843-852.
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Edward G. Janzen, Hong Sang, Yashige Kotake, Coit M. DuBose, J. Lee Poyer & Masana Arimura. (1995) Tandem mass spectrometry study of C -phenyl- N-tert -butyl nitrone spin adducts from in vitro rat liver microsomal metabolism of bromotrichloromethane and carbon tetrachloride . Journal of the American Society for Mass Spectrometry 6:9, pages 847-853.
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Aditya. Khindaria, Thomas A. Grover & Steven D. Aust. (2002) Reductive Dehalogenation of Aliphatic Halocarbons by Lignin Peroxidase of Phanerochaete chrysosporium. Environmental Science & Technology 29:3, pages 719-725.
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E.G. Janzen, J.L. Poyer, M.S. West, C. Crossley & P.B. McCay. (1994) Study of reproducibility of spin trapping results in the use of C-phenyl-N-tert-butyl nitrone (PBN) for trichloromethyl radical detection in CCl4 metabolism by rat liver microsomal dispersions Biological spin trapping I. Journal of Biochemical and Biophysical Methods 29:3-4, pages 189-205.
Crossref
Rheal A. Towner, Edward G. Janzen, Yong-Kang Zhang & Shigeto Yamashiro. (1993) MRI study of the inhibitory effect of new spin traps on in vivo CCl4-induced hepatotoxicity in rats. Free Radical Biology and Medicine 14:6, pages 677-681.
Crossref
Edward G. Janzen, Guoman Chen, Tammy M. Bray, Lester A. Reinke, J. Lee Poyer & Paul B. McCay. (1993) Study of the isolation and stability of α-trichloromethylbenzyl(tert-butyl)aminoxyl, the trichloromethyl radical adduct of α-phenyl-tert-butylnitrone (PBN). J. Chem. Soc., Perkin Trans. 2:11, pages 1983-1989.
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M. Sentjurc & Ronald P. Mason. (1992) Inhibition of radical adduct reduction and reoxidation of the corresponding hydroxylamines in in vivo spin trapping of carbon tetrachloride-derived radicals. Free Radical Biology and Medicine 13:2, pages 151-160.
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Rheal A. Towner, Edward G. Janzen, Simon C. Chu & Alan Rath. (1992) Use of and double frequency tuned birdcage coils to study in vivo carbon tetrachloride-induced hepatotoxicity in rats. Magnetic Resonance Imaging 10:4, pages 679-688.
Crossref
Chang-Ming Hu & Ming-Hu Tu. (1991) Reduction of polyhalofluoroalkanes with formate to hydrogen-bearing alternatives initiated by carbon dioxide anionic radical. Journal of Fluorine Chemistry 55:1, pages 105-107.
Crossref
Rheal A. Towner, Lester A. Reinke, Edward G. Janzen & S. Yamashiro. (1991) Enhancement of carbon tetrachloride-induced liver injury by a single dose of ethanol: proton magnetic resonance imaging (MRI) studies in vivo. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1096:3, pages 222-230.
Crossref
Edward G. Janzen. 1991. Oxidative Damage & Repair. Oxidative Damage & Repair 142 147 .
Chang-Ming Hu, Feng-Ling Qing & Hong-Gen Zhang. (1990) Reactions of perhalocarbons. Part IX. Conversion of per(poly)fluoroalkyl halides into the corresponding carboxylic acids with a redox system. Journal of Fluorine Chemistry 49:2, pages 275-280.
Crossref
Hu Chang-Ming & Qing Feng-Ling. (1990) Addition of 1,1,2-trichloro-1 1,2,2-trifluoroethane (F113) to alkenes and alkynes initiated by a redox system. Tetrahedron Letters 31:9, pages 1307-1308.
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Manfred Brauer, Rheal A. Towner & David L. Foxall. (1990) Sodium-23 and proton nuclear magnetic resonance imaging studies of carbon tetrachloride-induced liver damage in the rat. Magnetic Resonance Imaging 8:4, pages 459-465.
Crossref
Rheal A. Towner, Manfred Brauer, Edward G. Janzen & Ming-fu Ling. (1989) In vivo and in vitro31P-NMR spectroscopy of rat liver treated with halocarbons. Biochimica et Biophysica Acta (BBA) - General Subjects 993:1, pages 92-99.
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