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Original Article

Increased Lipid Peroxidation in Hyperthyroid Patients: Suppression by Propylthiouracil Treatment

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Pages 1-10 | Received 23 Nov 1987, Published online: 07 Jul 2009

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Graziano Ceresini, Gian Paolo Ceda, Fulvio Lauretani, Marcello Maggio, Stefania Bandinelli, Jack M. Guralnik, Anne R. Cappola, Elisa Usberti, Simonetta Morganti, Giorgio Valenti & Luigi Ferrucci. (2011) Mild thyroid hormone excess is associated with a decreased physical function in elderly men. The Aging Male 14:4, pages 213-219.
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Apjit Kaur, Sukant Pandey, Sandeep Kumar, Abbas A. Mehdi & Arvind Mishra. (2010) Oxidative Stress Profile in Graves’ Ophthalmopathy in Indian Patients. Orbit 29:2, pages 97-101.
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Eliana A. Miler, María del Carmen Ríos de Molina, Gabriela Domínguez & Liliana N. Guerra. (2008) Thyroid hormone effect in human hepatocytes. Redox Report 13:4, pages 185-191.
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E. A. Lissi, M. Salim-Hanna, M. Fauré & L. A. Videla. (1991) 2,2′-Azo-bis-amidinopropane as a radical source for lipid peroxidation and enzyme inactivation studies. Xenobiotica 21:8, pages 995-1001.
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Michele Marinò, Giulia Lanzolla, Giovanna Rotondo Dottore & Claudio Marcocci. 2020. Pathology. Pathology 335 344 .
Mohan K. Kale. 2015. Free Radicals in Human Health and Disease. Free Radicals in Human Health and Disease 159 173 .
D. Baraldi, K. Casali, R.O. Fernandes, C. Campos, C. Sartório, A. Conzatti, G.K. Couto, P.C. Schenkel, A. Belló-Klein & A.R.S. Araujo. (2013) The role of AT1-receptor blockade on reactive oxygen species and cardiac autonomic drive in experimental hyperthyroidism. Autonomic Neuroscience 177:2, pages 163-169.
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Paola Venditti, Lisa Di Stefano & Sergio Di Meo. (2012) Vitamin E management of oxidative damage-linked dysfunctions of hyperthyroid tissues. Cellular and Molecular Life Sciences 70:17, pages 3125-3144.
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Pamela Cornejo, Romina Vargas & Luis A. Videla. (2013) Nrf2-regulated phase-II detoxification enzymes and phase-III transporters are induced by thyroid hormone in rat liver. BioFactors 39:5, pages 514-521.
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A. S. R. Araujo, F. E. R. Seibel, U. O. Oliveira, T. Fernandes, S. Llesuy, L. Kucharski & A. Belló‐Klein. (2011) Thyroid hormone—induced haemoglobin changes and antioxidant enzymes response in erythrocytes. Cell Biochemistry and Function 29:5, pages 408-413.
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C. De Ciuceis, A. Pilu, C. Cappelli, E. Porteri, F. Zani, A. Santoro, E. Gandossi, G. E. M. Boari, N. Rizzardi, M. Castellano, D. Rizzoni & E. Agabiti Rosei. (2010) Decreased number of circulating endothelial progenitor cells in patients with Graves’ hyperthyroidism. Journal of Endocrinological Investigation 34:5, pages 335-339.
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Krishna P. Bhabak & Govindasamy Mugesh. (2010) Antithyroid Drugs and their Analogues Protect Against Peroxynitrite‐Mediated Protein Tyrosine Nitration—A Mechanistic Study. Chemistry – A European Journal 16:4, pages 1175-1185.
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Luis A. Videla. (2010) Hormetic responses of thyroid hormone calorigenesis in the liver: Association with oxidative stress. IUBMB Life, pages n/a-n/a.
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Manuela Gago-Dominguez & Jose Esteban Castelao. (2008) Role of lipid peroxidation and oxidative stress in the association between thyroid diseases and breast cancer. Critical Reviews in Oncology/Hematology 68:2, pages 107-114.
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Dilek Gogas YavuzDilek YazιcιAhmet ToprakOguzhan DeyneliHasan AydιnMeral YükselSema Akalιn. (2008) Exogenous Subclinical Hyperthyroidism Impairs Endothelial Function in Nodular Goiter Patients. Thyroid 18:4, pages 395-400.
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Osama M. Ahmed, A.W. El‐Gareib, A.M. El‐bakry, S.M. Abd El‐Tawab & R.G. Ahmed. (2007) Thyroid hormones states and brain development interactions. International Journal of Developmental Neuroscience 26:2, pages 147-209.
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Ariane Zamoner, Kátia Padilha Barreto, Danilo Wilhelm Filho, Fabíola Sell, Viviane Mara Woehl, Fátima Costa Rodrigues Guma, Fátima Regina Mena Barreto Silva & Regina Pessoa-Pureur. (2007) Hyperthyroidism in the developing rat testis is associated with oxidative stress and hyperphosphorylated vimentin accumulation. Molecular and Cellular Endocrinology 267:1-2, pages 116-126.
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Göksel Şener, Özer Şehirli, Ayliz Velioğlu-Öğünç, Feriha Ercan, Gözde Erkanlı, Nursal Gedik & Berrak Ç. Yeğen. (2006) Propylthiouracil (PTU)-induced hypothyroidism alleviates burn-induced multiple organ injury. Burns 32:6, pages 728-736.
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Alper Tokay, Michel Raymondjean & Yakup Alicig??zel. (2006) The Effect of Thyroid Hormones on Erythrocyte 2,3-Diphosphoglycerate. The Endocrinologist 16:2, pages 57-60.
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Virginia Fernández, Gladys Tapia, Patricia Varela, Pamela Romanque, Denise Cartier-Ugarte & Luis A. Videla. (2006) Thyroid hormone-induced oxidative stress in rodents and humans: A comparative view and relation to redox regulation of gene expression. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 142:3-4, pages 231-239.
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Manuela Gago-Dominguez, J. Esteban Castelao, Malcolm C. Pike, Alex Sevanian & Robert W. Haile. (2005) Role of Lipid Peroxidation in the Epidemiology and Prevention of Breast Cancer. Cancer Epidemiology, Biomarkers & Prevention 14:12, pages 2829-2839.
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Liliana N. Guerra, María del Carmen Ríos de Molina, Eliana A. Miler, Silvia Moiguer, Mirta Karner & José A. Burdman. (2005) Antioxidants and methimazole in the treatment of Graves' disease: effect on urinary malondialdehyde levels. Clinica Chimica Acta 352:1-2, pages 115-120.
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Dilek Gogas Yavuz, Meral Yuksel, Oguzhan Deyneli, Yesim Ozen, Hasan Aydin & Sema Akalin. (2004) Association of serum paraoxonase activity with insulin sensitivity and oxidative stress in hyperthyroid and TSH-suppressed nodular goitre patients. Clinical Endocrinology 61:4, pages 515-521.
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Paola Venditti, Anna Puca & Sergio Di Meo. (2003) Effect of thyroid state on rate and sites of H2O2 production in rat skeletal muscle mitochondria. Archives of Biochemistry and Biophysics 411:1, pages 121-128.
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F Karatas, M Karatepe & A Baysar. (2002) Determination of free malondialdehyde in human serum by high-performance liquid chromatography. Analytical Biochemistry 311:1, pages 76-79.
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Serap Utaş, Kader Köse, Cevad Yazici, Ahmet Akdaş & Fahrettin Keleştimur. (2002) Antioxidant potential of propylthiouracil in patients with psoriasis. Clinical Biochemistry 35:3, pages 241-246.
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K. Kose, S. Utas, C. Yazici, A. Akdas & F. Kelestimur. (2001) Effect of propylthiouracil on adenosine deaminase activity and thyroid function in patients with psoriasis. British Journal of Dermatology 144:6, pages 1121-1126.
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Yakup Alicigüzel, Sebahat Nacitarhan Özdem, Sadi S Özdem, Ümit Karayalçin, Sandra L Siedlak, George Perry & Mark A Smith. (2001) Erythrocyte, plasma, and serum antioxidant activities in untreated toxic multinodular goiter patients. Free Radical Biology and Medicine 30:6, pages 665-670.
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Sandra Kalmijn, Kala M. Mehta, Huibert A. P. Pols, Albert Hofman, Hemmo A. Drexhage & Monique M. B. Breteler. (2008) Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study. Clinical Endocrinology 53:6, pages 733-737.
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Gladys Tapia, Pamela Cornejo, Virginia Fernández & Luis A. Videla. (1999) Protein oxidation in thyroid hormone-induced liver oxidative stress: relation to lipid peroxidation. Toxicology Letters 106:2-3, pages 209-214.
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Arzu Seven, Ertuǧrul Taşan, Figen İnci, Hüsrev Hatemi & Gülden Burçak. (1998) Biochemical Evaluation of Oxidative Stress in Propylthiouracil Treated Hyperthyroid Patients. Effects of Vitamin C Supplementation. cclm 36:10, pages 767-770.
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G Frenzilli, A Lori, G Panasiuk, M Ferdeghini & R Barale. (1998) Comet assay on children's leukocytes 8 years after the Chernobyl disaster. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 415:1-2, pages 151-158.
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Cristine A Costa, Gilmar C Trivelato, Adriana M P Pinto & Etelvino J H Bechara. (1997) Correlation between plasma 5-aminolevulinic acid concentrations and indicators of oxidative stress in lead-exposed workers. Clinical Chemistry 43:7, pages 1196-1202.
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Pilar Troncoso, Gladys Smok & Luis A Videla. (1997) Potentiation of Ischemia-Reperfusion Liver Injury by Hyperthyroidism in the Rat. Free Radical Biology and Medicine 23:1, pages 19-25.
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Véronique Chajès, Wolfgang Sattler, Margit Stultschnig & Gert M. Kostner. (1996) Photometric evaluation of lipid peroxidation products in human plasma and copper oxidized low density lipoproteins: correlation of different oxidation parameters. Atherosclerosis 121:2, pages 193-203.
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Luis A. Videla, Gladys Smokt, Pilar Troncoso, Karin A. Simon, Virginia B.C. Junqueira & Virginia Fernández. (1995) Influence of hyperthyroidism on lindane-induced hepatotoxicity in the rat. Biochemical Pharmacology 50:10, pages 1557-1565.
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Luis A. Videla, Loreto Correa, Marcela Rivera & Teresa Sir. (1993) Zymosan-induced luminol-amplified chemiluminescence of whole blood phagocytes in experimental and human hyperthyroidism. Free Radical Biology and Medicine 14:6, pages 669-675.
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J.P. Teare, S.M. Greenfield, J.S. Marway, V.R. Preedy, N.A. Punchard, T.J. Peters & R.P.H. Thompson. (1993) Effect of thyroidectomy and adrenalectomy on changes in liver glutathione and malonaldehyde levels after acute ethanol injection. Free Radical Biology and Medicine 14:6, pages 655-660.
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Mark Hicks, Lisa S. Wong & Richard O. Day. (1992) Antioxid ant activity of propylthiouracil. Biochemical Pharmacology 43:3, pages 439-444.
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Eduardo A. Lissi, Marta Salim-Hanna, Teresa Sir & Luis A. Videla. (1992) Is spontaneous urinary visible chemiluminescence a reflection of in vivo oxidative stress?. Free Radical Biology and Medicine 12:4, pages 317-322.
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Marcelo Fauré, Eduardo A. Lissi & Luis A. Videla. (1991) Evaluation of the antioxidant properties of thyroid hormones and propylthiouracil in the brain-homogenate autoxidation system and in the free radical-mediated oxidation of erythrocyte membranes. Chemico-Biological Interactions 77:2, pages 173-185.
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