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Original Article

Inhibition Of Thioredoxin Reductase (E.C. 1.6.4.5.) By Antitumor Quinones

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Pages 365-372 | Received 21 Jun 1989, Accepted 05 Aug 1989, Published online: 07 Jul 2009

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S. Gromer, R.H. Schirmer & K. Becker. (1999) News and views on thioredoxin reductases. Redox Report 4:5, pages 221-228.
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Articles from other publishers (15)

Mingxin Chang, Hongge Wang, Jiajing Niu, Yan Song & Zhihua Zou. (2020) Alkannin-Induced Oxidative DNA Damage Synergizes With PARP Inhibition to Cause Cancer-Specific Cytotoxicity. Frontiers in Pharmacology 11.
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Ilknur Ozgencli, Harun Budak, Mehmet Ciftci & Mustafa Anar. (2019) Lichen Acids May Be Used as A Potential Drug For Cancer Therapy; by Inhibiting Mitochondrial Thioredoxin Reductase Purified From Rat Lung. Anti-Cancer Agents in Medicinal Chemistry 18:11, pages 1599-1605.
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Weiqian Chen, Peng Zou, Zhongwei Zhao, Qiaoyou Weng, Xi Chen, Shilong Ying, Qingqing Ye, Zhe Wang, Jiansong Ji & Guang Liang. (2016) Selective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation. Oncotarget 7:13, pages 16593-16609.
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Dongzhu Duan, Baoxin Zhang, Juan Yao, Yaping Liu & Jianguo Fang. (2014) Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells. Free Radical Biology and Medicine 70, pages 182-193.
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Shaojun Yang, Yi-Hua Jan, Joshua P. Gray, Vladimir Mishin, Diane E. Heck, Debra L. Laskin & Jeffrey D. Laskin. (2013) Sepiapterin Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells. Journal of Biological Chemistry 288:26, pages 19221-19237.
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Wenqing Cai, Liangwei Zhang, Yanlin Song, Baolin Wang, Baoxin Zhang, Xuemei Cui, Guanming Hu, Yaping Liu, Jincai Wu & Jianguo Fang. (2012) Small molecule inhibitors of mammalian thioredoxin reductase. Free Radical Biology and Medicine 52:2, pages 257-265.
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Markus SeleniusAnna-Klara RundlöfEric OlmAristi P. FernandesMikael Björnstedt. (2010) Selenium and the Selenoprotein Thioredoxin Reductase in the Prevention, Treatment and Diagnostics of Cancer. Antioxidants & Redox Signaling 12:7, pages 867-880.
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Dashnamoorthy Ravi & Kumuda C. Das. (2004) Redox-cycling of anthracyclines by thioredoxin system: increased superoxide generation and DNA damage. Cancer Chemotherapy and Pharmacology 54:5, pages 449-458.
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Stephan Gromer, Sabine Urig & Katja Becker. (2003) The thioredoxin system—From science to clinic. Medicinal Research Reviews 24:1, pages 40-89.
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Stephan Gromer, Heiko Merkle, R. Heiner Schirmer & Katja Becker. 2002. Protein Sensors and Reactive Oxygen Species - Part A: Selenoproteins and Thioredoxin. Protein Sensors and Reactive Oxygen Species - Part A: Selenoproteins and Thioredoxin 382 394 .
Jonas Nordberg & Elias S.J. Arnér. (2001) Reactive oxygen species, antioxidants, and the mammalian thioredoxin system1 1This review is based on the licentiate thesis “Thioredoxin reductase—interactions with the redox active compounds 1-chloro-2,4-dinitrobenzene and lipoic acid” by Jonas Nordberg, 2001, Karolinska Institute, Stockholm, ISBN 91-631-1064-4.. Free Radical Biology and Medicine 31:11, pages 1287-1312.
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B Korać & B Buzadžić. (2001) Doxorubicin toxicity to the skin: possibility of protection with antioxidants enriched yeast. Journal of Dermatological Science 25:1, pages 45-52.
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Vadim N. Gladyshev & Dolph L. Hatfield. (1999) Selenocysteine-containing proteins in mammals. Journal of Biomedical Science 6:3, pages 151-160.
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Peter C. Preusch. (1992) Is thioredoxin the physiological vitamin K epoxide reducing agent?. FEBS Letters 305:3, pages 257-259.
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Bey-Liing Mau & Garth Powis. (1992) Mechanism-based inhibition of thioredoxin reductase by antitumor quinoid compounds. Biochemical Pharmacology 43:7, pages 1613-1620.
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