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Free Radical Research Communications Volume 8, 1990 - Issue 4-6
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Original Article

Activation And Deactivation Of Quinones Catalyzed By Dt-Diaphorase. Evidence For Bioreductive Activation Of Diaziquone (Azq) In Human Tumor Cells And Detoxification Of Benzene Metabolites In Bone Marrow Stroma

D. Ross Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy University of Colorado, Boulder, CO, 80309, USA
,
D. Siegel Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy University of Colorado, Boulder, CO, 80309, USA
,
N. W. Gibson Lab. Pharmacology, AMC Cancer Research Center, Denver, CO, 80214, USA
,
D. Pacheco Lab. Pharmacology, AMC Cancer Research Center, Denver, CO, 80214, USA
,
D. J. Thomas Dept. Pharmacology and Toxicology, West Virginia University Health Sciences Center, Morgantown, WV, 26506, USA
,
M. Reasor Dept. Pharmacology and Toxicology, West Virginia University Health Sciences Center, Morgantown, WV, 26506, USA
&
D. Wierda Dept. Pharmacology and Toxicology, West Virginia University Health Sciences Center, Morgantown, WV, 26506, USA
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Pages 373-381 | Received 21 Aug 1989, Published online: 07 Jul 2009

Citations (37)

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Robert Snyder. (2002) Benzene and Leukemia. Critical Reviews in Toxicology 32:3, pages 155-210.
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John D. Robertson & Sten Orrenius. (2000) Molecular Mechanisms of Apoptosis Induced by Cytotoxic Chemicals. Critical Reviews in Toxicology 30:5, pages 609-627.
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Articles from other publishers (35)

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Xiu Yuan, Christopher J. Miller, A. Ninh Pham & T. David Waite. (2014) Kinetics and mechanism of auto- and copper-catalyzed oxidation of 1,4-naphthohydroquinone. Free Radical Biology and Medicine 71, pages 291-302.
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Sungkyoon Kim, Qing Lan, Suramya Waidyanatha, Stephen Chanock, Brent A. Johnson, Roel Vermeulen, Martyn T. Smith, Luoping Zhang, Guilan Li, Min Shen, Songnian Yin, Nathaniel Rothman & Stephen M. Rappaport. (2007) Genetic polymorphisms and benzene metabolism in humans exposed to a wide Range of air concentrations. Pharmacogenetics and Genomics 17:10, pages 789-801.
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R. Snyder. (2016) Benzene's toxicity: a consolidated short review of human and animal studies by HA Khan. Human & Experimental Toxicology 26:9, pages 687-696.
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Katsuaki Yasunaga, Akiko Kiyonari, Munehiro Nakagawa & Kunie Yoshikawa. (2006) Investigation into the ability of the Salmonella umu test to detect DNA damage using antitumor drugs. Toxicology in Vitro 20:5, pages 712-728.
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Marcel Van Raaij & Robert Snyder. 2005. Inhalation Toxicology, Second Edition. Inhalation Toxicology, Second Edition 669 693 .
Francesca Maffei, Patrizia Hrelia, Sabrina Angelini, Fabio Carbone, Giorgio Cantelli Forti, Anna Barbieri, Giovanni Sanguinetti, Stefano Mattioli & Francesco Saverio Violante. (2005) Effects of environmental benzene: Micronucleus frequencies and haematological values in traffic police working in an urban area. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 583:1, pages 1-11.
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Martijn Rooseboom, Jan N. M. Commandeur & Nico P. E. Vermeulen. (2004) Enzyme-Catalyzed Activation of Anticancer Prodrugs. Pharmacological Reviews 56:1, pages 53-102.
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Angela Maria Di Francesco, Timothy H. Ward & John Butler. 2004. Quinones and Quinone Enzymes, Part B. Quinones and Quinone Enzymes, Part B 174 193 .
Gabriela Tudor, Peter Gutierrez, Angelica Aguilera-Gutierrez & Edward A Sausville. (2003) Cytotoxicity and apoptosis of benzoquinones: redox cycling, cytochrome c release, and BAD protein expression. Biochemical Pharmacology 65:7, pages 1061-1075.
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David Ross, Jadwiga K Kepa, Shannon L Winski, Howard D Beall, Adil Anwar & David Siegel. (2000) NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chemico-Biological Interactions 129:1-2, pages 77-97.
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Peter L Gutierrez. (2000) The role of NAD(P)H oxidoreductase (DT-Diaphorase) in the bioactivation of quinone-containing antitumor agents: a review. Free Radical Biology and Medicine 29:3-4, pages 263-275.
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Ian Guest & Jack Uetrecht. (2000) Drugs toxic to the bone marrow that target the stromal cells. Immunopharmacology 46:2, pages 103-112.
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Julie L. Moran, David Siegel & David Ross. (1999) A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity. Proceedings of the National Academy of Sciences 96:14, pages 8150-8155.
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Joseph Wiemels, John K. Wiencke, Andrea Varykoni & Martyn T. Smith. (1999) Modulation of the Toxicity and Macromolecular Binding of Benzene Metabolites by NAD(P)H:Quinone Oxidoreductase in Transfected HL-60 Cells. Chemical Research in Toxicology 12:6, pages 467-475.
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Eliezer Flescher & Carroll A. Snyder. (1995) Aspirin-like drugs can protect human T lymphocytes against benzoquinone cytotoxicity:. Archives of Toxicology 69:10, pages 684-689.
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Tim H. Ward, M.Sally Haran, Dee Whittaker, Amanda J. Watson, Tina D. Howard & John Butler. (1995) Cross-resistance studies on two K562 sublines resistant to diaziridinylbenzoquinones. Biochemical Pharmacology 50:4, pages 459-464.
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Song J. Li, E.Hazel Rodgers & M.Helen Grant. (1995) The activity of xenobiotic enzymes and the cytotoxicity of mitoxantrone in MCF 7 human breast cancer cells treated with inducing agents. Chemico-Biological Interactions 97:2, pages 101-118.
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Jos? Goin, Cecilia Giulivi, John Butler & Enrique Cadenas. (1995) Enzymic- and thiol-mediated activation of halogen-substituted diaziridinylbenzoquinones: Redox transitions of the semiquinone and semiquinone-thioether species. Free Radical Biology and Medicine 18:3, pages 525-536.
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Martin Belinsky & Anil K. Jaiswal. (1993) NAD(P)H:Quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues. Cancer and Metastasis Reviews 12:2, pages 103-117.
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Alan Cahill, Terence C. Jenkins & Ian N.H. White. (1993) Metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) by purified DT-diaphorase under aerobic and anaerobic conditions. Biochemical Pharmacology 45:2, pages 321-329.
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Robert J. Riley & Paul Workman. (1992) DT-diaphorase and cancer chemotherapy. Biochemical Pharmacology 43:8, pages 1657-1669.
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Lorranine E. Twerdok, Stephen J. Rembish & Michael A. Trush. (1992) Induction of quinone reductase and glutathione in bone marrow cells by 1,2-dithiole-3-thione: Effect on hydroquinone-induced cytotoxicity. Toxicology and Applied Pharmacology 112:2, pages 273-281.
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Geoffrey R. Fisher, Peter L. Gutierrez, Mark A. Oldcorne & Laurence H. Patterson. (1992) NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based antitumour agents and generation of hydroxyl radicals. Biochemical Pharmacology 43:3, pages 575-585.
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Terrence J. Monks, Robert P. Hanzlik, Gerald M. Cohen, David Ross & Doyle G. Graham. (1992) Quinone chemistry and toxicity. Toxicology and Applied Pharmacology 112:1, pages 2-16.
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Robert J. Riley & Paul Workman. (1992) Enzymology of the reduction of the potent benzotriazine-di-n-oxide hypoxic cell cytotoxin SR 4233 (win 59075) by NAD(P)H: (Quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from walker 256 rat tumour cells. Biochemical Pharmacology 43:2, pages 167-174.
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Enrique Cadenas, Paul Hochstein & Lars Ernster. 1992. Advances in Enzymology and Related Areas of Molecular Biology. Advances in Enzymology and Related Areas of Molecular Biology 97 146 .
David Ross, David Siegel, Sherri B. Turnipseed, James A. Ruth, Peter C. Preusch & Neil W. Gibson. 1991. Oxidative Damage & Repair. Oxidative Damage & Repair 619 623 .
Enrique Cadenas. 1991. Oxidative Damage & Repair. Oxidative Damage & Repair 606 611 .
Geoffrey R. Fisher & Peter L. Gutierrez. (1991) Free radical formation and DNA strand breakage during metabolism of diaziquone by NAD(P)H quinone-acceptor oxidoreductase (DT-diaphorase) and NADPH cytochrome c reductase. Free Radical Biology and Medicine 11:6, pages 597-607.
Crossref
Geoffrey R. Fisher & Peter L. Gutierrez. (1991) The reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells: Free radical formation and NAD(P)H: Quinone-acceptor oxidoreductase (DT-diaphorase) activity. Free Radical Biology and Medicine 10:6, pages 359-370.
Crossref

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