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Free Radical Research Communications Volume 9, 1990 - Issue 3-6
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Original Article

Mass Spectroscopy and Chromatography of the Trichloromethyl Radical Adduct of Phenyl Ter T-Butyl Nitrone

Edward G. Janzen Department of Chemistry and Biochemistry, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
,
Rheal A. Towner Department of Chemistry and Biochemistry, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
,
Peter H. Krygsman Department of Chemistry and Biochemistry, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
,
Edward K. Lai Molecular Toxicology Research Group, Oklahoma Medical Research Foundation, 825 N.E. 13th St., Okalhoma City, Oklahoma, 73104, USA
,
J. Lee Poyer Molecular Toxicology Research Group, Oklahoma Medical Research Foundation, 825 N.E. 13th St., Okalhoma City, Oklahoma, 73104, USA
,
Gemma Brueggemann Molecular Toxicology Research Group, Oklahoma Medical Research Foundation, 825 N.E. 13th St., Okalhoma City, Oklahoma, 73104, USA
&
Paul B. McCay Molecular Toxicology Research Group, Oklahoma Medical Research Foundation, 825 N.E. 13th St., Okalhoma City, Oklahoma, 73104, USA
 show all
Pages 353-360 | Published online: 07 Jul 2009

Citations (19)

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Read on this site (3)

G. D. Castro, A. M. A. Delgado de Layño & J. A. Castro. (1997) Hydroxyl and 1-hydroxyethyl free radical detection using spin traps followed by derivatization and gas chromatography—mass spectrometry. Redox Report 3:5-6, pages 343-347.
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Rheal A. Towner, Renat I. Zhdanov & Edward G. Janzen. (1993) Use of Nitroxides as MRI Contrast Agents to Study in vivo Carbon Tetrachloride Induced Hepatotoxicity in Rats. Free Radical Research Communications 19:sup1, pages s211-s218.
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Hideo Iwahashi, Carol E. Parker, Kenneth B. Tomer & Ronald P. Mason. (1992) Detection of the Ethyl-and Pentyl-Radical Adducts of α-(4-Pyridyl-1-Oxide)-N-Ter J-Butylnitrone in Rat-Liver Microsomes Treated with ADP, NADPH and Ferric Chloride. Free Radical Research Communications 16:5, pages 295-301.
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Articles from other publishers (16)

Michael J. Davies. (2016) Detection and characterisation of radicals using electron paramagnetic resonance (EPR) spin trapping and related methods. Methods 109, pages 21-30.
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Clare L. Hawkins & Michael J. Davies. (2014) Detection and characterisation of radicals in biological materials using EPR methodology. Biochimica et Biophysica Acta (BBA) - General Subjects 1840:2, pages 708-721.
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Michael J. Davies. 2009. Electron Paramagnetic Resonance. Electron Paramagnetic Resonance 427 450 .
Yao‐Wei Tian, Shi‐Hao Sun, Jian‐Ping Xie, Yong‐Li Zong, Cong Nie & Yin‐Long Guo. (2007) Detection of Radical Adducts with Small Molecular Weights by Matrix‐Assisted Laser Desorption/Ionization with Fourier Transform Mass Spectrometry. Chinese Journal of Chemistry 25:8, pages 1139-1144.
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M.B. Kadiiska, A.J. Ghio & R.P. Mason. (2004) ESR investigation of the oxidative damage in lungs caused by asbestos and air pollution particles. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 60:6, pages 1371-1377.
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Angelo Filosa & Ann M. English. (2001) Mass Spectral Analysis of Protein-based Radicals Using DBNBS. Journal of Biological Chemistry 276:24, pages 21022-21027.
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James L Merdink, Richard J Bull & Irvin R Schultz. (2000) Trapping and identification of the dichloroacetate radical from the reductive dehalogenation of trichloroacetate by mouse and rat liver microsomes. Free Radical Biology and Medicine 29:2, pages 125-130.
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Andrew J Ghio, Maria B Kadiiska, Qun-Hui Xiang & Ronald P Mason. (1998) In Vivo Evidence of Free Radical Formation After Asbestos Instillation. Free Radical Biology and Medicine 24:1, pages 11-17.
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Hong Sang, Edward G. Janzen, J.Lee Poyer & Paul B. McCay. (1997) The Structure of Free Radical Metabolites Detected by EPR Spin Trapping and Mass Spectroscopy from Halocarbons in Rat Liver Microsomes. Free Radical Biology and Medicine 22:5, pages 843-852.
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David A. Becker. (1996) Highly Sensitive Colorimetric Detection and Facile Isolation of Diamagnetic Free Radical Adducts of Novel Chromotropic Nitrone Spin Trapping Agents Readily Derived from Guaiazulene. Journal of the American Chemical Society 118:4, pages 905-906.
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Edward G. Janzen, Hong Sang, Yashige Kotake, Coit M. DuBose, J. Lee Poyer & Masana Arimura. (1995) Tandem mass spectrometry study of C -phenyl- N-tert -butyl nitrone spin adducts from in vitro rat liver microsomal metabolism of bromotrichloromethane and carbon tetrachloride . Journal of the American Society for Mass Spectrometry 6:9, pages 847-853.
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E.G. Janzen, J.L. Poyer, M.S. West, C. Crossley & P.B. McCay. (1994) Study of reproducibility of spin trapping results in the use of C-phenyl-N-tert-butyl nitrone (PBN) for trichloromethyl radical detection in CCl4 metabolism by rat liver microsomal dispersions Biological spin trapping I. Journal of Biochemical and Biophysical Methods 29:3-4, pages 189-205.
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Rheal A. Towner, Edward G. Janzen, Yong-Kang Zhang & Shigeto Yamashiro. (1993) MRI study of the inhibitory effect of new spin traps on in vivo CCl4-induced hepatotoxicity in rats. Free Radical Biology and Medicine 14:6, pages 677-681.
Crossref
Edward G. Janzen, Guoman Chen, Tammy M. Bray, Lester A. Reinke, J. Lee Poyer & Paul B. McCay. (1993) Study of the isolation and stability of α-trichloromethylbenzyl(tert-butyl)aminoxyl, the trichloromethyl radical adduct of α-phenyl-tert-butylnitrone (PBN). J. Chem. Soc., Perkin Trans. 2:11, pages 1983-1989.
Crossref
Hideo Iwahashi, Phillip W. Albro, Steven R. McGown, Kenneth B. Tomer & Ronald P. Mason. (1991) Isolation and identification of α-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts formed by the decomposition of the hydroperoxides of linoleic acid, linolenic acid, and arachidonic acid by soybean lipoxygenase. Archives of Biochemistry and Biophysics 285:1, pages 172-180.
Crossref
Edward G. Janzen. 1991. Oxidative Damage & Repair. Oxidative Damage & Repair 142 147 .

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