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Original Article

The Oxyradical-Scavenging Activity of Azelaic Acid in Biological Systems

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Pages 17-28 | Received 15 Nov 1990, Published online: 07 Jul 2009

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Boni E Elewski. (2006) Azelaic acid 15% gel for treatment of rosacea. Expert Review of Dermatology 1:4, pages 535-545.
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Neha Parveen, Afsana Sheikh, Nagashekhara Molugulu, Sivakumar Annadurai, Shadma Wahab & Prashant Kesharwani. (2023) Drug permeation enhancement, efficacy, and safety assessment of azelaic acid loaded SNEDDS hydrogel to overcome the treatment barriers of atopic dermatitis. Environmental Research 236, pages 116850.
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Supriya Kumari Singh, Saumya Chaubey, Anil Bansal, Gurpreet Kaur & Deepinder Singh Malik. (2021) Cosmeceutical Aptitudes of Azelaic Acid. Current Drug Research Reviews 13:3, pages 222-229.
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Dongdong Zhang, Ziyi Luo, Yanxia Jin, Yanling Chen, Tian Yang, Qian Yang, Balu Wu, Yufeng Shang, Xiaoyan Liu, Yongchang Wei & Fuling Zhou. (2020) Azelaic Acid Exerts Antileukemia Effects against Acute Myeloid Leukemia by Regulating the Prdxs/ROS Signaling Pathway. Oxidative Medicine and Cellular Longevity 2020, pages 1-16.
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Anil Kumar, Rekha Rao & Poonam Yadav. (2020) Azelaic Acid: A Promising Agent for Dermatological Applications. Current Drug Therapy 15:3, pages 181-193.
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Michael Maes, Buranee Kanchanatawan, Sunee Sirivichayakul & André F. Carvalho. (2018) In Schizophrenia, Deficits in Natural IgM Isotype Antibodies Including those Directed to Malondialdehyde and Azelaic Acid Strongly Predict Negative Symptoms, Neurocognitive Impairments, and the Deficit Syndrome. Molecular Neurobiology 56:7, pages 5122-5135.
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Marta C. García Bustínduy & Vanesa García Fumero. (2016) Rosácea. Impacto psicosocial. Piel 31:2, pages 96-105.
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Cong Liu, Zhuo Wang, Yulong Song, Dan Wu, Xuan Zheng, Ping Li, Jin Jin, Nannan Xu & Ling Li. (2015) Effects of Berberine on Amelioration of Hyperglycemia and Oxidative Stress in High Glucose and High Fat Diet-Induced Diabetic Hamsters In Vivo. BioMed Research International 2015, pages 1-9.
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M.A. Sieber & J.K.E. Hegel. (2014) Azelaic Acid: Properties and Mode of Action. Skin Pharmacology and Physiology 27:Suppl. 1, pages 9-17.
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Anja Thielitz & Harald P. M. Gollnick. 2014. Pathogenesis and Treatment of Acne and Rosacea. Pathogenesis and Treatment of Acne and Rosacea 185 188 .
Stefania Briganti, Enrica Flori, Arianna Mastrofrancesco, Daniela Kovacs, Emanuela Camera, Matteo Ludovici, Giorgia Cardinali & Mauro Picardo. (2012) Azelaic acid reduced senescence‐like phenotype in photo‐irradiated human dermal fibroblasts: possible implication of PPARγ. Experimental Dermatology 22:1, pages 41-47.
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Jens Gaitzsch, Irene Canton, Dietmar Appelhans, Giuseppe Battaglia & Brigitte Voit. (2012) Cellular Interactions with Photo-Cross-Linked and pH-Sensitive Polymersomes: Biocompatibility and Uptake Studies. Biomacromolecules 13:12, pages 4188-4195.
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Summer G. Goodson, Yunping Qiu, Keith A. Sutton, Guoxiang Xie, Wei Jia & Deborah A. O'Brien. (2012) Metabolic Substrates Exhibit Differential Effects on Functional Parameters of Mouse Sperm Capacitation1. Biology of Reproduction 87:3.
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BE Elewski, Z Draelos, B Dréno, T Jansen, A Layton & M Picardo. (2011) Rosacea - global diversity and optimized outcome: proposed international consensus from the Rosacea International Expert Group. Journal of the European Academy of Dermatology and Venereology 25:2, pages 188-200.
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Y. G. Grigoriev, V. F. Mikhailov, A. A. Ivanov, V. N. Maltsev, A. M. Ulanova, N. M. Stavrakova, I. A. Nikolaeva & O. A. Grigoriev. (2011) Autoimmune processes after long-term low-level exposure to electromagnetic fields part 4. Oxidative intracellular stress response to the long-term rat exposure to nonthermal RF EMF. Biophysics 55:6, pages 1054-1058.
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Arianna Mastrofrancesco, Monica Ottaviani, Nicaela Aspite, Giorgia Cardinali, Enzo Izzo, Klaus Graupe, Christos C Zouboulis, Emanuela Camera & Mauro Picardo. (2010) Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARγ activation. Experimental Dermatology 19:9, pages 813-820.
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Thomas Jansen, Bodo C. Melnik & Dirk Schadendorf. (2010) Steroid-induced Periorificial Dermatitis in Children-Clinical Features and Response to Azelaic Acid. Pediatric Dermatology 27:2, pages 137-142.
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Ö. Bakar, Z. Demirçay, M. Yuksel, G. Haklar & Y. Sanisoglu. (2007) The effect of azithromycin on reactive oxygen species in rosacea. Clinical and Experimental Dermatology 32:2, pages 197-200.
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Francisco Solano, Stefania Briganti, Mauro Picardo & Ghanem Ghanem. (2006) Hypopigmenting agents: an updated review on biological, chemical and clinical aspects. Pigment Cell Research 19:6, pages 550-571.
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T. Jansen. (2004) Azelaic acid as a new treatment for perioral dermatitis: results from an open study. British Journal of Dermatology 151:4, pages 933-934.
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James E Frampton & Antona J Wagstaff. (2004) Azelaic Acid 15% Gel. American Journal of Clinical Dermatology 5:1, pages 57-64.
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Diane Thiboutot, Ruth Thieroff-Ekerdt & Klaus Graupe. (2003) Efficacy and safety of azelaic acid (15%) gel as a new treatment for papulopustular rosacea: Results from two vehicle-controlled, randomized phase III studies. Journal of the American Academy of Dermatology 48:6, pages 836-845.
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Andrea Krautheim & Harald Gollnick. (2003) Transdermal Penetration of Topical Drugs Used in the Treatment of Acne. Clinical Pharmacokinetics 42:14, pages 1287-1304.
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Jose Rodriguez-Vicente, Vicente Vicente-Ortega & Manuel Canteras-Jordana. (1998) The effects of different antineoplastic agents and of pretreatment by modulators on three melanoma lines. Cancer 82:3, pages 495-502.
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J RODRIGUEZ‐VICENTE, V. VICENTE‐ORTEGA & CANTERAS‐JORDANA. (2006) Azelaic Acid Has Sensitizing Effect in the Chemotherapeutic Treatment of Several Melanoma Cell Lines. Pigment Cell Research 9:6, pages 317-325.
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Aodan Breathnach & R. Levi-Montalcini. (1995) The story of azelaic acid. A tribute to Marcella Nazzaro-PorroLa narrazione dell’acido azelaico. Rendiconti Lincei 6:4, pages 313-320.
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QUAN H. NGUYEN & TRAN P. BUI. (1995) AZELAIC ACID: PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES AND ITS THERAPEUTIC ROLE IN HYPERPIGMENTARY DISORDERS AND ACNE. International Journal of Dermatology 34:2, pages 75-84.
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