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Original Article

A Water-Soluble Quaternary Ammonium Analog of α-Tocopherol, that Scavenges Lipoperoxyl, Superoxyl and Hydroxyl Radicals

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Pages 363-372 | Received 18 Dec 1990, Accepted 05 Feb 1991, Published online: 07 Jul 2009

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Xian-Liang Tang, Paul B. McCay, Jian-Zhong Sun, Craig J. Hartley, Margo Schleman & Roberto Bolli. (1995) Inhibitory Effect of a Hydrophilic α-Tocopherol Analogue, MDL 74, 405, on Generation of Free Radicals in Stunned Myocardium in Dogs. Free Radical Research 22:4, pages 293-302.
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David Shanks, Riccardo Amorati, Maria Grazia Fumo, Gian Franco Pedulli, Luca Valgimigli & Lars Engman. (2005) Synthesis and Antioxidant Profile of all- r ac -α-Selenotocopherol . The Journal of Organic Chemistry 71:3, pages 1033-1038.
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Piyush M. Vyas, Sanjoy Roychowdhury, Patrick M. Woster & Craig K. Svensson. (2005) Reactive oxygen species generation and its role in the differential cytotoxicity of the arylhydroxylamine metabolites of sulfamethoxazole and dapsone in normal human epidermal keratinocytes. Biochemical Pharmacology 70:2, pages 275-286.
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MK Walker, C Vergely, S Lecour, C Abadie, V Maupoil & L Rochette. (2009) Vitamin E analogues reduce the incidence of ventricular fibrillations and scavenge free radicals. Fundamental & Clinical Pharmacology 12:2, pages 164-172.
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Hironobu Murase, Jae-Hak Moon, Ryo Yamauchi, Koji Kato, Tsutomu Kunieda, Toshikazu Yoshikawa & Junji Terao. (1998) Antioxidant Activity of a Novel Vitamin E Derivative, 2-(α-l-Glucopyranosyl)Methyl-2,5,7,8-TetramethylChroman-6-Ol. Free Radical Biology and Medicine 24:2, pages 217-225.
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Hironobu Murase, Ryo Yamauchi, Koji Kato, Tsutomu Kunieda & Junji Terao. (1997) Synthesis of a novel vitamin E derivative, 2-(α-d-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol, by α-glucosidase-catalyzed transglycosylation. Lipids 32:1, pages 73-78.
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Frank N. Bolkenius, Joëlle Verne-Mismer, Joseph Wagner & J.Martin Grisar. (1996) Amphiphilic α-tocopherol analogues as inhibitors of brain lipid peroxidation. European Journal of Pharmacology 298:1, pages 37-43.
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Asko Riutta, Juha Alanko, István Mucha & Heikki Vapaatalo. (1994) Effects of Trolox C and SIN-1 on arachidonic acid metabolism and on cyclic GMP formation in leukocytes. European Journal of Pharmacology 262:3, pages 217-222.
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L.Ross C. Barclay & Melinda R. Vinqvist. (1994) Membrane peroxidation: Inhibiting effects of water- soluble antioxidants on phospholipids of different charge types. Free Radical Biology and Medicine 16:6, pages 779-788.
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Margaret A. Petty, Ludovit Lukovic, J.Martin Grisar, J. Dow, Frank N. Bolkenius & Wybren De Jong. (1994) Myocardial protection by a cardioselective free radical scavenger. European Journal of Pharmacology 255:1-3, pages 215-222.
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Guohua Cao & Richard G. Cutler. (1993) High concentrations of antioxidants may not improve defense against oxidative stress. Archives of Gerontology and Geriatrics 17:3, pages 189-201.
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Saskia A.B.E. van Acker, Luc M.H. Koymans & Aalt Bast. (1993) Molecular pharmacology of vitamin E: Structural aspects of antioxidant activity. Free Radical Biology and Medicine 15:3, pages 311-328.
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Ludovit Lukovic, Margaret A. Petty, Frank N. Bolkenius, J.Martin Grisar, James Dow & Wybren De Jong. (1993) Protection of infarcted, chronically reperfused hearts by an α-tocopherol analogue. European Journal of Pharmacology 233:1, pages 63-70.
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Anthony W. Parker & Roger H. Bisby. (1993) Time-resolved resonance Raman spectroscopy of α-tocopheroxyl and related radicals in solvent, micellar and membrane systems. J. Chem. Soc., Faraday Trans. 89:15, pages 2873-2878.
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M. A. PETTY. (2007) MDL 73,404: A Cardioselective Antioxidant that Protects Against Myocardial Reperfusion Injury. Cardiovascular Drug Reviews 10:4, pages 413-424.
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Frank N. Bolkenius. (1991) Leukocyte-mediated inactivation of α1-proteinase inhibitor is inhibited by amino analogues of α-tocopherol. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1095:1, pages 23-29.
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