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Original Article

Effects of 4-Hydroxynonenal, A Product of Lipid Peroxidation, on Cell Proliferation and Ornithine Decarboxylase Activity

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Pages 81-89 | Received 03 Jun 1990, Published online: 07 Jul 2009

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Thirunavukkarasu Palaniyandi, Asha Sivaji, Ramanathan Thiruganasambandam, Sudhakar Natarajan & Rajeshwari Hari. (2018) Avicennia alba mangrove derived squalene compound inhibited the MNNG induced gastric cancer in Albino rats. Journal of Herbs, Spices & Medicinal Plants 24:3, pages 302-314.
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T. Devasena, V. P. Menon Venugopal & K. N. Rajasekaran. (2005) Chemoprevention of Colon Cancer by a Synthetic Curcumin Analog Involves Amelioration of Oxidative Stress. Toxicology Mechanisms and Methods 15:5, pages 355-359.
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S. Mirunalini, C.R. Ramachandran & S. Nagini. (2004) Chemoprevention of Experimental Hamster Buccal Pouch Carcinogenesis by Garlic Oil. Journal of Herbs, Spices & Medicinal Plants 10:4, pages 89-101.
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Seetharaman Balasenthil, Chinnamanoor Rajamani Ramachandran & Siddavaram Nagini. (2001) S-Allylcysteine, a Garlic Constituent, Inhibits 7,12-Dimethylbenz[a]Anthracene-Induced Hamster Buccal Pouch Carcinogenesis. Nutrition and Cancer 40:2, pages 165-172.
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Monica Rinaldi, Giuseppina Barrera, Paola Spinsanti, Stefania Pizzimenti, Silvia Anna Ciafrè, Paola Parella, Maria Giulia Farace, Emanuela Signori, Mario Umberto Dianzani & Vito Michele Fazio. (2001) Growth inhibition and differentiation induction in murine erythroleukemia cells by 4-hydroxynonenal. Free Radical Research 34:6, pages 629-637.
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R. H. Burdon, D. Alliangana & V. Gill. (1995) Hydrogen Peroxide and the Proliferation of Bhk-21 Cells. Free Radical Research 23:5, pages 471-486.
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Miklós Csala, Tamás Kardon, Balázs Legeza, Beáta Lizák, József Mandl, Éva Margittai, Ferenc Puskás, Péter Száraz, Péter Szelényi & Gábor Bánhegyi. (2015) On the role of 4-hydroxynonenal in health and disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1852:5, pages 826-838.
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E. E. Dubinina & V. A. Dadali. (2010) Role of 4-hydroxy-trans-2-nonenal in cell functions. Biochemistry (Moscow) 75:9, pages 1069-1087.
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Nagarajan Sangeetha, Selvaraj Aranganathan & Namasivayam Nalini. (2009) Silibinin ameliorates oxidative stress induced aberrant crypt foci and lipid peroxidation in 1, 2 dimethylhydrazine induced rat colon cancer. Investigational New Drugs 28:3, pages 225-233.
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Yusong Yang & Yogesh Awasthi. 2006. Toxicology of Glutathione Transferases. Toxicology of Glutathione Transferases 205 230 .
Brad Patrick, Jie Li, Prince V.S. Jeyabal, Prasada M.R.V. Reddy, Yusong Yang, Rajendra Sharma, Mala Sinha, Bruce Luxon, Piotr Zimniak, Sanjay Awasthi & Yogesh C. Awasthi. (2005) Depletion of 4-hydroxynonenal in hGSTA4-transfected HLE B-3 cells results in profound changes in gene expression. Biochemical and Biophysical Research Communications 334:2, pages 425-432.
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Mark A. Babizhayev, Yuri A. Semiletov, Yuri A. Lul’kin, Natalia L. Sakina, Ekaterina L. Savel’yeva, Ludmila M. Alimbarova & Igor Ph. Barinskii. (2005) 3D molecular modeling, free radical modulating and immune cells signaling activities of the novel peptidomimetic l-glutamyl-histamine: possible immunostimulating role. Peptides 26:4, pages 551-563.
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M A Babizhayev, Y A Semiletov, Y A Lul’kin, N L Sakina, E L Savel’yeva, L M Alimbarova & I P Barinskii. (2005) Immunostimulating activities of the novel peptidomimetic L-glutamyl-histamine. Clinical and Experimental Immunology 139:3, pages 447-457.
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Yogesh C. Awasthi, G.A.S. Ansari & Sanjay Awasthi. 2005. Gluthione Transferases and Gamma-Glutamyl Transpeptidases. Gluthione Transferases and Gamma-Glutamyl Transpeptidases 379 407 .
Giuseppina Barrera, Stefania Pizzimenti & Mario U. Dianzani. (2004) 4-hydroxynonenal and regulation of cell cycle: effects on the pRb/E2F pathway. Free Radical Biology and Medicine 37:5, pages 597-606.
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Mario Umberto Dianzani. (2003) 4-Hydroxynonenal from pathology to physiology. Molecular Aspects of Medicine 24:4-5, pages 263-272.
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K Kolanjiappan, C.R Ramachandran & S Manoharan. (2003) Biochemical changes in tumor tissues of oral cancer patients. Clinical Biochemistry 36:1, pages 61-65.
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B Velmurugan, V Bhuvaneswari, Usha K Burra & S Nagini. (2002) Prevention of N-methyl-N ′-nitro-N-nitrosoguanidine and saturated sodium chloride-induced gastric carcinogenesis in Wistar rats by lycopene. European Journal of Cancer Prevention 11:1, pages 19-26.
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Monica Rinaldi, Giuseppina Barrera, Angelo Aquino, Paola Spinsanti, Stefania Pizzimenti, Maria Giulia Farace, Mario Umberto Dianzani & Vito Michele Fazio. (2000) 4-Hydroxynonenal-Induced MEL Cell Differentiation Involves PKC Activity Translocation. Biochemical and Biophysical Research Communications 272:1, pages 75-80.
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Ji-Zhong Cheng, Sharad S. Singhal, Manjit Saini, Jyotsana Singhal, John T. Piper, F.J.G.M. Van Kuijk, Piotr Zimniak, Yogesh C. Awasthi & Sanjay Awasthi. (1999) Effects of mGST A4 Transfection on 4-Hydroxynonenal-Mediated Apoptosis and Differentiation of K562 Human Erythroleukemia Cells. Archives of Biochemistry and Biophysics 372:1, pages 29-36.
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Maurizio ParolaGiorgio BellomoGaia RobinoGiuseppina BarreraMario Umberto Dianzani. (1999) 4-Hydroxynonenal As a Biological Signal: Molecular Basis and Pathophysiological Implications. Antioxidants & Redox Signaling 1:3, pages 255-284.
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Bing Xiao, Sharda P. Singh, Bindu Nanduri, Yogesh C. Awasthi, Piotr Zimniak & Xinhua Ji. (1999) Crystal Structure of a Murine Glutathione S -Transferase in Complex with a Glutathione Conjugate of 4-Hydroxynon-2-enal in One Subunit and Glutathione in the Other:  Evidence of Signaling across the Dimer Interface , . Biochemistry 38:37, pages 11887-11894.
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M. Saroja, S. Balasenthil & S. Nagini. (1999) Tissue lipid peroxidation and glutathione-dependent enzyme status in patients with oral squamous cell carcinoma. Cell Biochemistry and Function 17:3, pages 213-216.
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A. M. Gioacchini, N. Calonghi, C. Boga, C. Cappadone, L. Masotti, A. Roda & P. Traldi. (1999) Determination of 4-hydroxy-2-nonenal at cellular levels by means of electrospray mass spectrometry. Rapid Communications in Mass Spectrometry 13:15, pages 1573-1579.
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Ichitomo Miwa, Keiko Adachi, Shigeki Murase, Yoshiki Hamada & Michiharu Sugiura. (1997) 4-Hydroxy-2-Nonenal Hardly Affects Glycolysis. Free Radical Biology and Medicine 23:4, pages 610-615.
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Astrid Hammer, Margherita Ferro, Hilmar M. Tillian, Franz Tatzber, Helmward Zollner, Erwin Schauenstein & Rudolf J. Schaur. (1997) Effect of Oxidative Stress by Iron on 4-Hydroxynonenal Formation and Proliferative Activity In Hepatomas of Different Degrees of Differentiation. Free Radical Biology and Medicine 23:1, pages 26-33.
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Deniz Yildiz, Nuran Ercala, Ronald L. Frank & Richard H. Matthews. (1996) Effects of 4-hydroxynonenal and N-acetyl-L-cysteine on Myc-induced apoptosis. Toxicology Letters 89:3, pages 215-221.
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Giuseppina Barrera, Stefania Pizzimenti, Roberto Muraca, Giuseppe Barbiero, Gabriella Bonelli, Francesco M. Baccino, Vito M. Fazio & Mario U. Dianzani. (1996) Effect of 4-hydroxynonenal on cell cycle progression and expression of differentiation-associated antigens in HL-60 cells. Free Radical Biology and Medicine 20:3, pages 455-462.
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C J Van Noorden. (1995) Effects of n-3 and n-6 polyunsaturated fatty acid-enriched diets on lipid metabolism in periportal and pericentral compartments of female rat liver lobules and the consequences for cell proliferation after partial hepatectomy.. Journal of Lipid Research 36:8, pages 1708-1720.
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Roy H. Burdon. (1995) Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radical Biology and Medicine 18:4, pages 775-794.
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Bernd A. Bruenner, A. Daniel Jones & J. Bruce German. (2005) Maximum entropy deconvolution of heterogeneity in protein modification: Protein adducts of 4‐hydroxy‐2‐nonenal. Rapid Communications in Mass Spectrometry 8:7, pages 509-512.
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Roy H. BURDON. 1994. Free Radical Damage and its Control. Free Radical Damage and its Control 155 185 .
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Mario Umberto Dianzani. (1993) Lipid peroxidation and cancer. Critical Reviews in Oncology/Hematology 15:2, pages 125-147.
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Frederik Le Dily, Jean-Pierre Billard, Claude Huault, Claire Kevers & Thomas Gaspar. (1993) Fully habituated sugarbeet callus: Under permanent stress?. In Vitro Cellular & Developmental Biology - Plant 29:4, pages 149-154.
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Catherine Rice-Evans & Roy Burdon. (1993) Free radical-lipid interactions and their pathological consequences. Progress in Lipid Research 32:1, pages 71-110.
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V.M. Fazio, M. Rinaldi, S. Ciafrè, G. Barrera & M.G. Farace. (1993) Control of neoplastic cell proliferation and differentiation by restoration of 4-hydroxynonenal physiological concentrations. Molecular Aspects of Medicine 14:3, pages 217-228.
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Giuseppina Barrera, Clelia Di Mauro, Roberto Muraca, Dario Ferrero, Guido Cavalli, Vito Michele Fazio, Luciana Paradisi & Mario Umberto Dianzani. (1991) Induction of differentiation in human HL-60 cells by 4-hydroxynonenal, a product of lipid peroxidation. Experimental Cell Research 197:2, pages 148-152.
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