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Free Radical Research Communications Volume 13, 1991 - Issue 1
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Original Article

Vascular Oxidant Stress and Hepatic Ischemia/Reperfusion Injury

Hartmut Jaeschke Center for Experimental Therapeutics and Section on Hypertension Clinical Pharmacology, Department of Medicine, Houston, Texas, 77030, USA; Department of Pharmacology, Baylor College of Medicine, Houston, Texas, 77030, USA
Pages 737-743 | Received 17 Sep 1989, Published online: 07 Jul 2009

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M. Elias-Miró, M. B. Jiménez-Castro, J. Rodés & C. Peralta. (2013) Current knowledge on oxidative stress in hepatic ischemia/reperfusion. Free Radical Research 47:8, pages 555-568.
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P. T. Liu, C. Ioannides, A. M. Symons & D. V. Parke. (1993) Role of tissue glutathione in prevention of surgical trauma. Xenobiotica 23:8, pages 899-911.
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Peter H. Ward, Mafalda Maldonado & Ennio Vivald. (1992) Oxygen-Derived Free Radicals Mediate Liver Damage in Rats Subjected to Tourniquet Shock. Free Radical Research Communications 17:5, pages 313-325.
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Hartmut Jaeschke, Abraham P. Bautista, Zoltan Spolarics & John J. Spitzer. (1991) Superoxide Generation by Kupffer Cells and Priming of Neutrophils During Reperfusion After Hepatic Ischemia. Free Radical Research Communications 15:5, pages 277-284.
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Articles from other publishers (57)

H. Jaeschke & A. Ramachandran. 2018. Comprehensive Toxicology. Comprehensive Toxicology 277 295 .
Lida Suo, Kai Kang, Xun Wang, Yonggang Cao, Haifeng Zhao, Xueying Sun, Liquan Tong & Feng Zhang. (2014) Carvacrol Alleviates Ischemia Reperfusion Injury by Regulating the PI3K-Akt Pathway in Rats. PLoS ONE 9:8, pages e104043.
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Giuliano Ancelmo Bento, Viviani Reis da Cunha, Rodrigo Martinez, Flávia Carvalho Alcantara Gomes & Alberto Schanaider. (2013) Avaliação da proteína acídica fibrilar glial como marcador da injúria por isquemia-reperfusão hepática. Revista do Colégio Brasileiro de Cirurgiões 40:3, pages 215-220.
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Mitchell R. McGill & Hartmut Jaeschke. 2013. Drug-Induced Liver Disease. Drug-Induced Liver Disease 71 84 .
Hartmut Jaeschke & Benjamin L. Woolbright. (2012) Current strategies to minimize hepatic ischemia–reperfusion injury by targeting reactive oxygen species. Transplantation Reviews 26:2, pages 103-114.
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H. Jaeschke. 2010. Comprehensive Toxicology. Comprehensive Toxicology 319 337 .
Marc Hanschen, Stefan Zahler, Fritz Krombach & Andrej Khandoga. (2008) Reciprocal Activation Between CD4+ T Cells and Kupffer Cells During Hepatic Ischemia-Reperfusion. Transplantation 86:5, pages 710-718.
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Samuel Wyllie, Neal R Barshes, Feng-Qin Gao, Saul J Karpen & John A Goss. (2008) Failure of P-selectin blockade alone to protect the liver from ischemia-reperfusion injury in the isolated blood-perfused rat liver. World Journal of Gastroenterology 14:44, pages 6808.
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Sander Dinant, Reeta L. Veteläinen, Sandrine Florquin, Arlène K. van Vliet & Thomas M. van Gulik. (2007) IL-10 Attenuates Hepatic I/R Injury and Promotes Hepatocyte Proliferation. Journal of Surgical Research 141:2, pages 176-182.
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Araní Casillas-Ramírez, Ismail Ben Mosbah, Fernando Ramalho, Joan Roselló-Catafau & Carmen Peralta. (2006) Past and future approaches to ischemia-reperfusion lesion associated with liver transplantation. Life Sciences 79:20, pages 1881-1894.
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A. L. Piepoli, G. De Salvatore, M. A. De Salvia, C. I. Mitolo, G. Siro-Brigiani, A. Marzullo, I. Grattagliano, D. Mitolo-Chieppa, G. Palasciano & P. Portincasa. (2005) Indomethacin-induced ileitis is associated with tensiometric, vascular and oxidative changes in the experimental rat model.. European Journal of Clinical Investigation 35:4, pages 271-278.
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Piero Portincasa, Ignazio Grattagliano, Vincenzo O. Palmieri & Giuseppe Palasciano. (2005) Nonalcoholic steatohepatitis: recent advances from experimental models to clinical management. Clinical Biochemistry 38:3, pages 203-217.
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Jon D. Piganelli, Massimo Trucco & Nick Giannoukakis. 2005. Gene Therapy of Autoimmune Diseases. Gene Therapy of Autoimmune Diseases 17 42 .
R Bottino, P Lemarchand, M Trucco & N Giannoukakis. (2003) Gene- and cell-based therapeutics for type I diabetes mellitus. Gene Therapy 10:10, pages 875-889.
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Hartmut Jaeschke. (2003) Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. American Journal of Physiology-Gastrointestinal and Liver Physiology 284:1, pages G15-G26.
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Rita Bottino, A. N. Balamurugan, Nick Giannoukakis & Massimo Trucco. (2002) Islet/pancreas transplantation: challenges for pediatrics. Pediatric Diabetes 3:4, pages 210-223.
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Samuel Wyllie, Philip Seu, Feng Qin Gao, Phillippe Gros & John A Goss. (2002) Disruption of the Nramp1 (also known as Slc11a1) gene in Kupffer cells attenuates early-phase, warm ischemia-reperfusion injury in the mouse liver. Journal of Leukocyte Biology 72:5, pages 885-897.
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H Jaeschke. (2002) Xanthine oxidase–induced oxidant stress during hepatic ischemia-reperfusion: Are we coming full circle after 20 years?. Hepatology 36:3, pages 761-763.
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Hartmut Jaeschke & Anwar Farhood. (2002) Kupffer cell activation after no-flow ischemia versus hemorrhagic shock. Free Radical Biology and Medicine 33:2, pages 210-219.
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Nick Giannoukakis & Paul D. Robbins. 2001. Gene Therapy for Acute and Acquired Diseases. Gene Therapy for Acute and Acquired Diseases 247 271 .
Hartmut Jaeschke. (2001) Reactive oxygen and mechanisms of inflammatory liver injury. Journal of Gastroenterology and Hepatology 15:7, pages 718-724.
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Dev A. Samarasinghe, Michael Tapner & Geoffrey C. Farrell. (2000) Role of oxidative stress in hypoxia-reoxygenation injury to cultured rat hepatic sinusoidal endothelial cells. Hepatology 31:1, pages 160-165.
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Hartmut Jaeschke. (1999) Kupffer cell-induced oxidant stress during hepatic ischemia-reperfusion: Does the controversy continue?. Hepatology 30:6, pages 1527-1528.
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Koji Ito, Naho Miwa, Kiyokazu Hagiwara, Tomohiro Yano, Keiko Shimizu-Saito, Narihide Goseki, Takehisa Iwai & Saburo Horikawa. (1999) Regulation of methionine adenosyltransferase activity by the glutathione level in rat liver during ischemia-reperfusion. Surgery Today 29:10, pages 1053-1058.
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Ignazio Grattagliano, Gianluigi Vendemiale & Bernhard H. Lauterburg. (1999) Reperfusion Injury of the Liver: Role of Mitochondria and Protection by Glutathione Ester. Journal of Surgical Research 86:1, pages 2-8.
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Fusako Takayama, Toru Egashira & Yasumitsu Yamanaka. (1999) ESR measurement of endogenous nitric oxide in liver and blood of mice subjected to hepatic ischemia-reperfusion. Pathophysiology 6:1, pages 45-51.
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M. C. Blanc, C. Housset, E. Lasnier, C. Rey, J. Capeau, J. Giboudeau, R. Poupon & M. Vaubourdolle. (2008) Direct cytotoxicity of hypoxia‐reoxygenation towards sinusoidal endothelial cells in the rat. Liver 19:1, pages 42-49.
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Ion V Deaciuc, Nympha B D'Souza, Theodore G Sarphie, Jack Schmidt, Daniell B Hill & Craig J McClain. (1999) Effects of exogenous superoxide anion and nitric oxide on the scavenging function and electron microscopic appearance of the sinusoidal endothelium in the isolated, perfused rat liver. Journal of Hepatology 30:2, pages 213-221.
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I.A. Gamaley & I.V. Klyubin. 1999. 203 255 .
C. Wayne Smith, Scott I. Simon & Hartmut Jaeschke. 1999. Cytokines in Severe Sepsis and Septic Shock. Cytokines in Severe Sepsis and Septic Shock 173 197 .
Ekkehard Schütz, Eberhard Wieland, Andrea Hensel, Paul-Dieter Niedmann, Alexandra Dreiss, Victor William Armstrong, Peter Schuff-Werner & Michael Oellerich. (1997) Suppression of Leukocyte-Enhanced Cold Ischemia/Reperfusion Injury of Liver Endothelium with the Benzoquinone Antioxidant Idebenone. Clinical Biochemistry 30:8, pages 619-624.
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Chong-Jeh Lo, M. Terasaki, Richard Garcia & Scott Helton. (1997) Fish Oil-Supplemented Feeding Does Not Attenuate Warm Liver Ischemia and Reperfusion Injury in the Rat. Journal of Surgical Research 71:1, pages 54-60.
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Hartmut Jaeschke. (1996) Preservation injury: mechanisms, prevention and consequences. Journal of Hepatology 25:5, pages 774-780.
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S. Benz, F. Pfeffer, M. Busing, M. R. Clernens, A. Waladkhani, H. D. Becker & U. T. Hopt. (1996) Liposoluble antioxidants are not consumed in the pancreas after reperfusion in human simultaneous pancreas-kidney transplantation. Transplant International 9:s1, pages S258-S260.
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P.F. Smith. (2016) Mid-Western Regional Society of Toxicology: Novel Mechanisms of Hepatobiliary Toxicity. Toxicologic Pathology 24:3, pages 386-389.
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George M. Matuschak. (1996) LUNG-LIVER INTERACTIONS IN SEPSIS AND MULTIPLE ORGAN FAILURE SYNDROME. Clinics in Chest Medicine 17:1, pages 83-98.
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M. Teresa Portol�s, Myriam Catal�, Adolfo Ant�n & Raffaella Pagani. (1996) Hepatic response to the oxidative stress induced by E. coli endotoxin: Glutathione as an index of the acute phase during the endotoxic shock. Molecular and Cellular Biochemistry 159:2, pages 115-121.
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S. Benz, F. Pfeffer, M. Büsing, M. R. Clemens, A. R. Waladkhani, H. D. Becker & U. T. Hopt. 1996. Transplant International. Transplant International 258 260 .
F. Walcher, I. Marzi, U. Flecks & R. Larsen. (1995) N-Acetylcysteine failed to improve early microcirculatory alterations of the rat liver after transplantation. Transplant International 8:4, pages 317-323.
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Frederick A. Nunes, Chellappa Kumar, Britton Chance & Clifford A. Brass. (1995) Chemiluminescent measurement of increased free radical formation after ischemia/reperfusion. Digestive Diseases and Sciences 40:5, pages 1045-1053.
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G. M. Matuschak. 1995. The Splanchnic Circulation. The Splanchnic Circulation 73 93 .
G. M. Matuschak. 1995. Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine 413 421 .
S. Post, M. Goerig & M.D. Menger. (1994) Eicosanoids and hepatic preservation for organ transplantation. Prostaglandins, Leukotrienes and Essential Fatty Acids 51:5, pages 299-309.
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Hartmut Jaeschke. (1994) Pathophysiology of hepatic ischemia-reperfusion injury: The role of complement activation. Gastroenterology 107:2, pages 583-586.
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S. Ping Lim, Fiona J. Andrews, Chris Christophi & Paul E. O'Brien. (1994) Microvascular changes in liver after ischemia-reperfusion injury. Digestive Diseases and Sciences 39:8, pages 1683-1690.
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W.Rodney Mathews, David M. Guido, Michael A. Fisher & Hartmut Jaeschke. (1994) Lipid peroxidation as molecular mechanism of liver cell injury during reperfusion after ischemia. Free Radical Biology and Medicine 16:6, pages 763-770.
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Hartmut Jaeschke, Anwar Farhood & C. Wayne Smith. (1994) Contribution of complement-stimulated hepatic macrophages and neutrophils to endotoxin-induced liver injury in rats. Hepatology 19:4, pages 973-979.
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Jian Chang, Hartmut Jaeschke & Kurt Randerath. (1994) Effect of Ni(II) on tissue hydrogen peroxide content in mice as inferred from glutathione and glutathione disulfide measurements. Life Sciences 55:23, pages 1789-1796.
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Hartmut Jaeschke, Anwar Farhood, Abraham P. Bautista, Zoltan Spolarics, John J. Spitzer & C. Wayne Smith. (1993) Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver. Hepatology 17:5, pages 915-923.
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A. P. Bautista, I. V. Deaciuc, H. Jaeschke, Z. Spolarics & J. J. Spitzer. 1993. Pathophysiology of Shock, Sepsis, and Organ Failure. Pathophysiology of Shock, Sepsis, and Organ Failure 915 934 .
Hartmut Jaeschke & Arthur E. Benzick. (1992) Pathophysiological consequences of enhanced intracellular superoxide formation in isolated perfused rat liver. Chemico-Biological Interactions 84:1, pages 55-68.
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Pia Villa, Carmen Carugo & Amalia Guaitani. (1992) No evidence of intracellular oxidative stress during ischemia—reperfusion damage in rat liver in vivo. Toxicology Letters 61:2-3, pages 283-290.
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H. Hughes, A. Farhood & H. Jaeschke. (1992) Role of leukotriene B4 in the pathogenesis of hepatic ischemia-reperfusion injury in the rat. Prostaglandins, Leukotrienes and Essential Fatty Acids 45:2, pages 113-119.
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Masahiro Okuda, Hsien-Chang Lee, Britton Chance & Chellappa Kumar. (1992) Glutathione and ischemia-reperfusion injury in the perfused rat liver. Free Radical Biology and Medicine 12:4, pages 271-279.
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H. Jaeschke, V.B. Schini & A. Farhood. (1992) Role of nitric oxide in the oxidant stress during ischemia/reperfusion injury of the liver. Life Sciences 50:23, pages 1797-1804.
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Hartmut Jaeschke. (1991) Reactive oxygen and ischemia/reperfusion injury of the liver. Chemico-Biological Interactions 79:2, pages 115-136.
Crossref
Hartmut Jaeschke, Arthur E. Benzick, Charles V. Smith & Jerry R. Mitchell. 1991. Biological Reactive Intermediates IV. Biological Reactive Intermediates IV 295 298 .

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