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Free Radical Research Communications Volume 13, 1991 - Issue 1
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Original Article

Doxorubicin Resistance Conferred by Selective Enhancement of Intracellular Glutathione Peroxidase or Superoxide Dismutase Content in Human MCF-7 Breast Cancer Cells

J. H. Doroshow Department of Medical Oncology and Therapeutics Research., City of Hope National Medical Center, Duarte, California, 91010, USA
,
S. Akman Department of Medical Oncology and Therapeutics Research., City of Hope National Medical Center, Duarte, California, 91010, USA
,
S. Esworthy Department of Medical Oncology and Therapeutics Research., City of Hope National Medical Center, Duarte, California, 91010, USA
,
F. F. Chu Department of Medical Oncology and Therapeutics Research., City of Hope National Medical Center, Duarte, California, 91010, USA
&
T. Burke Department of Medical Oncology and Therapeutics Research., City of Hope National Medical Center, Duarte, California, 91010, USA
Pages 779-781 | Published online: 07 Jul 2009

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Daniel L. Gustafson, John D. Swanson & Chris A. Pritsos. (1993) Modulation of Glutathione and Glutathione Dependent Antioxidant Enzymes in Mouse Heart Following Doxorubicin Therapy. Free Radical Research Communications 19:2, pages 111-120.
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Articles from other publishers (30)

Noora A. Hadi, Rana I. Mahmood & Ali Z. Al-Saffar. (2021) Evaluation of antioxidant enzyme activity in doxorubicin treated breast cancer patients in Iraq: A molecular and cytotoxic study. Gene Reports 24, pages 101285.
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Marta Kepinska, Rene Kizek & Halina Milnerowicz. (2018) Metallothionein and Superoxide Dismutase—Antioxidative Protein Status in Fullerene-Doxorubicin Delivery to MCF-7 Human Breast Cancer Cells. International Journal of Molecular Sciences 19:10, pages 3253.
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Ganesh Chandra Jagetia. (2017) Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice. MOJ Anatomy & Physiology 4:2.
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Mehir un Nisa Iqbal & Taseer Ahmed Khan. 2017. A Critical Evaluation of Vitamin D - Clinical Overview. A Critical Evaluation of Vitamin D - Clinical Overview.
Cathrine Elisabeth Olsen, Kristian Berg, Pål Kristian Selbo & Anette Weyergang. (2013) Circumvention of resistance to photodynamic therapy in doxorubicin-resistant sarcoma by photochemical internalization of gelonin. Free Radical Biology and Medicine 65, pages 1300-1309.
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Nnenna A. Finn, Harry W. Findley & Melissa L. Kemp. (2011) A Switching Mechanism in Doxorubicin Bioactivation Can Be Exploited to Control Doxorubicin Toxicity. PLoS Computational Biology 7:9, pages e1002151.
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Kyu Kwang Kim, Nada M. Kawar, Rakesh K. Singh, Thilo S. Lange, Laurent Brard & Richard G. Moore. (2011) Tetrathiomolybdate induces doxorubicin sensitivity in resistant tumor cell lines. Gynecologic Oncology 122:1, pages 183-189.
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Yun Wang, Joshua P. Gray, Vladimir Mishin, Diane E. Heck, Debra L. Laskin & Jeffrey D. Laskin. (2010) Distinct Roles of Cytochrome P 450 Reductase in Mitomycin c Redox Cycling and Cytotoxicity . Molecular Cancer Therapeutics 9:6, pages 1852-1863.
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RUTH KOREN & AMIRAM RAVID. 2005. Vitamin D. Vitamin D 761 770 .
Amiram Ravid & Ruth Koren. 2003. Vitamin D Analogs in Cancer Prevention and Therapy. Vitamin D Analogs in Cancer Prevention and Therapy 357 367 .
Elżbieta Lidia Anuszewska & Jadwiga Hanna Koziorowska. (1999) Adaptive response towards adriamycin in vitro: circumvention with verapamil. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 431:1, pages 25-30.
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DavidA Gewirtz. (1999) A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochemical Pharmacology 57:7, pages 727-741.
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Elizabeta B Meyer & William W Wells. (1999) Thioltransferase overexpression increases resistance of MCF-7 cells to adriamycin. Free Radical Biology and Medicine 26:5-6, pages 770-776.
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Robert Clarke. (1997) Issues in experimental design and endpoint analysis in the study of experimental cytotoxic agents in vivo in breast cancer and other models. Breast Cancer Research and Treatment 46:2-3, pages 255-278.
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M. J. Siegsmund, C. Kreukler, A. Steidler, T. Nebe, K. -U. K�hrmann & P. Alken. (1997) Multidrug resistance in androgen-independent growing rat prostate carcinoma cells is mediated by P-glycoprotein. Urological Research 25:1, pages 35-42.
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Robert Clarke. (1996) Human breast cancer cell line xenografts as models of breast cancer — The immunobiologies of recipient mice and the characteristics of several tumorigenic cell lines. Breast Cancer Research and Treatment 39:1, pages 69-86.
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Susan E. Kane. 1996. Advances in Drug Research Volume 28. Advances in Drug Research Volume 28 181 252 .
D. Frank AndrewsIIIIII, Edward A. FaberJr.Jr., Holly Hawk & Stanley J. Geyer. 1996. Molecular Biology of Hematopoiesis 5. Molecular Biology of Hematopoiesis 5 417 430 .
James H. Doroshow. (1995) Glutathione peroxidase and oxidative stress. Toxicology Letters 82-83, pages 395-398.
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P.M. Ravdin. (1995) Anthracycline resistance in breast cancer: Clinical applications of current knowledge. European Journal of Cancer 31, pages S11-S14.
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John R. Arthur & Geoffrey J. Beckett. (2007) Symposium 2 Newer aspects of micronutrients in at risk groups. Proceedings of the Nutrition Society 53:3, pages 615-624.
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Jeffrey A. Moscow & Katharine H. Dixon. 1994. Multiple Drug Resistance in Cancer. Multiple Drug Resistance in Cancer 155 170 .
E. E. Voest, E. Van Faassen, J. P. Neijt, J. J. M. Marx & B. S. Van Asbeck. (2005) Doxorubicin‐mediated free radical generation in intact human tumor cells enhances nitroxide electron paramagnetic resonance absorption intensity decay. Magnetic Resonance in Medicine 30:3, pages 283-288.
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Ganapathirama Raghu, Mario Pierre‐Jerome, Margaret S. Dordal, Philip Simonian, Kenneth D. Bauer & Jane N. Winter. (2006) P‐glycoprotein and alterations in the glutathione/glutathione‐peroxidase cycle underlie doxorubicin resistance in HL‐60‐R, a subclone of the HL‐60 human leukemia cell line. International Journal of Cancer 53:5, pages 804-811.
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DAVID W. HEDLEY. (1993) Flow Cytometric Assays of Anticancer Drug Resistance. Annals of the New York Academy of Sciences 677:1 Clinical Flow, pages 341-353.
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M. Nabil BENCHEKROUN, Philippe POURQUIER, Brigitte SCHOTT & Jacques ROBERT. (1993) Doxorubicin-induced lipid peroxidation and glutathione peroxidase activity in tumor cell lines selected for resistance to doxorubicin. European Journal of Biochemistry 211:1-2, pages 141-146.
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Jean-Louis Merlin, Sophie Marchal, Carole Ramacci, Dominique Notter & Claude Vigneron. (1993) Antiproliferative activity of thermosensitive liposome-encapsulated doxorubicin combined with 43°C hyperthermia in sensitive and multidrug-resistant MCF-7 cells. European Journal of Cancer 29:16, pages 2264-2268.
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Jeffrey A. Moscow & Katharine H. Dixon. (1993) Glutathione-related enzymes, glutathione and multidrug resistance. Cytotechnology 12:1-3, pages 155-170.
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Richard D. H. Whelan & Bridget T. Hill. (1993) Differential expression of steroid receptors, hsp27, and pS2 in a series of drug resistant human breast tumor cell lines derived following exposure to antitumor drugs or to fractionated X-irradiation. Breast Cancer Research and Treatment 26:1, pages 23-39.
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Geoffrey R. Fisher & Laurence H. Patterson. (1992) Lack of involvement of reactive oxygen in the cytotoxicity of mitoxantrone, CI941 and ametantrone in MCF-7 cells: comparison with doxorubicin. Cancer Chemotherapy and Pharmacology 30:6, pages 451-458.
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