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Free Radical Research Communications Volume 15, 1992 - Issue 6
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Original Article

Hydroxyl Radicals are Generated by Hepatic Microsomes During Nadph Oxidation: Relationship to Ethanol Metabolism

Paul B. McCay Molecular Toxicology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA
,
Lester A. Reinke The Department of Pharmacology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73190, USA
&
James M. Rau Molecular Toxicology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA
Pages 335-346 | Received 08 Aug 1991, Published online: 07 Jul 2009

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G. D. Castro, A. M. A. Delgado de Layño & J. A. Castro. (1997) Hydroxyl and 1-hydroxyethyl free radical detection using spin traps followed by derivatization and gas chromatography—mass spectrometry. Redox Report 3:5-6, pages 343-347.
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Lester A. Reinke, Danny R. Moore & Paul B. McCay. (1996) Degradation of DMPO Adducts from Hydroxyl and 1-Hydroxyethyl Radicals by Rat Liver Microsomes. Free Radical Research 25:6, pages 467-474.
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G. P. Butcher, A. Raqabah, M. J. Jackson, J. Hoffman, Jonathan M. Rhodes & M. C. R. Symons. (1995) Failure of Electron Paramagnetic Resonance Spectroscopy Studies to Detect Elevated Free Radical Signals in Liver Biopsy Specimens from Patients with Alcoholic Liver Disease. Free Radical Research 22:2, pages 99-107.
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Lester A. Reinke, Shannon M. Bailey, James M. Rau & Paul B. McCay. (1994) Oxygen Radical Formation in Well-Washed Rat Liver Microsomes: Spin Trapping Studies. Free Radical Research 20:1, pages 51-60.
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Lester A. Reinke, Danny R. Moore, Christinia M. Hague & Paul B. McCay. (1994) Metabolism of Ethanol to 1-Hydroxyethyl Radicals in Rat Liver Microsomes: Comparative Studies with Three Spin Trapping Agents. Free Radical Research 21:4, pages 213-222.
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Articles from other publishers (19)

Lisa M. Torres, Bocena Konopnika, Liliana N. Berti‐Mattera, Carole Liedtke & Andrea Romani. (2010) Defective Translocation of PKCε in EtOH‐Induced Inhibition of Mg 2+ Accumulation in Rat Hepatocytes . Alcoholism: Clinical and Experimental Research 34:9, pages 1659-1669.
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Mario Comporti, Cinzia Signorini, Silvia Leoncini, Concetta Gardi, Lucia Ciccoli, Anna Giardini, Daniela Vecchio & Beatrice Arezzini. (2009) Ethanol-induced oxidative stress: basic knowledge. Genes & Nutrition 5:2, pages 101-109.
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Lisa M. Torres, Christie Cefaratti, Liliana Berti-Mattera & Andrea Romani. (2009) Delayed restoration of Mg 2+ content and transport in liver cells following ethanol withdrawal . American Journal of Physiology-Gastrointestinal and Liver Physiology 297:4, pages G621-G631.
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Lester A. Reinke. (2002) Spin trapping evidence for alcohol-associated oxidative stress1,2 1This article is part of a series of reviews on ?Alcohol, Oxidative Stress, and Cell Injury.? The full list of papers may be found on the homepage of the journal.. Free Radical Biology and Medicine 32:10, pages 953-957.
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Daniel L. Gilbert & Carol A. ColtonDale A. Parks, Kelly A. Skinner, Sidhartha Tan & Henry B. Skinner. 2002. Reactive Oxygen Species in Biological Systems. Reactive Oxygen Species in Biological Systems 397 420 .
Alejandro D Boveris, Andrea Galatro, Luis Sambrotta, Rafael Ricco, Alberto A Gurni & Susana Puntarulo. (2001) Antioxidant capacity of a 3-deoxyanthocyanidin from soybean. Phytochemistry 58:7, pages 1097-1105.
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O. Sergent, B. Griffon, P. Cillard & J. Cillard. (2001) Alcool et stress oxydatif. Pathologie Biologie 49:9, pages 689-695.
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Alejandro D. Boveris & Susana Puntarulo. (1998) Free-radical scavenging actions of natural antioxidants. Nutrition Research 18:9, pages 1545-1557.
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Dale A Parks, Kelly A Skinner, Henry B Skinner & Sidhartha Tan. (1998) Multiple organ dysfunction syndrome: Role of xanthine oxidase and nitric oxide. Pathophysiology 5:1, pages 49-66.
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Lester A. Reinke, Danny R. Moore & Paul B. McCay. (1997) Mechanisms for Metabolism of Ethanol to 1-Hydroxyethyl Radicals in Rat Liver Microsomes. Archives of Biochemistry and Biophysics 348:1, pages 9-14.
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S. C. Bondy, H. R. Lam, G. Østergaard, S. X. Guo & Ø. Ladefoged. (1995) Changes in markers of oxidative status in brain, liver and kidney of young and aged rats following exposure to aromatic white spirit. Archives of Toxicology 69:6, pages 410-414.
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E.G. Janzen, J.L. Poyer, M.S. West, C. Crossley & P.B. McCay. (1994) Study of reproducibility of spin trapping results in the use of C-phenyl-N-tert-butyl nitrone (PBN) for trichloromethyl radical detection in CCl4 metabolism by rat liver microsomal dispersions Biological spin trapping I. Journal of Biochemical and Biophysical Methods 29:3-4, pages 189-205.
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Stephen C. Bondy & Sassan Naderi. (1994) Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species. Biochemical Pharmacology 48:1, pages 155-159.
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Lester A. Reinke, James M. Rau & Paul B. McCay. (1994) Characteristics of an oxidant formed during iron (II) autoxidation. Free Radical Biology and Medicine 16:4, pages 485-492.
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Emanuele Albano, Aldo Tomasi & Magnus Ingelman-Sundberg. 1994. Oxygen Radicals in Biological Systems Part C. Oxygen Radicals in Biological Systems Part C 117 127 .
David A. Newsome, Michael V. Miceli, Mark R. Liles, David J. TateJr.Jr. & Peter D. Oliver. (1994) Antioxidants in the retinal pigment epithelium. Progress in Retinal and Eye Research 13:1, pages 101-123.
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Aldo Tomasi & Anna Iannone. 1993. EMR of Paramagnetic Molecules. EMR of Paramagnetic Molecules 353 384 .
Christine M. Jorm & Jonathan A. Stamford. (1992) Hepatic metabolism of xenobiotics with reference to anaesthesia. Baillière's Clinical Anaesthesiology 6:4, pages 751-779.
Crossref
Lester A. Reinke. (1992) Commentary on ?ethanol toxicity and oxidative stress? by S.C. Bondy. Toxicology Letters 63:3, pages 227-229.
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