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Original Article

Subcellular Distribution of Two Spin Trapping Agents in Rat Heart: Possible Explanation for Their Different Protective Effects Against Doxorubicin-Induced Cardiotoxicity

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Pages 353-360 | Received 29 Jan 1991, Published online: 07 Jul 2009

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Read on this site (4)

Catherine Vergely, Alain Tabard, Véronique Maupoil & Luc Rochette. (2001) Isolated perfused rat hearts release secondary free radicals during ischemia reperfusion injury: Cardiovascular effects of the spin trap α-phenyl N-tert-butylnitrone. Free Radical Research 35:5, pages 475-489.
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G. Rimbach, D. Höhler, A. Fischer, S. Roy, F. Virgili, J. Pallauf & L. Packer. (1999) Methods to assess free radicals and oxidative stress in biological systems. Archiv für Tierernaehrung 52:3, pages 203-222.
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Francesco Piccinini, Silvia Bradamante, Elena Monti, Yong-Kang Zhang & Edward G. Janzen. (1995) Pharmacological Action of a New Spin Trapping Compound, 2-Phenyl DMPO, In the Adriamycin-Induced cardiotoxicity. Free Radical Research 23:1, pages 81-87.
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John E. Baker, Eugene A. Konorev, Susanna Y.H. Tse, Joy Joseph & B. Kalyanaraman. (1994) Lack of Protection of Pbn in Isolated Heart During Ischemia and Reperfusion: Implications for Radical Scavenging Mechanism. Free Radical Research 20:3, pages 145-163.
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Articles from other publishers (40)

Marcel Culcasi, Caroline Delehedde, Mathieu Esgulian, Mathieu Cassien, Mathieu Chocry, Antal Rockenbauer, Sylvia Pietri & Sophie Thétiot‐Laurent. (2023) New Biocompatible β‐Phosphorylated Linear Nitrones Targeting Mitochondria: Protective Effect in Apoptotic Cells. ChemBioChem 24:8.
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Mingge Ding, Rui Shi, Shuli Cheng, Man Li, Dema De, Chaoyang Liu, Xiaoming Gu, Juan Li, Shumiao Zhang, Min Jia, Rong Fan, Jianming Pei & Feng Fu. (2022) Mfn2-mediated mitochondrial fusion alleviates doxorubicin-induced cardiotoxicity with enhancing its anticancer activity through metabolic switch. Redox Biology 52, pages 102311.
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Yang Liu, Aftab Nadeem, Sujeesh Sebastian, Martin A. Olsson, Sun N. Wai, Emelie Styring, Jacob Engellau, Hanna Isaksson, Magnus Tägil, Lars Lidgren & Deepak Bushan Raina. (2022) Bone mineral: A trojan horse for bone cancers. Efficient mitochondria targeted delivery and tumor eradication with nano hydroxyapatite containing doxorubicin. Materials Today Bio 14, pages 100227.
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Carmine Rocca, Ernestina Marianna De Francesco, Teresa Pasqua, Maria Concetta Granieri, Anna De Bartolo, Maria Eugenia Gallo Cantafio, Maria Grazia Muoio, Massimo Gentile, Antonino Neri, Tommaso Angelone, Giuseppe Viglietto & Nicola Amodio. (2022) Mitochondrial Determinants of Anti-Cancer Drug-Induced Cardiotoxicity. Biomedicines 10:3, pages 520.
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Bart De Geest & Mudit Mishra. (2021) Doxorubicin-induced cardiomyopathy: TERT gets to the heart of the matter. Molecular Therapy 29:4, pages 1363-1365.
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Consuelo Petrocchi, Sophie Thétiot-Laurent, Marcel Culcasi & Sylvia Pietri. 2021. Mitochondrial Medicine. Mitochondrial Medicine 65 85 .
Kendall B. WallaceVilma A. SardãoPaulo J. Oliveira. (2020) Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy. Circulation Research 126:7, pages 926-941.
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Grégory Durand. 2013. Molecular Basis of Oxidative Stress. Molecular Basis of Oxidative Stress 377 406 .
Marcel Culcasi, Gilles Casano, Céline Lucchesi, Anne Mercier, Jean-Louis Clément, Valérie Pique, Laure Michelet, Anja Krieger-Liszkay, Maxime Robin & Sylvia Pietri. (2013) Synthesis and Biological Characterization of New Aminophosphonates for Mitochondrial pH Determination by 31 P NMR Spectroscopy . Journal of Medicinal Chemistry 56:6, pages 2487-2499.
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Amlan Das, Bhavani Gopalakrishnan, Oliver H. Voss, Andrea I. Doseff & Frederick A. Villamena. (2012) Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling. Biochemical Pharmacology 84:4, pages 486-497.
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Gaëlle Gosset, Jean-Louis Clément, Marcel Culcasi, Antal Rockenbauer & Sylvia Pietri. (2011) CyDEPMPOs: A class of stable cyclic DEPMPO derivatives with improved properties as mechanistic markers of stereoselective hydroxyl radical adduct formation in biological systems. Bioorganic & Medicinal Chemistry 19:7, pages 2218-2230.
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S. Tanguy, G. Durand, C. Reboul, A. Polidori, B. Pucci, M. Dauzat & P. Obert. (2006) Protection Against Reactive Oxygen Species Injuries in Rat Isolated Perfused Hearts: Effect of LPBNAH, a New Amphiphilic Spin-Trap Derived from PBN. Cardiovascular Drugs and Therapy 20:2, pages 147-149.
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Zheng-Guo Cui, Takashi Kondo & Hideki Matsumoto. (2006) Enhancement of apoptosis by nitric oxide released from α-phenyl-tert-butyl nitrone under hyperthermic conditions. Journal of Cellular Physiology 206:2, pages 468-476.
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K. E. Merten. (2005) Modulation of Cytochrome c Oxidase-Va Is Possibly Involved in Metallothionein Protection from Doxorubicin Cardiotoxicity. Journal of Pharmacology and Experimental Therapeutics 315:3, pages 1314-1319.
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Catherine Vergely, Celine Renard, Daniel Moreau, Caroline Perrin- Sarrado, Valerie Roubaud, Beatrice Tuccio & Luc Rochette. (2003) Effect of two new PBN-derived phosphorylated nitrones against postischaemic ventricular dysrhythmias. Fundamental and Clinical Pharmacology 17:4, pages 433-442.
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Sylvia Pietri, Anne Mercier, Corinne Mathieu, Sophie Caffaratti & Marcel Culcasi. (2003) Hemodynamic and metabolic effects of the β-phosphorylated nitroxide 2-diethoxyphosphoryl-2,5,5-trimethylpyrrolidinoxyl during myocardial ischemia and reperfusion. Free Radical Biology and Medicine 34:9, pages 1167-1177.
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Y. James Kang, Xiuhua Sun, Yan Chen & Zhanxiang Zhou. (2001) Inhibition of Doxorubicin Chronic Toxicity in Catalase-Overexpressing Transgenic Mouse Hearts. Chemical Research in Toxicology 15:1, pages 1-6.
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J. W. Phillis. 2002. CNS Neuroprotection. CNS Neuroprotection 245 280 .
Meifeng Xu & Muhammad Ashraf. (2002) Melatonin Protection Against Lethal Myocyte Injury Induced by Doxorubicin as Reflected by Effects on Mitochondrial Membrane Potential. Journal of Molecular and Cellular Cardiology 34:1, pages 75-79.
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Srigiridhar Kotamraju, Eugene A. Konorev, Joy Joseph & B. Kalyanaraman. (2000) Doxorubicin-induced Apoptosis in Endothelial Cells and Cardiomyocytes Is Ameliorated by Nitrone Spin Traps and Ebselen. Journal of Biological Chemistry 275:43, pages 33585-33592.
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Won Soon Park, Yun Sil Chang & Munhyang Lee. (2001) Effect of α‐Phenyl‐ N‐tert ‐Butylnitrone on Brain Cell Membrane Function and Energy Metabolism in Experimental Escherichia coli Meningitis in the Newborn Piglet . Journal of Neurochemistry 74:2, pages 763-769.
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V. Castagné, K. Lefèvre, R. Natero, D.A. Becker & P.G.H. Clarke. (1999) An optimal redox status for the survival of axotomized ganglion cells in the developing retina. Neuroscience 93:1, pages 313-320.
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Russell T. Matthews, Peter Klivenyi, Gerald Mueller, Lichuan Yang, Marike Wermer, Craig E. Thomas & M.Flint Beal. (1999) Novel Free Radical Spin Traps Protect against Malonate and MPTP Neurotoxicity. Experimental Neurology 157:1, pages 120-126.
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GIORGIO MINOTTI, GAETANO CAIRO & ELENA MONTI. (1999) Role of iron in anthracycline cardiotoxicity: new tunes for an old song?. The FASEB Journal 13:2, pages 199-212.
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Marina Chiappe-Gutierrez, Erwin Kitzmueller, Olga Labudova, Gerhard Fuerst, Harald Hoeger, Rosmarie Hardmeier, Hans Nohl, Lars Gille & Barbara Lubec. (1998) mRNA Levels of the hypoxia inducible factor (HIF-1) and DNA repair genes in perinatal asphyxia of the rat. Life Sciences 63:13, pages 1157-1167.
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Peter Klivenyi, Russell T. Matthews, Marieke Wermer, Lichuan Yang, Usha MacGarvey, David A. Becker, Reina Natero & M.Flint Beal. (1998) Azulenyl Nitrone Spin Traps Protect against MPTP Neurotoxicity. Experimental Neurology 152:1, pages 163-166.
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Salvatore Guarini, Carla Bazzani, Guido Mattera Ricigliano, Anna Bini, Aldo Tomasi & Alfio Bertolini. (1996) Influence of ACTH-(1-24) on free radical levels in the blood of haemorrhage-shocked rats: direct ex vivo detection by electron spin resonance spectrometry. British Journal of Pharmacology 119:1, pages 29-34.
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Craig E. Thomas, David F. Ohlweiler, Albert A. Carr, Thaddeus R. Nieduzak, David A. Hay, Ginette Adams, Roy Vaz & Ronald C. Bernotas. (1996) Characterization of the Radical Trapping Activity of a Novel Series of Cyclic Nitrone Spin Traps. Journal of Biological Chemistry 271:6, pages 3097-3104.
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Silvia Bradamante, Andrea Jotti, Luisa Paracchini & Elena Morti. (1993) The hydrophilic spin trap, 5,5-dimethyl-1-pyrroline-1-oxide, does not protect the rat heart from reperfusion injury. European Journal of Pharmacology 234:1, pages 113-116.
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