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Free Radical Research Communications Volume 17, 1992 - Issue 1
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Original Article

Thioctic Acid Protects Against Ischemia-Reperfusion Injury in the Isolated Perfused Langendorff Heart

Elena Serbinova 251 LSA Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720, USA
,
Shamsuddin Khwaja Abraham Z. Reznick 251 LSA Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720, USA
&
Lester Packer 251 LSA Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720, USA
Pages 49-58 | Received 06 Apr 1992, Published online: 07 Jul 2009

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Prem Kumar, Uma Devi, Sabir Ali, Ramya Upadhya, Sailaja Pillai, Annaswamy Raja, Suryanarayana Rao & Anjali Rao. (2009) Plasma protein oxidation in patients with brain tumors. Neurological Research 31:3, pages 270-273.
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A. Z. Reznick, D. Han & L. Packer. (1997) Cigarette smoke induced oxidation of human plasma proteins, lipids, and antioxidants; selective protection by the biothiols dihydrolipoic acid and glutathione. Redox Report 3:3, pages 169-174.
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Articles from other publishers (56)

Yueming Ding, Yiming Zhang, Wunong Zhang, Jia Shang, Zhenxing Xie & Chaoran Chen. (2021) Effects of Lipoic Acid on Ischemia-Reperfusion Injury. Oxidative Medicine and Cellular Longevity 2021, pages 1-15.
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Ajit Kumar Prasad & Phool Chand Mishra. (2017) Catalytic action of Mn-superoxide dismutase in scavenging superoxide radical anion by double hydrogen abstraction from dihydrolipoic acid: A theoretical study. International Journal of Quantum Chemistry 117:11, pages e25355.
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Kitti Sárközi, András Papp, Edina Horváth, Zsuzsanna Máté, Edit Hermesz, Gábor Kozma, Zoltán Péter Zomborszki, Ildikó Kálomista, Gábor Galbács & Andrea Szabó. (2017) Protective effect of green tea against neuro-functional alterations in rats treated with MnO 2 nanoparticles . Journal of the Science of Food and Agriculture 97:6, pages 1717-1724.
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Krisztina N. Dugmonits, Ágnes Ferencz, Szabolcs Zahorán, Renáta Lázár, Petra Talapka, Hajnalka Orvos & Edit Hermesz. (2016) Elevated levels of macromolecular damage are correlated with increased nitric oxide synthase expression in erythrocytes isolated from twin neonates. British Journal of Haematology 174:6, pages 932-941.
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Jun Zhang & Peter A. McCullough. (2016) Lipoic Acid in the Prevention of Acute Kidney Injury. Nephron 134:3, pages 133-140.
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Ágnes Ferencz, Hajnalka Orvos & Edit Hermesz. (2015) Major differences in the levels of redox status and antioxidant defence markers in the erythrocytes of pre- and full-term neonates with intrauterine growth restriction. Reproductive Toxicology 53, pages 10-14.
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Ágnes Ferencz & Edit Hermesz. (2014) Impact of acute Cd2+ exposure on the antioxidant defence systems in the skin and red blood cells of common carp (Cyprinus carpio). Environmental Science and Pollution Research 22:9, pages 6912-6919.
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Zsanett Jancsó & Edit Hermesz. (2015) Impact of acute arsenic and cadmium exposure on the expression of two haeme oxygenase genes and other antioxidant markers in common carp ( Cyprinus carpio ) . Journal of Applied Toxicology 35:3, pages 310-318.
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Luc Rochette & Catherine Vergely. 2014. Systems Biology of Free Radicals and Antioxidants. Systems Biology of Free Radicals and Antioxidants 1523 1536 .
Krisztina Dugmonits, Ágnes Ferencz, Zsanett Jancsó, Renáta Juhász & Edit Hermesz. (2013) Major distinctions in the antioxidant responses in liver and kidney of Cd2+-treated common carp (Cyprinus carpio). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 158:4, pages 225-230.
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Xueming Cao, Aihua Chen, Pingzhen Yang, Xudong Song, Yingfeng Liu, Zhiliang Li, Xianbao Wang, Lizi Wang & Yunpeng Li. (2013) Alpha-lipoic acid protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy. Biochemical and Biophysical Research Communications 441:4, pages 935-940.
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Carey A. Williams. 2013. Equine Applied and Clinical Nutrition. Equine Applied and Clinical Nutrition 351 366 .
David Bonda, Mark Smith, George Perry, Hyoung-gon Lee, Xinglong Wang & Xiongwei Zhu. 2012. Mitochondrial Signaling in Health and Disease. Mitochondrial Signaling in Health and Disease 455 467 .
Szabolcs Ábrahám, Edit Hermesz, Andrea Szabó, Ágnes Ferencz, Zsanett Jancsó, Ernő Duda, Magdolna Ábrahám, György Lázár & György LázárJr.Jr.. (2012) Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice. Life Sciences 90:3-4, pages 140-146.
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Hakan Emmez, Zuhal Yildirim, Aydemir Kale, Mehmet Tönge, Emre Durdağ, Alp Özgün Börcek, Lortlar Neşe Uçankuş, Fikret Doğulu, Nedret Kiliç & M. Kemali Baykaner. (2010) Anti-apoptotic and neuroprotective effects of alpha-lipoic acid on spinal cord ischemia–reperfusion injury in rabbits. Acta Neurochirurgica 152:9, pages 1591-1601.
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Stéliana Ghibu, Carole Richard, Catherine Vergely, Marianne Zeller, Yves Cottin & Luc Rochette. (2009) Antioxidant Properties of an Endogenous Thiol: Alpha-lipoic Acid, Useful in the Prevention of Cardiovascular Diseases. Journal of Cardiovascular Pharmacology 54:5, pages 391-398.
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Salvatore Pepe, Jee-Yoong Leong, Juliana Van der Merwe, Silvana F. Marasco, Anthony Hadj, Robyn Lymbury, Anthony Perkins & Franklin L. Rosenfeldt. (2008) Targeting oxidative stress in surgery: Effects of ageing and therapy. Experimental Gerontology 43:7, pages 653-657.
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Krisztina Kovacs, Ambrus Toth, Peter Deres, Tamas Kalai, Kalman Hideg, Ferenc GallyasJr.Jr. & Balazs Sumegi. (2006) Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia–reperfusion. Biochemical Pharmacology 71:4, pages 441-452.
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Julien Finaud, G??rard Lac & Edith Filaire. (2006) Oxidative Stress. Sports Medicine 36:4, pages 327-358.
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Mark F. McCarty. (2006) Induction of heat shock proteins may combat insulin resistance. Medical Hypotheses 66:3, pages 527-534.
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Anita Pálfi, Ambrus Tóth, Győző Kulcsár, Katalin Hantó, Péter Deres, Éva Bartha, Róbert Halmosi, Eszter Szabados, László Czopf, Tamás Kálai, Kálmán Hideg, Balázs Sümegi & Kálmán Tóth. (2005) The Role of Akt and Mitogen-Activated Protein Kinase Systems in the Protective Effect of Poly(ADP-Ribose) Polymerase Inhibition in Langendorff Perfused and in Isoproterenol-Damaged Rat Hearts. Journal of Pharmacology and Experimental Therapeutics 315:1, pages 273-282.
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U. Wenzel, A. Nickel & H. Daniel. (2005) α-lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2−.-generation. Apoptosis 10:2, pages 359-368.
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John M. HollanderJody L. MartinDarrell D. BelkeBrian T. ScottEric SwansonVignesh KrishnamoorthyWolfgang H. Dillmann. (2004) Overexpression of Wild-Type Heat Shock Protein 27 and a Nonphosphorylatable Heat Shock Protein 27 Mutant Protects Against Ischemia/Reperfusion Injury in a Transgenic Mouse Model. Circulation 110:23, pages 3544-3552.
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Qiong Guo, Charles D. Detweiler & Ronald P. Mason. (2004) Protein Radical Formation during Lactoperoxidase-mediated Oxidation of the Suicide Substrate Glutathione. Journal of Biological Chemistry 279:13, pages 13272-13283.
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Ambrus Toth, Robert Halmosi, Krisztina Kovacs, Peter Deres, Tamas Kalai, Kalman Hideg, Kalman Toth & Balazs Sumegi. (2003) Akt activation induced by an antioxidant compound during ischemia-reperfusion. Free Radical Biology and Medicine 35:9, pages 1051-1063.
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A V Balachandar, K P Malarkodi & P Varalakshmi. (2016) Protective role of DLa-lipoic acid against adriamycin-induced cardiac lipid peroxidation. Human & Experimental Toxicology 22:5, pages 249-254.
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Sergei Shnizer, Tamara Kagan, Amos Lanir, Irit Maor & Abraham Z. Reznick. (2003) Modifications and oxidation of lipids and proteins in human serum detected by thermochemiluminescence. Luminescence 18:2, pages 90-96.
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Robert Halmosi, Zoltan Berente, Erzsebet Osz, Kalman Toth, Peter Literati-Nagy & Balazs Sumegi. (2001) Effect of Poly(ADP-Ribose) Polymerase Inhibitors on the Ischemia-Reperfusion-Induced Oxidative Cell Damage and Mitochondrial Metabolism in Langendorff Heart Perfusion System. Molecular Pharmacology 59:6, pages 1497-1505.
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M.F. McCarty. (2000) Monoselenolipoic acid may be an outstanding pharmaceutical antioxidant with direct thioredoxin-like activity. Medical Hypotheses 55:3, pages 185-186.
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Ippolita Cantuti‐Castelvetri, Barbara Shukitt‐Hale & James A. Joseph. (2000) Neurobehavioral aspects of antioxidants in aging. International Journal of Developmental Neuroscience 18:4-5, pages 367-381.
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Paulo C. Grisotto, Antonio C. dos Santos, Joaquim Coutinho-Netto, Jesualdo Cherri & Carlos E. Piccinato. (2000) Indicators of Oxidative Injury and Alterations of the Cell Membrane in the Skeletal Muscle of Rats Submitted to Ischemia and Reperfusion. Journal of Surgical Research 92:1, pages 1-6.
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Eszter Szabados, Peter Literati-Nagy, Beatrix Farkas & Balazs Sumegi. (2000) BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase. Biochemical Pharmacology 59:8, pages 937-945.
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M.F. McCarty. (1999) The reported clinical utility of taurine in ischemic disorders may reflect a down-regulation of neutrophil activation and adhesion. Medical Hypotheses 53:4, pages 290-299.
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M.F. McCarty. (1999) Oxidants downstream from superoxide inhibit nitric oxide production by vascular endothelium – a key role for selenium-dependent enzymes in vascular health. Medical Hypotheses 53:4, pages 315-325.
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Xavier Préville, Francesca Salvemini, Stéphane Giraud, Sylvain Chaufour, Catherine Paul, Georges Stepien, Matilde Valeria Ursini & André-Patrick Arrigo. (1999) Mammalian Small Stress Proteins Protect against Oxidative Stress through Their Ability to Increase Glucose-6-phosphate Dehydrogenase Activity and by Maintaining Optimal Cellular Detoxifying Machinery. Experimental Cell Research 247:1, pages 61-78.
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Jens J Thiele, Maret G Traber, Roberta Re, Nathalie Espuno, Liang-Jun Yan, Carroll E Cross & Lester Packer. (1998) Macromolecular carbonyls in human stratum corneum: a biomarker for environmental oxidant exposure?. FEBS Letters 422:3, pages 403-406.
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Derick Han, Garry Handelman, Lucia Marcocci, Chandan K. Sen, Sashwati Roy, Hirotsugu Kobuchi, Hans J. Tritschler, Leopold Flohé & Lester Packer. (2008) Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization . BioFactors 6:3, pages 321-338.
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Katrin Schönheit, Lars Gille & Hans Nohl. (1995) Effect of α-lipoic acid and dihydrolipoic acid on ischemia/reperfusion injury of the heart and heart mitochondria. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1271:2-3, pages 335-342.
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Indrani Maitra, Elena Serbinova, Hans Trischler & Lester Packer. (1995) α-lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats. Free Radical Biology and Medicine 18:4, pages 823-829.
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