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Original Article

Antioxidant Activities of Dihydrolipoic Acid and its Structural Homologues

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Pages 115-122 | Received 09 Jun 1992, Accepted 27 Oct 1992, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Emrah Tekdemir, Arzu Tatlipinar, Dilek Özbeyli, Özge Tekdemir & Emrah Kınal. (2018) The effects of lipoic acid and methylprednisolone on nerve healing in rats with facial paralysis. Acta Oto-Laryngologica 138:6, pages 537-541.
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Hale Z. Toklu, Tayfun Hakan, Hasan Celik, Necat Biber, Can Erzik, Ayliz V. Ogunc, Dilek Akakin, Esra Cikler, Sule Cetinel, Mehmet Ersahin & Goksel Sener. (2010) Neuroprotective Effects of Alpha-Lipoic Acid in Experimental Spinal Cord Injury in Rats. The Journal of Spinal Cord Medicine 33:4, pages 401-409.
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Amitt Gupta & Kanwaljit Chopra. (2009) Effect of tocotrienols on iron-induced renal dysfunction and oxidative stress in rats. Drug and Chemical Toxicology 32:4, pages 319-325.
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Hideki Yamamoto, Tomohiro Watanabe, Hatsue Mizuno, Kazuo Endo, Junichiro Fukushige, Tsunemichi Hosokawa, Akio Kazusaka & Shoichi Fujita. (2001) The antioxidant effect of DL-α-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats. Free Radical Research 34:1, pages 69-80.
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Victor Schepkin, Teruyuki Kawabata, Hans J. Tritschler & Lester Packer. (1996) 2D NMR of the Metabolic Antioxidant Dihydrolipoic Acid and its Derivatives. Free Radical Research 25:3, pages 195-205.
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J. Gutierrez-correa & A. O. M. Stoppani. (1995) Inactivation of Heart Dihydrolipoamide Dehydrogenase by Copper Fenton Systems. Effect of Thiol Compounds and Metal Chelators. Free Radical Research 22:3, pages 239-250.
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Articles from other publishers (51)

N.A. Kravchun, I.P. Dunaieva & P.P. Kravchun. (2021) R-enantiomer of α-lipoic acid. Opportunities and prospects for clinical use. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) 17:3, pages 258-270.
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Elodie Bacou, Carrie Walk, Sebastien Rider, Gilberto Litta & Estefania Perez-Calvo. (2021) Dietary Oxidative Distress: A Review of Nutritional Challenges as Models for Poultry, Swine and Fish. Antioxidants 10:4, pages 525.
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Behzad Abbasi, Newsha Molavi, Marziyeh Tavalaee, Homayoun Abbasi & Mohammad H. Nasr-Esfahani. (2020) Alpha-lipoic acid improves sperm motility in infertile men after varicocelectomy: a triple-blind randomized controlled trial. Reproductive BioMedicine Online 41:6, pages 1084-1091.
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Ahmet Ö. Sehirli, Umut Aksoy, Fatma Kermeoglu, Atakan Kalender, Gokce Savtekin, Hanife Ozkayalar & Serkan Sayiner. (2019) Protective effect of alpha‐lipoic acid against apical periodontitis‐induced cardiac injury in rats. European Journal of Oral Sciences 127:4, pages 333-339.
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Abeer I. Abd El-Fattah, M.S. Zaghloul, N.A. Eltablawy & L.A. Rashed. (2019) α-Lipoic acid and amlodipine/perindopril combination potentiate the therapeutic effect of mesenchymal stem cells on isoproterenol induced cardiac injury in rats. Biochimie 156, pages 59-68.
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Erfaneh Shaygannia, Marziyeh Tavalaee, Gholam R. Akhavanfarid, Mahshid Rahimi, Maurizio Dattilo & Mohammad H. Nasr-Esfahani. (2018) Alpha-Lipoic Acid improves the testicular dysfunction in rats induced by varicocele. Andrologia 50:9, pages e13085.
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Masahiko Tsuchiya, Kazumasa Shiomoto, Koh Mizutani, Kazuya Fujioka, Koichi Suehiro, Tokuhiro Yamada, Eisuke F. Sato & Kiyonobu Nishikawa. (2018) Reduction of oxidative stress a key for enhanced postoperative recovery with fewer complications in esophageal surgery patients. Medicine 97:47, pages e12845.
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Fabienne T.E. Alban, Daniel Gyamfi, Rowan F. van Golen & Michal Heger. 2018. The Liver. The Liver 109 119 .
Anjeza PashajMengna XiaRégis Moreau. (2015) α-Lipoic acid as a triglyceride-lowering nutraceutical. Canadian Journal of Physiology and Pharmacology 93:12, pages 1029-1041.
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Marilia Brito Gomes & Carlos Antonio Negrato. (2014) Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases. Diabetology & Metabolic Syndrome 6:1.
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Arif Showkat, William R. Bastnagel & Joanna Q. Hudson. (2014) Effect of α -Lipoic Acid on Oxidative Stress in End-Stage Renal Disease Patients Receiving Intravenous Iron . ISRN Nephrology 2014, pages 1-7.
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Jianbo Song, Lichao Liu, Lingrui Li, Jing Liu, Erqun Song & Yang Song. (2014) Protective effects of lipoic acid and mesna on cyclophosphamide-induced haemorrhagic cystitis in mice. Cell Biochemistry and Function 32:2, pages 125-132.
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Ah-Ng KongKate Shay, Regis Moreau & Tory Hagen. 2013. Inflammation, Oxidative Stress, and Cancer. Inflammation, Oxidative Stress, and Cancer 563 574 .
David Bonda, Mark Smith, George Perry, Hyoung-gon Lee, Xinglong Wang & Xiongwei Zhu. 2012. Mitochondrial Signaling in Health and Disease. Mitochondrial Signaling in Health and Disease 455 467 .
Nagaraja Haleagraha, Tan Jackie, Srikumar Chakravart & Anupama Bangra Kulur. (2011) Protective Effect of Alpha-lipoic Acid Against Lead Acetate-Induced Oxidative Stress in the Bone Marrow of Rats. International Journal of Pharmacology 7:2, pages 217-227.
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Kate Petersen Shay, Régis F. Moreau, Eric J. Smith, Anthony R. Smith & Tory M. Hagen. (2009) Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential. Biochimica et Biophysica Acta (BBA) - General Subjects 1790:10, pages 1149-1160.
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Heidi C. O'NeillRaymond C. RancourtCarl W. White. (2008) Lipoic Acid Suppression of Neutrophil Respiratory Burst: Effect of NADPH. Antioxidants & Redox Signaling 10:2, pages 277-286.
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C. Prahalathan, E. Selvakumar, P. Varalakshmi, P. Kumarasamy & R. Saravanan. (2006) Salubrious effects of lipoic acid against adriamycin-induced clastogenesis and apoptosis in Wistar rat bone marrow cells. Toxicology 222:3, pages 225-232.
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Chidambaram Prahalathan, Elangovan Selvakumar & Palaninathan Varalakshmi. (2006) Modulatory role of lipoic acid on adriamycin-induced testicular injury. Chemico-Biological Interactions 160:2, pages 108-114.
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Chidambaram Prahalathan, Elangovan Selvakumar & Palaninathan Varalakshmi. (2006) Lipoic acid modulates adriamycin-induced testicular toxicity. Reproductive Toxicology 21:1, pages 54-59.
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Chidambaram Prahalathan, Elangovan Selvakumar & Palaninathan Varalakshmi. (2005) Protective effect of lipoic acid on adriamycin-induced testicular toxicity. Clinica Chimica Acta 360:1-2, pages 160-166.
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Chidambaram Prahalathan, Elangovan Selvakumar & Palaninathan Varalakshmi. (2005) Lipoic acid ameliorates adriamycin-induced testicular mitochondriopathy. Reproductive Toxicology 20:1, pages 111-116.
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Gail H. Marracci, Gabriel P. McKeon, Whitney E. Marquardt, Rolf W. Winter, Michael K. Riscoe & Dennis N. Bourdette. (2004) α lipoic acid inhibits human T‐cell migration: Implications for multiple sclerosis. Journal of Neuroscience Research 78:3, pages 362-370.
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Jens Teichert, Robert Hermann, Peter Ruus & Rainer Preiss. (2013) Plasma Kinetics, Metabolism, and Urinary Excretion of Alpha‐Lipoic Acid following Oral Administration in Healthy Volunteers. The Journal of Clinical Pharmacology 43:11, pages 1257-1267.
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Jeremiah J Harnett, Michel Auguet, Isabelle Viossat, Christine Dolo, Dennis Bigg & Pierre-E Chabrier. (2002) Novel lipoic acid analogues that inhibit nitric oxide synthase. Bioorganic & Medicinal Chemistry Letters 12:11, pages 1439-1442.
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Maxim Balakirev, Guy Schoehn & Jadwiga Chroboczek. (2000) Lipoic acid-derived amphiphiles for redox-controlled DNA delivery. Chemistry & Biology 7:10, pages 813-819.
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Abdullah I Haj-Yehia, Peter Assaf, Taher Nassar & Jehoshua Katzhendler. (2000) Determination of lipoic acid and dihydrolipoic acid in human plasma and urine by high-performance liquid chromatography with fluorimetric detection. Journal of Chromatography A 870:1-2, pages 381-388.
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Hande Gurer, Hilal Ozgunes, Serdar Oztezcan & Nuran Ercal. (1999) Antioxidant role of α-lipoic acid in lead toxicity. Free Radical Biology and Medicine 27:1-2, pages 75-81.
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Valentin Borcea, Jaffar Nourooz-Zadeh, Simon P Wolff, Martina Klevesath, Marion Hofmann, Heinz Urich, Peter Wahl, Reinhard Ziegler, Hans Tritschler, Barry Halliwell & Peter P Nawroth. (1999) α-lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria. Free Radical Biology and Medicine 26:11-12, pages 1495-1500.
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Savita Khanna, Mustafa Atalay, David E. Laaksonen, Mustafa Gul, Sashwati Roy & Chandan K. Sen. (1999) α-Lipoic acid supplementation: tissue glutathione homeostasis at rest and after exercise. Journal of Applied Physiology 86:4, pages 1191-1196.
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Hiroyuki Kataoka. (1998) Chromatographic analysis of lipoic acid and related compounds. Journal of Chromatography B: Biomedical Sciences and Applications 717:1-2, pages 247-262.
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Jens Lykkesfeldt, Tory M. Hagen, Vladimir Vinarsky & Bruce N. Ames. (1998) Age‐associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes—reversal with ( R )‐α‐lipoic acid supplementation . The FASEB Journal 12:12, pages 1183-1189.
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Toshihiko Ozawa, Kouichi Tatsumi & Tada-aki HoriLester Packer. 1998. Biodefence Mechanisms Against Environmental Stress. Biodefence Mechanisms Against Environmental Stress 33 46 .
Gerreke Ph. Biewenga, Guido R.M.M. Haenen & Aalt Bast. (1997) The pharmacology of the antioxidant lipoic acid. General Pharmacology: The Vascular System 29:3, pages 315-331.
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Nobuya Haramaki, Derick Han, Garry J Handelman, Hans J Tritschler & Lester Packer. (1997) Cytosolic and Mitochondrial Systems for NADH- and NADPH-dependent Reduction of α-Lipoic Acid. Free Radical Biology and Medicine 22:3, pages 535-542.
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H. Nohl, L. Gille & K. Staniek. (1997) Endogenous and exogenous regulation of redox-properties of coenzyme Q. Molecular Aspects of Medicine 18, pages 33-40.
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H. Nohl, L. Gille & K. Staniek. 1997. Free Radicals in Biology and Environment. Free Radicals in Biology and Environment 181 192 .
P. Wolz & J. Krieglstein. (1996) Neuroprotective effects of α-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia. Neuropharmacology 35:3, pages 369-375.
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Gerreke Ph. Biewenga, Marco A. Dorstijn, Justus V. Verhagen, Guido R.M.M. Haenen & Aalt Bast. (1996) Reduction of lipoic acid by lipoamide dehydrogenase. Biochemical Pharmacology 51:3, pages 233-238.
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Kerstin N. Schmidt, E. Britta-Mareen Traenckner, Beate Meier & Patrick A. Baeuerle. (1995) Induction of Oxidative Stress by Okadaic Acid Is Required for Activation of Transcription Factor NF-κB. Journal of Biological Chemistry 270:45, pages 27136-27142.
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Lester Packer, Eric H. Witt & Hans Jürgen Tritschler. (1995) Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine 19:2, pages 227-250.
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Robert R. Wise. (1995) Chilling-enhanced photooxidation: The production, action and study of reactive oxygen species produced during chilling in the light. Photosynthesis Research 45:2, pages 79-97.
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Ute Müller & Josef Krieglstein. (2016) Prolonged Pretreatment with α-Lipoic Acid Protects Cultured Neurons against Hypoxic, Glutamate-, or Iron-Induced Injury. Journal of Cerebral Blood Flow & Metabolism 15:4, pages 624-630.
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Katrin Schönheit, Lars Gille & Hans Nohl. (1995) Effect of α-lipoic acid and dihydrolipoic acid on ischemia/reperfusion injury of the heart and heart mitochondria. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1271:2-3, pages 335-342.
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Teruyuki Kawabata, Hans-Jürgen Tritschler & Lester Packer. 1995. Biothiols Part A Monothiols and Dithiols, Protein Thiols, and Thiyl Radicals. Biothiols Part A Monothiols and Dithiols, Protein Thiols, and Thiyl Radicals 325 332 .
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