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Free Radical Research Volume 21, 1994 - Issue 2
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Original Article

Neurodegeneration Produced by Intrahippocampal Injection of Paraquat is Reduced by Systemic Administration of the 21-Aminosteroid U74389F in Rats

Giacinto Bagetta Faculty of Pharmacy, Calabria University, 87030, Cosenza, (Italy)
,
Michelangelo Iannone Chair of Pharmacology and “Mondino-Tor Vergata”, Neurobiology Centre, Department of Biology, University of Rome “Tor Vergata”, 00133, Rome, (Italy)
,
Immacolata Vecchio Chair of Pharmacology and “Mondino-Tor Vergata”, Neurobiology Centre, Department of Biology, University of Rome “Tor Vergata”, 00133, Rome, (Italy)
,
Vincenzo Rispoli Faculty of Pharmacy, University of Reggio Calabria, Catanzaro, (Italy)
,
Domenicantonio Rotiroti Faculty of Pharmacy, University of Reggio Calabria, Catanzaro, (Italy)
&
Giuseppe Nisticó Chair of Pharmacology and “Mondino-Tor Vergata”, Neurobiology Centre, Department of Biology, University of Rome “Tor Vergata”, 00133, Rome, (Italy)
Pages 85-93 | Received 14 Feb 1994, Published online: 07 Jul 2009

Citations (12)

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S. Alcaro, R. Arcone, I. Vecchio, F. Ortuso, A. Gallelli, R. Pasceri, A. Procopio & M. Iannone. (2007) Molecular modelling and enzymatic studies of acetylcholinesterase and butyrylcholinesterase recognition with paraquat and related compounds. SAR and QSAR in Environmental Research 18:5-6, pages 595-602.
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Articles from other publishers (11)

Nathalia Ferrazzo Naspolini, Carla Elise Heinz Rieg, Vitoria Hayduck Cenci, Daiane Cattani & Ariane Zamoner. (2021) Paraquat induces redox imbalance and disrupts glutamate and energy metabolism in the hippocampus of prepubertal rats. NeuroToxicology 85, pages 121-132.
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Mirjana M. Djukic, Marina D. Jovanovic, Milica Ninkovic, Ivana Stevanovic, Katarina Ilic, Marijana Curcic & Jelena Vekic. (2012) Protective role of glutathione reductase in paraquat induced neurotoxicity. Chemico-Biological Interactions 199:2, pages 74-86.
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Edward A Lock & Martin F Wilks. 2010. Hayes' Handbook of Pesticide Toxicology. Hayes' Handbook of Pesticide Toxicology 1771 1827 .
Thida Chanyachukul, Krongtong Yoovathaworn, Watchareewan Thongsaard, Sukumal Chongthammakun, Panida Navasumrit & Jutamaad Satayavivad. (2004) Attenuation of paraquat-induced motor behavior and neurochemical disturbances by l-valine in vivo. Toxicology Letters 150:3, pages 259-269.
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Giacinto Bagetta, Ernesto Palma, Silvia Piccirilli, Claudio Del Duca, A. Luigi Morrone, Giuseppe Nappi, M. Tiziana Corasaniti & J. Oliver Dolly. (2004) Involvement of a Glutamatergic Mechanism in δ-Dendrotoxin-Induced Hippocampal Neuronal Cell Loss in the Rat. Basic & Clinical Pharmacology & Toxicology 94:3, pages 132-138.
Crossref
Edward A. Lock & Martin F. Wilks. 2001. Handbook of Pesticide Toxicology. Handbook of Pesticide Toxicology 1559 1603 .
Maria Tiziana Corasaniti, Maria Concetta Strongoli, Domenicantonio Rotiroti, Giacinto Bagetta & Giuseppe Nisticò. (2009) Paraquat: A Useful Tool for the in vivo Study of Mechanisms of Neuronal Cell Death . Pharmacology & Toxicology 83:1, pages 1-7.
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Daniela Melchiorri, Claudio Del Duca, Silvia Piccirilli, Giuseppe Trombetta, Giacinto Bagetta & Giuseppe Nisticò. (1998) Intrahippocampal injection of paraquat produces apoptotic cell death which is prevented by the lazaroid U74389G, in rats. Life Sciences 62:21, pages 1927-1932.
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Giacinto Bagetta, Ernesto Palma, Silvia Piccirilli, Giuseppe Nisticò & James Oliver Dolly. (1997) Seizures and Hippocampal Damage Produced by Dendrotoxin-K in Rats Is Prevented by the 21-Aminosteroid U-74389G. Experimental Neurology 147:1, pages 204-210.
Crossref
Elisa Lucca, Nadia Angeretti & Gianluigi Forloni. (1997) Influence of cell culture conditions on the protective effect of antioxidants against β-amyloid toxicity: studies with lazaroids. Brain Research 764:1-2, pages 293-298.
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M. Bagchi, S. Ghosh, D. Bagchi, E. Hassoun & S.J. Stohs. (1995) Protective effects of lazaroid U74389F (16-desmethyl tirilazad) on endrin-induced lipid peroxidation and DNA damage in brain and liver and regional distribution of catalase activity in rat brain. Free Radical Biology and Medicine 19:6, pages 867-872.
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