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Original Article

The Mechanism of Iron (III) Stimulation of Lipid Peroxidation

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Pages 221-227 | Received 16 Jan 1996, Published online: 07 Jul 2009

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F. S. H. Lu, N. S. Nielsen, C. P. Baron & C. Jacobsen. (2017) Marine phospholipids: The current understanding of their oxidation mechanisms and potential uses for food fortification. Critical Reviews in Food Science and Nutrition 57:10, pages 2057-2070.
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Bruna Tadolini, Claudia Juliano, Luisella Piu, Flavia Franconi & Luciana Cabrini. (2000) Resveratrol inhibition of lipid peroxidation. Free Radical Research 33:1, pages 105-114.
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Luca Deiana, Ciriaco Carru, Gianni Pes & Bruna Tadolini. (1999) Spectrophotometric measurement of hydroperoxides at increased sensitivity by oxidation of Fe2+ in the presence of xylenol orange. Free Radical Research 31:3, pages 237-244.
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Bruna Tadolini & Flavia Franconi. (1998) Carvedilol inhibition of lipid peroxidation. A new antioxidative mechanism. Free Radical Research 29:5, pages 377-387.
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Bruna Tadolini, Luciana Cabrini, Carolina Menna, Gavino Giovannzi Pinna & Gabriele Hakim. (1997) Iron (III) Stimulation of Lipid Hydroperoxide-Dependent Lipid Peroxidation. Free Radical Research 27:6, pages 563-576.
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M. B. Gavazza, M. E. Marmunti & A. Palacios. (2023) Effect of silymarin on oxidative damage in chicken liver cell membranes. Revista de la Facultad de Medicina Veterinaria y de Zootecnia 70:1.
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Efstathios Kavvadas. (2022) C3d(g), iron nanoparticles, hemin and cytochrome c may induce oxidative cytotoxicity in tumors and reduce tumor-associated myeloid cells-mediated immunosuppression. Medical Hypotheses 167, pages 110944.
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Yujia Huo, Hongqing Zhu & Xin He. (2022) Study of Butylated Hydroxytoluene Inhibiting the Coal Oxidation at Low Temperature: Combining Experiments and Quantum Chemical Calculations. ACS Omega 7:22, pages 18552-18568.
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Yu-Rim Song, Boyun Jang, Sung-Min Lee, Su-Jin Bae, Seon-Been Bak & Young-Woo Kim. (2022) Angelica gigas NAKAI and Its Active Compound, Decursin, Inhibit Cellular Injury as an Antioxidant by the Regulation of AMP-Activated Protein Kinase and YAP Signaling. Molecules 27:6, pages 1858.
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P. A. Zeinsteger, J. L. Barberón, P. J. Leaden & A. Palacios. (2018) Antioxidant properties of Calendula officinalis L. (Asteraceae) on Fe2+-initiated peroxidation of rat brain mitochondria. Medicinal Chemistry Research 27:11-12, pages 2523-2529.
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Revilija Mozuraityte, Vera Kristinova, Turid Rustad & Ivar Storrø. (2015) The role of iron in peroxidation of PUFA: Effect of pH and chelators. European Journal of Lipid Science and Technology 118:4, pages 658-668.
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Marian Valko, Klaudia Jomova, Christopher J. Rhodes, Kamil Kuča & Kamil Musílek. (2015) Redox- and non-redox-metal-induced formation of free radicals and their role in human disease. Archives of Toxicology 90:1, pages 1-37.
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Rhitajit Sarkar, Bibhabasu Hazra & Nripendranath Mandal. (2013) Amelioration of iron overload-induced liver toxicity by a potent antioxidant and iron chelator, Emblica officinalis Gaertn . Toxicology and Industrial Health 31:7, pages 656-669.
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Guang-Zhi Dong, Ju-Hee Lee, Sung Hwan Ki, Ji Hye Yang, Il Je Cho, Seung Ho Kang, Rong Jie Zhao, Sang Chan Kim & Young Woo Kim. (2014) AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial dysfunction. European Journal of Pharmacology 740, pages 634-640.
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Vera Kristinova, Revilija Mozuraityte, Jorunn Aaneby, Ivar Storrø & Turid Rustad. (2013) Iron‐mediated peroxidation in marine emulsions and liposomes studied by dissolved oxygen consumption. European Journal of Lipid Science and Technology 116:2, pages 207-225.
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Marcelo Farina, Daiana Silva Avila, João Batista Teixeira da Rocha & Michael Aschner. (2013) Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury. Neurochemistry International 62:5, pages 575-594.
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Juraj Gáll, Jan ŠkrhaJr.Jr., Richard Buchal, Eva Sedláčková, Karina Verébová & Jan Pláteník. (2012) Induction of the mitochondrial permeability transition (MPT) by micromolar iron: Liberation of calcium is more important than NAD(P)H oxidation. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1817:9, pages 1537-1549.
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JoséÁngel Pérez‐Alvarez & Juana Fernández‐López. 2012. Handbook of Meat, Poultry and Seafood Quality. Handbook of Meat, Poultry and Seafood Quality 1 24 .
Marisa G. Repetto, Nidia F. Ferrarotti & Alberto Boveris. (2009) The involvement of transition metal ions on iron-dependent lipid peroxidation. Archives of Toxicology 84:4, pages 255-262.
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Sang Mi Shin, Il Je Cho & Sang Geon Kim. (2009) Resveratrol Protects Mitochondria against Oxidative Stress through AMP-Activated Protein Kinase-Mediated Glycogen Synthase Kinase-3β Inhibition Downstream of Poly(ADP-ribose)polymerase-LKB1 Pathway. Molecular Pharmacology 76:4, pages 884-895.
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Sang Mi Shin & Sang Geon Kim. (2009) Inhibition of Arachidonic Acid and Iron-Induced Mitochondrial Dysfunction and Apoptosis by Oltipraz and Novel 1,2-Dithiole-3-thione Congeners. Molecular Pharmacology 75:1, pages 242-253.
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G.L. Zapata, M.H. Guajardo & A.M. Terrasa. (2008) The in vitro protective effect of α-tocopherol on oxidative injury in the dog retina. The Veterinary Journal 177:2, pages 266-272.
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J. A. Pérez‐Alvarez & J. Fernández‐López. 2007. Handbook of Meat, Poultry and Seafood Quality. Handbook of Meat, Poultry and Seafood Quality 25 44 .
Zhiyong Cheng & Yuanzong Li. (2007) What Is Responsible for the Initiating Chemistry of Iron-Mediated Lipid Peroxidation:  An Update. Chemical Reviews 107:3, pages 748-766.
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Revilija Mozuraityte, Turid Rustad & Ivar Storr⊘. (2006) Oxidation of cod phospholipids in liposomes: Effects of salts, pH and zeta potential. European Journal of Lipid Science and Technology 108:11, pages 944-950.
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Revilija Mozuraityte, Turid Rustad & Ivar Storrø. (2006) Pro‐oxidant activity of Fe 2+ in oxidation of cod phospholipids in liposomes . European Journal of Lipid Science and Technology 108:3, pages 218-226.
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Paolo Bruni, Michela Pisani, Marco Iacussi & Oriano Francescangeli. (2005) Fe2+ promoted peroxidation of 1,2-diacyl-sn-glycero-3-phosphocholine liposomes in the presence of calf thymus DNA. Organic & Biomolecular Chemistry 3:19, pages 3524.
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Gene A. Morrill, Adele Kostellow, Lawrence M. Resnick & Raj K. Gupta. (2004) Interaction between ferric ions, phospholipid hydroperoxides, and the lipid phosphate moiety at physiological pH. Lipids 39:9, pages 881-889.
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Mark P. Richards & Rong Li. (2004) Effects of Released Iron, Lipid Peroxides, and Ascorbate in Trout Hemoglobin-Mediated Lipid Oxidation of Washed Cod Muscle. Journal of Agricultural and Food Chemistry 52:13, pages 4323-4329.
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Takao Ohyashiki, Akinori Kadoya & Katsumi Kushida. (2002) The Role of Fe3+ on Fe2+-Dependent Lipid Peroxidation in Phospholipid Liposomes.. Chemical and Pharmaceutical Bulletin 50:2, pages 203-207.
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Guillaume Garçon, Farid Zerimech, Marie-Hélène Hannothiaux, Pierre Gosset, Annie Martin, Thierry Marez & Pirouz Shirali. (2001) Antioxidant defense disruption by polycyclic aromatic hydrocarbons-coated onto Fe2O3 particles in human lung cells (A549). Toxicology 166:3, pages 129-137.
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Guillaume Garçon, Sébastien Garry, Pierre Gosset, Farid Zerimech, Annie Martin, Marie-Hélène Hannothiaux & Pirouz Shirali. (2001) Benzo(a)pyrene-coated onto Fe2O3 particles-induced lung tissue injury: role of free radicals. Cancer Letters 167:1, pages 7-15.
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Guillaume Garçon, Pierre Gosset, Sébastien Garry, Thierry Marez, Marie-Hélène Hannothiaux & Pirouz Shirali. (2001) Pulmonary induction of proinflammatory mediators following the rat exposure to benzo(a)pyrene-coated onto Fe2O3 particles. Toxicology Letters 121:2, pages 107-117.
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Guillaume Garçon, Pirouz Shirali, Sébastien Garry, Monique Fontaine, Farid Zerimech, Annie Martin & Marie-Hélène Hannothiaux. (2000) Polycyclic aromatic hydrocarbon coated onto Fe2O3 particles: assessment of cellular membrane damage and antioxidant system disruption in human epithelial lung cells (L132) in culture. Toxicology Letters 117:1-2, pages 25-35.
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Qiu-Tian Li, Mui Huang Yeo & Boon Kheng Tan. (2000) Lipid Peroxidation in Small and Large Phospholipid Unilamellar Vesicles Induced by Water-Soluble Free Radical Sources. Biochemical and Biophysical Research Communications 273:1, pages 72-76.
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Takao Ohyashiki & Masaki Nunomura. (2000) A marked stimulation of Fe3+-dependent lipid peroxidation in phospholipid liposomes under acidic conditions. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1484:2-3, pages 241-250.
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Roger F. Castilho, André R. Meinicke, Anibal E. Vercesi & Marcelo Hermes-Lima. 1999. Stress Adaptation, Prophylaxis and Treatment. Stress Adaptation, Prophylaxis and Treatment 163 168 .
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L.X. Tang, J.L. Yang & X. Shen. (1997) Effects of additional iron-chelators on Fe2+-initiated lipid peroxidation: Evidence to support the Fe2+ … Fe3+ complex as the initiator. Journal of Inorganic Biochemistry 68:4, pages 265-272.
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