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Original Article

Possible Role of Nitric Oxide on Fertile and Asthenozoospermic Infertile Human Sperm Functions

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Pages 347-354 | Received 19 Apr 1996, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Markus Lipovac, Verena Nairz, Judith Aschauer & Claus Riedl. (2021) The effect of micronutrient supplementation on spermatozoa DNA integrity in subfertile men and subsequent pregnancy rate. Gynecological Endocrinology 37:8, pages 711-715.
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Linda Lefièvre, Gisela Machado-Oliveira, Chris Ford, Jackson Kirkman-Brown, Christopher Barratt & Steve Publicover. (2009) Communication between female tract and sperm. Communicative & Integrative Biology 2:2, pages 82-85.
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Edward J. Calabrese. (2001) Nitric Oxide: Biphasic Dose Responses. Critical Reviews in Toxicology 31:4-5, pages 489-501.
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Articles from other publishers (49)

Edward J. Calabrese, Evgenios Agathokleous, Gaurav Dhawan, Rachna Kapoor, Vikas Dhawan, Prabhjot Kaur Manes & Vittorio Calabrese. (2023) Nitric oxide and hormesis. Nitric Oxide 133, pages 1-17.
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Sulagna Dutta, Pallav Sengupta, Sanghamitra Das, Petr Slama & Shubhadeep Roychoudhury. (2022) Reactive Nitrogen Species and Male Reproduction: Physiological and Pathological Aspects. International Journal of Molecular Sciences 23:18, pages 10574.
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Rebeca Serrano, Nicolás Garrido, Jose A. Céspedes, Lauro González-Fernández, Luis J. García-Marín & María J. Bragado. (2020) Molecular Mechanisms Involved in the Impairment of Boar Sperm Motility by Peroxynitrite-Induced Nitrosative Stress. International Journal of Molecular Sciences 21:4, pages 1208.
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LinQuan Ge, YongKai Zhou, HaoTian Gu, Qing Wu, Ze Zhou, Sui Zheng, David Stanley & QiSheng Song. (2019) Male Selenoprotein F-Like (SPF-L) Influences Female Reproduction and Population Growth in Nilaparvata lugens (Hemiptera: Delphacidae). Frontiers in Physiology 10.
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Fiona Eidenberger, Kim-Lien Huber, Patricia Fuchs, Nikola Simkovicova & Martin Imhof. (2019) Measured with Sperm Chromatin Dispersion (SCD) Technique: Will DNA Integrity in Spermatozoa Increase After Micronutrient Supplementation? Comparative Controlled Study. Fertility & Reproduction 01:03, pages 136-140.
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Mehmet Kocabaş, Filiz Kutluyer, Mine Erişir & Fulya Benzer. (2018) l-Arginine Improves Sperm Motility in Threatened Coruh Trout Salmo coruhensis (Teleostei: Salmonidae). Iranian Journal of Science and Technology, Transactions A: Science 43:4, pages 1433-1437.
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Damayanthi Durairajanayagam. 2019. Oxidants, Antioxidants and Impact of the Oxidative Status in Male Reproduction. Oxidants, Antioxidants and Impact of the Oxidative Status in Male Reproduction 65 78 .
Lin-Quan Ge, Ting Xia, Bo Huang, Hao-Tian Gu, Qi-Sheng Song, Guo-Qing Yang, Fang Liu & Jin-Cai Wu. (2017) PHF7, a novel male gene influences female fecundity and population growth in Nilaparvata lugens Stål (Hemiptera: Delphacidae). Scientific Reports 7:1.
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Sumiharu Nagaoka, Maiko Asagoshi, Keita Kato & Yuki Takata. (2017) Success in the acquisition of Bombyx mori sperm motility is influenced by the extracellular production of nitric oxide (NO) in the presence of seminal fluid nitric oxide synthase (NOS). Insect Biochemistry and Molecular Biology 84, pages 40-47.
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Yulieth Catherine Quintero Quinchia & Walter D. Cardona Maya. (2017) Óxido nítrico y fertilidad masculina: relación directa con los parámetros seminales. Urología Colombiana 26:1, pages 53-60.
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Rakesh Sharma, Shubhadeep Roychoudhury, Rakan Alsaad & Fares Bamajbuor. 2017. Oxidative Stress in Human Reproduction. Oxidative Stress in Human Reproduction 65 87 .
Markus Lipovac, Florian Bodner, Martin Imhof & Peter Chedraui. (2016) Comparison of the effect of a combination of eight micronutrients versus a standard mono preparation on sperm parameters. Reproductive Biology and Endocrinology 14:1.
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María Melgarejo, Jaime Mendiola, Miriam Moñino-García, Juan Cabezas-Herrera, Isabel Tovar-Zapata, José A. Noguera-Velasco & Alberto M. Torres-Cantero. (2016) Associations between oxidative stress biomarkers in different body fluids and reproductive parameters in male partners of subfertile couples. Revista Internacional de Andrología 14:2, pages 46-52.
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Elizabeth G. Bromfield, R. John Aitken, Amanda L. Anderson, Eileen A. McLaughlin & Brett Nixon. (2015) The impact of oxidative stress on chaperone-mediated human sperm–egg interaction. Human Reproduction 30:11, pages 2597-2613.
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Oleg N. Burov, Mikhail E. Kletskii, Nikita S. Fedik, Anton V. Lisovin & Sergey V. Kurbatov. (2016) Mechanism of Thiol-Induced Nitrogen(II) Oxide Donation by Furoxans: a Quantum-Chemical Study. Chemistry of Heterocyclic Compounds 51:11-12, pages 951-960.
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Jiangtao Wang, Qingliu He, Xingyu Yan, Youmei Cai & Junyi Chen. (2014) Effect of exogenous nitric oxide on sperm motility in vitro. Biological Research 47:1.
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M. S. Rahman, W.‐S. Kwon, J.‐S. Lee, J. Kim, S.‐J. Yoon, Y.‐J. Park, Y.‐A. You, S. Hwang & M.‐G. Pang. (2014) Sodium nitroprusside suppresses male fertility in vitro. Andrology 2:6, pages 899-909.
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Y. Yang, Y. Ma, H. Yang, Y. Jin, K. Hu, H.-X. Wang, Y.-X. Wang, Y.-R. Huang & B. Chen. (2014) Effect of acute tadalafil on sperm motility and acrosome reaction: in vitro and in vivo studies . Andrologia 46:4, pages 417-422.
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Ehsan Hashemi, Omid Akhavan, Mehdi Shamsara, Reza Rahighi, Ali Esfandiar & Aidin Rahim Tayefeh. (2014) Cyto and genotoxicities of graphene oxide and reduced graphene oxide sheets on spermatozoa. RSC Advances 4:52, pages 27213.
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Ali Karimi Goudarzi, Hossein Hassanpour & Masood Teshfam. (2012) Effect of cAMP-dependent protein kinase inhibitor (H89) on kinematic parameters of ram epididymal sperm in vitro. Comparative Clinical Pathology 22:4, pages 781-784.
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R.A. Siddique & S.K. Atreja. (2013) Effect of l-Arginine and spermine-NONOate on motility, viability, membrane integrity and lipid peroxidation of Murrah buffalo (Bubalus bubalis) spermatozoa. Livestock Science 153:1-3, pages 147-153.
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Sejal B Doshi, Karishma Khullar, Rakesh K Sharma & Ashok Agarwal. (2012) Role of reactive nitrogen species in male infertility. Reproductive Biology and Endocrinology 10:1.
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Xiaoyu Huang, Yijun Zhou, Jiying Ma, Ning Wang, Zhen Zhang, Jiajia Ji, Qing Ding & Guoyuan Chen. (2012) Nitric oxide mediated effects on reproductive toxicity caused by carbon disulfide in male rats. Environmental Toxicology and Pharmacology 34:3, pages 679-687.
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Slobodan M. Janković, Ana Djeković, Živadin Bugarčić, Snezana V. Janković, Goran Lukić, Marko Folić & Dragan Čanović. (2012) Effects of aurothiomalate and gold(III) complexes on spontaneous motility of isolated human oviduct. BioMetals 25:5, pages 919-925.
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Martin Imhof, Jakob Lackner, Markus Lipovac, Peter Chedraui & Claus Riedl. (2012) Improvement of sperm quality after micronutrient supplementation. e-SPEN Journal 7:1, pages e50-e53.
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Lin-Quan Ge, Yao Cheng, Jin-Cai Wu & Gary C. Jahn. (2011) Proteomic Analysis of Insecticide Triazophos-Induced Mating-Responsive Proteins of Nilaparvata lugens Stål (Hemiptera: Delphacidae) . Journal of Proteome Research 10:10, pages 4597-4612.
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Erica Miraglia, Federico De Angelis, Elena Gazzano, Hossain Hassanpour, Angela Bertagna, Elisabetta Aldieri, Alberto Revelli & Dario Ghigo. (2011) Nitric oxide stimulates human sperm motility via activation of the cyclic GMP/protein kinase G signaling pathway. REPRODUCTION 141:1, pages 47-54.
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Ali Karimi Goodarzi, Hossein Hassanpour & Masood Teshfam. (2009) Different effects of cGMP and cAMP analogs on kinematic parameters of ram epididymal sperm in vitro. Comparative Clinical Pathology 19:6, pages 559-563.
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Hossein Hassanpour, Masood Teshfam & Ali Karimi Goodarzi. (2009) Effects of NOC-18 (nitric oxide donor) and TRIM (nitric oxide synthase inhibitor) on kinematic parameters of ram epididymal sperm. Comparative Clinical Pathology 19:5, pages 487-491.
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Eddi Buldreghini, Reda Z. Mahfouz, Arianna Vignini, Laura Mazzanti, Giuseppe Ricciardo‐Lamonica, Andrea Lenzi, Ashok Agarwal & Giancarlo Balercia. (2013) Single Nucleotide Polymorphism (SNP) of the Endothelial Nitric Oxide Synthase ( eNOS ) Gene (Glu298Asp Variant) in Infertile Men With Asthenozoospermia . Journal of Andrology 31:5, pages 482-488.
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A. Laudat & K. Lecourbe. (2008) Diminution du pourcentage d’acrosomes malformés après un test de migration–survie des spermatozoïdes. Immuno-analyse & Biologie Spécialisée 23:6, pages 394-397.
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Gisela Machado-OliveiraLinda LefièvreChristopher FordM. Belen HerreroChristopher BarrattThomas J. ConnollyKatherine NashAduen Morales-GarciaJackson Kirkman-BrownSteve Publicover. (2008) Mobilisation of Ca2+ stores and flagellar regulation in human sperm by S-nitrosylation: a role for NO synthesised in the female reproductive tract. Development 135:22, pages 3677-3686.
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F. Dimitriadis, D. Giannakis, N. Pardalidis, K. Zikopoulos, E. Paraskevaidis, N. Giotitsas, V. Kalaboki, P. Tsounapi, D. Baltogiannis, I. Georgiou, M. Saito, T. Watanabe, I. Miyagawa & N. Sofikitis. (2008) Effects of phosphodiesterase 5 inhibitors on sperm parameters and fertilizing capacity. Asian Journal of Andrology 10:1, pages 115-133.
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Hossein Hassanpour, Pejman Mirshokrai, Abolfazl Shirazi & Atefe Aminian. (2007) Effect of Nitric Oxide on Ram Sperm Motility in vitro. Pakistan Journal of Biological Sciences 10:14, pages 2374-2378.
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Hong Zhang, Qingming Zhou, Xiaoda Li, Weiping Zhao, Yanling Wang, Hui Liu & Ning Li. (2007) Ginsenoside Re promotes human sperm capacitation through nitric oxide-dependent pathway. Molecular Reproduction and Development 74:4, pages 497-501.
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M. Matteo, E. Cicinelli, D. Baldini, Y. S. Cho, L. J. Ignarro, A. Vitarelli, D. Boffoli & P. Greco. (2006) Influence of human menopausal gonadotrophin treatment on testicular blood flow and on seminal plasma nitric oxide levels in infertile males1. International Journal of Andrology 29:4, pages 441-445.
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Hong Zhang, Qing-Ming Zhou, Xiao-Da Li, Yi Xie, Xin Duan, Feng-Ling Min, Bing Liu & Zhi-Gang Yuan. (2006) Ginsenoside Re increases fertile and asthenozoospermic infertile human sperm motility by induction of nitric oxide synthase. Archives of Pharmacal Research 29:2, pages 145-151.
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Giancarlo Balercia, Simona Moretti, Arianna Vignini, Mattia Magagnini, Franco Mantero, Marco Boscaro, Giuseppe Ricciardo-Lamonica & Laura Mazzanti. (2004) Role of Nitric Oxide Concentrations on Human Sperm Motility. Journal of Andrology 25:2, pages 245-249.
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Ariane Germeyer & Linda Giudice. 2003. Endometriosis. Endometriosis 151 165 .
Antoine Laudat, Karine Lecourbe, J?r?me Gu?chot & Anne-Marie Palluel. (2002) Values of sperm thiobarbituric acid-reactive substance in fertile men. Clinica Chimica Acta 325:1-2, pages 113-115.
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Alberto Revelli, Dario Ghigo, Federica Moffa, Marco Massobrio & Ilan Tur-Kaspa. (2002) Guanylate Cyclase Activity and Sperm Function. Endocrine Reviews 23:4, pages 484-494.
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Barbara H Osborn, A.F Haney, Mary A Misukonis & J.Brice Weinberg. (2002) Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertility. Fertility and Sterility 77:1, pages 46-51.
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Alberto Revelli, Loredana Bergandi, Marco Massobrio, Bo Lindblom, Amalia Bosia & Dario Ghigo. (2001) The concentration of nitrite in seminal plasma does not correlate with sperm concentration, sperm motility, leukocytospermia, or sperm culture. Fertility and Sterility 76:3, pages 496-500.
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Alberto Revelli, Costanzo Costamagna, Federica Moffa, Elisabetta Aldieri, Simona Ochetti, Amalia Bosia, Marco Massobrio, Bo Lindblom & Dario Ghigo. (2001) Signaling Pathway of Nitric Oxide-Induced Acrosome Reaction in Human Spermatozoa1. Biology of Reproduction 64:6, pages 1708-1712.
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Ratnasooriya, Dharmasiri & Wadsworth. (2001) Reduction in libido and fertility of male rats by administration of the nitric oxide (NO) synthase inhibitor N‐nitro‐ L ‐arginine methyl ester . International Journal of Andrology 23:3, pages 187-192.
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M.S. Davidoff & R. Middendorff. 2000. Functional Neuroanatomy of the Nitric Oxide System. Functional Neuroanatomy of the Nitric Oxide System 267 314 .
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Kazuo SengokuM.D.M.D., Kenichi TamateM.D.M.D., Toshiaki YoshidaM.D.M.D., Yasuo TakaokaM.D.M.D., Toshinobu MiyamotoM.D.M.D. & Mutsuo IshikawaM.D.M.D.. (1998) Effects of Low Concentrations of Nitric Oxide on the Zona Pellucida Binding Ability of Human Spermatozoa. Fertility and Sterility 69:3, pages 522-527.
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RICHARD R. YEOMAN, WILLIAM D. JONES & BOTROS M. RIZK. (2013) Evidence for Nitric Oxide Regulation of Hamster Sperm Hyperactivation. Journal of Andrology 19:1, pages 58-64.
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