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Free Radical Research Volume 25, 1996 - Issue 6
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Original Article

Differential Depletion of Human Respiratory Tract Antioxidants in Response to Ozone Challenge

Ian S. Mudway Cardiovascular Research, The Rayne Institute, St Thomas' Hospital, London, SE1 7EH
,
David Housley Cardiovascular Research, The Rayne Institute, St Thomas' Hospital, London, SE1 7EH
,
Ronald Eccles Cardiovascular Research, The Rayne Institute, St Thomas' Hospital, London, SE1 7EH
,
Roy J. Richards Cardiovascular Research, The Rayne Institute, St Thomas' Hospital, London, SE1 7EH
,
Avijit K. Datta School of Molecular & Medical Biosciences, University of Wales, College of Cardiff, Cardiff, CF1 3US
,
Teresa D. Tetley Department of Medicine, Charing Cross & Westminster Medical School, London, W6 8RF
&
Frank J. Kelly School of Molecular & Medical Biosciences, University of Wales, College of Cardiff, Cardiff, CF1 3USCorrespondence[email protected]
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Pages 499-513 | Received 19 Mar 1996, Published online: 07 Jul 2009

Citations (27)

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Sonika Patial & Yogesh Saini. (2020) Lung macrophages: current understanding of their roles in Ozone-induced lung diseases. Critical Reviews in Toxicology 50:4, pages 310-323.
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Robyn L. Prueitt & Julie E. Goodman. (2016) Evaluation of neural reflex activation as a mode of action for the acute respiratory effects of ozone. Inhalation Toxicology 28:11, pages 484-499.
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Allen S. Lefohn, Milan J. Hazucha, Douglas Shadwick & William C. Adams. (2010) An alternative form and level of the human health ozone standard. Inhalation Toxicology 22:12, pages 999-1011.
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Annelie F. Behndig, Anders Blomberg, Ragnberth Helleday, Sean T. Duggan, Frank J. Kelly & Ian S. Mudway. (2009) Antioxidant responses to acute ozone challenge in the healthy human airway. Inhalation Toxicology 21:11, pages 933-942.
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Monique Saintot, Nadine Bernard, Cécile Astre, Mariette Gerber & Inserm-crlc. (1999) Ozone Exposure and Blood Antioxidants: A Study in a Periurban Area in Southern France. Archives of Environmental Health: An International Journal 54:1, pages 34-39.
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Anna Clouter Catherine E. Houghton Leon R. Hibbs John A. Hoskins. (1998) EFFECT OF INHALATION OF LOW DOSES OF CROCIDOLITE AND FIBROUS GYPSUM ON THE GLUTATHIONE CONCENTRATION AND-GLUTAMYL TRANSPEPTIDASE ACTIVITY IN MACROPHAGES AND BRONCHOALVEOLAR LAVAGE FLUID. Inhalation Toxicology 10:1, pages 3-14.
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F. J. Kelly & I. S. Mudway. (1997) Sensitivity to ozone: could it be related to an individual's complement of antioxidants in lung epithelium lining fluid?. Redox Report 3:4, pages 199-206.
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Articles from other publishers (20)

Sumita B. Khatri, Jeannie Peabody, Leandrea Burwell, Frank Harris & LouAnnE S. Brown. (2014) Systemic Antioxidants and Lung Function in Asthmatics during High Ozone Season: A Closer Look at Albumin, Glutathione, and Associations with Lung Function. Clinical and Translational Science 7:4, pages 314-318.
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Julie E. Goodman, Robyn L. Prueitt, Juhi Chandalia & Sonja N. Sax. (2014) Evaluation of adverse human lung function effects in controlled ozone exposure studies. Journal of Applied Toxicology 34:5, pages 516-524.
Crossref
Borut Poljšak & Rok Fink. (2014) The Protective Role of Antioxidants in the Defence against ROS/RNS-Mediated Environmental Pollution. Oxidative Medicine and Cellular Longevity 2014, pages 1-22.
Crossref
Ronald Eccles. 2014. Middleton's Allergy. Middleton's Allergy 640 651 .
Min-Sung LeeKuk-Young MoonDa-Jeong BaeMoo-Kyun ParkAn-Soo Jang. (2013) The effects of pycnogenol on antioxidant enzymes in a mouse model of ozone exposure. The Korean Journal of Internal Medicine 28:2, pages 216.
Crossref
Joseph M. Rutkowski, Lizzie Y. Santiag, Abdellaziz Ben-Jebria & James S. Ultman. (2011) Comparison of ozone-specific (OZAC) and oxygen radical (ORAC) antioxidant capacity assays for use with nasal lavage fluid. Toxicology in Vitro 25:7, pages 1406-1413.
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Sanaz Kermani, Abdellaziz Ben-Jebria & James S. Ultman. (2006) Kinetics of ozone reaction with uric acid, ascorbic acid, and glutathione at physiologically relevant conditions. Archives of Biochemistry and Biophysics 451:1, pages 8-16.
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C. M. DEATON, D. J. MARLIN, N. C. SMITH, C. A. ROBERTS, P. A. HARRIS, R. C. SCHROTER & F. J. KELLY. (2010) Antioxidant and inflammatory responses of healthy horses and horses affected by recurrent airway obstruction to inhaled ozone. Equine Veterinary Journal 37:3, pages 243-249.
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K Lund, C Dunster, I Ramis, T Sandstrom, F J Kelly, P SøStrand, P Schwarze, E Skovlund, J Boe, J Kongerud & M Refsnes. (2016) Inflammatory markers in bronchoalveolar lavage fluid from human volunteers 2 hours after hydrogen fluoride exposure. Human & Experimental Toxicology 24:3, pages 101-108.
Crossref
Bettina C. Schock, John Koostra, Sunye Kwack, Robert M. Hackman, Albert van der Vliet & Carroll E. Cross. (2004) Ascorbic acid in nasal and tracheobronchial airway lining fluids. Free Radical Biology and Medicine 37:9, pages 1393-1401.
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J J SIENRA-MONGE, M RAMIREZ-AGUILAR, H MORENO-MACIAS, N I REYES-RUIZ, B E DEL RÍO-NAVARRO, M X RUIZ-NAVARRO, G HATCH, K CRISSMAN, R SLADE, R B DEVLIN & I ROMIEU. (2004) Antioxidant supplementation and nasal inflammatory responses among young asthmatics exposed to high levels of ozone. Clinical and Experimental Immunology 138:2, pages 317-322.
Crossref
Bettina C Schock, Ian S Young, Vanessa Brown, Patrick S Fitch, Michael D Shields & Madeleine Ennis. (2003) Antioxidants and Oxidative Stress in BAL Fluid of Atopic Asthmatic Children. Pediatric Research 53:3, pages 375-381.
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Nancy C. Long, Jung Suh, Jason D. Morrow, Robert H. SchiestlG. G. Krishna Murthy, Joseph D. Brain & Balz Frei. (2001) Ozone causes lipid peroxidation but little antioxidant depletion in exercising and nonexercising hamsters. Journal of Applied Physiology 91:4, pages 1694-1700.
Crossref
Blomberg. (2001) Airway inflammatory and antioxidant responses to oxidative and particulate air pollutants − experimental exposure studies in humans. Clinical & Experimental Allergy 30:3, pages 310-317.
Crossref
Dianne M. Meacher & Daniel B. Menzel. 2000. Handbook of Oxidants and Antioxidants in Exercise. Handbook of Oxidants and Antioxidants in Exercise 513 554 .
Jane Q. KoenigJane Q. Koenig. 2000. Health Effects of Ambient Air Pollution. Health Effects of Ambient Air Pollution 139 163 .
I. S. Mudway, M. T. Krishna, A. J. Frew, D. MacLeod, T. Sandstrom, S. T. Holgate & F. J. Kelly. (1999) Compromised concentrations of ascorbate in fluid lining the respiratory tract in human subjects after exposure to ozone. Occupational and Environmental Medicine 56:7, pages 473-481.
Crossref
Frank J Kelly & Roy Richards. 1999. Air Pollution and Health. Air Pollution and Health 341 355 .
Edward M. Postlethwait, Rafael Cueto, Leonard W. Velsor & William A. Pryor. (1998) O 3 -induced formation of bioactive lipids: estimated surface concentrations and lining layer effects . American Journal of Physiology-Lung Cellular and Molecular Physiology 274:6, pages L1006-L1016.
Crossref
Ian S. Mudway & Frank J. Kelly. (1998) Modeling the Interactions of Ozone with Pulmonary Epithelial Lining Fluid Antioxidants. Toxicology and Applied Pharmacology 148:1, pages 91-100.
Crossref

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