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Original Article

EPR Evidence for the Involvement of Free Radicals in the Iron-Catalysed Decomposition of Qinghaosu (Artemisinin) and Some Derivatives; Antimalarial Action of Some Polycyclic Endoperoxides

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Pages 471-476 | Received 20 Oct 1997, Published online: 07 Jul 2009

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Naokazu KUMURA, Hirotaka FURUKAWA, Michiyo KOBAYASHI, Arnold N. ONYANGO, Minoru IZUMI, Shuhei NAKAJIMA, Hye-Sook KIM, Yusuke WATAYA & Naomichi BABA. (2009) Synthesis of Novel Conjugates of Tetraoxane Endoperoxide with Bis(Quaternary Ammonium Salts). Bioscience, Biotechnology, and Biochemistry 73:1, pages 217-220.
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Sunita Bhatnagar & P. Das. (2007) Antimalarial Activity in Tropical Plants: A Review. Journal of Herbs, Spices & Medicinal Plants 13:1, pages 103-132.
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PG Fuochi, G Marconi & QG Mulazzani. (2005) Radiolytically induced one-electron reduction of artemisinin in H2O/ethanol (1:1 v/v) solution: a pulse radiolysis study.. International Journal of Radiation Biology 81:4, pages 319-326.
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Articles from other publishers (66)

Christopher M. Woodley, Patrícia S. M. Amado, Maria L. S. Cristiano & Paul M. O'Neill. (2021) Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies. Medicinal Research Reviews 41:6, pages 3062-3095.
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Jing Yang, Yingke He, Yinbao Li, Xing Zhang, Yin-Kwan Wong, Shengnan Shen, Tianyu Zhong, Jianbin Zhang, Qian Liu & Jigang Wang. (2020) Advances in the research on the targets of anti-malaria actions of artemisinin. Pharmacology & Therapeutics 216, pages 107697.
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Lorenzo Botta, Silvia Filippi, Claudio Zippilli, Silvia Cesarini, Bruno Mattia Bizzarri, Angela Cirigliano, Teresa Rinaldi, Alessandro Paiardini, Diego Fiorucci, Raffaele Saladino, Rodolfo Negri & Pietro Benedetti. (2020) Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1. ACS Medicinal Chemistry Letters 11:5, pages 1035-1040.
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Lorenzo Botta, Silvia Filippi, Bruno M. Bizzarri, Claudio Zippilli, Roberta Meschini, Rebecca Pogni, Maria Camilla Baratto, Luciano Villanova & Raffaele Saladino. (2019) Synthesis and Evaluation of Artemisinin-Based Hybrid and Dimer Derivatives as Antimelanoma Agents. ACS Omega 5:1, pages 243-251.
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Greanious Alfred Mavondo, Blessing Nkazimulo Mkhwanazi, Joy Mavondo, Wisdom Peresuh & Obadiah Moyo. 2019. Malaria. Malaria.
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Katsunori Tsuda, Licht Miyamoto, Shuichi Hamano, Yuri Morimoto, Yumi Kangawa, Chika Fukue, Yoko Kagawa, Yuya Horinouchi, Wenting Xu, Yasumasa Ikeda, Toshiaki Tamaki & Koichiro Tsuchiya. (2018) Mechanisms of the pH- and Oxygen-Dependent Oxidation Activities of Artesunate. Biological and Pharmaceutical Bulletin 41:4, pages 555-563.
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Marie Asano & Hideo Iwahashi. (2017) Determination of the structures of radicals formed in the reaction of antimalarial drug artemisinin with ferrous ions. European Journal of Medicinal Chemistry 127, pages 740-747.
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