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Drug Delivery Volume 17, 2010 - Issue 7
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Research Article

Stability and in vivo evaluation of pullulan acetate as a drug nanocarrier

Hong-Bo TangInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College, The Key Laboratory of Biomedical Material of Tianjin, Tianjin 300192, PR China
,
Lei LiInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College, The Key Laboratory of Biomedical Material of Tianjin, Tianjin 300192, PR China
,
Han ChenInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College, The Key Laboratory of Biomedical Material of Tianjin, Tianjin 300192, PR China
,
Zhi-Min ZhouInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College, The Key Laboratory of Biomedical Material of Tianjin, Tianjin 300192, PR China
,
Hong-Li ChenInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College, The Key Laboratory of Biomedical Material of Tianjin, Tianjin 300192, PR China
,
Xue-Min LiInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College, The Key Laboratory of Biomedical Material of Tianjin, Tianjin 300192, PR China
,
Ling-Rong LiuInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College, The Key Laboratory of Biomedical Material of Tianjin, Tianjin 300192, PR China
,
Yin-Song WangCollege of Pharmacy, TianJin Medical University, Tianjin, 300070, PR China
&
Qi-Qing ZhangCorrespondence[email protected]
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Pages 552-558 | Received 26 Dec 2009, Accepted 28 Apr 2010, Published online: 15 Jun 2010

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Hongbo Tang, Ziwen Jiang, Haibo He, Xiaoqin Li, Haipeng Hu, Ning Zhang, Yinmei Dai & Zhimin Zhou. (2018) Uptake and transport of pullulan acetate nanoparticles in the BeWo b30 placental barrier cell model. International Journal of Nanomedicine 13, pages 4073-4082.
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Hongli Chen, WenBin Nan, Xiangjuan Wei, Yan Wang, Feng Lv, Hongbo Tang, Yonghai Li, Chenyan Zhou, Juntang Lin, Wuling Zhu & Qiqing Zhang. (2017) Toxicity, pharmacokinetics, and in vivo efficacy of biotinylated chitosan surface-modified PLGA nanoparticles for tumor therapy. Artificial Cells, Nanomedicine, and Biotechnology 45:6, pages 1115-1122.
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Jing Lu, Long Xie, Anxin Wu, Xian Wang, Youdan Liang, Xiaolin Dai, Yi Cao & Xiaofang Li. (2022) Delivery of silybin using a zein-pullulan nanocomplex: Fabrication, characterization, in vitro release properties and antioxidant capacity. Colloids and Surfaces B: Biointerfaces 217, pages 112682.
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Yi Zhang, Qing Jiang, Xinyi Liu, Liping Peng, Xinyi Tang, Ling Li, Xiao Ling, Xiaoping Yang, Chunlian He, Xiaojun Tao & Defu Hou. (2021) A Study of Hydrophobically Modified Pullulan Nanoparticles with Different Hydrophobic Densities on the Effect of Anti-Colon Cancer Cell Efficiency. Journal of Biomedical Nanotechnology 17:10, pages 1972-1983.
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Martin Gericke, Peter Schulze & Thomas Heinze. (2020) Nanoparticles Based on Hydrophobic Polysaccharide Derivatives—Formation Principles, Characterization Techniques, and Biomedical Applications. Macromolecular Bioscience 20:4.
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Anca Giorgiana Grigoras. (2019) Drug delivery systems using pullulan, a biocompatible polysaccharide produced by fungal fermentation of starch. Environmental Chemistry Letters 17:3, pages 1209-1223.
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Muhammad Raza Shah, Muhammad Imran & Shafi Ullah. 2019. Nanocarriers for Cancer Diagnosis and Targeted Chemotherapy. Nanocarriers for Cancer Diagnosis and Targeted Chemotherapy 79 106 .
V.N. Pandey, Neha Tiwari, V.S. Pandey, Anita Rao & Ishwar Das. 2019. Nanoarchitectonics in Biomedicine. Nanoarchitectonics in Biomedicine 437 472 .
Anca Giorgiana Grigoras. 2019. Pharmaceuticals from Microbes. Pharmaceuticals from Microbes 99 141 .
Xiaojun Tao, Ting Tao, Yi Wen, Jiajin Yi, Lihua He, Zixuan Huang, Yu Nie, Xiaoyan Yao, Yingying Wang, Chunlian He & Xiaoping Yang. (2018) Novel Delivery of Mitoxantrone with Hydrophobically Modified Pullulan Nanoparticles to Inhibit Bladder Cancer Cell and the Effect of Nano-drug Size on Inhibition Efficiency. Nanoscale Research Letters 13:1.
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Ming Wang, Meiling Huang, Jianting Wang, Mingquan Ye, Yan Deng, Honghao Li, Wensi Qian, Bolin Zhu, Yao Zhang & Renmin Gong. (2016) Facile One-Pot Synthesis of Self-Assembled Folate-Biotin-Pullulan Nanoparticles for Targeted Intracellular Anticancer Drug Delivery. Journal of Nanomaterials 2016, pages 1-10.
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Moorthy Ganeshkumar, Thangavel Ponrasu, Muthaiya Kannappan Subamekala, Murthy Janani & Lonchin Suguna. (2016) Curcumin loaded on pullulan acetate nanoparticles protects the liver from damage induced by DEN. RSC Advances 6:7, pages 5599-5610.
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Xiaojun Tao, Shu Jin, Dehong Wu, Kai Ling, Liming Yuan, Pingfa Lin, Yongchao Xie & Xiaoping Yang. (2015) Effects of Particle Hydrophobicity, Surface Charge, Media pH Value and Complexation with Human Serum Albumin on Drug Release Behavior of Mitoxantrone-Loaded Pullulan Nanoparticles. Nanomaterials 6:1, pages 2.
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Yan Wang, Yuanyuan Liu, Yang Liu, Wen Zhou, Hemei Wang, Guoyun Wan, Duxin Sun, Ning Zhang & Yinsong Wang. (2015) A polymeric prodrug of cisplatin based on pullulan for the targeted therapy against hepatocellular carcinoma. International Journal of Pharmaceutics 483:1-2, pages 89-100.
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Mohammad Tariq, Md. Aftab Alam, Anu T. Singh, Zeenat Iqbal, Amulya K. Panda & Sushama Talegaonkar. (2015) Biodegradable polymeric nanoparticles for oral delivery of epirubicin: In vitro, ex vivo, and in vivo investigations. Colloids and Surfaces B: Biointerfaces 128, pages 448-456.
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Yuanyuan Liu, Yan Wang, Cong Zhang, Ping Zhou, Yang Liu, Tong An, Duxin Sun, Ning Zhang & Yinsong Wang. (2014) Core–Shell Nanoparticles Based on Pullulan and Poly(β-amino) Ester for Hepatoma-Targeted Codelivery of Gene and Chemotherapy Agent. ACS Applied Materials & Interfaces 6:21, pages 18712-18720.
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Hua Guo, Yuanyuan Liu, Yan Wang, Jing Wu, Xiaoying Yang, Rongshan Li, Yinsong Wang & Ning Zhang. (2014) pH-sensitive pullulan-based nanoparticle carrier for adriamycin to overcome drug-resistance of cancer cells. Carbohydrate Polymers 111, pages 908-917.
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Yinsong Wang, Yang Liu, Yuanyuan Liu, Yan Wang, Jing Wu, Rongshan Li, Jinrong Yang & Ning Zhang. (2014) pH-sensitive pullulan-based nanoparticles for intracellular drug delivery. Polym. Chem. 5:2, pages 423-432.
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Wenzhi Yang, Miaomiao Wang, Lilan Ma, Haiying Li & Le Huang. (2014) Synthesis and characterization of biotin modified cholesteryl pullulan as a novel anticancer drug carrier. Carbohydrate Polymers 99, pages 720-727.
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Yinsong Wang, Hongli Chen, Yuanyuan Liu, Jing Wu, Ping Zhou, Yan Wang, Rongshan Li, Xiaoying Yang & Ning Zhang. (2013) pH-sensitive pullulan-based nanoparticle carrier of methotrexate and combretastatin A4 for the combination therapy against hepatocellular carcinoma. Biomaterials 34:29, pages 7181-7190.
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