2,381
Views
25
CrossRef citations to date
0
Altmetric
Research Article

Formulation and evaluation of novel solid lipid microparticles as a sustained release system for the delivery of metformin hydrochloride

, &
Pages 102-111 | Received 25 Aug 2012, Accepted 20 Feb 2013, Published online: 08 May 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Kainat Nousheen, Fakhar Ud Din, Humzah Jamshaid, Rabia Afza, Saif Ullah Khan, Maimoona Malik, Zakir Ali, Sibgha Batool, Alam Zeb, Abid Mehmood Yousaf, Ali H. Almari, Saud Alqahtani, Salman Khan & Gul Majid Khan. (2023) Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model. Drug Delivery 30:1.
Read now
Zhengwei Huang, Han Wu, Beibei Yang, Longkai Chen, Ying Huang, Guilan Quan, Chune Zhu, Xing Li, Xin Pan & Chuanbin Wu. (2017) Anhydrous reverse micelle nanoparticles: new strategy to overcome sedimentation instability of peptide-containing pressurized metered-dose inhalers. Drug Delivery 24:1, pages 527-538.
Read now
Meltem Cetin & Selma Sahin. (2016) Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride. Drug Delivery 23:8, pages 2796-2805.
Read now
Xiaoyuan Dong, Wen Wang, Hui Qu, Dong Han, Junmin Zheng & Guorui Sun. (2016) Targeted delivery of doxorubicin and vincristine to lymph cancer: evaluation of novel nanostructured lipid carriers in vitro and in vivo. Drug Delivery 23:4, pages 1374-1378.
Read now
Qiang Xu, Tao Zhu, Chaoli Yi & Qi Shen. (2016) Characterization and evaluation of metformin-loaded solid lipid nanoparticles for celluar and mitochondrial uptake. Drug Development and Industrial Pharmacy 42:5, pages 701-706.
Read now
Franklin C. Kenechukwu, Mumuni A. Momoh, Petra O. Nnamani & Anthony A. Attama. (2015) Solid lipid micro-dispersions (SLMs) based on PEGylated solidified reverse micellar solutions (SRMS): a novel carrier system for gentamicin. Drug Delivery 22:6, pages 710-722.
Read now
Santo Scalia, Paul M Young & Daniela Traini. (2015) Solid lipid microparticles as an approach to drug delivery. Expert Opinion on Drug Delivery 12:4, pages 583-599.
Read now

Articles from other publishers (16)

Franklin Chimaobi Kenechukwu, Daniel Okwudili Nnamani, Bright Ugochukwu Nmesirionye, God’spower Tochukwu Isaac, Mumuni Audu Momoh & Anthony Amaechi Attama. (2022) PEGylated Lipid Nanocontainers Tailored with Sunseed-Oil-Based Solidified Reverse Micellar Solution for Enhanced Pharmacodynamics and Pharmacokinetics of Metformin. Journal of Pharmaceutical Innovation 18:2, pages 437-460.
Crossref
Eliza Wolska & Martyna Szymańska. (2023) Comparison of the In Vitro Drug Release Methods for the Selection of Test Conditions to Characterize Solid Lipid Microparticles. Pharmaceutics 15:2, pages 511.
Crossref
Masoud Eskandani, Morteza Eskandani, Somayeh Vandghanooni, Bahman Navidshad, Farzad Mirzaei Aghjehgheshlagh & Ali Nobakht. (2022) Protective effect of l-carnitine-loaded solid lipid nanoparticles against H2O2-induced genotoxicity and apoptosis. Colloids and Surfaces B: Biointerfaces 212, pages 112365.
Crossref
Franklin Chimaobi Kenechukwu, God’spower Tochukwu Isaac, Daniel Okwudili Nnamani, Mumuni Audu Momoh & Anthony Amaechi Attama. (2022) Enhanced circulation longevity and pharmacodynamics of metformin from surface-modified nanostructured lipid carriers based on solidified reverse micellar solutions. Heliyon 8:3, pages e09100.
Crossref
Franklin Chimaobi Kenechukwu, Daniel Okwudili Nnamani, Judith Chekwube Duhu, Bright Ugochukwu Nmesirionye, Mumuni Audu Momoh, Paul Achile Akpa & Anthony Amaechi Attama. (2022) Potential enhancement of metformin hydrochloride in solidified reverse micellar solution-based PEGylated lipid nanoparticles targeting therapeutic efficacy in diabetes treatment. Heliyon 8:3, pages e09099.
Crossref
Eliza Wolska & Marta Brach. (2022) Distribution of Drug Substances in Solid Lipid Microparticles (SLM)—Methods of Analysis and Interpretation. Pharmaceutics 14:2, pages 335.
Crossref
Xiaowei Yang, Qi Lai, Xinmin Yang, Banglin Xie, Bin Zhang, Xiaoyong Zhang & Yen Wei. (2022) Recent development and advances in the fabrication and biomedical applications of nanoparticle-based drug delivery systems for metformin. Materials Chemistry Frontiers 6:2, pages 128-144.
Crossref
Muhammad Hanif, Hafeez Ullah Khan, Safirah Maheen, Syed Salman Shafqat, Shahid Shah, Syeda Amna Masood, Ghulam Abbas, Muhammad Rizwan, Tahir Rasheed & Muhammad Bilal. (2021) Formulation, characterization, and pharmacokinetic evaluation of Ivabradine-Nebivolol co-encapsulated lipospheres. Journal of Molecular Liquids 344, pages 117704.
Crossref
Akhtar Rasul, Safirah Maheen, Hafeez Ullah Khan, Maria Rasool, Shahid Shah, Ghulam Abbas, Khurram Afzal, Fatima Tariq, Irum Shahzadi & Muhammad Hassham Hassan Bin Asad. (2021) Formulation, Optimization, In Vitro and In Vivo Evaluation of Saxagliptin-Loaded Lipospheres for an Improved Pharmacokinetic Behavior. BioMed Research International 2021, pages 1-17.
Crossref
Eliza Wolska. (2021) Fine powder of lipid microparticles – spray drying process development and optimization. Journal of Drug Delivery Science and Technology 64, pages 102640.
Crossref
Safirah Maheen & Akhtar Rasul. (2020) Formulation, characterization and statistical optimization of enalapril-loaded lipospheres. Bioinspired, Biomimetic and Nanobiomaterials 9:4, pages 202-212.
Crossref
Safirah Maheen, Akhtar Rasul, Muhammad Hanif & Hafeez Ullah Khan. (2020) Lipospheres for Simultaneous Controlled Release and Improved Pharmacokinetic Profiles of Saxagliptin-Enalapril: Formulation, Optimization, and Comparative In Vitro-In Vivo Evaluation. AAPS PharmSciTech 21:5.
Crossref
A. Katrolia, S. B. Chauhan & V. K. Shukla. (2019) Formulation and evaluation of Metformin Hydrochloride-loaded Curcumin–Lycopene Niosomes. SN Applied Sciences 1:12.
Crossref
Atul Kumar Sahu & Amita Verma. (2016) Development and statistical optimization of chitosan and eudragit based gastroretentive controlled release multiparticulate system for bioavailability enhancement of metformin HCl. Journal of Pharmaceutical Investigation 46:3, pages 239-252.
Crossref
Naser Mirazi, Jamileh Shoaei, Ardeshir Khazaei & Abdolkarim Hosseini. (2014) A comparative study on effect of metformin and metformin-conjugated nanotubes on blood glucose homeostasis in diabetic rats. European Journal of Drug Metabolism and Pharmacokinetics 40:3, pages 343-348.
Crossref
Shasha Rao, Angel Tan, Nicky Thomas & Clive A. Prestidge. (2014) Perspective and potential of oral lipid-based delivery to optimize pharmacological therapies against cardiovascular diseases. Journal of Controlled Release 193, pages 174-187.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.