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Research Article

Long-circulating nanoliposomes (LCNs) sustained delivery of baicalein (BAI) with desired oral bioavailability in vivo

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Pages 319-323 | Received 29 May 2013, Accepted 10 Aug 2013, Published online: 12 Sep 2013

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Shraddha Srivastava, Abhiram Kumar, Pavan Kumar Yadav, Madhaw Kumar, Jose Mathew, Avinash Chandra Pandey & Manish Kumar Chourasia. (2021) Formulation and performance evaluation of polymeric mixed micelles encapsulated with baicalein for breast cancer treatment. Drug Development and Industrial Pharmacy 47:9, pages 1512-1522.
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Hengfeng Liao, Yue Gao, Chunfang Lian, Yun Zhang, Bangyuan Wang, Yanfang Yang, Jun Ye, Yu Feng & Yuling Liu. (2019) Oral absorption and lymphatic transport of baicalein following drug–phospholipid complex incorporation in self-microemulsifying drug delivery systems. International Journal of Nanomedicine 14, pages 7291-7306.
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Juntao Yin, Cuiyu Xiang, Peiqing Wang, Yuyun Yin & Yantao Hou. (2017) Biocompatible nanoemulsions based on hemp oil and less surfactants for oral delivery of baicalein with enhanced bioavailability. International Journal of Nanomedicine 12, pages 2923-2931.
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Yang Zhou, Wujun Dong, Jun Ye, Huazhen Hao, Junzhuo Zhou, Renyun Wang & Yuling Liu. (2017) A novel matrix dispersion based on phospholipid complex for improving oral bioavailability of baicalein: preparation, in vitro and in vivo evaluations. Drug Delivery 24:1, pages 720-728.
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Biswanath Dinda, Manikarna Dinda, Subhajit Dinda & Utpal Chandra De. (2023) An overview of anti-SARS-CoV-2 and anti-inflammatory potential of baicalein and its metabolite baicalin: Insights into molecular mechanisms. European Journal of Medicinal Chemistry 258, pages 115629.
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Zhaoxuan Low, Rafidah Lani, Vunjia Tiong, Chitlaa Poh, Sazaly AbuBakar & Pouya Hassandarvish. (2023) COVID-19 Therapeutic Potential of Natural Products. International Journal of Molecular Sciences 24:11, pages 9589.
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A K M Helal Morshed, Supti Paul, Arafat Hossain, Tuli Basak, Md. Sanower Hossain, Md. Mehedi Hasan, Md. Al Hasibuzzaman, Tanjim Ishraq Rahaman, Md. Abdur Rashid Mia, Pollob Shing, Md Sohel, Shabana Bibi, Dipta Dey, Partha Biswas, Md. Nazmul Hasan, Long Chiau Ming & Ching Siang Tan. (2023) Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives. Cancers 15:7, pages 2128.
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Shraddha Srivastava, Jose Mathew & Avinash chandra Pandey. (2023) Baicalein—A review on its molecular mechanism against breast cancer and delivery strategies. Medicinal Chemistry Research 32:4, pages 643-658.
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Adam Markowski, Magdalena Zaremba-Czogalla, Anna Jaromin, Ewa Olczak, Adrianna Zygmunt, Haniyeh Etezadi, Ben J. Boyd & Jerzy Gubernator. (2023) Novel Liposomal Formulation of Baicalein for the Treatment of Pancreatic Ductal Adenocarcinoma: Design, Characterization, and Evaluation. Pharmaceutics 15:1, pages 179.
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Jilin Wang, Xiaojiao Feng, Ziwei Li, Yiting Liu, Wenzhuo Yang, Tingen Zhang, Pan Guo, Zhidong Liu, Dongli Qi & Jiaxin Pi. (2023) The Flavonoid Components of Scutellaria baicalensis: Biopharmaceutical Properties and their Improvement using Nanoformulation Techniques. Current Topics in Medicinal Chemistry 23:1, pages 17-29.
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Arshad Husain Rahmani, Ahmad Almatroudi, Amjad Ali Khan, Ali Yousif Babiker, Malak Alanezi & Khaled S. Allemailem. (2022) The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways. Molecules 27:22, pages 8023.
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Tamires Cunha Almeida, Janaína Brandão Seibert, Tatiane Roquete Amparo, Gustavo Henrique Bianco de Souza, Glenda Nicioli da Silva & Orlando David Henrique dos Santos. (2022) Modulation of Long Non-coding RNAs by Different Classes of Secondary Metabolites from Plants: A Mini-review on Antitumor Effects. Mini-Reviews in Medicinal Chemistry 22:9, pages 1232-1255.
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María Plaza-Oliver, Manuel Jesús Santander-Ortega & María Victoria. Lozano. (2021) Current approaches in lipid-based nanocarriers for oral drug delivery. Drug Delivery and Translational Research 11:2, pages 471-497.
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Harsh A. Joshi, Raghavendra S. Patwardhan, Deepak Sharma, Santosh K. Sandur & Padma V. Devarajan. (2021) Pre-clinical evaluation of an innovative oral nano-formulation of baicalein for modulation of radiation responses. International Journal of Pharmaceutics 595, pages 120181.
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Daniel E. Otzen, Dina Morshedi, Hossein Mohammad-Beigi & Farhang Aliakbari. (2021) A Triple Role for a Bilayer: Using Nanoliposomes to Cross and Protect Cellular Membranes. The Journal of Membrane Biology 254:1, pages 29-39.
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Li Zhang, Shili Yang, Lizhen Huang & Paul Chi-Lui Ho. (2020) Poly (ethylene glycol)-block-poly (D, L-lactide) (PEG-PLA) micelles for brain delivery of baicalein through nasal route for potential treatment of neurodegenerative diseases due to oxidative stress and inflammation: An in vitro and in vivo study. International Journal of Pharmaceutics 591, pages 119981.
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Hardeep Singh Tuli, Vaishali Aggarwal, Jagjit Kaur, Diwakar Aggarwal, Gaurav Parashar, Nidarshana Chaturvedi Parashar, Muobarak Tuorkey, Ginpreet Kaur, Raj Savla, Katrin Sak & Manoj Kumar. (2020) Baicalein: A metabolite with promising antineoplastic activity. Life Sciences 259, pages 118183.
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Maria Manconi, Carla Caddeo, Maria Letizia Manca & Anna Maria Fadda. (2020) Oral delivery of natural compounds by phospholipid vesicles. Nanomedicine 15:18, pages 1795-1803.
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Mozhgan Aghajanzadeh, Sina Andalib, Hossein Danafar, Kobra Rostamizadeh & Ali Sharafi. (2020) The effect of baicalein-loaded Y-shaped miktoarm copolymer on spatial memory and hippocampal expression of DHCR24, SELADIN and SIRT6 genes in rat model of Alzheimer. International Journal of Pharmaceutics 586, pages 119546.
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Tao Su, Chunhua Huang, Chunfang Yang, Ting Jiang, Junfang Su, Minting Chen, Sarwat Fatima, Ruihong Gong, Xianjing Hu, Zhaoxiang Bian, Zhongqiu Liu & Hiu Yee Kwan. (2020) Apigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity. Pharmacological Research 152, pages 104586.
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Robert Ancuceanu, Mihaela Dinu, Cristina Dinu-Pirvu, Valentina Anuţa & Vlad Negulescu. (2019) Pharmacokinetics of B-Ring Unsubstituted Flavones. Pharmaceutics 11:8, pages 370.
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Scarlet Wang, Xuesong Wen, Celia Bell & Sandra Appiah. (2018) Liposome‑delivered baicalein induction of myeloid leukemia K562 cell death via reactive oxygen species generation. Molecular Medicine Reports.
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Wei-yi Gong, Zheng-xiao Zhao, Bao-jun Liu, Lin-wei Lu & Jing-cheng Dong. (2017) Exploring the chemopreventive properties and perspectives of baicalin and its aglycone baicalein in solid tumors. European Journal of Medicinal Chemistry 126, pages 844-852.
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Biswajit Mukherjee, Bhabani S. Satapathy, Sanchari Bhattacharya, Rhitabrita Chakraborty & Vimal P. Mishra. 2017. Nano- and Microscale Drug Delivery Systems. Nano- and Microscale Drug Delivery Systems 357 375 .
Aneta Ostróżka-Cieślik & Beata Sarecka-Hujar. 2017. Multifunctional Systems for Combined Delivery, Biosensing and Diagnostics. Multifunctional Systems for Combined Delivery, Biosensing and Diagnostics 139 158 .
Nagendra Sastry Yarla, Anupam Bishayee, Gautam Sethi, Pallu Reddanna, Arunasree M. Kalle, Bhadrapura Lakkappa Dhananjaya, Kaladhar S.V.G.K. Dowluru, Ramakrishna Chintala & Govinda Rao Duddukuri. (2016) Targeting arachidonic acid pathway by natural products for cancer prevention and therapy. Seminars in Cancer Biology 40-41, pages 48-81.
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Ying Gao, Shane A. Snyder, Jaclyn N. Smith & Yi Charlie Chen. (2016) Anticancer properties of baicalein: a review. Medicinal Chemistry Research 25:8, pages 1515-1523.
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Kun Li, Haizhao Zhang, Liming Gao, Yue Zhai, Ming Shi, Jian Li, Chenlin Xiu, Junli Cao, Shaohui Cheng, Li Jiang & Hao Di. (2016) Preparation and Characterization of Baicalein-Loaded Nanoliposomes for Antitumor Therapy. Journal of Nanomaterials 2016, pages 1-9.
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Chao Hong, Yang Dang, Guobei Lin, Yashu Yao, Guowen Li, Guang Ji, Hongyi Shen & Yan Xie. (2014) Effects of stabilizing agents on the development of myricetin nanosuspension and its characterization: An in vitro and in vivo evaluation. International Journal of Pharmaceutics 477:1-2, pages 251-260.
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