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Drug Delivery Volume 22, 2015 - Issue 5: Liposomes and other lipid-based drug delivery systems
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Original Article

Influence of phospholipid types and animal models on the accelerated blood clearance phenomenon of PEGylated liposomes upon repeated injection

Huan XuDepartment of Pharmacy, School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, PR China and Correspondence[email protected]
,
Feifei YeDepartment of Pharmacy, School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, PR China and
,
Meina HuDepartment of Pharmacy, School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, PR China and
,
Pengpeng YinDepartment of Pharmacy, School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, PR China and
,
Wei ZhangDepartment of Pharmacy, School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, PR China and
,
Yan LiDepartment of Pharmacy, School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, PR China and
,
Xiu YuDepartment of Pharmacy, School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, PR China and
&
Yihui DengSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, PR ChinaCorrespondence[email protected]
 show all
Pages 598-607 | Received 13 Dec 2013, Accepted 17 Jan 2014, Published online: 13 Feb 2014

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Marwa Mohamed, Amr S. Abu Lila, Taro Shimizu, Eman Alaaeldin, Amal Hussein, Hatem A. Sarhan, Janos Szebeni & Tatsuhiro Ishida. (2019) PEGylated liposomes: immunological responses. Science and Technology of Advanced Materials 20:1, pages 710-724.
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Yan Fang, Jianxiu Xue, Shan Gao, Anqi Lu, Dongjuan Yang, Hong Jiang, Yang He & Kai Shi. (2017) Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery. Drug Delivery 24:2, pages 22-32.
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Xiao Hu, Feifei Yang, Yonghong Liao, Lin Li & Lan Zhang. (2017) Cholesterol–PEG comodified poly (N-butyl) cyanoacrylate nanoparticles for brain delivery: in vitro and in vivo evaluations. Drug Delivery 24:1, pages 121-132.
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Christopher N. Subasic, Neville J. Butcher, Rodney F. Minchin & Lisa M. Kaminskas. (2023) Dose-Dependent Production of Anti-PEG IgM after Intramuscular PEGylated-Hydrogenated Soy Phosphatidylcholine Liposomes, but Not Lipid Nanoparticle Formulations of DNA, Correlates with the Plasma Clearance of PEGylated Liposomal Doxorubicin in Rats. Molecular Pharmaceutics 20:7, pages 3494-3504.
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Ahmed M. Abu-Dief, Mosa Alsehli & Aziz Awaad. (2022) A higher dose of PEGylated gold nanoparticles reduces the accelerated blood clearance phenomenon effect and induces spleen B lymphocytes in albino mice. Histochemistry and Cell Biology 157:6, pages 641-656.
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Liwang Shi, Jinqiu Zhang, Man Zhao, Shukun Tang, Xu Cheng, Wenyuan Zhang, Wenhua Li, Xiaoying Liu, Haisheng Peng & Qun Wang. (2021) Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery. Nanoscale 13:24, pages 10748-10764.
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Ruyi Wang, Zhongtao Zhang, Bowen Liu, Jingwei Xue, Fulei Liu, Tongzhong Tang, Wenyuan Liu, Feng Feng & Wei Qu. (2021) Strategies for the design of nanoparticles: starting with long-circulating nanoparticles, from lab to clinic. Biomaterials Science 9:10, pages 3621-3637.
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Saeed A. AlQahtani, Gamaleldin I. Harisa, Abdullah H. Alomrani, Fars K. Alanazi & Mohamed M. Badran. (2021) Improved pharmacokinetic and biodistribution of 5-fluorouracil loaded biomimetic nanoerythrocytes decorated nanocarriers for liver cancer treatment. Colloids and Surfaces B: Biointerfaces 197, pages 111380.
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Fengling Wang, Huihui Wang, Yifan Wu, Lei Wang, Ling Zhang, Xi Ye, Daiyin Peng & Weidong Chen. (2019) Activation of Pregnane X Receptor–Cytochrome P450s Axis: A Possible Reason for the Enhanced Accelerated Blood Clearance Phenomenon of PEGylated Liposomes In Vivo. Drug Metabolism and Disposition 47:8, pages 785-793.
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Fengling Wang, Yifan Wu, Jiwen Zhang, Huihui Wang, Xiaoting Xie, Xi Ye, Daiyin Peng & Weidong Chen. (2019) Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo. Drug Metabolism and Disposition 47:4, pages 364-376.
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Hidenori Ando, Amr S. Abu Lila, Munehira Kawanishi, Taro Shimizu, Keiichiro Okuhira, Yu Ishima & Tatsuhiro Ishida. (2018) Reactivity of IgM antibodies elicited by PEGylated liposomes or PEGylated lipoplexes against auto and foreign antigens. Journal of Controlled Release 270, pages 114-119.
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Quan Zhang, Caifeng Deng, Yao Fu, Xun Sun, Tao Gong & Zhirong Zhang. (2016) Repeated Administration of Hyaluronic Acid Coated Liposomes with Improved Pharmacokinetics and Reduced Immune Response. Molecular Pharmaceutics 13:6, pages 1800-1808.
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Qi Yang & Samuel K. Lai. (2015) Anti-PEG immunity: emergence, characteristics, and unaddressed questions. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 7:5, pages 655-677.
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