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Drug Delivery Volume 23, 2016 - Issue 7
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Original Article

Novel flurbiprofen derivatives with improved brain delivery: synthesis, in vitro and in vivo evaluations

Dan ZhengKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, People’s Republic of China and
,
Xiao ShuaiWest China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China
,
Yanping LiKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, People’s Republic of China and
,
Peng ZhouKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, People’s Republic of China and
,
Tao GongKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, People’s Republic of China and
,
Xun SunKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, People’s Republic of China and
&
Zhirong ZhangKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, People’s Republic of China and Correspondence[email protected]
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Pages 2183-2192 | Received 15 Jun 2014, Accepted 09 Aug 2014, Published online: 03 Sep 2014

Citations (9)

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Qiming Yue, Yao Peng, Yi Zhao, Runxin Lu, Qiuyi Fu, Yang Chen, Yang Yang, Li Hai, Li Guo & Yong Wu. (2018) Dual-targeting for brain-specific drug delivery: synthesis and biological evaluation. Drug Delivery 25:1, pages 426-434.
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Articles from other publishers (8)

Aftab Alam, Mumtaz Ali, Najeeb Ur Rehman, Abdul Latif, Abdul Jabbar Shah, Nadeem Ullah Wazir, Muhammad Arif Lodhi, Masroor Kamal, Muhammad Ayaz, Ahmed Al-Harrasi & Manzoor Ahmad. (2023) Synthesis and characterization of biologically active flurbiprofen amide derivatives as selective prostaglandin-endoperoxide synthase II inhibitors: In vivo anti-inflammatory activity and molecular docking. International Journal of Biological Macromolecules 228, pages 659-670.
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Yuxuan Dai, Chenyi Lei, Zhenhao Zhang, Yan Qi, Kejing Lao & Xingchun Gou. (2022) Amyloid-beta Targeted Therapeutic Approaches for Alzheimer’s Disease: Long Road Ahead. Current Drug Targets 23:11, pages 1040-1056.
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Asfree Gwanyanya, Christie Nicole Godsmark & Roisin Kelly-Laubscher. (2022) Ethanolamine: A Potential Promoiety with Additional Effects on the Brain. CNS & Neurological Disorders - Drug Targets 21:2, pages 108-117.
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Honglin Xiang, Qiang Zhang, Yikun Han, Lan Yang, Yan Zhang, Qiang Liu, Zhirong Zhang & Ling Zhang. (2021) Novel brain-targeting 3-n-butylphthalide prodrugs for ischemic stroke treatment. Journal of Controlled Release 335, pages 498-514.
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Brandon D. Eden, Andrew J. Rice, Troy D. Lovett, Olivia M. Toner, Evan P. Geissler, William E. Bowman & Sherri C. Young. (2019) Microwave-assisted synthesis and in vitro stability of N-benzylamide non-steroidal anti-inflammatory drug conjugates for CNS delivery. Bioorganic & Medicinal Chemistry Letters 29:12, pages 1487-1491.
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Astrid Bergmann, Thomas Schilling, Göran Hedenstierna, Kerstin Ahlgren, Anders Larsson, Moritz Kretzschmar, Alf Kozian & Thomas Hachenberg. (2019) Pulmonary effects of remote ischemic preconditioning in a porcine model of ventilation-induced lung injury. Respiratory Physiology & Neurobiology 259, pages 111-118.
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Goutam Biswas, Wanil Kim, Kyong-Tai Kim, Junhwi Cho, Dongjun Jeong, Keon-Hyoung Song & Jungkyun Im. (2017) Synthesis of Ibuprofen Conjugated Molecular Transporter Capable of Enhanced Brain Penetration. Journal of Chemistry 2017, pages 1-10.
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Yanping Li, Yangyang Zhou, Jiayu Jiang, Xinyi Wang, Yao Fu, Tao Gong, Xun Sun & Zhirong Zhang. (2015) Mechanism of Brain Targeting by Dexibuprofen Prodrugs Modified with Ethanolamine-Related Structures. Journal of Cerebral Blood Flow & Metabolism 35:12, pages 1985-1994.
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