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Drug Delivery Volume 23, 2016 - Issue 8
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Research Article

In vitro cytotoxicity and in vivo efficacy of 5-fluorouracil-loaded enteric-coated PEG-cross-linked chitosan microspheres in colorectal cancer therapy in rats

Kuntal GangulyDepartment of Pharmacology, Soniya Education Trust’s College of Pharmacy, Dharwad, Karnataka, India and
,
Anandrao R. KulkarniDepartment of Pharmacology, Soniya Education Trust’s College of Pharmacy, Dharwad, Karnataka, India and
&
Tejraj M. AminabhaviDepartment of Pharmacology, Soniya Education Trust’s College of Pharmacy, Dharwad, Karnataka, India and ;Department of Pharmaceutics, All India Council for Technical Education, New Delhi, IndiaCorrespondence[email protected] [email protected]
Pages 2838-2851 | Received 22 Aug 2015, Accepted 05 Oct 2015, Published online: 04 Nov 2015

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Yuanbiao An, Rui Zhai, Jinni Chen & Peng Xie. (2023) Preparation and application of a novel pH-responsive linalool carboxymethyl chitosan hydrogel. Journal of Macromolecular Science, Part A 60:5, pages 336-345.
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Prabha Singh, Pramita Waghambare, Tabassum Asif Khan & Abdelwahab Omri. (2022) Colorectal cancer management: strategies in drug delivery. Expert Opinion on Drug Delivery 19:6, pages 653-670.
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Nastaran Hashemzadeh, Ayuob Aghanejad, Elaheh Dalir Abdolahinia, Mitra Dolatkhah, Mohammad Barzegar-Jalali, Yadollah Omidi, Jaleh Barar & Khosro Adibkia. (2021) Targeted combined therapy in 2D and 3D cultured MCF-7 cells using metformin and erlotinib-loaded mesoporous silica magnetic nanoparticles. Journal of Microencapsulation 38:7-8, pages 472-485.
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Articles from other publishers (12)

Dongwei Wang, Yingang Zhang, Menglan Wang, Shasha Luo, Lewei Li, Yibo Yang, Qiufang Zhang, Xiaojun Tao & Chunlian He. (2023) Anti-Colon Cancer Effect of Folic Acid-Modified Chitosan-Loaded 5-Fluorouracil Nanoparticles. Journal of Biomedical Nanotechnology 19:3, pages 364-375.
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T. Arokia Femina, V. Barghavi, K. Archana, N.G. Swethaa & Ravi Maddaly. (2023) Non-uniformity in in vitro drug-induced cytotoxicity as evidenced by differences in IC50 values – implications and way forward. Journal of Pharmacological and Toxicological Methods 119, pages 107238.
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Ankita Tiwari, Virendra Gajbhiye, Ankit Jain, Amit Verma, Aazam Shaikh, Rajesh Salve & Sanjay K. Jain. (2022) Hyaluronic acid functionalized liposomes embedded in biodegradable beads for duo drugs delivery to oxaliplatin-resistant colon cancer. Journal of Drug Delivery Science and Technology 77, pages 103891.
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Ahana Hazra, Dwipanjan Sanyal, Arnab De, Sohini Chatterjee, Krishnananda Chattopadhyay & Amalesh Samanta. (2022) Development and in vitro characterization of capecitabine loaded biopolymeric vehicle for the treatment of colon cancer. Journal of Applied Polymer Science 139:26.
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Mohamed Adel Sayed, Hayam M. El-Zeiny, Jong Seong Khim, Jamaan S. Ajarem, Ahmed A. Allam & Mostafa R. Abukhadra. (2022) Insight into the Loading Properties of Na + Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity . ACS Omega 7:8, pages 6991-7001.
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Ali Mashhadian, Homa Afjoul & Amir Shamloo. (2022) An integrative method to increase the reliability of conventional double emulsion method. Analytica Chimica Acta 1197, pages 339523.
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Bharath S Padya, Aswathi R Hegde, Sadhana P Mutalik, Swati Biswas & Srinivas Mutalik. (2022) Analytical and bioanalytical HPLC method for simultaneous estimation of 5-fluorouracil and sonidegib. Bioanalysis 14:1, pages 29-45.
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Kripi Vohra, Meenu Mehta, Vandana Garg, Kamal Dua & Harish Dureja. (2021) Formulation, Characterisation and In vitro Cytotoxic Effect of Lens culinaris Medikus Seeds Extract Loaded Chitosan Microspheres. Current Molecular Pharmacology 14:3, pages 448-457.
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Katarzyna Wegrzynowska-Drzymalska, Patrycja Grebicka, Dariusz T. Mlynarczyk, Dorota Chelminiak-Dudkiewicz, Halina Kaczmarek, Tomasz Goslinski & Marta Ziegler-Borowska. (2020) Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications. Materials 13:15, pages 3413.
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Cheng-Yun Zhu, Jin-Yue Wang, Jin Huang, Guo-Hua Han, Yan-Yan Ji, Xiang-Rong Zhang & Dong Liang. (2019) Preparation and evaluation of gastro-floating hollow adhesive microspheres of carbomer/ethyl cellulose encapsulating dipyridamole. New Journal of Chemistry 43:15, pages 5897-5903.
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Nafisah Musa & Tin Wui Wong. 2019. Functional Chitosan. Functional Chitosan 135 161 .
Müşerref Günseli Yüksel Tilkan & Nurten Özdemir. (2018) Investigation of the parameters affecting the release of flurbiprofen from chitosan microspheres. Brazilian Journal of Pharmaceutical Sciences 53:4.
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