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Research Article

A comprehensive study of novel microcapsules incorporating gliclazide and a permeation enhancing bile acid: hypoglycemic effect in an animal model of Type-1 diabetes

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Pages 2869-2880 | Received 05 Oct 2015, Accepted 18 Oct 2015, Published online: 26 Nov 2015

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Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Corina Mihaela Ionescu, Umar Shah, Goran Stojanovic, Sanja Kojic, Armin Mooranian & Hani Al-Salami. (2020) Alginate-based drug oral targeting using bio-micro/nano encapsulation technologies. Expert Opinion on Drug Delivery 17:10, pages 1361-1376.
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Articles from other publishers (27)

Susbin R Wagle, Corina M Ionescu, Bozica Kovacevic, Melissa Jones, Thomas Foster, Patrick Lim, Michael Lewkowicz, Maja Ðanić, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2023) Pharmaceutical characterization of probucol bile acid–lithocholic acid nanoparticles to prevent chronic hearing related and similar cellular oxidative stress pathologies. Nanomedicine 18:12, pages 923-940.
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Wee Ling Koh, Thomas Foster, Armin Mooranian & Hani Al-Salami. (2022) Applications of bile acids as biomaterials-based modulators, in biomedical science and microfluidics. Therapeutic Delivery 13:12, pages 591-604.
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Maisarah Azman, Akmal H. Sabri, Qonita Kurnia Anjani, Mohd Faiz Mustaffa & Khuriah Abdul Hamid. (2022) Intestinal Absorption Study: Challenges and Absorption Enhancement Strategies in Improving Oral Drug Delivery. Pharmaceuticals 15:8, pages 975.
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Armin Mooranian, Corina Mihaela Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Jafri Kuthubutheen, Daniel Brown, Marcus D. Atlas, Momir Mikov & Hani Al-Salami. (2022) Single-Cellular Biological Effects of Cholesterol-Catabolic Bile Acid-Based Nano/Micro Capsules as Anti-Inflammatory Cell Protective Systems. Biomolecules 12:1, pages 73.
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Armin Mooranian, Louise Carey, Corina Mihaela Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Thomas Foster, Jacqueline Chester, Edan Johnston, Momir Mikov & Hani Al-Salami. (2021) The Effects of Accelerated Temperature-Controlled Stability Systems on the Release Profile of Primary Bile Acid-Based Delivery Microcapsules. Pharmaceutics 13:10, pages 1667.
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Thomas Foster, Corina Ionescu, Daniel Walker, Melissa Jones, Susbin Wagle, Božica Kovacevic, Daniel Brown, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2021) Chemotherapy-induced hearing loss: the applications of bio-nanotechnologies and bile acid-based delivery matrices. Therapeutic Delivery 12:10, pages 723-737.
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Armin Mooranian, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Melissa Jones, Jacqueline Chester, Thomas Foster, Edan Johnston, Momir Mikov, Marcus D. Atlas & Hani Al-Salami. (2021) Probucol Pharmacological and Bio-Nanotechnological Effects on Surgically Transplanted Graft Due to Powerful Anti-Inflammatory, Anti-Fibrotic and Potential Bile Acid Modulatory Actions. Pharmaceutics 13:8, pages 1304.
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Armin Mooranian, Melissa Jones, Corina Mihaela Ionescu, Daniel Walker, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Momir Mikov & Hani Al-Salami. (2021) Advancements in Assessments of Bio-Tissue Engineering and Viable Cell Delivery Matrices Using Bile Acid-Based Pharmacological Biotechnologies. Nanomaterials 11:7, pages 1861.
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Xintong Zhang, Ying Han, Wei Huang, Mingji Jin & Zhonggao Gao. (2021) The influence of the gut microbiota on the bioavailability of oral drugs. Acta Pharmaceutica Sinica B 11:7, pages 1789-1812.
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Kuan-Fu Chen, Lingtak-Neander Chan & Yvonne S. Lin. (2020) PBPK modeling of CYP3A and P-gp substrates to predict drug–drug interactions in patients undergoing Roux-en-Y gastric bypass surgery. Journal of Pharmacokinetics and Pharmacodynamics 47:5, pages 493-512.
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Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Corina Mihaela Ionescu, Melissa Jones, Goran Stojanovic, Sanja Kojic, Armin Mooranian & Hani Al-Salami. (2020) Pharmacological and Advanced Cell Respiration Effects, Enhanced by Toxic Human-Bile Nano-Pharmaceuticals of Probucol Cell-Targeting Formulations. Pharmaceutics 12:8, pages 708.
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Susbin Raj Wagle, Daniel Walker, Bozica Kovacevic, Ahmed Gedawy, Momir Mikov, Svetlana Golocorbin-Kon, Armin Mooranian & Hani Al-Salami. (2020) Micro-Nano formulation of bile-gut delivery: rheological, stability and cell survival, basal and maximum respiration studies. Scientific Reports 10:1.
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Armin Mooranian, Nassim Zamani, Corina M. Ionescu, Ryu Takechi, Giuseppe Luna, Momir Mikov, Svetlana Goločorbin-Kon, Božica Kovačević & Hani Al-Salami. (2020) Oral gavage of nano-encapsulated conjugated acrylic acid-bile acid formulation in type 1 diabetes altered pharmacological profile of bile acids, and improved glycaemia and suppressed inflammation. Pharmacological Reports 72:2, pages 368-378.
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Sangeetha Mathavan, Corina M Ionescu, Bozica Kovacevic, Momir Mikov, Svetlana Golocorbin-Kon, Armin Mooranian, Crispin R Dass & Hani Al-Salami. (2020) Histological effects of pharmacologically active human bile acid nano/micro-particles in Type-1 diabetes. Therapeutic Delivery 11:3, pages 157-171.
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Armin Mooranian, Susbin Raj Wagle, Bozica Kovacevic, Ryu Takechi, John Mamo, Virginie Lam, Gerald F. Watts, Momir Mikov, Svetlana Golocorbin-Kon, Goran Stojanovic, Hesham Al-Sallami & Hani Al-Salami. (2020) Bile acid bio-nanoencapsulation improved drug targeted-delivery and pharmacological effects via cellular flux: 6-months diabetes preclinical study. Scientific Reports 10:1.
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Jelena Jović, Boris Milijašević, Saša Vukmirović, Velibor Vasović, Momir Mikov, Armin Mooranian, Hani Al-Salami & Svetlana Golocorbin-Kon. (2020) Pharmacokinetic and drug absorption profiles of the anti-hyperglycaemic agent gliclazide in oral tissue-targeted microcapsules in rats. Scripta Medica 51:1, pages 15-20.
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Sangeetha Mathavan, Corina M Ionescu, Bozica Kovacevic, Momir Mikov, Svetlana Golocorbin-Kon, Armin Mooranian, Crispin R Dass & Hani Al-Salami. (2019) Formulation buoyancy of nanoencapsulated gliclazide using primary, conjugated and deconjugated bile acids. Therapeutic Delivery 10:9, pages 573-583.
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Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso & Hani Al-Salami. (2019) Stability and biological testing of taurine-conjugated bile acid antioxidant microcapsules for diabetes treatment. Therapeutic Delivery 10:2, pages 99-106.
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Chang Liu, Yongqiang Kou, Xin Zhang, Wei Dong, Hongbo Cheng & Shirui Mao. (2019) Enhanced oral insulin delivery via surface hydrophilic modification of chitosan copolymer based self-assembly polyelectrolyte nanocomplex. International Journal of Pharmaceutics 554, pages 36-47.
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Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso & Hani Al-Salami. (2018) Eudragit ® -based microcapsules of probucol with a gut-bacterial processed secondary bile acid . Therapeutic Delivery 9:11, pages 811-821.
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Sangeetha Mathavan, Nigel Chen-Tan, Frank Arfuso & Hani Al-Salami. (2018) Morphological, Stability, and Hypoglycemic Effects of New Gliclazide-Bile Acid Microcapsules for Type 1 Diabetes Treatment: the Microencapsulation of Anti-diabetics Using a Microcapsule-Stabilizing Bile Acid. AAPS PharmSciTech 19:7, pages 3009-3018.
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Momir Mikov, Maja Đanić, Nebojša Pavlović, Bojan Stanimirov, Svetlana Goločorbin-Kon, Karmen Stankov & Hani Al-Salami. (2017) Potential Applications of Gliclazide in Treating Type 1 Diabetes Mellitus: Formulation with Bile Acids and Probiotics. European Journal of Drug Metabolism and Pharmacokinetics 43:3, pages 269-280.
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Armin Mooranian, Rebecca Negrulj, Ryu Takechi, Emma Jamieson, Grant Morahan & Hani Al-Salami. (2017) Influence of Biotechnological Processes, Speed of Formulation Flow and Cellular Concurrent Stream-Integration on Insulin Production from β-cells as a Result of Co-Encapsulation with a Highly Lipophilic Bile Acid. Cellular and Molecular Bioengineering 11:1, pages 65-75.
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Senthil Arun Kumar & Lindsay Brown. 2018. Alginates and Their Biomedical Applications. Alginates and Their Biomedical Applications 223 235 .
Poulami Sarkar, Priyanka Basak, Sumit Ghosh, Mousumi Kundu & Parames C. Sil. (2017) Prophylactic role of taurine and its derivatives against diabetes mellitus and its related complications. Food and Chemical Toxicology 110, pages 109-121.
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Svetlana Golocorbin-Kon, Jelena Calasan, Boris Milijasevic, Sasa Vukmirovic, Mladena Lalic-Popovic, Momir Mikov & Hani Al-Salami. (2017) High-Loading Dose of Microencapsulated Gliclazide Formulation Exerted a Hypoglycaemic Effect on Type 1 Diabetic Rats and Incorporation of a Primary Deconjugated Bile Acid, Diminished the Hypoglycaemic Antidiabetic Effect. European Journal of Drug Metabolism and Pharmacokinetics 42:6, pages 1005-1011.
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Sangeetha Mathavan, Momir Mikov, Svetlana Golocorbin-Kon & Hani Al-Salami. (2017) Diabetes development increased concentrations of the conjugated bile acid, taurocholic acid in serum, while treatment with microencapsulated-taurocholic acid exerted no hypoglycaemic effects. European Journal of Pharmaceutical Sciences 106, pages 1-9.
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