Advanced search
Publication Cover
Biomaterials, Medical Devices, and Artificial Organs Volume 1, 1973 - Issue 3
Journal homepage
83
Views
45
CrossRef citations to date
0
Altmetric
Original Article

Human Cell Culture Toxicity Testing of Medical Devices and Correlation to Animal Tests

R. E. Wilsnack Huntingdon Research Center Division of Becton Dickinson, Baltimore, Maryland, 21204
,
F. J. Meyer Extracorporeal Medical Specialties, King of Prussia, Pennsylvania, 19406
&
J. G. Smith Huntingdon Research Center Division of Becton Dickinson, Baltimore, Maryland, 21204
Pages 543-562 | Received 05 Mar 1973, Published online: 11 Jul 2009

Citations (45)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Edward M. Jackson. (1994) The Way we were: Beyond Monolayers. Journal of Toxicology: Cutaneous and Ocular Toxicology 13:4, pages 329-331.
Read now
RichardM. Engeman & StephenA. Shumake. (1993) Animal Welfare and the Statistical Consultant. The American Statistician 47:3, pages 229-233.
Read now
F. Wallin Richard, R. Douglas Hume & M. Jackson Edward. (1987) The agarose diffusion method for ocular irritancy screening: cosmetic products, part i. Journal of Toxicology: Cutaneous and Ocular Toxicology 6:4, pages 239-250.
Read now
R. E. Wilsnack. (1976) Quantitative Cell Culture Biocompatibility Testing of Medical Devices and Correlation to Animal Tests. Biomaterials, Medical Devices, and Artificial Organs 4:3-4, pages 235-261.
Read now

Articles from other publishers (41)

Shayne C. GadShayne C. Gad. 2019. Integrated Safety and Risk Assessment for Medical Devices and Combination Products. Integrated Safety and Risk Assessment for Medical Devices and Combination Products 57 238 .
Elmar Willbold, Andreas Weizbauer, Anneke Loos, Jan-Marten Seitz, Nina Angrisani, Henning Windhagen & Janin Reifenrath. (2017) Magnesium alloys: A stony pathway from intensive research to clinical reality. Different test methods and approval-related considerations. Journal of Biomedical Materials Research Part A 105:1, pages 329-347.
Crossref
A. Neumann, C. Unkel, C. Werry, C. U. Herborn, H. R. Maier, C. Ragoß & K. Jahnke. (2006) Osteosynthese im GesichtsschädelbereichOsteosynthesis in facial bones. HNO 54:12, pages 937-942.
Crossref
Andreas Neumann, Claus Unkel, Christoph Werry, Christoh U. Herborn, Horst R. Maier, Christian Ragoß & Klaus Jahnke. (2016) Prototype of a Silicon Nitride Ceramic‐Based Miniplate Osteofixation System for the Midface. Otolaryngology–Head and Neck Surgery 134:6, pages 923-930.
Crossref
A. Neumann, M. Kramps, Chr. Ragoß, H.R. Maier & K. Jahnke. (2004) Histological and microradiographic appearances of Silicon Nitride and Aluminum Oxide in a rabbit femur implantation model*. Materialwissenschaft und Werkstofftechnik 35:9, pages 569-573.
Crossref
C. Viennet, J. Bride, A.C. Gabiot & P. Humbert. (2003) Comparison of different wound dressings on cultured human fibroblasts and collagen lattices. Journal of Wound Care 12:10, pages 385-390.
Crossref
Per Kjellstrand, Eva Lindqvist & Carin Nilsson-Thorell. (2000) Toxicity Testing of Polymer Materials for Dialysis Equipment: Reconsidering In Vivo Testing . Alternatives to Laboratory Animals 28:3, pages 495-502.
Crossref
Axel WilkeMaximilian LandgraffJoachim OrthHolger PoenitzHeino KienapfelKerstin BoeltePeter GrissRolf P. Franke. (2019) Human Bone Marrow Cell Culture: A Sensitive Method for Determination of the Biocompatibility of Implant Materials. Alternatives to Laboratory Animals 27:1, pages 137-151.
Crossref
A. Wilke, J. Orth, M. Lomb, R. Fuhrmann, H. Kienapfel, P. Griss & R. P. Franke. (1998) Biocompatibility analysis of different biomaterials in human bone marrow cell cultures. Journal of Biomedical Materials Research 40:2, pages 301-306.
Crossref
G.L. Polyzois. (1994) In vitro evaluation of dental materials. Clinical Materials 16:1, pages 21-60.
Crossref
J. D. Bumgardner & L. C. Lucas. (1994) Corrosion and cell culture evaluations of nickel-chromium dental casting alloys. Journal of Applied Biomaterials 5:3, pages 203-213.
Crossref
Martine Cottin, Alain Zanvit, Brigitte Faquet, André Rougier & Koovi G. Dossou. (2020) Critical Evaluation of an Agarose Diffusion Method for the Assessment of Eye Irritancy. Alternatives to Laboratory Animals 21:4, pages 427-440.
Crossref
Sharon J. Northup. (1993) Chapter 12 Cytotoxicity, mutagenicity, and immunotoxicity. Cardiovascular Pathology 2:3, pages 129-136.
Crossref
G.R. Bruce, N.J. McDonald & R.J. Sydiskis. (1993) Cytotoxicity of retrofill materials. Journal of Endodontics 19:6, pages 288-292.
Crossref
Helen Kazemi‐Shirazi, Heinrich Gruber & Gerd Greber. (2003) New silicone rubbers, 2. Biocompatible silicone rubbers. Die Angewandte Makromolekulare Chemie 205:1, pages 193-201.
Crossref
Val L. Kudryk, Michael J. Scheidt, Michael J. McQuade, Donald E. Sutherland, Thomas E. Vandyke & Jeffery O. Hollinger. (2004) Toxic effect of ethylene‐oxide‐sterilized freeze‐dried bone allograft on human gingival fibroblasts. Journal of Biomedical Materials Research 26:11, pages 1477-1488.
Crossref
P. Kjellstrand & U. Boberg. (1991) Toxicity testing of polymer materials for use in haemodialysis. Toxicology in Vitro 5:5-6, pages 443-448.
Crossref
D. ARENHOLT‐BINDSLEV & H. BLEEG. (2007) Characterization of two types of human oral fibroblast with a potential application to cellular toxicity studies: tooth pulp fibroblasts and buccal mucosa fibroblasts. International Endodontic Journal 23:2, pages 84-91.
Crossref
Dorthe Arenholt‐Bindslev & Preben Hörsted‐Bindslev. (2006) A simple model for evaluating relative toxicity of root filling materials in cultures of human oral fibroblasts. Dental Traumatology 5:5, pages 219-226.
Crossref
P. Blais. (2004) Vinyl in medicine—a special case. Journal of Vinyl Technology 11:2, pages 71-80.
Crossref
A.K. Jowett, M.W.J. Ferguson & E.C. Combe. (1988) In vitro biocompatibility testing: A new organ culture model. Journal of Dentistry 16:2, pages 55-65.
Crossref
A. HENSTEN-PETTERSEN. (2007) Comparison of the methods available for assessing cytotoxicity. International Endodontic Journal 21:2, pages 89-99.
Crossref
G. SCHMALZ. (2007) Agar overlay method. International Endodontic Journal 21:2, pages 59-66.
Crossref
S. A. Burton, R. V. Petersen, S. N. Dickman & J. R. Nelson. (1986) Comparison ofin vitro bacterial bioluminescence and tissue culture bioassays andin vivo tests for evaluating acute toxicity of biomaterials. Journal of Biomedical Materials Research 20:6, pages 827-838.
Crossref
L. Niemi & A. Hensten‐Pettersen. (2004) In vitro cytotoxicity of Ag‐Pd‐Cu‐based casting alloys . Journal of Biomedical Materials Research 19:5, pages 549-561.
Crossref
Alf Wennberg. (2020) Cell Culture in the Biological Evaluation of Dental Materials: A Review. Alternatives to Laboratory Animals 13:3, pages 194-202.
Crossref
H. J. Johnson, S. J. Northup, P. A. Seagraves, P. J. Garvin & R. F. Wallin. (2004) Biocompatibility test procedures for materials evaluation in vitro . I. Comparative test system sensitivity . Journal of Biomedical Materials Research 17:4, pages 571-586.
Crossref
GRAHAM ENGEL. (1983) Adverse events with catheters and toxicity testing. Medical Journal of Australia 1:10, pages 444-445.
Crossref
A. Wennberg, I. A. Mjör & A. Hensten‐Pettersen. (2004) Biological evaluation of dental restorative materials—a comparison of different test methods. Journal of Biomedical Materials Research 17:1, pages 23-36.
Crossref
Attar S. Chawla. (2004) Toxicity evaluation of a novel filler free silicone rubber biomaterial by cell culture techniques. Journal of Biomedical Materials Research 16:4, pages 501-508.
Crossref
Judith B. Ulreich & Milos Chvapil. (2004) A quantitative microassay for in‐vitro toxicity testing of biomaterials . Journal of Biomedical Materials Research 15:6, pages 913-922.
Crossref
C. R. Culliton, M. A. Meenaghan, S. E. Sorensen, G. W. Greene & J. D. Eick. (2004) A critical evaluation of the acute systemic toxicity test for dental alloys using histopathologic criteria. Journal of Biomedical Materials Research 15:4, pages 565-575.
Crossref
ARNE HENSTEN‐PETTERSEN & KRISTEN HELGELAN. (2007) Sensitivity of different human cell lines in the biologic evaluation of dental resin‐based restorative materials. European Journal of Oral Sciences 89:1, pages 102-107.
Crossref
Alf Wennberg. (1980) Biological evaluation of root canal sealers using in vitro and in vivo methods. Journal of Endodontics 6:10, pages 784-787.
Crossref
ALF WENNBERG. (2007) Biological evaluation of root canal antiseptics using in vitro and in vivo methods. European Journal of Oral Sciences 88:1, pages 46-52.
Crossref
M. V. GRIFFITHS. (1979) Biomaterials in reconstructive head and neck surgery. Clinical Otolaryngology 4:5, pages 363-376.
Crossref
A. Wennberg, G. Hasselgren & L. Tronstad. (2004) A method for toxicity screening of biomaterials using cells cultured on millipore filters. Journal of Biomedical Materials Research 13:1, pages 109-120.
Crossref
Robert M. Rice, Andrew F. Hegyeli, Stuart J. Gourlay, Clarence W. R. Wade, James G. Dillon, Howard Jaffe & R. K. Kulkarni. (2004) Biocompatibility testing of polymers: In vitro studies with in vivo correlation . Journal of Biomedical Materials Research 12:1, pages 43-54.
Crossref
RL Meltzer, YR Fiorini, RT Horstman, IC Moore, AL Batik, CWR Wade, AF Hegyeli & RK Kulkarni. (1977) Standards for In-Vitro and In-Vivo Comparison and Qualification of Bioabsorbable Polymers. Journal of Testing and Evaluation 5:5, pages 397.
Crossref
Oscar Sudilovsky. (1977) A tissue culture method for toxicity testing of biomaterials. Tissue Culture Association Manual 3:2, pages 607-612.
Crossref
T. N. Salthouse. (2004) Cellular enzyme activity at the polymer–tissue interface: A review. Journal of Biomedical Materials Research 10:2, pages 197-229.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.