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Original Article

Pyridoxylated Polyhemoglobin as a Red Cell Substitute for Resuscitation of Lethal Hemorrhagic Shock in Conscious Rats

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Pages 1-15 | Published online: 11 Jul 2009

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Wen-Hsiang Chang, Yen Chang, Yi-Chien Chen & Hsing-Wen Sung. (2004) Hemoglobin Polymerized with a Naturally Occurring Crosslinking Agent as a Blood Substitute: In Vitro and In Vivo Studies. Artificial Cells, Blood Substitutes, and Biotechnology 32:2, pages 243-262.
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N. Kochetygov, E. Selivanov, K. Gerbut, I. Bystrova, I. Molokovskaya, N. Kuznezova, L. Gudkin & R. Mishaeva. (1998) Study of Polymerized Hemoglobin in Experiment. Artificial Cells, Blood Substitutes, and Biotechnology 26:2, pages 173-180.
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J. C. Briceño, I. E. Rincón, J. F. Vélez, A. García, I. Castro, M. Arias, C. Velásquez, M. L. Anzola, M. Matallana, C. E. Isaza & M. I. Arcos. (1997) Description of a Project for the Production and Evaluation of Oxygen-Carrying Hemosubstitutes. Artificial Cells, Blood Substitutes, and Biotechnology 25:5, pages 473-479.
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T. M.S Chang & R. Varma. (1994) Assessment of Blood Substitutes: I. Efficacy Studies in Anesthetized and Conscious Rats with LOSS of 1/3, 1/2 and 2/3 Blood Volume. Artificial Cells, Blood Substitutes, and Biotechnology 22:2, pages 159-169.
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Scott A. Fowler, Mark Andracki, Gerald Hurst, Vidya A. Honkan, Joseph Waldorf & Dee Ann Casteel. (1994) Prolongation of the Intravascular Retention of Hemoglobin Modified with a Long-Chain Fatty Acid Derivative. Artificial Cells, Blood Substitutes, and Biotechnology 22:1, pages 27-42.
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Jing Ning, Peter J Anderson & George P Biro. (1992) Resuscitation of Bled Dogs with Fyridoxalated-Folymerized Hemoglobin Solution. Biomaterials, Artificial Cells and Immobilization Biotechnology 20:2-4, pages 525-530.
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Thomas M. S. Chang. (1992) Blood Substitutes Based on Modified Hemoglobin Prepared by Encapsulation or Crosslinking: an Overview. Biomaterials, Artificial Cells and Immobilization Biotechnology 20:2-4, pages 159-179.
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P. Menu, C. Geschier, P. Labrude & C. Vigneron. (1990) Haemoglobin Pyridoxalation in Phosphate Buffer: Comparison of Results with Those Obtained with Tris-Hcl Buffer. Biomaterials, Artificial Cells and Artificial Organs 18:2, pages 157-168.
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W. K. R. Barnikol & O. Burkhard. (1988) Huge Compact Soluble Molecules: A New Old Concept to Develop an Oxygen Carrying Blood Substitute. Biomaterials, Artificial Cells and Artificial Organs 16:1-3, pages 639-642.
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Thomas Ming Swi Chang & Rahul Varma. (1988) Immunological and Systemic Effects of Transfusions in Rats Using Pyridoxylated Hemoglobin and Polyhemoglobin from Homologous and Heterogenous Sources. Biomaterials, Artificial Cells and Artificial Organs 16:1-3, pages 205-215.
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P. E. Keipert & T. M.S. Chang. (1988) Pyridoxylated-Polyhemoglobin Solution: A Low Viscosity Oxygen-Delivering Blood Replacement Fluid with Normal Oncotic Pressure and Long-Term Storage Feasibility. Biomaterials, Artificial Cells and Artificial Organs 16:1-3, pages 185-196.
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Thomas Ming Swi Chang. (1988) Red Blood Cell Substitutes: Microencapsulated Hemoglobin and Cross-Linked Hemoglobin Including Pyridoxylated Polyhemoglobin & Conjugated Hemoglobin. Biomaterials, Artificial Cells and Artificial Organs 16:1-3, pages 11-29.
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Thomas Ming Swi Chang & Rahul Varma. (1987) Pyridoxalated Heterogenous and Homologous Polyhemoglobin and Hemoglobin: Systemic Effects of Replacement Transfusion in Rats Previously Received Immunizing Doses. Biomaterials, Artificial Cells and Artificial Organs 15:2, pages 443-451.
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Thomas Ming Swi Chang. (1987) Modified Hemoglobin as Red Blood Cell Substitutes. Biomaterials, Artificial Cells and Artificial Organs 15:2, pages 323-328.
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T. M.S. Chang. (1987) Applications of Artificial Cells in Medicine and Biotechnology. Biomaterials, Artificial Cells and Artificial Organs 15:1, pages 1-20.
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Articles from other publishers (16)

Thomas Ming Swi Chang. 2022. Blood Substitutes and Oxygen Biotherapeutics. Blood Substitutes and Oxygen Biotherapeutics 199 206 .
Thomas Ming Swi Chang. 2013. Biomaterials Science. Biomaterials Science 811 827 .
Yi‐Chien Chen, Wen‐Hsiang Chang, Yen Chang, Chun‐Ming Huang & Hsing‐Wen Sung. (2004) A natural compound (reuterin) produced by Lactobacillus reuteri for hemoglobin polymerization as a blood substitute . Biotechnology and Bioengineering 87:1, pages 34-42.
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Jean G. Riess. (2001) Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some Physiology Blut ist ein ganz besondrer Saft . Chemical Reviews 101:9, pages 2797-2920.
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Thomas Ming Swi Chang. (2000) Red blood cell substitutes. Best Practice & Research Clinical Haematology 13:4, pages 651-667.
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T.M.S. Chang. 1998. Biotechnolgy Annual Review. Biotechnolgy Annual Review 75 112 .
Suzanne K. Swan, Charles E. Halstenson, Allan J. Collins, Wayne A. Colbum, John Blue & Robert J. Przybelski. (1995) Pharmacologic profile of diaspirin cross-linked hemoglobin in hemodialysis patients. American Journal of Kidney Diseases 26:6, pages 918-923.
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Alan S. Rudolph, Richard O. Cliff, Barry J. Spargo & Helmut Spielberg. (1994) Transient changes in the mononuclear phagocyte system following administration of the blood substitute liposome-encapsulated haemoglobin. Biomaterials 15:10, pages 796-804.
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Steven R. Snyder & Joseph A. Walder. 1991. Biotechnology of Blood. Biotechnology of Blood 101 116 .
Thomas M.S. Chang. (1989) The Use of Modified Hemoglobin as an Oxygen Carrying Blood Substitute. Transfusion Medicine Reviews 3:3, pages 213-218.
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THOMAS MING SWI CHANG. (1988) Medical Applications of Artificial Cells in Transfusion, Phenylketonuria, Essential Amino Acid Production, and Liver Support. Annals of the New York Academy of Sciences 542:1 Enzyme Engine, pages 507-514.
Crossref
P. Labrude, P. Mouelle, P. Menu, C. Vigneron, E. Dellacherie, M. Leonard & J.L. Tayots. (2018) Hemoglobin Solutions Coupled with Polyethylene Glycol 1900: Preparation, Purification, Quality Control and Pharmacological Trials by Hemorrhagic Shock. The International Journal of Artificial Organs 11:5, pages 393-402.
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T.M.S. Chang. 1988. Immobilized Enzymes and Cells Part D. Immobilized Enzymes and Cells Part D 444 457 .
T. M. S. Chang. 1988. Biotechnological Applications of Lipid Microstructures. Biotechnological Applications of Lipid Microstructures 215 223 .
P. E. Keipert & T. M. S. Chang. (1987) Effects of Partial and Total Isovolemic Exchange Transfusion in Fully Conscious Rats Using Pyridoxylated Polyhemoglobin Solution as a Colloidal Oxygen-Delivering Blood Replacement Fluid. Vox Sanguinis 53:1, pages 7-14.
Crossref
Witold J. Rudowski. (1987) Blood transfusion: Yesterday, today, and tomorrow. World Journal of Surgery 11:1, pages 86-93.
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