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Biomaterials, Artificial Cells and Artificial Organs Volume 16, 1988 - Issue 1-3
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Original Article

In Vivo Evaluation of a Pyridoxalated-Hemoglobin-Polyoxyethylene Conjugate

M. Matsushita Department of Artificial Organs, The Cleveland Clinic Foundation Cleveland, Ohio, 44106, USA
,
A. Yabuki Department of Artificial Organs, The Cleveland Clinic Foundation Cleveland, Ohio, 44106, USA
,
P. S. Malchesky Department of Artificial Organs, The Cleveland Clinic Foundation Cleveland, Ohio, 44106, USA
,
H. Harasaki Department of Artificial Organs, The Cleveland Clinic Foundation Cleveland, Ohio, 44106, USA
&
Y Nosé Department of Artificial Organs, The Cleveland Clinic Foundation Cleveland, Ohio, 44106, USA
Pages 247-260 | Published online: 11 Jul 2009

Citations (28)

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Read on this site (2)

Richard M. Millis, Joan D. Barber, Winston A. Anderson & Ozra Dehkordi. (1995) Effects of a Stroma-Free Hemoglobin and Perfluorochemical Combination on Ultrastructure and Function of the Isolated Rat Kidney. Renal Failure 17:6, pages 675-687.
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Thomas M. S. Chang. (1992) Blood Substitutes Based on Modified Hemoglobin Prepared by Encapsulation or Crosslinking: an Overview. Biomaterials, Artificial Cells and Immobilization Biotechnology 20:2-4, pages 159-179.
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Articles from other publishers (26)

Christopher Priavalle & Joe De Angelo. 2022. Blood Substitutes and Oxygen Biotherapeutics. Blood Substitutes and Oxygen Biotherapeutics 375 382 .
Jonathan Ball. (2015) Sadly, Pyridoxalated Hemoglobin Polyoxyethylene Is More a Dodo Than a PHOENIX*. Critical Care Medicine 43:1, pages 235-236.
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Donald J. AbrahamStefano Bruno, Luca Ronda, Serena Faggiano, Stefano Bettati & Andrea Mozzarelli. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 609 660 .
Robert M. Winslow. 2006. Blood Substitutes. Blood Substitutes 341 353 .
Jacques Creteur & Jean-Louis Vincent. (2003) Hemoglobin solutions. Critical Care Medicine 31:Supplement, pages S698-S707.
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Robert M. Winslow. 2001. Kirk-Othmer Encyclopedia of Chemical Technology. Kirk-Othmer Encyclopedia of Chemical Technology.
Donald J. AbrahamBarbara Campanini, Stefano Bruno, Samanta Raboni & Andrea Mozzarelli. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 385 441 .
Ernest E Moore. (2003) Blood Substitutes: The Future is Now. Journal of the American College of Surgeons 196:1, pages 1-17.
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Audrey M. Chen & Mark D. Scott. (2001) Current and Future Applications of Immunological Attenuation via Pegylation of Cells and Tissue. BioDrugs 15:12, pages 833-847.
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Robert M. Winslow. 2001. Kirk-Othmer Encyclopedia of Chemical Technology. Kirk-Othmer Encyclopedia of Chemical Technology.
Jacques Creteur, William Sibbald & Jean-Louis Vincent. (2000) Hemoglobin solutions—Not just red blood cell substitutes. Critical Care Medicine 28:8, pages 3025-3034.
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Rameshraja Palaparthy, Huashan Wang & Anil Gulati. (2000) Current aspects in pharmacology of modified hemoglobins. Advanced Drug Delivery Reviews 40:3, pages 185-198.
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Mark D. Scott, Amanda J. Bradley & Kari L. Murad. (2000) Camouflaged blood cells: Low-technology bioengineering for transfusion medicine?. Transfusion Medicine Reviews 14:1, pages 53-63.
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T.M.S. Chang. 1998. Biotechnolgy Annual Review. Biotechnolgy Annual Review 75 112 .
Charles D. Conover, Carl W. Gilbert, Kwok L. Shurn & Robert G.L. Shorr. (2008) The Impact of Polyethylene Glycol Conjugation on Bovine Hemoglobin's Circulatory Half‐Life and Renal Effects in a Rabbit Top‐Loaded Transfusion Model. Artificial Organs 21:8, pages 907-915.
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Charles D. Conover, Laura Lejeune, Kwok Shum, Carl Gilbert & Robert G. L. Shorr. (2008) Physiological Effect of Polyethylene Glycol Conjugation on Stroma‐Free Bovine Hemoglobin in the Conscious Dog After Partial Exchange Transfusion. Artificial Organs 21:5, pages 369-378.
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Juraj Sprung, Colin F. Mackenzie, George M. Barnas, John E. Williams, Michael Parr, Robert H. Christenson, Brian H. Hoff, Ronald Sakamoto, Andrew Kramer & Mark Lottes. (1995) Oxygen transport and cardiovascular effects of resuscitation from severe hemorrhagic shock using hemoglobin solutions. Critical Care Medicine 23:9, pages 1540-1553.
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J. Pincemail, O. Detry, C. Philippart, J.O. Defraigne, C. Franssen, K. Burhop, C. Deby, M. Meurisse & M. Lamy. (1995) Diaspirin crosslinked hemoglobin (DCLHbTM): Absence of increased free radical generation following administration in a rabbit model of renal ischemia and reperfusion. Free Radical Biology and Medicine 19:1, pages 1-9.
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Hui Liu, Tetsuzo Agishi, Hideiku Suga, Yutaro Hayasaka, Satoshi Teraoka & Kazuo Ota. (2008) The Effect of Total Blood Exchange with PHP Solution on Cardiac Xenotransplantation. Artificial Organs 19:4, pages 324-327.
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G. Deby-Dupont, J. Pincemail & M. Lamy. 1994. Yearbook of Intensive Care and Emergency Medicine 1994. Yearbook of Intensive Care and Emergency Medicine 1994 264 275 .
Tsuyoshi Takahashi, Keiji Iwasaki, Paul S. Malchesky, Hiroaki Harasaki, Michiaki Matsushita, Yukihiko Nosé, Henry Rolin III & Phillip M. Hall. (2008) Renal Effects of Multiple Infusion of Pyridoxalated‐Hemoglobin‐Polyoxyethylene Conjugate (PHP) Solution in Dogs. Artificial Organs 17:3, pages 153-163.
Crossref
Kwang Nho, Samuel Zalipsky, Abraham Abuchowski & Frank F. Davis. 1992. Poly(Ethylene Glycol) Chemistry. Poly(Ethylene Glycol) Chemistry 171 182 .
Mary L. Nucci, Robert Shorr & Abraham Abuchowski. (1991) The therapeutic value of poly(ethylene glycol)-modified proteins. Advanced Drug Delivery Reviews 6:2, pages 133-151.
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A. Yabuki, K. Yamaji, H. Ohki & Y. Iwashita. (2003) Characterization of a pyridoxalated hemoglobin‐polyoxyethylene conjugate as a physiologic oxygen carrier. Transfusion 30:6, pages 516-520.
Crossref
P.S. MalcheskyT. TakahashiK. IwasakiH. HarasakiY. Nosé. (2018) Conjugated Human Hemoglobin as a Physiological Oxygen Carrier - Pyridoxalated Hemoglobin Polyoxyethylene Conjugate (PHP). The International Journal of Artificial Organs 13:7, pages 442-450.
Crossref
Thomas M.S. Chang. (1989) The Use of Modified Hemoglobin as an Oxygen Carrying Blood Substitute. Transfusion Medicine Reviews 3:3, pages 213-218.
Crossref

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