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Original Article

Nephrotoxicity of Hemoglobin Solutions

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Pages 233-249 | Published online: 11 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (11)

Sven Hungerer, Dirk Nolte, Andreas Botzlar & Konrad Messmer. (2006) Effects of Diaspirin Crosslinked Hemoglobin (DCLHb) on Microcirculation and Local Tissue PO2 of Striated Skin Muscle Following Resuscitation from Hemorrhagic Shock. Artificial Cells, Blood Substitutes, and Biotechnology 34:5, pages 455-471.
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Kwok L. Shum, Albert León, Anna T. Viau, Denis Pilon, Mary Nucci & Robert G. L. Shorr. (1996) The Physiological and Histopathological Response of Dogs to Exchange Transfusion with Polyethylene Glycol-Modified Bovine Hemoglobin (PEG-Hb). Artificial Cells, Blood Substitutes, and Biotechnology 24:6, pages 655-683.
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J. Amend, C. Ou, C. Ryan-Macfariane, P. J. Anderson, N. Amend & G. P. Biro. (1996) Systemic Responses to Sfhs-Infusion in Hemorrhaged Dogs. Artificial Cells, Blood Substitutes, and Biotechnology 24:1, pages 19-34.
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Janos Szebeni, Nabila M. Wassef, Alan S. Rudolph & Carl R. Alving. (1995) Complement Activation by Liposome-Encapsulated Hemoglobin In Vitro: The Role of Endotoxin Contamination. Artificial Cells, Blood Substitutes, and Biotechnology 23:3, pages 355-363.
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Richard M. Millis, Joan D. Barber, Winston A. Anderson & Ozra Dehkordi. (1995) Effects of a Stroma-Free Hemoglobin and Perfluorochemical Combination on Ultrastructure and Function of the Isolated Rat Kidney. Renal Failure 17:6, pages 675-687.
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Thomas F. Zuck, Jean G. Riess & G. P. Biro. (1994) Current Status of Injectable Oxygen Carriers. Critical Reviews in Clinical Laboratory Sciences 31:4, pages 295-324.
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Richard M. Millis, Joan D. Barber, Winston A. Anderson, Ozra Dehkordi, Rose-Marie Toussaint & Levent Ertugrul. (1994) Acute Beneficial Effect of Fluosol-DA on Urinary Excretion of Stroma-Free Hemoglobin in the Isolated Rat Kidney. Renal Failure 16:3, pages 325-335.
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G. P. Biro, N. Jing & P. J. Anderson. (1992) Studies on Blood Substitutes Based on Hemoglobin and Perfluorocarbon. Biomaterials, Artificial Cells and Immobilization Biotechnology 20:2-4, pages 1013-1020.
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Jing Ning, Linda MN Peterson, Peter J Anderson & George P Biro. (1992) Systemic Hemodynamic and Renal Effects of Unmodified Human Sfhs in Dogs. Biomaterials, Artificial Cells and Immobilization Biotechnology 20:2-4, pages 723-727.
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Kenneth E. Burhop, L. Fan-Ell, C. Nigro, D. Tan & T. Estep. (1992) Effects of Intravenous Infusions of Diaspirin Cross-Linked Hemoglobin (Dclhb) on Sheep. Biomaterials, Artificial Cells and Immobilization Biotechnology 20:2-4, pages 581-585.
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Jing Ning, Peter J Anderson & George P Biro. (1992) Resuscitation of Bled Dogs with Fyridoxalated-Folymerized Hemoglobin Solution. Biomaterials, Artificial Cells and Immobilization Biotechnology 20:2-4, pages 525-530.
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Jan Simoni. 2022. Blood Substitutes and Oxygen Biotherapeutics. Blood Substitutes and Oxygen Biotherapeutics 227 234 .
Chris E. Cooper, Matthew Bird, XiaoBo Sheng, Ji-Won Choi, Gary G.A. Silkstone, Michelle Simons, Natalie Syrett, Riccardo Piano, Luca Ronda, Stefano Bettati, Gianluca Paredi, Andrea Mozzarelli & Brandon J. Reeder. (2021) Stability of Maleimide-PEG and Mono-Sulfone-PEG Conjugation to a Novel Engineered Cysteine in the Human Hemoglobin Alpha Subunit. Frontiers in Chemistry 9.
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Chris E. Cooper, Gary G. A. Silkstone, Michelle Simons, Svetlana Gretton, Badri S. Rajagopal, Victoria Allen-Baume, Natalie Syrett, Thoufieq Shaik, Gina Popa, XiaoBo Sheng, Matthew Bird, Ji-Won Choi, Riccardo Piano, Luca Ronda, Stefano Bettati, Gianluca Paredi, Andrea Mozzarelli & Brandon J. Reeder. (2020) Engineering hemoglobin to enable homogenous PEGylation without modifying protein functionality. Biomaterials Science 8:14, pages 3896-3906.
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Bin Li, Yanxin Qi, ShaSha He, Yupeng Wang, Zhigang Xie, Xiabin Jing & Yubin Huang. (2014) Asymmetric copolymer vesicles to serve as a hemoglobin vector for ischemia therapy. Biomaterials Science 2:9, pages 1254.
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Christopher Cebra. 2014. Llama and Alpaca Care. Llama and Alpaca Care 464 476 .
Antoine G. Schneider, Rinaldo Bellomo, Michael Reade, Leah Peck, Helen Young, Glenn M. Eastwood, Mercedes Garcia, Elizabeth Moore & Nerina Harley. (2013) Safety evaluation of a trial of lipocalin-directed sodium bicarbonate infusion for renal protection in at-risk critically ill patients. Critical Care and Resuscitation 15:2, pages 126-133.
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Michael Haase, Rinaldo Bellomo & Anja Haase-Fielitz. (2010) Novel Biomarkers, Oxidative Stress, and the Role of Labile Iron Toxicity in Cardiopulmonary Bypass-Associated Acute Kidney Injury. Journal of the American College of Cardiology 55:19, pages 2024-2033.
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Róbert Huszánk, György Lendvay & Ottó Horváth. (2007) Air-stable, heme-like water-soluble iron(II) porphyrin: in situ preparation and characterization. JBIC Journal of Biological Inorganic Chemistry 12:5, pages 681-690.
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ZHONG QIAN, PETER KVAMME, DINA RAGHED, MANUEL MAYNAR, JOHN HAMIDE, WILLIAM D. SCHEER, CARMEN ESPINOZA, BEATRIZ LOSCERTALES & WILFRIDO R. CASTAÑEDA. (2002) Comparison of a New Recirculation Thrombectomy Catheter With Other Devices of the Same Type. Investigative Radiology 37:9, pages 503-511.
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Jean G. Riess. (2001) Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some Physiology Blut ist ein ganz besondrer Saft . Chemical Reviews 101:9, pages 2797-2920.
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Xavier M. Mueller, Hendrik T. Tevaearai, David Jegger, Iker Mallabiabarrena, Jean Patrice Gardaz & Ludwig K. von Segesser. (2000) Hemoglobin Substitute and Cardiopulmonary Bypass. ASAIO Journal 46:4, pages 403-408.
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B. M. Stubenitsky, M. H. Booster, A. P. Nederstigt, J. K. Kievit, R. W. A. Jacobs & G. Kootstra. (1999) Kidney preservation in the next millenium. Transplant International 12:2, pages 83-91.
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Gladys L.G. Alonsozana, Mahmoud D. Elfath, Colin Mackenzie, Linda C. Gregory, Show Hong Duh, Benjamin Trump & Robert H. Christenson. (1997) In vitro interference of the red cell substitute pyridoxalated hemoglobin-polyoxyethylene with blood compatibility, coagulation, and clinical chemistry testing. Journal of Cardiothoracic and Vascular Anesthesia 11:7, pages 845-850.
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Charles D. Conover, Rita Linberg, Carl W. Gilbert, Kwok L. Shum & Robert G.L. Shorr. (2008) Effect of Polyethylene Glycol Conjugated Bovine Hemoglobin in Both Top‐Load and Exchange Transfusion Rat Models. Artificial Organs 21:10, pages 1066-1075.
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Charles D. Conover, Carl W. Gilbert, Kwok L. Shurn & Robert G.L. Shorr. (2008) The Impact of Polyethylene Glycol Conjugation on Bovine Hemoglobin's Circulatory Half‐Life and Renal Effects in a Rabbit Top‐Loaded Transfusion Model. Artificial Organs 21:8, pages 907-915.
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Jack Levin, Robert I. Roth, Wieslaw Kaca, Minora Yoshida & Donghui Su. 1996. Blood Substitutes. Blood Substitutes 185 202 .
Juraj Sprung, Colin F. Mackenzie, George M. Barnas, John E. Williams, Michael Parr, Robert H. Christenson, Brian H. Hoff, Ronald Sakamoto, Andrew Kramer & Mark Lottes. (1995) Oxygen transport and cardiovascular effects of resuscitation from severe hemorrhagic shock using hemoglobin solutions. Critical Care Medicine 23:9, pages 1540-1553.
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Wieslaw Kaca & Robert Roth. (1995) Activation of complement by human hemoglobin and by mixtures of hemoglobin and bacterial endotoxin. Biochimica et Biophysica Acta (BBA) - General Subjects 1245:1, pages 49-56.
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J.G. Riess. (1995) Perspectives d'utilisation de transporteurs d'oxygène comme substituts des érythrocytes en chirurgie. Annales Françaises d'Anesthésie et de Réanimation 14, pages 107-117.
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M P BowesK E BurhopJ A Zivin. (1994) Diaspirin cross-linked hemoglobin improves neurological outcome following reversible but not irreversible CNS ischemia in rabbits.. Stroke 25:11, pages 2253-2257.
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Kunihiko Nakai, Noriko Matsuda, Toshio Ohta, Miyuki Amano, Tsuneo A. Takahashi, Ichiro Sakuma, Akira Kitabatake, Shigeo Ito, Yoshikazu Nakazato & Sadayoshi Sekiguchi. (2008) Lysophosphatidylcholine, a Component of Stromal Phospholipids, as a Candidate Vasoconstrictive Factor in Stroma‐Free Hemoglobin. Artificial Organs 18:3, pages 198-205.
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Richard K. Spence, Aurel C. Cernaianu, Jeffrey Carson & Anthony J. DelRossi. (1993) Transfusion and surgery. Current Problems in Surgery 30:12, pages 1112-1180.
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P. Lestavel. (1992) I Substituts du sang: transporteurs artificiels d'oxygène. Réanimation Urgences 1:6, pages 927-946.
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Richard A. Bauman, Robert J. Przybelski & Marilyn J. Bounds. (1991) The effects of α-α cross-linked hemoglobin on the feeding and locomotor activity of rats. Physiology & Behavior 50:1, pages 205-211.
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